NO992503D0 - Guanidinylamino heterocykelforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister - Google Patents
Guanidinylamino heterocykelforbindelser nyttige som <alfa>-2 adrenerge reseptoragonisterInfo
- Publication number
- NO992503D0 NO992503D0 NO992503A NO992503A NO992503D0 NO 992503 D0 NO992503 D0 NO 992503D0 NO 992503 A NO992503 A NO 992503A NO 992503 A NO992503 A NO 992503A NO 992503 D0 NO992503 D0 NO 992503D0
- Authority
- NO
- Norway
- Prior art keywords
- guanidinylamino
- alfa
- receptor agonists
- adrenergic receptor
- compounds useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3183396P | 1996-11-25 | 1996-11-25 | |
| PCT/US1997/020550 WO1998023591A1 (en) | 1996-11-25 | 1997-11-21 | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO992503D0 true NO992503D0 (no) | 1999-05-25 |
| NO992503L NO992503L (no) | 1999-07-23 |
| NO313286B1 NO313286B1 (no) | 2002-09-09 |
Family
ID=21861650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19992503A NO313286B1 (no) | 1996-11-25 | 1999-05-25 | Guanidinylamino heterocykelforbindelser nyttige som alfa-2 adrenerge reseptoragonister |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0944601B1 (no) |
| JP (1) | JP2001504839A (no) |
| KR (1) | KR20000069130A (no) |
| CN (1) | CN1163486C (no) |
| AR (1) | AR009144A1 (no) |
| AT (1) | ATE232518T1 (no) |
| AU (1) | AU729421B2 (no) |
| BR (1) | BR9714362A (no) |
| CA (1) | CA2272098C (no) |
| CZ (1) | CZ183799A3 (no) |
| DE (1) | DE69719068T2 (no) |
| DK (1) | DK0944601T3 (no) |
| ES (1) | ES2192703T3 (no) |
| HU (1) | HUP0000479A3 (no) |
| ID (1) | ID23038A (no) |
| IL (1) | IL130023A0 (no) |
| NO (1) | NO313286B1 (no) |
| NZ (1) | NZ335859A (no) |
| PE (1) | PE16499A1 (no) |
| SK (1) | SK68599A3 (no) |
| TR (1) | TR199901467T2 (no) |
| WO (1) | WO1998023591A1 (no) |
| ZA (1) | ZA9710575B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306877B1 (en) | 1999-08-09 | 2001-10-23 | The Procter & Gamble Co. | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists |
| US6172095B1 (en) | 1996-11-25 | 2001-01-09 | The Procter & Gamble Company | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists |
| NL1009376C1 (nl) * | 1998-06-11 | 1998-07-06 | Boardwalk Ag | Datasysteem voor het verschaffen van relatiepatronen tussen personen. |
| US6294553B1 (en) * | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5576437A (en) * | 1993-12-17 | 1996-11-19 | The Procter & Gamble Company | 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists |
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
-
1997
- 1997-11-21 ES ES97949399T patent/ES2192703T3/es not_active Expired - Lifetime
- 1997-11-21 IL IL13002397A patent/IL130023A0/xx unknown
- 1997-11-21 BR BR9714362A patent/BR9714362A/pt not_active IP Right Cessation
- 1997-11-21 EP EP97949399A patent/EP0944601B1/en not_active Expired - Lifetime
- 1997-11-21 ID IDW990404D patent/ID23038A/id unknown
- 1997-11-21 JP JP52468598A patent/JP2001504839A/ja active Pending
- 1997-11-21 KR KR1019997004618A patent/KR20000069130A/ko active Search and Examination
- 1997-11-21 AT AT97949399T patent/ATE232518T1/de not_active IP Right Cessation
- 1997-11-21 DE DE69719068T patent/DE69719068T2/de not_active Expired - Fee Related
- 1997-11-21 AU AU74025/98A patent/AU729421B2/en not_active Ceased
- 1997-11-21 WO PCT/US1997/020550 patent/WO1998023591A1/en not_active Application Discontinuation
- 1997-11-21 CA CA002272098A patent/CA2272098C/en not_active Expired - Fee Related
- 1997-11-21 NZ NZ335859A patent/NZ335859A/xx unknown
- 1997-11-21 TR TR1999/01467T patent/TR199901467T2/xx unknown
- 1997-11-21 CZ CZ991837A patent/CZ183799A3/cs unknown
- 1997-11-21 SK SK685-99A patent/SK68599A3/sk unknown
- 1997-11-21 CN CNB971810753A patent/CN1163486C/zh not_active Expired - Fee Related
- 1997-11-21 HU HU0000479A patent/HUP0000479A3/hu unknown
- 1997-11-21 DK DK97949399T patent/DK0944601T3/da active
- 1997-11-25 PE PE1997001066A patent/PE16499A1/es not_active Application Discontinuation
- 1997-11-25 ZA ZA9710575A patent/ZA9710575B/xx unknown
- 1997-11-25 AR ARP970105528A patent/AR009144A1/es unknown
-
1999
- 1999-05-25 NO NO19992503A patent/NO313286B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU729421B2 (en) | 2001-02-01 |
| DK0944601T3 (da) | 2003-06-10 |
| NO992503L (no) | 1999-07-23 |
| CN1163486C (zh) | 2004-08-25 |
| CN1242001A (zh) | 2000-01-19 |
| CZ183799A3 (cs) | 1999-09-15 |
| EP0944601A1 (en) | 1999-09-29 |
| NZ335859A (en) | 2000-11-24 |
| BR9714362A (pt) | 2000-03-21 |
| PE16499A1 (es) | 1999-03-12 |
| CA2272098A1 (en) | 1998-06-04 |
| DE69719068D1 (de) | 2003-03-20 |
| KR20000069130A (ko) | 2000-11-25 |
| ATE232518T1 (de) | 2003-02-15 |
| TR199901467T2 (xx) | 1999-10-21 |
| AU7402598A (en) | 1998-06-22 |
| HUP0000479A3 (en) | 2002-06-28 |
| SK68599A3 (en) | 2000-06-12 |
| ID23038A (id) | 2000-01-06 |
| ES2192703T3 (es) | 2003-10-16 |
| EP0944601B1 (en) | 2003-02-12 |
| JP2001504839A (ja) | 2001-04-10 |
| ZA9710575B (en) | 1998-06-10 |
| DE69719068T2 (de) | 2003-11-27 |
| NO313286B1 (no) | 2002-09-09 |
| AR009144A1 (es) | 2000-03-08 |
| HUP0000479A2 (hu) | 2000-09-28 |
| CA2272098C (en) | 2003-11-11 |
| IL130023A0 (en) | 2000-02-29 |
| WO1998023591A1 (en) | 1998-06-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20010603D0 (no) | 2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister | |
| NO992470L (no) | 2-amidazolinyl-amino-indolforbindelser anvendelige som <alfa>-2-adreno-reseptoragonister | |
| HK1041486A1 (zh) | 作為前列腺素e2激動劑或拮抗劑的噁唑化合物 | |
| NO20001141D0 (no) | Aromatisk C16-C20-substituert tetrahydro-prostaglandiner anvendbare som FP-agonister | |
| NO20001142L (no) | Aromatisk C16-C20-substituert tetrahydro-prostaglandiner anvendbare som FP-agonister | |
| NO20001139L (no) | Aromatisk C16-C20-substituert tetrahydro-prostaglandiner anvendbare som FP-agonister | |
| TR970073A2 (tr) | Alfa adrenerjik resentör antagonistleri olarak pirimidindion pirimidintrion,triazindion, tetrahidrokinazolindion türevleri. | |
| FI970328A (fi) | Heterosykliset yhdisteet, jotka ovat käyttökelpoisia allosteerisinä effektoreina muskariinireseptoreissa | |
| NO992498D0 (no) | Guanidinylheterocykelforbindelser anvendelige som <alfa>-2 adrenoceptoragonister | |
| BR9711970A (pt) | Derivados 6,5-substitu¡do-heterobic¡clicos | |
| DK0975623T3 (da) | Indazolamidforbindelser som sertoninerge midler | |
| NL1009835A1 (nl) | Vloeibaar-kristallijne verbindingen. | |
| NO983594D0 (no) | Heterosykliske tioetere som additiver for smöremidler | |
| NO20012526L (no) | Sammensetninger som innbefatter cefuroksimaksetil | |
| NO992500L (no) | 2-imidazolinylaminobenzoksazolforbindelser anvendelige som <alfa>-2 adrenoceptoragonister | |
| NO20013013D0 (no) | <alfa>v<beta>6-integrininhibitorer | |
| NO994106L (no) | Oksazolidiner som 5-HT2A-antagonister | |
| NO992503L (no) | Guanidinylamino heterocykelforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister | |
| NO20011270D0 (no) | Tricykliske <delta>3-piperidiner som <alfa>2-antagonister | |
| NO992502D0 (no) | 2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister | |
| NO995030D0 (no) | 5-(2-imidazolinylamino)benzimidazolforbindelser nyttige som <alfa>-2-adrenoseptoragonister | |
| DK1073651T3 (da) | Indolylderivater som serotonerge midler | |
| NO20012783L (no) | Benzisoksazoler og fenoner som <alfa>-2-antagonister | |
| NO20010280L (no) | <Alfa>-aminosyrefenylesterderivater | |
| ZA987969B (en) | Compounds useful as novel antiatherosclerotic agents. |