NO990850L - Katalytisk nukleinsyre og dens medisinske bruk - Google Patents

Katalytisk nukleinsyre og dens medisinske bruk

Info

Publication number
NO990850L
NO990850L NO990850A NO990850A NO990850L NO 990850 L NO990850 L NO 990850L NO 990850 A NO990850 A NO 990850A NO 990850 A NO990850 A NO 990850A NO 990850 L NO990850 L NO 990850L
Authority
NO
Norway
Prior art keywords
nucleic acid
molecules
medical use
catalytic nucleic
factor
Prior art date
Application number
NO990850A
Other languages
English (en)
Other versions
NO990850D0 (no
Inventor
Nathan Asher
Yaron Tikochinski
Andy Ellington
Original Assignee
Intelligene Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL119135A external-priority patent/IL119135A/en
Priority claimed from IL12046697A external-priority patent/IL120466A0/xx
Application filed by Intelligene Ltd filed Critical Intelligene Ltd
Publication of NO990850D0 publication Critical patent/NO990850D0/no
Publication of NO990850L publication Critical patent/NO990850L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/124—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes based on group I or II introns
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/337—Ribozyme

Abstract

Foreliggende oppfinnelse omfatter nukleinsyremolekyler, eller kompleks av molekyler, som ikke har katalytisk aktivitet i fravær av en spesifikk kofaktor og utviser katalytisk aktivitet bare ved tilstedeværelse av en spesifikk kofaktor. Foreliggende oppfinnelse omfatter ytterligere metoder for produksjon av nevnte molekyler, eller kompleks av molekyler, spesielt ved å utnytte in v/rro-evolusjon, såvel som deres bruk i diagnostikk og terapi.
NO990850A 1996-08-26 1999-02-23 Katalytisk nukleinsyre og dens medisinske bruk NO990850L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL119135A IL119135A (en) 1996-08-26 1996-08-26 Catalytic nucleic acid molecules
IL12046697A IL120466A0 (en) 1997-03-17 1997-03-17 In vitro evolution of oligonucleotides
PCT/IL1997/000282 WO1998008974A2 (en) 1996-08-26 1997-08-26 Catalytic nucleic acid and its medical use

Publications (2)

Publication Number Publication Date
NO990850D0 NO990850D0 (no) 1999-02-23
NO990850L true NO990850L (no) 1999-04-23

Family

ID=26323298

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990850A NO990850L (no) 1996-08-26 1999-02-23 Katalytisk nukleinsyre og dens medisinske bruk

Country Status (11)

Country Link
US (1) US6387617B1 (no)
EP (2) EP1350854B1 (no)
JP (1) JP2000517181A (no)
CN (1) CN1232509A (no)
AT (2) ATE253128T1 (no)
AU (1) AU717736B2 (no)
CA (1) CA2264246A1 (no)
DE (2) DE69725861T2 (no)
NO (1) NO990850L (no)
NZ (1) NZ334492A (no)
WO (1) WO1998008974A2 (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU724627B2 (en) 1996-12-19 2000-09-28 Yale University Bioreactive allosteric polynucleotides
IL120714A0 (en) * 1997-04-21 1997-08-14 Intelligene Ltd Continuous in vitro evolution of oligonucleotides
AU756301B2 (en) * 1997-08-20 2003-01-09 Somagenics, Inc. Antisense and antigene therapeutics with improved binding properties and methods for their use
IL126732A0 (en) * 1998-10-23 1999-08-17 Intelligene Ltd Pro drug
IL126731A0 (en) * 1998-10-23 1999-08-17 Intelligene Ltd A method of detection
WO2000024912A1 (en) * 1998-10-23 2000-05-04 The Children's Medical Center Corporation Use of a self-cleaving rna motif to modulate gene expression
IL130606A0 (en) * 1999-06-23 2000-06-01 Intelligene Ltd An array of nucleic acid sequence
US6506887B1 (en) 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
IL132710A0 (en) * 1999-11-02 2001-03-19 Intelligene Ltd Catalytic nucleic acid sequences
MXPA02008470A (es) * 2000-03-01 2002-12-13 Amgen Inc Identificacion y uso de efectores y moleculas alostericas para la alteracion de la expresion de genes.
US20030104520A1 (en) * 2000-06-15 2003-06-05 Ellington Andrew D. Regulatable, catalytically active nucleic acids
AU2001266917A1 (en) * 2000-06-15 2001-12-24 Board Of Regents Allosterically regulated ribozymes
US6706474B1 (en) * 2000-06-27 2004-03-16 Board Of Trustees Of The University Of Illinois Nucleic acid enzyme biosensors for ions
US7125660B2 (en) 2000-09-13 2006-10-24 Archemix Corp. Nucleic acid sensor molecules and methods of using same
US20030219422A1 (en) * 2001-11-15 2003-11-27 Noxxon Pharma Ag Allosteric ribozymes and uses thereof
US6890719B2 (en) * 2002-05-10 2005-05-10 The Board Of Trustess Of The University Of Illinois Fluorescence based biosensor
US20040110235A1 (en) 2002-07-25 2004-06-10 David Epstein Regulated aptamer therapeutics
US8039443B2 (en) 2002-11-21 2011-10-18 Archemix Corporation Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US10100316B2 (en) 2002-11-21 2018-10-16 Archemix Llc Aptamers comprising CPG motifs
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
AU2003296945A1 (en) * 2002-12-12 2004-07-09 Chiron Corporation Device and method for in-line blood testing using biochips
US7892734B2 (en) * 2005-08-11 2011-02-22 The Board Of Trustees Of The University Of Illinois Aptamer based colorimetric sensor systems
US7799554B2 (en) * 2006-03-16 2010-09-21 The Board Of Trustees Of The University Of Illinois Lateral flow devices
WO2008089248A2 (en) * 2007-01-19 2008-07-24 The Board Of Trustees Of The University Of Illinois Amphiphilic substances and triggered liberation from lipid vesicles
US20080207885A1 (en) * 2007-02-23 2008-08-28 Silverman Scott K Method for site-specific labeling of RNA using a deoxyribozyme
US8058415B2 (en) * 2007-04-24 2011-11-15 The Board Of Trustees Of The University Of Illinois Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes
US8409800B2 (en) * 2007-07-16 2013-04-02 The Board Of Trustees Of The University Of Illinois Nucleic acid based fluorescent sensor for copper detection
US8568690B2 (en) * 2007-07-31 2013-10-29 The Board Of Trustees Of The University Of Illinois MRI contrast agents and high-throughput screening by MRI
WO2009045632A2 (en) 2007-08-10 2009-04-09 The Board Of Trustees Of The University Of Illinois Nucleic acid based fluorescent sensor for mercury detection
US20100105039A1 (en) * 2008-06-03 2010-04-29 Yi Lu Label-free colorimetric detection
US8062893B2 (en) 2008-10-10 2011-11-22 The Board Of Trustees Of The University Of Illinois Fluorescent sensor for mercury
US20100305197A1 (en) * 2009-02-05 2010-12-02 Massachusetts Institute Of Technology Conditionally Active Ribozymes And Uses Thereof
US8815156B2 (en) 2010-07-19 2014-08-26 Andalyze, Inc. Sensor housing and reagent chemistry
US20150240238A1 (en) * 2011-11-17 2015-08-27 The Regents Of The University Of California Therapeutic rna switches compositions and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3276955B2 (ja) 1988-09-30 2002-04-22 ジーン−トラック・システムス Ｒｎａの鋳型の末端に結合したプローブ構造およびその使用方法
JP3595841B2 (ja) * 1992-12-04 2004-12-02 サーナ セラピューティクス，インコーポレイテッド リボザイム増幅診断用薬
JPH08507203A (ja) 1992-12-04 1996-08-06 イノーバー ラボラトリーズ，インコーポレイテッド 調節可能な核酸治療およびそれらの使用方法
US5807718A (en) * 1994-12-02 1998-09-15 The Scripps Research Institute Enzymatic DNA molecules
JP3256972B2 (ja) 1995-02-03 2002-02-18 株式会社デンソー 燃料供給装置
WO1996027026A1 (en) * 1995-02-27 1996-09-06 Intelligene Ltd. Detection of biomolecules

Also Published As

Publication number Publication date
CN1232509A (zh) 1999-10-20
EP1350854A1 (en) 2003-10-08
JP2000517181A (ja) 2000-12-26
CA2264246A1 (en) 1998-03-05
NZ334492A (en) 2000-09-29
AU3862097A (en) 1998-03-19
DE69735684D1 (de) 2006-05-24
WO1998008974A3 (en) 1998-07-02
EP0922114B1 (en) 2003-10-29
EP0922114A2 (en) 1999-06-16
WO1998008974A2 (en) 1998-03-05
NO990850D0 (no) 1999-02-23
DE69725861T2 (de) 2004-08-19
US6387617B1 (en) 2002-05-14
ATE323180T1 (de) 2006-04-15
AU717736B2 (en) 2000-03-30
ATE253128T1 (de) 2003-11-15
DE69735684T2 (de) 2007-04-05
EP1350854B1 (en) 2006-04-12
DE69725861D1 (de) 2003-12-04

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