NO985205L - Krystallinsk (-)-3R,4R-trans-7-metoksy-2,2-dimetyl-3-fenyl-4-{4-[2-(pyrrolidin-1-yl)etoksyl]fenyl}kroman-hydrogenfumarat - Google Patents

Krystallinsk (-)-3R,4R-trans-7-metoksy-2,2-dimetyl-3-fenyl-4-{4-[2-(pyrrolidin-1-yl)etoksyl]fenyl}kroman-hydrogenfumarat

Info

Publication number
NO985205L
NO985205L NO985205A NO985205A NO985205L NO 985205 L NO985205 L NO 985205L NO 985205 A NO985205 A NO 985205A NO 985205 A NO985205 A NO 985205A NO 985205 L NO985205 L NO 985205L
Authority
NO
Norway
Prior art keywords
phenyl
pyrrolidin
trans
methoxy
dimethyl
Prior art date
Application number
NO985205A
Other languages
English (en)
Other versions
NO985205D0 (no
Inventor
Svend Treppendahl
Klaus Snej Jensen
Scott E Mcgraw
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO985205D0 publication Critical patent/NO985205D0/no
Publication of NO985205L publication Critical patent/NO985205L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse til- veiebringer nytt, krystallinsk (-)-3R,4R-trans-7-metoksy-2,2-dimetyl- 3-fenyl-4-{4-[2-(pyrrolidin-l-yl)- etoksy]fenyl}kroman-hydrogenfumarat som kan anvendes til reduksjon eller forhindring av bentap, samt far- masøytiske preparater som inneholder dette. En fremgangsmåte for fremstil- ling av (-)-3R,4R-trans-7-metoksy-2,2- dimetyl-3-fenyl-4-{4-[2-(pyrrolidin-l- yl)etoksy]fenyl}kroman-hydrogenfumarat er beskrevet.
NO985205A 1996-05-08 1998-11-06 Krystallinsk (-)-3R,4R-trans-7-metoksy-2,2-dimetyl-3-fenyl-4-{4-[2-(pyrrolidin-1-yl)etoksyl]fenyl}kroman-hydrogenfumarat NO985205L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK55296 1996-05-08
PCT/DK1997/000211 WO1997042184A1 (en) 1996-05-08 1997-05-07 Crystalline (-)-3r,4r-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen fumarate

Publications (2)

Publication Number Publication Date
NO985205D0 NO985205D0 (no) 1998-11-06
NO985205L true NO985205L (no) 1998-11-06

Family

ID=8094838

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985205A NO985205L (no) 1996-05-08 1998-11-06 Krystallinsk (-)-3R,4R-trans-7-metoksy-2,2-dimetyl-3-fenyl-4-{4-[2-(pyrrolidin-1-yl)etoksyl]fenyl}kroman-hydrogenfumarat

Country Status (17)

Country Link
EP (1) EP0912543B1 (no)
JP (1) JP2951410B2 (no)
KR (1) KR20000010644A (no)
CN (1) CN1218462A (no)
AT (1) ATE262516T1 (no)
AU (1) AU710334B2 (no)
BR (1) BR9709060A (no)
CA (1) CA2253284A1 (no)
CZ (1) CZ359898A3 (no)
DE (1) DE69728271D1 (no)
HU (1) HUP9901738A3 (no)
IL (1) IL126345A (no)
NO (1) NO985205L (no)
PL (1) PL329624A1 (no)
RU (1) RU2182149C2 (no)
WO (1) WO1997042184A1 (no)
ZA (1) ZA973961B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104166678B (zh) * 2014-07-09 2018-04-10 苏州市职业大学 一种面向汉语微博的多种潜在属性整体挖掘系统及方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5280040A (en) * 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease

Also Published As

Publication number Publication date
CA2253284A1 (en) 1997-11-13
IL126345A (en) 2001-07-24
RU2182149C2 (ru) 2002-05-10
EP0912543A1 (en) 1999-05-06
WO1997042184A1 (en) 1997-11-13
AU2763897A (en) 1997-11-26
ZA973961B (en) 1997-12-04
NO985205D0 (no) 1998-11-06
HUP9901738A2 (en) 2000-07-28
CZ359898A3 (cs) 1999-05-12
PL329624A1 (en) 1999-03-29
IL126345A0 (en) 1999-05-09
DE69728271D1 (en) 2004-04-29
JP2951410B2 (ja) 1999-09-20
AU710334B2 (en) 1999-09-16
KR20000010644A (ko) 2000-02-25
BR9709060A (pt) 1999-08-03
HUP9901738A3 (en) 2000-12-28
CN1218462A (zh) 1999-06-02
EP0912543B1 (en) 2004-03-24
JPH11501953A (ja) 1999-02-16
ATE262516T1 (de) 2004-04-15

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