NO984356L - FremgangsmÕte og apparat for pr°ving og analyse av immunofluorescent materiale - Google Patents

FremgangsmÕte og apparat for pr°ving og analyse av immunofluorescent materiale

Info

Publication number
NO984356L
NO984356L NO984356A NO984356A NO984356L NO 984356 L NO984356 L NO 984356L NO 984356 A NO984356 A NO 984356A NO 984356 A NO984356 A NO 984356A NO 984356 L NO984356 L NO 984356L
Authority
NO
Norway
Prior art keywords
analyte
molecules
high concentration
interest
interface
Prior art date
Application number
NO984356A
Other languages
English (en)
Other versions
NO984356D0 (no
Inventor
James N Herron
Douglas A Christensen
Scott D Miles
Original Assignee
Univ Utah Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found filed Critical Univ Utah Res Found
Publication of NO984356D0 publication Critical patent/NO984356D0/no
Publication of NO984356L publication Critical patent/NO984356L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Apparat (100, 300, 400, 600, 1302) og fremgangsmåte for hurtig analyse av prøver for å undersøke om prøvene inne- holder analytter av interesse, basert på immunfluorescensanalyse av homogent materiale. Apparatet er i form av en kassett med en høykonsentrasjonsdel for referansemåling, en tilsvarende lavkonsen- trasjonsdel, også for referansemåling, og en måledel for undersøkelsene. Disse deler har minst en forhåndsinnlagt reagens i et reagensrom (106), mens lavkonsentrasjons- delen inneholder en kjent lav konsentrasjon av en analytt av interesse, og høykonsentrasjonsdelen en tilsvarende høy konsentrasjon av en tilsvarende analytt. Apparatet omfatter en biosensor med en plan bølgeleder (164) med plane grenseflater (166, 500, 501) og en kant mellom dem. Kanten har et opptaksområde 126 for å motta en innfallende lysstråle (170). Måle- og ref eransedelene har et rom med en bølgelederf late som danner den ene grenseflate ( 500) og hvor analyttens (503) molekyler (510) får kontakt med bindings- molekyler (504) på grenseflaten (500). Bindingsmolekylene er slik at de binder molekylene i bestemte analytter til seg og bringer dem til fluorescens når de bestråles av lys som passerer grense- flaten. Konsentrasjonen av analytten av interesse i prøvefluidet bestemmes ved sammenligning mellom fluorescensintensi- tetene for områdene for de kaptive mole- kyler i rommet, og ved tilsvarende intensitet i de tilsvarende rom i lav- og høykonsentrasjonsdelen med kjente konsentrasjoner.
NO984356A 1996-03-19 1998-09-18 FremgangsmÕte og apparat for pr°ving og analyse av immunofluorescent materiale NO984356L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1471396P 1996-03-19 1996-03-19
PCT/US1997/004378 WO1997035203A1 (en) 1996-03-19 1997-03-19 Oscillation apparatus and methods for multi-analyte homogeneous fluoro-immunoassays

Publications (2)

Publication Number Publication Date
NO984356D0 NO984356D0 (no) 1998-09-18
NO984356L true NO984356L (no) 1998-11-18

Family

ID=21767222

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984356A NO984356L (no) 1996-03-19 1998-09-18 FremgangsmÕte og apparat for pr°ving og analyse av immunofluorescent materiale

Country Status (7)

Country Link
US (1) US6242267B1 (no)
EP (1) EP0888546A1 (no)
JP (1) JP3647470B2 (no)
AU (1) AU2583797A (no)
CA (1) CA2248190A1 (no)
NO (1) NO984356L (no)
WO (1) WO1997035203A1 (no)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052633A1 (en) * 1998-04-14 1999-10-21 Ivd Systems Test cartridge with a single inlet port
US7708945B1 (en) 1999-08-13 2010-05-04 Bayer Technology Services Gmbh Device and method for determining multiple analytes
EP1237654B9 (de) 1999-12-17 2004-07-21 Zeptosens AG Anordnung von probenbehältnissen und deren verwendung zur multianalytbestimmung
US20020132267A1 (en) * 2000-07-21 2002-09-19 Wong Raphael C. Combination drug test and adulterant test device
AU2001289853A1 (en) 2000-09-04 2002-03-22 Zeptosens Ag Multianalyte determination system and methods
US6767733B1 (en) * 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
FI115343B (fi) * 2001-10-22 2005-04-15 Filtronic Lk Oy Sisäinen monikaista-antenni
US6612499B2 (en) * 2002-01-24 2003-09-02 Exabyte Corporation Calibration cartridge for automated cartridge library and method of using same
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
US20040077104A1 (en) * 2002-07-09 2004-04-22 Valentino Montegrande Antigen detection device
US6861251B2 (en) 2003-02-24 2005-03-01 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
EP1616169B1 (en) * 2003-03-27 2009-06-24 Corning Incorporated Label-free evanescent-field detection of biological and chemical agents
US7178978B2 (en) * 2003-09-08 2007-02-20 Boston Scientific Santa Rosa Corp., Fluid mixing apparatus and method
CN103082996A (zh) 2003-10-27 2013-05-08 通用医疗公司 用于使用频域干涉测量法进行光学成像的方法和设备
US20060068490A1 (en) * 2004-03-05 2006-03-30 Cha-Mei Tang Flow-through chemical and biological sensor
US20060148103A1 (en) * 2004-12-30 2006-07-06 Yin-Peng Chen Highly sensitive biological assays
JP2007010341A (ja) * 2005-06-28 2007-01-18 Sumitomo Bakelite Co Ltd 免疫分析方法
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
EP3756767B1 (en) * 2007-10-02 2024-05-01 Labrador Diagnostics LLC Modular point-of-care devices and uses thereof
JP2011501183A (ja) * 2007-10-29 2011-01-06 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 漏れ全反射バイオセンサカートリッジ
JP5442713B2 (ja) * 2008-04-02 2014-03-12 ビバクタ、リミテッド 化学物質検出方法
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US8331751B2 (en) 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
WO2010127001A1 (en) * 2009-04-29 2010-11-04 Plc Diagnostics Inc. Waveguide-based detection system with scanning light source
EP2616797B1 (en) 2010-09-15 2017-01-11 MBIO Diagnostics Inc. System and method for detecting multiple molecules in one assay
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
EP3161121A4 (en) 2014-06-27 2017-12-27 Pulse Health LLC Fluorescence detection assembly
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU604364B2 (en) * 1987-08-13 1990-12-13 Dow Chemical Company, The Sulfur dioxide removal from gas streams using hydroxyalkyl substituted piperazinones
GB8807486D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Waveguide sensor
GB8827853D0 (en) * 1988-11-29 1988-12-29 Ares Serono Res & Dev Ltd Sensor for optical assay
US5156976A (en) * 1991-06-07 1992-10-20 Ciba Corning Diagnostics Corp. Evanescent wave sensor shell and apparatus
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5919712A (en) * 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
ES2169079T3 (es) * 1993-05-18 2002-07-01 Univ Utah Res Found Aparato y metodos para fluoroinmunoensayos homogeneos multianalitos.
US5639428A (en) * 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples

Also Published As

Publication number Publication date
EP0888546A1 (en) 1999-01-07
WO1997035203A1 (en) 1997-09-25
JP3647470B2 (ja) 2005-05-11
US6242267B1 (en) 2001-06-05
NO984356D0 (no) 1998-09-18
JP2000506981A (ja) 2000-06-06
CA2248190A1 (en) 1997-09-25
AU2583797A (en) 1997-10-10

Similar Documents

Publication Publication Date Title
NO984356L (no) FremgangsmÕte og apparat for pr°ving og analyse av immunofluorescent materiale
US5622868A (en) Analytical apparatus utilizing a colorimetric or other optically detectable effect
US6195158B1 (en) Apparatus and method for rapid spectrophotometric pre-test screen of specimen for a blood analyzer
US4125372A (en) Method and device for testing liquids
CA2357732A1 (en) Raman optrode processes and devices for detection of chemicals and microorganisms
MY117022A (en) Visually-readable reagent test strip
DE59914979D1 (de) Verfahren zur photometrischen auswertung von testelementen
DK0731951T3 (da) System og fremgangsmåde til optisk analyse af et emne
BR9812728A (pt) Dispositivo de teste para a identificação de um analito de interesse em uma amostra, e, processos para conduzir um ensaio para identificar um analito de interesse em uma amostra, para conduzir um ensaio imunocromatográfico, e para identificação de um analito de interesse em uma pluralidade de amostras
DK183088D0 (da) Fremgangsmaade til bestemmelse af koncentrationen af en analyt ved hjaelp af to markoerer
ATE461450T1 (de) Verwendung von kontrollflächen zur detektion von störproben in einem nachweisverfahren
ATE249049T1 (de) Verfahren zur bestimmung des prozentualen anteils von glykosiliertem hämoglobin
US20010004285A1 (en) Apparatus and method for rapid spectrophotometric pre-test screen of specimen for a blood analyzer
IE841371L (en) Carrier matrix analytical test device
DK1513878T3 (da) Sammensætninger og fremgangsmåder til analyse af Apo B48 og Apo B100
CA2054702C (en) Analytical apparatus
US10222324B1 (en) Dried blood sample analysis
EP1293780A3 (en) Specific binding analysis method
JP2001004540A (ja) 分析要素における試験層の液体吸収を検査するための方法および装置
JP5057377B2 (ja) 生体成分又はその機能の測定方法及び装置
BR9608331A (pt) Método para análise espectroscópica de amostra inhomogênea
Wang et al. Selective detection of neurotransmitters by fluorescence and chemiluminescence imaging
KR960018583A (ko) 면역 분석법
WO2002014869A3 (en) Assay method and device for detecting the presence and concentration of analytes
FI96365B (fi) Menetelmä ja anturi aineen analysoimiseksi fotometrisesti