NO983332L - Gas bubble suspensions and their use as an ultrasonic contrast agent - Google Patents

Gas bubble suspensions and their use as an ultrasonic contrast agent

Info

Publication number
NO983332L
NO983332L NO983332A NO983332A NO983332L NO 983332 L NO983332 L NO 983332L NO 983332 A NO983332 A NO 983332A NO 983332 A NO983332 A NO 983332A NO 983332 L NO983332 L NO 983332L
Authority
NO
Norway
Prior art keywords
contrast agent
gas bubble
ultrasonic contrast
bubble suspensions
suspensions
Prior art date
Application number
NO983332A
Other languages
Norwegian (no)
Other versions
NO983332D0 (en
Inventor
Martina Bergmann
Dieter Heldmann
Werner Weitschies
Thomas Fritzsch
Violetta Sudmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO983332L publication Critical patent/NO983332L/en
Publication of NO983332D0 publication Critical patent/NO983332D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C08J9/147—Halogen containing compounds containing carbon and halogen atoms only
    • C08J9/148—Halogen containing compounds containing carbon and halogen atoms only perfluorinated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Oppfinnelsen angår porøse matrikser av lavmolekylære substanser for dannelse av stabile gassboblesuspensjoner, deres anvendelse som ultralydkontrastmiddel og fremgangsmåte for fremstilling av matrikser og middel.The invention relates to porous matrices of low molecular weight substances for the formation of stable gas bubble suspensions, their use as ultrasonic contrast agent and to the method of preparation of matrices and agents.

NO983332A 1996-01-18 1998-07-17 Gas bubble suspensions and their use as an ultrasonic contrast agent NO983332D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602930A DE19602930A1 (en) 1996-01-18 1996-01-18 Porous matrices made of low molecular weight substances for the generation of stable gas bubble suspensions, their use as ultrasound contrast agents and processes for their production
PCT/EP1997/000208 WO1997026016A2 (en) 1996-01-18 1997-01-16 Gas bubble suspensions and their application as an ultrasound contrast medium

Publications (2)

Publication Number Publication Date
NO983332L true NO983332L (en) 1998-07-17
NO983332D0 NO983332D0 (en) 1998-07-17

Family

ID=7783852

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983332A NO983332D0 (en) 1996-01-18 1998-07-17 Gas bubble suspensions and their use as an ultrasonic contrast agent

Country Status (8)

Country Link
EP (1) EP0874644A2 (en)
JP (1) JP2000504317A (en)
AU (1) AU1592597A (en)
CA (1) CA2243174A1 (en)
DE (1) DE19602930A1 (en)
NO (1) NO983332D0 (en)
WO (1) WO1997026016A2 (en)
ZA (1) ZA97414B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070123478A1 (en) * 2005-11-28 2007-05-31 Rowe Vernon D Compositions useful for reducing nephrotoxicity and methods of use thereof
JP5196896B2 (en) * 2007-07-13 2013-05-15 花王株式会社 Method for producing fine bubble precursor
JP2010005512A (en) * 2008-06-25 2010-01-14 Kao Corp Microbubble precursor composition
KR101927614B1 (en) 2017-03-30 2018-12-10 숭실대학교산학협력단 Preparing method of contrast agent with stable oxygen-nanobubble or ultrasound imaging
JP7211699B2 (en) * 2017-09-11 2023-01-24 バイエル ファーマ アクチエンゲゼルシャフト Ultrasound contrast agent
US20240226418A1 (en) * 2021-01-26 2024-07-11 Agitated Solutions Inc. Syringe-Based Microbubble Generator

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3141641A1 (en) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
DE3834705A1 (en) * 1988-10-07 1990-04-12 Schering Ag ULTRASONIC CONTRASTING AGENTS FROM GAS BUBBLES AND MICROPARTICLES CONTAINING FATTY ACID
DE3313946A1 (en) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
DE3313947A1 (en) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
DE3709851A1 (en) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te NMR DIAGNOSTIC LIQUID COMPOSITIONS
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
ATE151992T1 (en) * 1991-06-03 1997-05-15 Nycomed Imaging As IMPROVEMENTS REGARDING CONTRAST AGENTS
EP0593627A1 (en) * 1991-07-05 1994-04-27 The University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
AU675050B2 (en) * 1991-07-05 1997-01-23 Nycomed Imaging As Improvements in or relating to contrast agents
RU2114637C1 (en) * 1991-09-17 1998-07-10 Сонус Фармасьютикалз, Инк. Biologically compatible contrast medium and method for producing ultrasonic images
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
EP1550464A1 (en) * 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
PL182223B1 (en) * 1993-12-15 2001-11-30 Bracco Research Sa Usg contrast medium
GB9402867D0 (en) * 1994-02-15 1994-04-06 Nycomed Imaging As Improvements in or relating to contrast agents
DE4406474A1 (en) * 1994-02-23 1995-08-24 Schering Ag Gas-containing microparticles, agents containing them, their use in ultrasound diagnostics, and methods for producing the particles and agents

Also Published As

Publication number Publication date
EP0874644A2 (en) 1998-11-04
WO1997026016A2 (en) 1997-07-24
ZA97414B (en) 1997-07-17
DE19602930A1 (en) 1997-07-24
CA2243174A1 (en) 1997-07-24
WO1997026016A3 (en) 1997-10-23
AU1592597A (en) 1997-08-11
NO983332D0 (en) 1998-07-17
JP2000504317A (en) 2000-04-11

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application