NO981501L - Dimer-selektive RXR modulatorer og fremgangsmÕte for anvendelse derav - Google Patents
Dimer-selektive RXR modulatorer og fremgangsmÕte for anvendelse deravInfo
- Publication number
- NO981501L NO981501L NO981501A NO981501A NO981501L NO 981501 L NO981501 L NO 981501L NO 981501 A NO981501 A NO 981501A NO 981501 A NO981501 A NO 981501A NO 981501 L NO981501 L NO 981501L
- Authority
- NO
- Norway
- Prior art keywords
- dimer
- image
- selective rxr
- rxr
- rxr modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07C233/00—Carboxylic acid amides
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- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
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- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
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- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
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- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
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- C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
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- C07D221/06—Ring systems of three rings
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- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US489795P | 1995-10-06 | 1995-10-06 | |
US988496P | 1996-01-10 | 1996-01-10 | |
US1831896P | 1996-05-24 | 1996-05-24 | |
US2183996P | 1996-07-10 | 1996-07-10 | |
PCT/US1996/014876 WO1997012853A1 (en) | 1995-10-06 | 1996-09-17 | Dimer-selective rxr modulators and methods for their use |
Publications (3)
Publication Number | Publication Date |
---|---|
NO981501D0 NO981501D0 (no) | 1998-04-02 |
NO981501L true NO981501L (no) | 1998-06-02 |
NO313186B1 NO313186B1 (no) | 2002-08-26 |
Family
ID=27485410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19981501A NO313186B1 (no) | 1995-10-06 | 1998-04-02 | Dimer-selektive RXR modulatorer, farmasöytisk preparat omfattende samme og anvendelse derav for fremstilling avmedikament |
Country Status (14)
Country | Link |
---|---|
US (2) | US6545049B1 (no) |
EP (2) | EP1336600A3 (no) |
JP (1) | JP2002515025A (no) |
KR (1) | KR100625255B1 (no) |
AT (1) | ATE236115T1 (no) |
AU (1) | AU726450B2 (no) |
BR (1) | BR9610875A (no) |
CA (1) | CA2233888A1 (no) |
DE (1) | DE69627193T2 (no) |
DK (1) | DK0873295T3 (no) |
ES (1) | ES2190479T3 (no) |
NO (1) | NO313186B1 (no) |
PT (1) | PT873295E (no) |
WO (1) | WO1997012853A1 (no) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7655699B1 (en) | 1992-04-22 | 2010-02-02 | Eisai Inc. | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors |
US7115728B1 (en) | 1995-01-30 | 2006-10-03 | Ligand Pharmaceutical Incorporated | Human peroxisome proliferator activated receptor γ |
WO1997010813A1 (en) | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Ppar gamma antagonists for treating obesity |
EP0859608B1 (en) * | 1995-09-18 | 2004-02-11 | Ligand Pharmaceuticals, Inc. | Treating niddm with rxr agonists |
US6005007A (en) * | 1997-07-18 | 1999-12-21 | Farmer; Luc J. | Retinoids, methods for their production and use |
US7098025B1 (en) * | 1997-07-25 | 2006-08-29 | Ligand Pharmaceuticals Incorporated | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor |
US5998654A (en) * | 1997-07-25 | 1999-12-07 | Ligand Pharmaceuticals Incorporated | Retinoic acid receptor antagonist compounds and methods |
AU749810B2 (en) * | 1997-11-12 | 2002-07-04 | Basilea Pharmaceutica Ag | Treatment of T-helper cell type 2 mediated immune diseases |
JP4204657B2 (ja) | 1997-12-05 | 2009-01-07 | 有限会社ケムフィズ | 糖尿病の予防・治療剤 |
WO1999058486A1 (en) * | 1998-05-11 | 1999-11-18 | Novo Nordisk A/S | New compounds, their preparation and use |
WO1999058487A1 (en) * | 1998-05-11 | 1999-11-18 | Novo Nordisk A/S | New compounds, their preparation and use |
CA2334545A1 (en) | 1998-06-12 | 1999-12-16 | Ligand Pharmaceuticals Incorporated | Treatment of anti-estrogen resistant breast cancer using rxr modulators |
FR2780512B1 (fr) * | 1998-06-25 | 2003-10-17 | Lipha | Utilisation de recepteurs de la famille rev-erb pour le criblage de substances utiles dans le traitement des dysfonctionnements du metabolisme lipidique |
US6403638B1 (en) | 1998-10-01 | 2002-06-11 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
US6048873A (en) * | 1998-10-01 | 2000-04-11 | Allergan Sales, Inc. | Tetrahdroquinolin-2-one 6 or 7-yl, tetrahdroquinilin-2-thione 6 or 7-yl pentadienoic acid and related derivatives having retinoid-like biological activity |
US6147224A (en) * | 1998-10-01 | 2000-11-14 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
AU9556398A (en) * | 1998-11-03 | 2000-05-22 | Ligand Pharmaceuticals Incorporated | Novel retinoids, methods for their production and use |
US6869959B1 (en) | 1999-04-28 | 2005-03-22 | Institute Of Medicinal Molecular Design Inc. | Heterocyclic carboxylic acid derivatives |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
AU6941200A (en) | 1999-08-27 | 2001-03-26 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators |
BR0013597A (pt) | 1999-08-27 | 2002-07-16 | Ligand Pharm Inc | Compostos e métodos moduladores de receptor de androgênio |
AU1291901A (en) * | 1999-09-01 | 2001-03-26 | University Of British Columbia, The | Compositions and methods for modulating hdl cholesterol and triglyceride levels |
PE20010647A1 (es) * | 1999-09-14 | 2001-06-23 | Lilly Co Eli | Moduladores de receptores de retinoide x (rxr) con perfil farmacologico mejorado |
US7026484B2 (en) | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
EP1385549A2 (en) * | 2001-03-12 | 2004-02-04 | Novartis AG | Combination of nateglinide or repaglinide with at least one further antidiabetic compound |
MXPA03008229A (es) * | 2001-03-14 | 2004-11-12 | Lilly Co Eli | Trienos fluorados y su uso como moduladores rxr. |
AU2002319583B2 (en) * | 2001-07-20 | 2005-08-25 | Eli Lilly And Company | (Pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid X receptor modulators |
JP5249484B2 (ja) * | 2001-12-11 | 2013-07-31 | 第一三共株式会社 | 医薬組成物 |
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-
1996
- 1996-09-17 DK DK96935837T patent/DK0873295T3/da active
- 1996-09-17 WO PCT/US1996/014876 patent/WO1997012853A1/en not_active Application Discontinuation
- 1996-09-17 CA CA002233888A patent/CA2233888A1/en not_active Abandoned
- 1996-09-17 EP EP03007532A patent/EP1336600A3/en not_active Withdrawn
- 1996-09-17 JP JP51427597A patent/JP2002515025A/ja not_active Ceased
- 1996-09-17 DE DE69627193T patent/DE69627193T2/de not_active Expired - Fee Related
- 1996-09-17 BR BR9610875A patent/BR9610875A/pt not_active Application Discontinuation
- 1996-09-17 PT PT96935837T patent/PT873295E/pt unknown
- 1996-09-17 KR KR1019980702487A patent/KR100625255B1/ko not_active IP Right Cessation
- 1996-09-17 ES ES96935837T patent/ES2190479T3/es not_active Expired - Lifetime
- 1996-09-17 EP EP96935837A patent/EP0873295B1/en not_active Expired - Lifetime
- 1996-09-17 AT AT96935837T patent/ATE236115T1/de not_active IP Right Cessation
- 1996-09-17 AU AU73624/96A patent/AU726450B2/en not_active Ceased
-
1998
- 1998-04-02 NO NO19981501A patent/NO313186B1/no unknown
-
1999
- 1999-09-02 US US09/388,888 patent/US6545049B1/en not_active Expired - Fee Related
-
2003
- 2003-02-05 US US10/360,580 patent/US20040019072A1/en not_active Abandoned
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EP0873295B1 (en) | 2003-04-02 |
NO313186B1 (no) | 2002-08-26 |
KR19990064010A (ko) | 1999-07-26 |
NO981501D0 (no) | 1998-04-02 |
CA2233888A1 (en) | 1997-04-10 |
ES2190479T3 (es) | 2003-08-01 |
PT873295E (pt) | 2003-08-29 |
BR9610875A (pt) | 1999-07-13 |
EP1336600A2 (en) | 2003-08-20 |
ATE236115T1 (de) | 2003-04-15 |
KR100625255B1 (ko) | 2008-01-30 |
EP0873295A1 (en) | 1998-10-28 |
DK0873295T3 (da) | 2003-07-14 |
US6545049B1 (en) | 2003-04-08 |
AU726450B2 (en) | 2000-11-09 |
EP1336600A3 (en) | 2004-07-07 |
WO1997012853A1 (en) | 1997-04-10 |
JP2002515025A (ja) | 2002-05-21 |
AU7362496A (en) | 1997-04-28 |
DE69627193D1 (de) | 2003-05-08 |
DE69627193T2 (de) | 2004-01-29 |
US20040019072A1 (en) | 2004-01-29 |
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