NO975717L - Dehydroepiandrosteron-derivater for å forhindre progressiv vevsnekrose-reperfusjons-skade, bakteriell translokasjon og voksen respiratorisk lidelse-syndrom - Google Patents
Dehydroepiandrosteron-derivater for å forhindre progressiv vevsnekrose-reperfusjons-skade, bakteriell translokasjon og voksen respiratorisk lidelse-syndromInfo
- Publication number
- NO975717L NO975717L NO975717A NO975717A NO975717L NO 975717 L NO975717 L NO 975717L NO 975717 A NO975717 A NO 975717A NO 975717 A NO975717 A NO 975717A NO 975717 L NO975717 L NO 975717L
- Authority
- NO
- Norway
- Prior art keywords
- injury
- respiratory distress
- distress syndrome
- adult respiratory
- reperfusion injury
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Den foreliggende oppfinnelse relaterer til en metode for å forhindre eller redusere effektene av ischemi. Denne ischemi kan være assosiert med skade eller reperfusjonsskade, slik som oppstår som et resultat av infarkter, varmeskader (brannskade), kirurglsY skade, tilfeldig skade, blødningssjokk og lignende. Oppfinnelsen er også relatert til metoder for å forhindre eller redusere bakteriell translokasjon, voksen respiratorisk lidelsesyndrom, adheranse av blodceller og blodplater til endotelceller og pulmonær hypertensjon. l overensstemmelse med den foreliggende oppfinnelse blir disse tilstander forhindret eller redusert ved tilførsel av dehydroepiandrosteron-3-sulfat (DHEAS) eller en DHEA-lignende forbindelse.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/480,744 US5587369A (en) | 1993-03-09 | 1995-06-07 | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome |
US08/480,748 US5686438A (en) | 1993-03-09 | 1995-06-07 | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome |
US08/480,745 US5635496A (en) | 1993-03-09 | 1995-06-07 | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome |
US08/516,540 US5846963A (en) | 1995-06-07 | 1995-08-18 | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome |
PCT/US1995/010990 WO1996040152A1 (en) | 1995-06-07 | 1995-09-08 | Dehydroepiandrosterone derivatives for preventing progressive tissue necrosis reperfusion injury, bacterial translocation and adult respiratory distress syndrome |
Publications (2)
Publication Number | Publication Date |
---|---|
NO975717D0 NO975717D0 (no) | 1997-12-05 |
NO975717L true NO975717L (no) | 1998-02-04 |
Family
ID=27504245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO975717A NO975717L (no) | 1995-06-07 | 1997-12-05 | Dehydroepiandrosteron-derivater for å forhindre progressiv vevsnekrose-reperfusjons-skade, bakteriell translokasjon og voksen respiratorisk lidelse-syndrom |
Country Status (8)
Country | Link |
---|---|
US (1) | US5846963A (no) |
EP (1) | EP0835113A1 (no) |
JP (1) | JPH11124393A (no) |
AU (1) | AU699749B2 (no) |
CA (1) | CA2223739A1 (no) |
FI (1) | FI974346A (no) |
NO (1) | NO975717L (no) |
WO (1) | WO1996040152A1 (no) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5977095A (en) * | 1993-03-09 | 1999-11-02 | University Of Utah Research Foundation | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and respiratory distress syndrome |
ID24720A (id) * | 1997-12-12 | 2000-08-03 | Novartis Ag | Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis |
US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
US7238711B1 (en) | 1999-03-17 | 2007-07-03 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
WO2001023405A2 (en) | 1999-09-30 | 2001-04-05 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
FR2803750B1 (fr) * | 2000-01-17 | 2004-04-02 | Assist Publ Hopitaux De Paris | Utilisation par voie orale de la dehydroepiandrosterone, de ses precurseurs biologiques et de ses derives metaboliques comme anti-atrophiant |
GB0003524D0 (en) * | 2000-02-15 | 2000-04-05 | Btg Int Ltd | Cytoprotective steroids (II) |
GB2363983A (en) | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 7-hydroxyepiandrosterone |
JP2004537506A (ja) | 2001-03-01 | 2004-12-16 | ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド | 血液細胞欠乏症を治療するためのある種のステロイドの使用 |
GB2378898A (en) * | 2001-08-14 | 2003-02-26 | Hunter Fleming Ltd | Prophylactic and therapeutic use of hydroxysteroids |
EP2298316A1 (en) | 2002-08-28 | 2011-03-23 | Harbor BioSciences, Inc. | Therapeutic treatment methods |
US20040121991A1 (en) * | 2002-12-20 | 2004-06-24 | Araneo Barbara A. | Dehydroepiandrosterone (DHEA) congeners for prevention and/or treatment of ulcers |
US20050026883A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
JP2010511611A (ja) * | 2006-12-01 | 2010-04-15 | シマ ラブス インク. | 口腔経粘膜ニコチン剤形 |
US20090214442A1 (en) * | 2006-12-01 | 2009-08-27 | Cephalon, Inc. | Oral Transmucosal Nicotine Dosage Form |
WO2010107922A1 (en) * | 2009-03-17 | 2010-09-23 | Duke University | Neuroactive steroid compositions and methods of use for lowering cholesterol |
BR112012008352A2 (pt) * | 2009-09-11 | 2016-03-22 | Bionature E A Ltd | uso de compostos esteroides para distúrbios inflamatório e autoimune |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4898694A (en) * | 1987-11-25 | 1990-02-06 | Schwartz Arthur G | 17-Hydroxy-steroids |
US5175154A (en) * | 1987-11-25 | 1992-12-29 | Research Corporation Technologies, Inc. | 5 α-pregnan-20-ones and 5-pregnen-20-ones and related compounds |
US5001119A (en) * | 1987-11-25 | 1991-03-19 | Schwartz Arthur G | 16-substituted androstanes and 16-substituted androstenes |
US5110810A (en) * | 1991-02-08 | 1992-05-05 | Virginia Commonwealth University | Method of using dehydroepiandrosterone and dehydroepiandrosterone-sulfate as inhibitors of platelet aggregation |
US5162198A (en) * | 1991-02-08 | 1992-11-10 | Virginia Commonwealth University | Method of using dehydroepiandrosterone and dehydroepiandrosterone-sulfate as inhibitors of thrombuxane production and platelet aggregation |
HUT72968A (en) * | 1993-03-09 | 1996-06-28 | Univ Utah Res Found | Process for producing pharmaceutical composition which is applicable for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome |
-
1995
- 1995-08-18 US US08/516,540 patent/US5846963A/en not_active Expired - Lifetime
- 1995-09-08 WO PCT/US1995/010990 patent/WO1996040152A1/en not_active Application Discontinuation
- 1995-09-08 AU AU35413/95A patent/AU699749B2/en not_active Ceased
- 1995-09-08 CA CA002223739A patent/CA2223739A1/en not_active Abandoned
- 1995-09-08 JP JP7267607A patent/JPH11124393A/ja active Pending
- 1995-09-08 EP EP95932345A patent/EP0835113A1/en not_active Withdrawn
-
1997
- 1997-11-26 FI FI974346A patent/FI974346A/fi unknown
- 1997-12-05 NO NO975717A patent/NO975717L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU699749B2 (en) | 1998-12-10 |
US5846963A (en) | 1998-12-08 |
AU3541395A (en) | 1996-12-30 |
WO1996040152A1 (en) | 1996-12-19 |
EP0835113A1 (en) | 1998-04-15 |
JPH11124393A (ja) | 1999-05-11 |
FI974346A (fi) | 1998-01-16 |
FI974346A0 (fi) | 1997-11-26 |
NO975717D0 (no) | 1997-12-05 |
CA2223739A1 (en) | 1996-12-19 |
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