NO970172L - Cationic amphiphiles - Google Patents

Cationic amphiphiles

Info

Publication number
NO970172L
NO970172L NO970172A NO970172A NO970172L NO 970172 L NO970172 L NO 970172L NO 970172 A NO970172 A NO 970172A NO 970172 A NO970172 A NO 970172A NO 970172 L NO970172 L NO 970172L
Authority
NO
Norway
Prior art keywords
cationic amphiphiles
amphiphiles
cationic
diacylphosphatidyl
phosphatidylethanolamine
Prior art date
Application number
NO970172A
Other languages
Norwegian (no)
Other versions
NO970172D0 (en
Inventor
Timothy D Heath
Original Assignee
Megabios Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Megabios Corp filed Critical Megabios Corp
Publication of NO970172L publication Critical patent/NO970172L/en
Publication of NO970172D0 publication Critical patent/NO970172D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Kationiske amfifiler som er alkyl eller alkoksyalkyl O-fosfatestere av diacylfosfatidyl zwitterioniske forbindelser så som fosfatidylcholin eller fosfatidyletanolamin er beskrevet. Amfifiler kan bli anvendt som bærere for levering av makromolekyler intracellulært.Cationic amphiphiles which are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidylethanolamine are described. Amphiphiles can be used as carriers for the delivery of macromolecules intracellularly.

NO970172A 1994-06-22 1997-01-15 Cationic amphiphiles NO970172D0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/007071 WO1995035301A1 (en) 1994-06-22 1994-06-22 Cationic amphiphiles

Publications (2)

Publication Number Publication Date
NO970172L true NO970172L (en) 1997-01-15
NO970172D0 NO970172D0 (en) 1997-01-15

Family

ID=22242692

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970172A NO970172D0 (en) 1994-06-22 1997-01-15 Cationic amphiphiles

Country Status (6)

Country Link
EP (1) EP0807116A4 (en)
JP (1) JPH10506093A (en)
AU (1) AU696881B2 (en)
CA (1) CA2194221C (en)
NO (1) NO970172D0 (en)
WO (1) WO1995035301A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
EP1489184A1 (en) * 1995-06-07 2004-12-22 Inex Pharmaceutical Corp. Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6235310B1 (en) 1997-04-04 2001-05-22 Valentis, Inc. Methods of delivery using cationic lipids and helper lipids
AU3703100A (en) 1999-02-22 2000-09-14 Georgetown University Antibody fragment-targeted immunoliposomes for systemic gene delivery
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
ATE407684T1 (en) * 2001-04-02 2008-09-15 Univ Georgetown SIMPLIFIED AND IMPROVED METHOD FOR PRODUCING AN ANTIBODY OR ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOME OR POLYPLEX FOR SYSTEMIC ADMINISTRATION OF A THERAPEUTIC OR DIAGNOSTIC AGENT
DE10207178A1 (en) * 2002-02-19 2003-09-04 Novosom Ag Components for the production of amphoteric liposomes
CA2491164C (en) 2002-06-28 2012-05-08 Cory Giesbrecht Method and apparatus for producing liposomes
CA2532228C (en) 2003-07-16 2017-02-14 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
NZ592917A (en) 2003-09-15 2012-12-21 Protiva Biotherapeutics Inc Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates
EP1781593B1 (en) 2004-06-07 2011-12-14 Protiva Biotherapeutics Inc. Cationic lipids and methods of use
JP4796062B2 (en) 2004-06-07 2011-10-19 プロチバ バイオセラピューティクス インコーポレイティッド Lipid-encapsulating interfering RNA
WO2006002538A1 (en) 2004-07-02 2006-01-12 Protiva Biotherapeutics, Inc. Immunostimulatory sirna molecules and uses therefor
US8101741B2 (en) 2005-11-02 2012-01-24 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
KR20140135267A (en) 2006-05-15 2014-11-25 조지타운 유니버시티 Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7915399B2 (en) 2006-06-09 2011-03-29 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
DK2279254T3 (en) 2008-04-15 2017-09-18 Protiva Biotherapeutics Inc PRESENT UNKNOWN LIPID FORMS FOR NUCLEIC ACID ADMINISTRATION
CA2984026C (en) 2008-10-09 2020-02-11 Arbutus Biopharma Corporation Improved amino lipids and methods for the delivery of nucleic acids
WO2011000106A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Improved cationic lipids and methods for the delivery of therapeutic agents
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
EP2449114B9 (en) 2009-07-01 2017-04-19 Protiva Biotherapeutics Inc. Novel lipid formulations for delivery of therapeutic agents to solid tumors
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
JP6557659B2 (en) 2013-07-16 2019-08-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Increased bone formation potential of bone grafts
JP2023553343A (en) 2020-11-25 2023-12-21 アカゲラ・メディスンズ，インコーポレイテッド Lipid nanoparticles and related methods of use for delivering nucleic acids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239817A1 (en) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen NEW GLYCER DERIVATIVES FOR THE SYNTHESIS OF PHOSPHOLIPIDES
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5334761A (en) * 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
US5651981A (en) * 1994-03-29 1997-07-29 Northwestern University Cationic phospholipids for transfection

Also Published As

Publication number Publication date
EP0807116A4 (en) 1998-01-07
AU7471194A (en) 1996-01-15
AU696881B2 (en) 1998-09-24
JPH10506093A (en) 1998-06-16
CA2194221C (en) 2001-01-02
CA2194221A1 (en) 1995-12-28
EP0807116A1 (en) 1997-11-19
NO970172D0 (en) 1997-01-15
WO1995035301A1 (en) 1995-12-28

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