CA2194221A1 - Cationic amphiphiles - Google Patents

Cationic amphiphiles

Info

Publication number
CA2194221A1
CA2194221A1 CA2194221A CA2194221A CA2194221A1 CA 2194221 A1 CA2194221 A1 CA 2194221A1 CA 2194221 A CA2194221 A CA 2194221A CA 2194221 A CA2194221 A CA 2194221A CA 2194221 A1 CA2194221 A1 CA 2194221A1
Authority
CA
Canada
Prior art keywords
cationic amphiphiles
amphiphiles
cationic
diacylphosphatidyl
intracellularly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2194221A
Other languages
French (fr)
Other versions
CA2194221C (en
Inventor
Timothy D. Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Urigen Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2194221A1 publication Critical patent/CA2194221A1/en
Application granted granted Critical
Publication of CA2194221C publication Critical patent/CA2194221C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cationic amphiphiles are provided that are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidyl ethanolamine. The amphiphiles can be used as carriers for delivering macromolecules intracellularly.
CA002194221A 1994-06-22 1994-06-22 Cationic amphiphiles Expired - Fee Related CA2194221C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/007071 WO1995035301A1 (en) 1994-06-22 1994-06-22 Cationic amphiphiles

Publications (2)

Publication Number Publication Date
CA2194221A1 true CA2194221A1 (en) 1995-12-28
CA2194221C CA2194221C (en) 2001-01-02

Family

ID=22242692

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002194221A Expired - Fee Related CA2194221C (en) 1994-06-22 1994-06-22 Cationic amphiphiles

Country Status (6)

Country Link
EP (1) EP0807116A4 (en)
JP (1) JPH10506093A (en)
AU (1) AU696881B2 (en)
CA (1) CA2194221C (en)
NO (1) NO970172D0 (en)
WO (1) WO1995035301A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122290A0 (en) * 1995-06-07 1998-04-05 Inex Pharmaceuticals Corp Lipid-nucleic acid complex its preparation and use
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6235310B1 (en) 1997-04-04 2001-05-22 Valentis, Inc. Methods of delivery using cationic lipids and helper lipids
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
EP1154756B1 (en) 1999-02-22 2007-01-03 Georgetown University Antibody fragment-targeted immunoliposomes for systemic gene delivery
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
AU2002307035A1 (en) * 2001-04-02 2002-10-15 Georgetown University A simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome or polyplex for systemic administration of a therapeutic or diagnostic agent
DE10207178A1 (en) * 2002-02-19 2003-09-04 Novosom Ag Components for the production of amphoteric liposomes
JP4722481B2 (en) 2002-06-28 2011-07-13 プロティバ バイオセラピューティクス リミテッド Liposome production method and apparatus
CA2532228C (en) 2003-07-16 2017-02-14 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
JP4842821B2 (en) 2003-09-15 2011-12-21 プロチバ バイオセラピューティクス インコーポレイティッド Polyethylene glycol modified lipid compounds and uses thereof
WO2005120152A2 (en) 2004-06-07 2005-12-22 Protiva Biotherapeutics, Inc. Cationic lipids and methods of use
US7799565B2 (en) 2004-06-07 2010-09-21 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering RNA
CA2572439A1 (en) 2004-07-02 2006-01-12 Protiva Biotherapeutics, Inc. Immunostimulatory sirna molecules and uses therefor
EP2395012B8 (en) 2005-11-02 2018-06-06 Arbutus Biopharma Corporation Modified siRNA molecules and uses thereof
KR101573928B1 (en) 2006-05-15 2015-12-03 조지타운 유니버시티 - - preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7915399B2 (en) 2006-06-09 2011-03-29 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
DK2279254T3 (en) 2008-04-15 2017-09-18 Protiva Biotherapeutics Inc PRESENT UNKNOWN LIPID FORMS FOR NUCLEIC ACID ADMINISTRATION
CN102245590B (en) 2008-10-09 2014-03-19 泰米拉制药公司 Improved amino lipids and methods for the delivery of nucleic acids
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
IL292615B2 (en) 2009-07-01 2023-11-01 Protiva Biotherapeutics Inc Nucleic acid-lipid particles, compositions comprising the same and uses thereof
WO2011000106A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Improved cationic lipids and methods for the delivery of therapeutic agents
WO2012000104A1 (en) 2010-06-30 2012-01-05 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
GB2530224B (en) 2013-07-16 2020-08-05 Univ Leland Stanford Junior Enhancement of osteogenic potential of bone grafts
IL303195A (en) 2020-11-25 2023-07-01 Akagera Medicines Inc Lipid nanoparticles for delivery of nucleic acids, and related methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239817A1 (en) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen NEW GLYCER DERIVATIVES FOR THE SYNTHESIS OF PHOSPHOLIPIDES
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5334761A (en) * 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
US5651981A (en) * 1994-03-29 1997-07-29 Northwestern University Cationic phospholipids for transfection

Also Published As

Publication number Publication date
NO970172L (en) 1997-01-15
CA2194221C (en) 2001-01-02
NO970172D0 (en) 1997-01-15
WO1995035301A1 (en) 1995-12-28
AU7471194A (en) 1996-01-15
EP0807116A4 (en) 1998-01-07
JPH10506093A (en) 1998-06-16
EP0807116A1 (en) 1997-11-19
AU696881B2 (en) 1998-09-24

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Legal Events

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