NO965157L - Transgen fisk for behandling av diabetes - Google Patents
Transgen fisk for behandling av diabetesInfo
- Publication number
- NO965157L NO965157L NO965157A NO965157A NO965157L NO 965157 L NO965157 L NO 965157L NO 965157 A NO965157 A NO 965157A NO 965157 A NO965157 A NO 965157A NO 965157 L NO965157 L NO 965157L
- Authority
- NO
- Norway
- Prior art keywords
- diabetes
- fish
- treatment
- insulin
- tissue
- Prior art date
Links
- 241000251468 Actinopterygii Species 0.000 title abstract 6
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 4
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 abstract 4
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 238000009413 insulation Methods 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002611 ovarian Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Farming Of Fish And Shellfish (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Transgen fisk inneholdende et humanisert insulingen som er blitt endret for å utskille humant insulin og anvendelse for behandling av diabetes er beskrevet. I den transgene fisken er fiske insulin genet blitt modifisert slik at det koder for humant insulingen, men etterlater regulatoriske sekvenser til fiskeinsulin genet intakt. Øy transplantasjon kan tilveiebringe nøyaktig glycemi kontroll som er nødvendig ved behandling av diabetes. Øyvevet ifølge foreliggende oppfinnelse tilveiebringer en billig og nesten ubegrenset tilførsel av humant insulin-produserende vev og kan derfor være nyttig for behandling av diabetes. I dette henseendet er det beskrevet en forbedret fremgangsmåte for masseisolering av øyvev. Anvendelse av humanisert insulin gen for å fremme vekst i fisk er også beskrevet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41786695A | 1995-04-06 | 1995-04-06 | |
| PCT/CA1996/000171 WO1996032087A2 (en) | 1995-04-06 | 1996-03-22 | Transgenic fish in the treatment of diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO965157L true NO965157L (no) | 1996-12-03 |
| NO965157D0 NO965157D0 (no) | 1996-12-03 |
Family
ID=23655683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO965157A NO965157D0 (no) | 1995-04-06 | 1996-12-03 | Transgen fisk for behandling av diabetes |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6015713A (no) |
| EP (1) | EP0769021A2 (no) |
| JP (1) | JPH10504725A (no) |
| AU (1) | AU4935596A (no) |
| BR (1) | BR9606298A (no) |
| CA (1) | CA2191969A1 (no) |
| NO (1) | NO965157D0 (no) |
| WO (1) | WO1996032087A2 (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6476290B1 (en) * | 1995-04-19 | 2002-11-05 | Dalhousie University | Transgenic tilapia comprising a humanized insulin gene |
| GB9621113D0 (en) * | 1996-10-10 | 1996-11-27 | Univ Southampton | Transgenic fish |
| US6380458B1 (en) | 1997-06-09 | 2002-04-30 | Medical College Of Georgia Research Institute, Inc. | Cell-lineage specific expression in transgenic zebrafish |
| JP4447705B2 (ja) | 1999-10-20 | 2010-04-07 | 独立行政法人科学技術振興機構 | 糖尿病発症モデル哺乳動物 |
| AU2003228471A1 (en) * | 2002-04-09 | 2003-10-27 | F.C. Thomas Allnut | Enclosed aquacultural systems for production of purified recombinant proteins |
| US7183079B2 (en) * | 2002-11-06 | 2007-02-27 | Auburn University | Compositions and methods for enhancing disease resistance in fish |
| CN1294808C (zh) * | 2003-09-26 | 2007-01-17 | 中国科学院水生生物研究所 | 不育转基因鱼的制备方法 |
| US20100077654A1 (en) * | 2008-09-23 | 2010-04-01 | LiveFuels, Inc. | Systems and methods for producing biofuels from algae |
| WO2010059598A1 (en) * | 2008-11-18 | 2010-05-27 | LiveFuels, Inc. | Methods for producing fish with high lipid content |
| US8753851B2 (en) | 2009-04-17 | 2014-06-17 | LiveFuels, Inc. | Systems and methods for culturing algae with bivalves |
| US9487716B2 (en) | 2011-05-06 | 2016-11-08 | LiveFuels, Inc. | Sourcing phosphorus and other nutrients from the ocean via ocean thermal energy conversion systems |
| US11172656B2 (en) * | 2012-12-11 | 2021-11-16 | Signify Holding B.V. | Methods for controlling sex of oviparous embryos using light sources |
| US10455819B2 (en) | 2012-12-11 | 2019-10-29 | Signify North America Corporation | Methods for controlling sex of oviparous embryos using light sources |
| US11140879B2 (en) | 2012-12-11 | 2021-10-12 | Signify North America Corporation | Methods for controlling sex of oviparous embryos using light sources |
| CN109566469B (zh) | 2012-12-11 | 2021-10-22 | 昕诺飞北美公司 | 使用光控制卵生胚胎的性别 |
| US10201152B2 (en) | 2015-09-15 | 2019-02-12 | Once Innovations, Inc. | Systems and methods for promoting biological responses in incubated eggs |
| CN109694870A (zh) * | 2019-01-28 | 2019-04-30 | 河南师范大学 | 草鱼insulin基因及含有该基因的重组表达载体、重组菌及其应用 |
| US20210217488A1 (en) * | 2020-01-09 | 2021-07-15 | Cryoocyte, Inc. | Fish farm material handling |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6196985A (ja) * | 1984-10-19 | 1986-05-15 | Taisho Pharmaceut Co Ltd | 細胞クロ−ンの製造方法 |
| DE3545237A1 (de) * | 1985-12-20 | 1987-06-25 | Juergen Dr Med Schrezenmeir | Vorrichtung fuer die aufnahme und zum einbringen von geweben in den menschlichen koerper sowie hierfuer verwendbares instrument |
| AU669844B2 (en) * | 1991-03-15 | 1996-06-27 | Hsc Research And Development Limited Partnership | Gene construct for production of transgenic fish |
| US5476779A (en) * | 1992-09-30 | 1995-12-19 | University Of Maryland At College Park | DNA encoding insulin-like growth factor II isolated from rainbow trout |
-
1996
- 1996-03-22 WO PCT/CA1996/000171 patent/WO1996032087A2/en not_active Application Discontinuation
- 1996-03-22 JP JP8530591A patent/JPH10504725A/ja active Pending
- 1996-03-22 BR BR9606298A patent/BR9606298A/pt unknown
- 1996-03-22 US US08/750,391 patent/US6015713A/en not_active Expired - Fee Related
- 1996-03-22 AU AU49355/96A patent/AU4935596A/en not_active Abandoned
- 1996-03-22 CA CA002191969A patent/CA2191969A1/en not_active Abandoned
- 1996-03-22 EP EP96905643A patent/EP0769021A2/en not_active Withdrawn
- 1996-12-03 NO NO965157A patent/NO965157D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4935596A (en) | 1996-10-30 |
| US6015713A (en) | 2000-01-18 |
| EP0769021A2 (en) | 1997-04-23 |
| BR9606298A (pt) | 1997-12-23 |
| JPH10504725A (ja) | 1998-05-12 |
| WO1996032087A3 (en) | 1996-11-14 |
| WO1996032087A2 (en) | 1996-10-17 |
| NO965157D0 (no) | 1996-12-03 |
| CA2191969A1 (en) | 1996-10-17 |
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