NO962348L - C5a reseptorantagonister uten agonist aktivitet - Google Patents
C5a reseptorantagonister uten agonist aktivitetInfo
- Publication number
- NO962348L NO962348L NO962348A NO962348A NO962348L NO 962348 L NO962348 L NO 962348L NO 962348 A NO962348 A NO 962348A NO 962348 A NO962348 A NO 962348A NO 962348 L NO962348 L NO 962348L
- Authority
- NO
- Norway
- Prior art keywords
- analogs
- derivatives
- receptor antagonists
- human
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Polypeptidanaloger av human C5a som er C5a reseptorantagonister som utviser vesentlig ingen analfylatoksin eller agonistisk aktivitet, og derivater av analogene, og dimeriske former av analogene eller derivatene, er beskrevet. DNA molekyler som koder for polypeptidene og fremgangsmåter for fremstilling av analogene er også beskrevet. Farmasøytiske formuleringer inneholdende en C5a analog blir anvendt terapeutisk for behandling av C5a-formidlede sykdommer og inflammatoriske tilstander i pattedyr, og profylaktisk for å forhindre eller redusere inflammasjon forårsaket av en heneldse som forårsaket inflammasjon eller forverrer en eksisterende inflammatorisk tilstand. Antistoffer spesifikke for C5a analoger, derivater derav og dimerer av anlogene og derivater som utviser vesentlig ingen kryss-reaktivitet med human C5a er også beskrevet. Antistoffene blir anvendt for å detektere eller kvantifisere sirkulerende C5a analog eller derivat og også modifisere, for eksempel nøytralisere aktiviteten til C5a reseptorantagonisten in vivo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16259193A | 1993-12-06 | 1993-12-06 | |
PCT/IB1994/000359 WO1995016033A1 (en) | 1993-12-06 | 1994-11-16 | C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY |
Publications (2)
Publication Number | Publication Date |
---|---|
NO962348D0 NO962348D0 (no) | 1996-06-05 |
NO962348L true NO962348L (no) | 1996-08-05 |
Family
ID=22586301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO962348A NO962348L (no) | 1993-12-06 | 1996-06-05 | C5a reseptorantagonister uten agonist aktivitet |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0733107A1 (no) |
JP (1) | JPH09506258A (no) |
CN (1) | CN1142854A (no) |
AU (1) | AU698919B2 (no) |
BR (1) | BR9408265A (no) |
CA (1) | CA2176825A1 (no) |
FI (1) | FI962319A0 (no) |
HU (1) | HUT75990A (no) |
IL (1) | IL111792A0 (no) |
MX (1) | MXPA99008669A (no) |
NO (1) | NO962348L (no) |
NZ (1) | NZ274917A (no) |
TW (1) | TW429262B (no) |
WO (1) | WO1995016033A1 (no) |
ZA (1) | ZA949647B (no) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5837499A (en) * | 1993-12-06 | 1998-11-17 | Ciba-Geigy Corporation | DNA encoding C5A receptor antagonists having substantially no agonist activity and methods of expressing same |
WO1996039503A1 (en) * | 1995-06-05 | 1996-12-12 | Novartis Ag | C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY AND METHODS FOR PREPARATION |
CN1087572C (zh) * | 1995-12-13 | 2002-07-10 | 北方电讯网络有限公司 | 集成蜂窝话音和数字分组数据电信系统及该系统的运行方法 |
AUPO755097A0 (en) * | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
TWI767415B (zh) * | 2020-11-18 | 2022-06-11 | 中國醫藥大學 | 自動化血液分析系統及自動化血液分析方法 |
CN113150106B (zh) * | 2021-04-26 | 2022-08-16 | 华中农业大学 | 来源于补体成分C5a的抗菌肽及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0305615A1 (en) * | 1987-09-03 | 1989-03-08 | Immunetech Pharmaceuticals, Inc. | Peptide antagonists for the C5a anaphylatoxin |
JP2703764B2 (ja) * | 1986-04-28 | 1998-01-26 | シータス オンコロジー コーポレイション | 補体成分C5aに対するモノクローナル抗体 |
-
1994
- 1994-11-16 NZ NZ274917A patent/NZ274917A/en unknown
- 1994-11-16 EP EP94931155A patent/EP0733107A1/en not_active Withdrawn
- 1994-11-16 HU HU9601538A patent/HUT75990A/hu unknown
- 1994-11-16 CA CA002176825A patent/CA2176825A1/en not_active Abandoned
- 1994-11-16 CN CN94194914A patent/CN1142854A/zh active Pending
- 1994-11-16 JP JP7516068A patent/JPH09506258A/ja active Pending
- 1994-11-16 AU AU80025/94A patent/AU698919B2/en not_active Ceased
- 1994-11-16 WO PCT/IB1994/000359 patent/WO1995016033A1/en not_active Application Discontinuation
- 1994-11-16 BR BR9408265A patent/BR9408265A/pt not_active Application Discontinuation
- 1994-11-28 IL IL11179294A patent/IL111792A0/xx unknown
- 1994-12-05 ZA ZA949647A patent/ZA949647B/xx unknown
- 1994-12-13 TW TW083111578A patent/TW429262B/zh not_active IP Right Cessation
-
1996
- 1996-06-03 FI FI962319A patent/FI962319A0/fi unknown
- 1996-06-05 NO NO962348A patent/NO962348L/no not_active Application Discontinuation
-
1999
- 1999-09-21 MX MXPA99008669A patent/MXPA99008669A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR9408265A (pt) | 1996-12-10 |
JPH09506258A (ja) | 1997-06-24 |
EP0733107A1 (en) | 1996-09-25 |
IL111792A0 (en) | 1995-01-24 |
FI962319A (fi) | 1996-06-03 |
CN1142854A (zh) | 1997-02-12 |
NO962348D0 (no) | 1996-06-05 |
FI962319A0 (fi) | 1996-06-03 |
MXPA99008669A (es) | 2004-09-01 |
WO1995016033A1 (en) | 1995-06-15 |
CA2176825A1 (en) | 1995-06-15 |
TW429262B (en) | 2001-04-11 |
HU9601538D0 (en) | 1996-07-29 |
AU698919B2 (en) | 1998-11-12 |
AU8002594A (en) | 1995-06-27 |
NZ274917A (en) | 1998-03-25 |
HUT75990A (en) | 1997-05-28 |
ZA949647B (en) | 1995-06-06 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |