NO954985D0 - O6-substituerte guaninderivater, fremgangsmåte for fremstilling derav og anvendelse derav ved behandling av tumorceller - Google Patents

O6-substituerte guaninderivater, fremgangsmåte for fremstilling derav og anvendelse derav ved behandling av tumorceller

Info

Publication number
NO954985D0
NO954985D0 NO954985A NO954985A NO954985D0 NO 954985 D0 NO954985 D0 NO 954985D0 NO 954985 A NO954985 A NO 954985A NO 954985 A NO954985 A NO 954985A NO 954985 D0 NO954985 D0 NO 954985D0
Authority
NO
Norway
Prior art keywords
preparation
heterocyclic ring
treatment
derivatives
tumor cells
Prior art date
Application number
NO954985A
Other languages
English (en)
Other versions
NO313331B1 (no
NO954985L (no
Inventor
Thomas Brian Mcmurry
Robert Stanley Mcelhinney
Joan Elizabeth Mccormick
Rhoderick Hugh Elder
Jane Kelly
Geoffrey Margison
Joseph Anthony Raffery
Amanda Jean Watson
Mark Andrew Willington
Original Assignee
Cancer Res Campaign Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9410421A external-priority patent/GB9410421D0/en
Application filed by Cancer Res Campaign Tech filed Critical Cancer Res Campaign Tech
Publication of NO954985D0 publication Critical patent/NO954985D0/no
Publication of NO954985L publication Critical patent/NO954985L/no
Publication of NO313331B1 publication Critical patent/NO313331B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19954985A 1993-06-08 1995-12-07 O6-alkylguaninderivater, fremgangsmåte for fremstilling og anvendelse derav samt farmasöytiske preparater NO313331B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE930432 1993-06-08
GB9410421A GB9410421D0 (en) 1993-06-08 1994-05-23 O (six)-substituted guanine derivatives
PCT/IE1994/000031 WO1994029312A1 (en) 1993-06-08 1994-06-08 O6-substituted guanine derivatives, a process for their preparation and their use in treating tumour cells

Publications (3)

Publication Number Publication Date
NO954985D0 true NO954985D0 (no) 1995-12-07
NO954985L NO954985L (no) 1996-02-07
NO313331B1 NO313331B1 (no) 2002-09-16

Family

ID=26304937

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19954985A NO313331B1 (no) 1993-06-08 1995-12-07 O6-alkylguaninderivater, fremgangsmåte for fremstilling og anvendelse derav samt farmasöytiske preparater

Country Status (19)

Country Link
EP (1) EP0702683B8 (no)
JP (1) JP4054057B2 (no)
CN (1) CN1048493C (no)
AT (1) ATE250060T1 (no)
AU (1) AU697977B2 (no)
CA (1) CA2164847C (no)
CZ (1) CZ290951B6 (no)
DE (1) DE69433161T2 (no)
DK (1) DK0702683T3 (no)
ES (1) ES2207638T3 (no)
FI (1) FI955906A (no)
HU (1) HU217779B (no)
NO (1) NO313331B1 (no)
NZ (1) NZ266527A (no)
PL (1) PL180681B1 (no)
PT (1) PT702683E (no)
RU (1) RU2154646C2 (no)
SK (1) SK282621B6 (no)
WO (1) WO1994029312A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043228A (en) * 1993-06-08 2000-03-28 Cancer Research Campaign Technology Limited O6 -substituted guanine derivatives, a process for their preparation and their use in treating tumor cells
US5929046A (en) * 1994-06-08 1999-07-27 Cancer Research Campaign Technology Limited Pyrimidine and purine derivatives and their use in treating tumour cells
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
DE19618727C2 (de) * 1996-05-09 2000-02-17 Deutsches Krebsforsch Herstellung alkylierter Nucleosid-3'-Phosphate
AU6771198A (en) * 1997-03-24 1998-10-20 Glaxo Group Limited Method for treating b-cell tumors with ara-g nucleoside derivatives
AU744986B2 (en) 1997-07-12 2002-03-07 Cancer Research Technology Limited Cyclin dependent kinase inhibiting purine derivatives
US6060458A (en) * 1998-02-13 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use
DE60237792D1 (de) * 2001-04-10 2010-11-04 Ecole Polytech Verfahren zur Verwendung von O6-Alkylguanin-DNS Alkyltransferasen
AU2003231098A1 (en) 2002-04-25 2003-11-10 University Of Connecticut Health Center Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
US6984389B2 (en) * 2002-04-25 2006-01-10 University Of Connecticut Health Center Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
WO2005107472A1 (en) * 2004-05-12 2005-11-17 Bayer Cropscience Gmbh Plant growth regulation
CN100350975C (zh) * 2005-02-03 2007-11-28 山东蓝金生物工程有限公司 抗癌药物组合物
GB0502573D0 (en) * 2005-02-08 2005-03-16 Topotarget As Therapeutic compounds
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CN104031047B (zh) * 2014-05-28 2016-03-09 北京工业大学 一种具有抗癌活性的氯乙基亚硝基脲及其合成方法
CN104031048B (zh) * 2014-05-28 2016-03-09 北京工业大学 一种β-氯乙基亚硝基脲类化合物及其合成方法和用途
CN107098906B (zh) * 2017-05-19 2020-05-05 四川大学 苄基鸟嘌呤衍生物及其有机盐类化合物和药物组合物及其应用
AU2019216531A1 (en) 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2139107A1 (de) * 1971-08-04 1973-02-15 Merck Patent Gmbh Heterocyclisch substituierte adenosinverbindungen
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity

Also Published As

Publication number Publication date
HU9503522D0 (en) 1996-02-28
NO313331B1 (no) 2002-09-16
FI955906A (fi) 1996-02-02
PL311950A1 (en) 1996-03-18
CN1145622A (zh) 1997-03-19
PL180681B1 (pl) 2001-03-30
DK0702683T3 (da) 2004-02-02
SK154795A3 (en) 1996-07-03
DE69433161D1 (de) 2003-10-23
EP0702683A1 (en) 1996-03-27
HU217779B (hu) 2000-04-28
CZ290951B6 (cs) 2002-11-13
NZ266527A (en) 1999-10-28
CZ323395A3 (en) 1996-06-12
ATE250060T1 (de) 2003-10-15
JPH08511773A (ja) 1996-12-10
EP0702683B1 (en) 2003-09-17
ES2207638T3 (es) 2004-06-01
RU2154646C2 (ru) 2000-08-20
DE69433161T2 (de) 2004-07-08
FI955906A0 (fi) 1995-12-08
CA2164847A1 (en) 1994-12-22
EP0702683B8 (en) 2004-09-08
WO1994029312A1 (en) 1994-12-22
CN1048493C (zh) 2000-01-19
CA2164847C (en) 2005-11-15
AU697977B2 (en) 1998-10-22
PT702683E (pt) 2004-01-30
AU6805994A (en) 1995-01-03
SK282621B6 (sk) 2002-10-08
HUT74574A (en) 1997-01-28
NO954985L (no) 1996-02-07
JP4054057B2 (ja) 2008-02-27

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