NO950986L - Kryssbundne og reduserte kontrastmidler - Google Patents
Kryssbundne og reduserte kontrastmidlerInfo
- Publication number
- NO950986L NO950986L NO950986A NO950986A NO950986L NO 950986 L NO950986 L NO 950986L NO 950986 A NO950986 A NO 950986A NO 950986 A NO950986 A NO 950986A NO 950986 L NO950986 L NO 950986L
- Authority
- NO
- Norway
- Prior art keywords
- contrast agents
- gas
- proteinaceous
- crosslinked
- size distribution
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 4
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001299 aldehydes Chemical class 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 abstract 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Abstract
Proteinholdige mikroboble-kontrastmidler inneholdende gass- eller gass-forløpere, f.eks. til bruk i ultralyd- og/eller MR-avbildning, der protein-matrixen er kryssbundet ved reaksjon med et bifunksjonelt aldehyd (f.eks. et dialdehyd som glutaraldehyd eller et a, p-umettet aldehyd som akrolein), i et vandig medium ved hovedsakelig nøytral pH, viser forbedret stabilitet in vivo og ved lagring, særlig hvis matrixen også reageres med et SchifFs base reduksjonsmiddel slik som et borhydrid. Modifisering av størrelsesfordelingen av slike kryssbunde protein- og gassholdige kontrastmidler, f. eks. ved å redusere gjennomsnittstørrelse av mikroboblene, forbedrer deres stabilitet ytterligere og tillater framstilling kv nye kontrastmidler med en særlig smal størrelsesfordeling for mikroboblene.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929219595A GB9219595D0 (en) | 1992-09-16 | 1992-09-16 | Improvements in or relating to contrast agents |
GB929220639A GB9220639D0 (en) | 1992-09-30 | 1992-09-30 | Improvements in or relating to contrast agents |
GB929220638A GB9220638D0 (en) | 1992-09-30 | 1992-09-30 | Improvements in or relating to contrast agents |
PCT/GB1993/001861 WO1994006477A1 (en) | 1992-09-16 | 1993-09-03 | Improvements in or relating to contrast agents |
Publications (2)
Publication Number | Publication Date |
---|---|
NO950986D0 NO950986D0 (no) | 1995-03-14 |
NO950986L true NO950986L (no) | 1995-03-14 |
Family
ID=27266368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO950986A NO950986L (no) | 1992-09-16 | 1995-03-14 | Kryssbundne og reduserte kontrastmidler |
Country Status (14)
Country | Link |
---|---|
US (1) | US5718884A (no) |
EP (2) | EP0835664A3 (no) |
JP (1) | JPH08501776A (no) |
CN (1) | CN1048410C (no) |
AT (1) | ATE167805T1 (no) |
AU (1) | AU689086B2 (no) |
CA (1) | CA2144749A1 (no) |
DE (1) | DE69319438T2 (no) |
DK (1) | DK0660724T3 (no) |
ES (1) | ES2117715T3 (no) |
FI (1) | FI951210A (no) |
HK (1) | HK1003293A1 (no) |
NO (1) | NO950986L (no) |
WO (1) | WO1994006477A1 (no) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
DK0711179T3 (da) | 1993-07-30 | 2005-02-14 | Imcor Pharmaceutical Co | Stabiliserede sammensætninger med mikrobobler til ultralyd |
NO940711D0 (no) * | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging |
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
AU1354497A (en) * | 1995-12-21 | 1997-07-14 | Drexel University | Hollow polymer microcapsules and method of producing |
DE19626530A1 (de) * | 1996-07-02 | 1998-01-15 | Byk Gulden Lomberg Chem Fab | MR-Kontrastmittelzubereitungen |
US6108637A (en) | 1996-09-03 | 2000-08-22 | Nielsen Media Research, Inc. | Content display monitor |
US6083484A (en) | 1996-10-17 | 2000-07-04 | Molecular Biosystems, Inc. | Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US7462366B2 (en) * | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
US7094369B2 (en) * | 2002-03-29 | 2006-08-22 | Scimed Life Systems, Inc. | Processes for manufacturing polymeric microspheres |
US7131997B2 (en) * | 2002-03-29 | 2006-11-07 | Scimed Life Systems, Inc. | Tissue treatment |
US7053134B2 (en) * | 2002-04-04 | 2006-05-30 | Scimed Life Systems, Inc. | Forming a chemically cross-linked particle of a desired shape and diameter |
CA2418229A1 (en) * | 2002-05-16 | 2003-11-16 | Rohan Dharmakumar | Microbubble construct for sensitivity enhanced mr manometry |
CA2492339A1 (en) * | 2002-06-12 | 2003-12-24 | Boston Scientific Limited | Bulking agents |
US7449236B2 (en) * | 2002-08-09 | 2008-11-11 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
US7842377B2 (en) * | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
US7588825B2 (en) * | 2002-10-23 | 2009-09-15 | Boston Scientific Scimed, Inc. | Embolic compositions |
US7883490B2 (en) * | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
US7976823B2 (en) * | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
US20050074406A1 (en) * | 2003-10-03 | 2005-04-07 | Scimed Life Systems, Inc. | Ultrasound coating for enhancing visualization of medical device in ultrasound images |
US7901770B2 (en) * | 2003-11-04 | 2011-03-08 | Boston Scientific Scimed, Inc. | Embolic compositions |
US7736671B2 (en) * | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
US20050238870A1 (en) * | 2004-04-22 | 2005-10-27 | Marcia Buiser | Embolization |
US7311861B2 (en) * | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
US8012457B2 (en) * | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
US8425550B2 (en) | 2004-12-01 | 2013-04-23 | Boston Scientific Scimed, Inc. | Embolic coils |
US7727555B2 (en) * | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
US7858183B2 (en) * | 2005-03-02 | 2010-12-28 | Boston Scientific Scimed, Inc. | Particles |
US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
US20070004973A1 (en) * | 2005-06-15 | 2007-01-04 | Tan Sharon M L | Tissue treatment methods |
US8123693B2 (en) | 2005-06-20 | 2012-02-28 | Conceptus, Inc. | Methods and devices for determining lumen occlusion |
US9463426B2 (en) * | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
US8007509B2 (en) * | 2005-10-12 | 2011-08-30 | Boston Scientific Scimed, Inc. | Coil assemblies, components and methods |
US20070083219A1 (en) * | 2005-10-12 | 2007-04-12 | Buiser Marcia S | Embolic coil introducer sheath locking mechanisms |
US20070142859A1 (en) * | 2005-12-19 | 2007-06-21 | Boston Scientific Scimed, Inc. | Embolic coils |
US8101197B2 (en) | 2005-12-19 | 2012-01-24 | Stryker Corporation | Forming coils |
US8152839B2 (en) * | 2005-12-19 | 2012-04-10 | Boston Scientific Scimed, Inc. | Embolic coils |
US7501179B2 (en) * | 2005-12-21 | 2009-03-10 | Boston Scientific Scimed, Inc. | Block copolymer particles |
US20070142560A1 (en) * | 2005-12-21 | 2007-06-21 | Young-Ho Song | Block copolymer particles |
US7947368B2 (en) * | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
DE102006023456A1 (de) * | 2006-05-18 | 2007-11-22 | Siemens Ag | Kontrastmittel für die Röntgen- und Computertomographie-Diagnostik |
US20070299461A1 (en) * | 2006-06-21 | 2007-12-27 | Boston Scientific Scimed, Inc. | Embolic coils and related components, systems, and methods |
US8414927B2 (en) | 2006-11-03 | 2013-04-09 | Boston Scientific Scimed, Inc. | Cross-linked polymer particles |
US20080145658A1 (en) * | 2006-12-15 | 2008-06-19 | Boston Scientific Scimed, Inc. | Freeze Thaw Methods For Making Polymer Particles |
US8585616B2 (en) * | 2009-10-09 | 2013-11-19 | Conceptus, Inc. | Methods and apparatus for determining fallopian tube occlusion |
KR101853948B1 (ko) * | 2013-07-05 | 2018-05-02 | 사회복지법인 삼성생명공익재단 | X-선 조영제 및 기포 촉진제를 함유하는 조영 조성물 및 그 제조방법 |
CN104174040A (zh) * | 2014-08-13 | 2014-12-03 | 中国科学院宁波材料技术与工程研究所 | 一种造影材料、其制备方法及应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
US5284646A (en) * | 1986-07-03 | 1994-02-08 | Advanced Magnetics Inc. | Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents |
DE3709851A1 (de) * | 1987-03-24 | 1988-10-06 | Silica Gel Gmbh Adsorptions Te | Nmr-diagnostische fluessigkeitszusammensetzungen |
DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
JP3247374B2 (ja) * | 1990-10-05 | 2002-01-15 | ブラッコ インターナショナル ベスローテン フェンノートシャップ | 超音波エコグラフィーに適切な中空気体封入微小球の安定懸濁物の製造のための方法 |
-
1993
- 1993-09-03 CA CA002144749A patent/CA2144749A1/en not_active Abandoned
- 1993-09-03 JP JP6507878A patent/JPH08501776A/ja not_active Ceased
- 1993-09-03 US US08/397,065 patent/US5718884A/en not_active Expired - Lifetime
- 1993-09-03 DK DK93919497T patent/DK0660724T3/da active
- 1993-09-03 AU AU49734/93A patent/AU689086B2/en not_active Ceased
- 1993-09-03 AT AT93919497T patent/ATE167805T1/de not_active IP Right Cessation
- 1993-09-03 EP EP97203948A patent/EP0835664A3/en not_active Withdrawn
- 1993-09-03 WO PCT/GB1993/001861 patent/WO1994006477A1/en active IP Right Grant
- 1993-09-03 ES ES93919497T patent/ES2117715T3/es not_active Expired - Lifetime
- 1993-09-03 DE DE69319438T patent/DE69319438T2/de not_active Expired - Fee Related
- 1993-09-03 EP EP93919497A patent/EP0660724B1/en not_active Expired - Lifetime
- 1993-09-14 CN CN93117692A patent/CN1048410C/zh not_active Expired - Fee Related
-
1995
- 1995-03-14 NO NO950986A patent/NO950986L/no unknown
- 1995-03-15 FI FI951210A patent/FI951210A/fi unknown
-
1998
- 1998-03-23 HK HK98102427A patent/HK1003293A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI951210A (fi) | 1995-05-10 |
AU689086B2 (en) | 1998-03-26 |
NO950986D0 (no) | 1995-03-14 |
WO1994006477A1 (en) | 1994-03-31 |
DE69319438D1 (de) | 1998-08-06 |
FI951210A0 (fi) | 1995-03-15 |
EP0835664A3 (en) | 1998-08-12 |
CA2144749A1 (en) | 1994-03-31 |
US5718884A (en) | 1998-02-17 |
EP0835664A2 (en) | 1998-04-15 |
CN1048410C (zh) | 2000-01-19 |
EP0660724A1 (en) | 1995-07-05 |
JPH08501776A (ja) | 1996-02-27 |
HK1003293A1 (en) | 1998-10-23 |
CN1088114A (zh) | 1994-06-22 |
ATE167805T1 (de) | 1998-07-15 |
EP0660724B1 (en) | 1998-07-01 |
DK0660724T3 (da) | 1998-11-02 |
ES2117715T3 (es) | 1998-08-16 |
DE69319438T2 (de) | 1998-12-03 |
AU4973493A (en) | 1994-04-12 |
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