NO950986L - Kryssbundne og reduserte kontrastmidler - Google Patents

Kryssbundne og reduserte kontrastmidler

Info

Publication number
NO950986L
NO950986L NO950986A NO950986A NO950986L NO 950986 L NO950986 L NO 950986L NO 950986 A NO950986 A NO 950986A NO 950986 A NO950986 A NO 950986A NO 950986 L NO950986 L NO 950986L
Authority
NO
Norway
Prior art keywords
contrast agents
gas
proteinaceous
crosslinked
size distribution
Prior art date
Application number
NO950986A
Other languages
English (en)
Other versions
NO950986D0 (no
Inventor
Jo Klaveness
Paal Rongved
John Henrik Johansen
Per Antonius Foss
Anders Hoegseth
Anne Marie Hvoslef
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929219595A external-priority patent/GB9219595D0/en
Priority claimed from GB929220639A external-priority patent/GB9220639D0/en
Priority claimed from GB929220638A external-priority patent/GB9220638D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of NO950986L publication Critical patent/NO950986L/no
Publication of NO950986D0 publication Critical patent/NO950986D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

Proteinholdige mikroboble-kontrastmidler inneholdende gass- eller gass-forløpere, f.eks. til bruk i ultralyd- og/eller MR-avbildning, der protein-matrixen er kryssbundet ved reaksjon med et bifunksjonelt aldehyd (f.eks. et dialdehyd som glutaraldehyd eller et a, p-umettet aldehyd som akrolein), i et vandig medium ved hovedsakelig nøytral pH, viser forbedret stabilitet in vivo og ved lagring, særlig hvis matrixen også reageres med et SchifFs base reduksjonsmiddel slik som et borhydrid. Modifisering av størrelsesfordelingen av slike kryssbunde protein- og gassholdige kontrastmidler, f. eks. ved å redusere gjennomsnittstørrelse av mikroboblene, forbedrer deres stabilitet ytterligere og tillater framstilling kv nye kontrastmidler med en særlig smal størrelsesfordeling for mikroboblene.
NO950986A 1992-09-16 1995-03-14 Kryssbundne og reduserte kontrastmidler NO950986D0 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929219595A GB9219595D0 (en) 1992-09-16 1992-09-16 Improvements in or relating to contrast agents
GB929220639A GB9220639D0 (en) 1992-09-30 1992-09-30 Improvements in or relating to contrast agents
GB929220638A GB9220638D0 (en) 1992-09-30 1992-09-30 Improvements in or relating to contrast agents
PCT/GB1993/001861 WO1994006477A1 (en) 1992-09-16 1993-09-03 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
NO950986L true NO950986L (no) 1995-03-14
NO950986D0 NO950986D0 (no) 1995-03-14

Family

ID=27266368

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950986A NO950986D0 (no) 1992-09-16 1995-03-14 Kryssbundne og reduserte kontrastmidler

Country Status (14)

Country Link
US (1) US5718884A (no)
EP (2) EP0660724B1 (no)
JP (1) JPH08501776A (no)
CN (1) CN1048410C (no)
AT (1) ATE167805T1 (no)
AU (1) AU689086B2 (no)
CA (1) CA2144749A1 (no)
DE (1) DE69319438T2 (no)
DK (1) DK0660724T3 (no)
ES (1) ES2117715T3 (no)
FI (1) FI951210A (no)
HK (1) HK1003293A1 (no)
NO (1) NO950986D0 (no)
WO (1) WO1994006477A1 (no)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
ES2231775T5 (es) 1993-07-30 2011-02-02 Imcor Pharmaceutical Co. Composición de microburbujas estabilizadas para ecografía.
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5955143A (en) * 1995-12-21 1999-09-21 Drexel University Hollow polymer microcapsules and method of producing the same
DE19626530A1 (de) * 1996-07-02 1998-01-15 Byk Gulden Lomberg Chem Fab MR-Kontrastmittelzubereitungen
US6108637A (en) 1996-09-03 2000-08-22 Nielsen Media Research, Inc. Content display monitor
US6083484A (en) 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US7131997B2 (en) * 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7462366B2 (en) * 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7053134B2 (en) * 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
CA2418229A1 (en) * 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
WO2003105917A2 (en) 2002-06-12 2003-12-24 Scimed Life Systems, Inc. Bulking agents
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7449236B2 (en) * 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7588825B2 (en) * 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7976823B2 (en) * 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20050074406A1 (en) * 2003-10-03 2005-04-07 Scimed Life Systems, Inc. Ultrasound coating for enhancing visualization of medical device in ultrasound images
US7901770B2 (en) * 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7736671B2 (en) * 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US20050238870A1 (en) * 2004-04-22 2005-10-27 Marcia Buiser Embolization
US7311861B2 (en) * 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7858183B2 (en) * 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US20070004973A1 (en) * 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US8123693B2 (en) 2005-06-20 2012-02-28 Conceptus, Inc. Methods and devices for determining lumen occlusion
US9463426B2 (en) * 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) * 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US20070083219A1 (en) * 2005-10-12 2007-04-12 Buiser Marcia S Embolic coil introducer sheath locking mechanisms
US8152839B2 (en) * 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US20070142859A1 (en) * 2005-12-19 2007-06-21 Boston Scientific Scimed, Inc. Embolic coils
US20070142560A1 (en) * 2005-12-21 2007-06-21 Young-Ho Song Block copolymer particles
US7501179B2 (en) * 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) * 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
DE102006023456A1 (de) * 2006-05-18 2007-11-22 Siemens Ag Kontrastmittel für die Röntgen- und Computertomographie-Diagnostik
US20070299461A1 (en) * 2006-06-21 2007-12-27 Boston Scientific Scimed, Inc. Embolic coils and related components, systems, and methods
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US20080145658A1 (en) * 2006-12-15 2008-06-19 Boston Scientific Scimed, Inc. Freeze Thaw Methods For Making Polymer Particles
US8585616B2 (en) * 2009-10-09 2013-11-19 Conceptus, Inc. Methods and apparatus for determining fallopian tube occlusion
KR101853948B1 (ko) * 2013-07-05 2018-05-02 사회복지법인 삼성생명공익재단 X-선 조영제 및 기포 촉진제를 함유하는 조영 조성물 및 그 제조방법
CN104174040A (zh) * 2014-08-13 2014-12-03 中国科学院宁波材料技术与工程研究所 一种造影材料、其制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US5284646A (en) * 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
DE3709851A1 (de) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te Nmr-diagnostische fluessigkeitszusammensetzungen
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
AU635449B2 (en) * 1990-10-05 1993-03-18 Bracco International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography

Also Published As

Publication number Publication date
WO1994006477A1 (en) 1994-03-31
EP0835664A3 (en) 1998-08-12
ES2117715T3 (es) 1998-08-16
AU4973493A (en) 1994-04-12
US5718884A (en) 1998-02-17
JPH08501776A (ja) 1996-02-27
FI951210A0 (fi) 1995-03-15
DK0660724T3 (da) 1998-11-02
NO950986D0 (no) 1995-03-14
EP0660724A1 (en) 1995-07-05
DE69319438D1 (de) 1998-08-06
DE69319438T2 (de) 1998-12-03
CN1048410C (zh) 2000-01-19
AU689086B2 (en) 1998-03-26
CA2144749A1 (en) 1994-03-31
EP0835664A2 (en) 1998-04-15
HK1003293A1 (en) 1998-10-23
ATE167805T1 (de) 1998-07-15
FI951210A (fi) 1995-05-10
CN1088114A (zh) 1994-06-22
EP0660724B1 (en) 1998-07-01

Similar Documents

Publication Publication Date Title
NO950986L (no) Kryssbundne og reduserte kontrastmidler
US5529766C1 (en) Contrast agents
US5558094B1 (en) Methods for using persistent gases as ultrasound contrast media
FI940027A0 (fi) Parannuksia itse varjoaineisiin tai parannuksia, jotka liittyvät niihin
ATE180170T1 (de) Liposome als kontrastmittel für ultraschallabbildung
PT788348E (pt) Recipiente contendo uma composicao polifasica para utilizacao e terapeutica
NO934366L (no) Kovalent modifiserte mikropartikulaere kontrastmidler
AU4301996A (en) Chalcones and esters thereof with antiproliferative activityin uterus, ovary and breast tumours
JPS57109797A (en) Preparation of low-molecular weight keratinous substance
PL337287A1 (en) Application of intravenous contrast media in projection mammography
CA2161305A1 (fr) Nouveaux composes sous forme de polymere de 5,6-dihydroxyindole, leur procede et compositions les comprenant
IT8019327A0 (it) Procedimento d'ottenimento di leghe di manganese a medio tenore in carbonio.
Stewart On the road to scandal.
Ingold 6.1. 8.3. 3.3 5-Nitroimidazoles: 6.1. 8.3. 3 Heterocyclic nitro radical anions
O'Donnell et al. Hard bargain.
Jones James Rouse sparked new life in old cities.
TH12925A (th) สารให้ความเปรียบต่างสำหรับการสร้างภาพด้วยอุลตร้าซาวด์
RU92004556A (ru) Контрастное вещество для ультразвуковой диагностики и способ его получения