NO940084L - Fremgangsmåte for behandling av motor-neuron sykdommer ved anvendelse av medlemmer av BDNF/NT-3/NGF familien av molekyler - Google Patents

Fremgangsmåte for behandling av motor-neuron sykdommer ved anvendelse av medlemmer av BDNF/NT-3/NGF familien av molekyler

Info

Publication number
NO940084L
NO940084L NO940084A NO940084A NO940084L NO 940084 L NO940084 L NO 940084L NO 940084 A NO940084 A NO 940084A NO 940084 A NO940084 A NO 940084A NO 940084 L NO940084 L NO 940084L
Authority
NO
Norway
Prior art keywords
bdnf
molecules
members
neuron diseases
treating motor
Prior art date
Application number
NO940084A
Other languages
English (en)
Other versions
NO940084D0 (no
Inventor
Vivien Wong
Czeslaw Radziejewski
Peter Distefano
Original Assignee
Regeneron Pharma
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Max Planck Gesellschaft filed Critical Regeneron Pharma
Publication of NO940084D0 publication Critical patent/NO940084D0/no
Publication of NO940084L publication Critical patent/NO940084L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physical Water Treatments (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Water Treatment By Sorption (AREA)
  • Medicines Containing Plant Substances (AREA)
  • External Artificial Organs (AREA)

Abstract

Fremgangsmåter for behandling av motor-neuron forstyrrelser, så som amyotroflsk lateral sklerose (Lou Gehrlgs sykdom) omfattende administrering til en pasient som trenger en slik behandling, en effektiv mengde av en neurotrofisk faktor som er et medlem av BDNF/NT-3/NGF familien av molekyler og som understøtter overlevelsen, veksten og/eller differensiering av motorneuroner, er beskrevet. Den er delvis basert på oppdagelsen av at BDNF og NT-3 hver kan ake cholin- acetyltransferase aktiviteten l motor-neuron kulturer. I en kombinasjon av BDNF eller NT-3 og et annet middel, så som CNTF kan bil anvendt for behandling av motor- neuron sykdommen. Fremgangsmåter for å fremme over- levelsen, veksten og/el]er differensieringen av motor- neuroner in vltro, fremgangsmåte for diagnostikk og analysesystemer som kan bli anvendt for å identifisere midler som har BDNF eller NT-3-1ignende aktivitet og som kan være nytt for behandling av motor-neuron sykdommer, er også beskrevet. Dyremodeller for motor- neuron sykdom produsert ved immunisering av dyr overfor BDNF/NT-3/NGF familiemedlemmer eller derivater derav eller ved administrering til dyrene anti-BDNF/Nt-3/NGF famile medlem anistoffer er også omtalt.
NO940084A 1991-07-10 1994-01-10 Fremgangsmåte for behandling av motor-neuron sykdommer ved anvendelse av medlemmer av BDNF/NT-3/NGF familien av molekyler NO940084L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72770491A 1991-07-10 1991-07-10
PCT/US1992/004228 WO1993001300A1 (en) 1991-07-10 1992-05-19 Methods of treatment of motor neuron diseases using members of the bdnf/nt-3/ngf family of molecules

Publications (2)

Publication Number Publication Date
NO940084D0 NO940084D0 (no) 1994-01-10
NO940084L true NO940084L (no) 1994-03-08

Family

ID=24923677

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940084A NO940084L (no) 1991-07-10 1994-01-10 Fremgangsmåte for behandling av motor-neuron sykdommer ved anvendelse av medlemmer av BDNF/NT-3/NGF familien av molekyler

Country Status (20)

Country Link
EP (2) EP0755682A1 (no)
JP (1) JPH06509094A (no)
CN (1) CN1065768C (no)
AT (1) ATE202939T1 (no)
AU (2) AU675409B2 (no)
CA (1) CA2113083A1 (no)
DE (1) DE69231930T2 (no)
DK (1) DK0593516T3 (no)
ES (1) ES2157903T3 (no)
FI (1) FI940098A (no)
GR (1) GR3036776T3 (no)
HU (1) HUT70275A (no)
IE (1) IE921602A1 (no)
IL (1) IL101928A0 (no)
NO (1) NO940084L (no)
PT (1) PT100501A (no)
RU (1) RU94016525A (no)
SK (1) SK2694A3 (no)
WO (1) WO1993001300A1 (no)
ZA (1) ZA923639B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07509600A (ja) * 1992-06-12 1995-10-26 リジェネロン　ファーマシューティカルズ，インコーポレーテッド ニューロトロフィン−４発現に基づく治療および診断法
FR2717496B1 (fr) * 1994-03-18 1996-04-12 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
CN1112215C (zh) * 1999-12-28 2003-06-25 潘晓东 神经生长因子在治疗有机溶剂中毒性周围神经病中的用途
EP1278537B1 (en) * 2000-05-05 2009-01-14 The Research Foundation Of the City university of New York Compositions for stimulating nervous system regeneration and repair by regulating arginase i and polyamine synthesis
WO2006055685A2 (en) * 2004-11-17 2006-05-26 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
WO2008156418A1 (en) * 2007-06-19 2008-12-24 Astrazeneca Ab A method for screening or diagnosis of postpolio syndrome and fibromyalgia
WO2009023540A1 (en) * 2007-08-10 2009-02-19 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human nerve growth factor
WO2014111525A2 (en) 2013-01-18 2014-07-24 Anaxomics Biotech, Sl New combination therapies for treating nervous system diseases
US10349890B2 (en) 2015-06-26 2019-07-16 C. R. Bard, Inc. Connector interface for ECG-based catheter positioning system
WO2023164311A2 (en) * 2022-02-28 2023-08-31 Bioincept, Llc Compositions and methods of treating amyotrophic lateral sclerosis (als) and related disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923696A (en) * 1987-05-04 1990-05-08 Baylor College Of Medicine Method to prepare a neurotrophic composition
IL95511A (en) * 1989-08-30 2000-10-31 Max Planck Gesellschaft Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor

Also Published As

Publication number Publication date
CA2113083A1 (en) 1993-01-21
GR3036776T3 (en) 2002-01-31
DE69231930T2 (de) 2002-04-11
FI940098A0 (fi) 1994-01-10
WO1993001300A1 (en) 1993-01-21
EP0593516A1 (en) 1994-04-27
EP0755682A1 (en) 1997-01-29
FI940098A (fi) 1994-03-10
CN1065768C (zh) 2001-05-16
IE921602A1 (en) 1993-01-13
DK0593516T3 (da) 2001-09-17
SK2694A3 (en) 1995-02-08
PT100501A (pt) 1993-09-30
ZA923639B (en) 1993-02-24
HU9400063D0 (en) 1994-06-28
AU2009592A (en) 1993-02-11
ES2157903T3 (es) 2001-09-01
JPH06509094A (ja) 1994-10-13
CN1071585A (zh) 1993-05-05
HUT70275A (en) 1995-09-28
AU7067696A (en) 1997-01-16
NO940084D0 (no) 1994-01-10
AU675409B2 (en) 1997-02-06
ATE202939T1 (de) 2001-07-15
IL101928A0 (en) 1992-12-30
RU94016525A (ru) 1996-06-10
EP0593516B1 (en) 2001-07-11
EP0593516A4 (en) 1995-01-18
DE69231930D1 (de) 2001-08-16

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