NO940009L - Pyrazolopyrimidin og pyrimidinylbisfosfonsyreestere som anti-inflammatoriske midler - Google Patents

Pyrazolopyrimidin og pyrimidinylbisfosfonsyreestere som anti-inflammatoriske midler

Info

Publication number
NO940009L
NO940009L NO940009A NO940009A NO940009L NO 940009 L NO940009 L NO 940009L NO 940009 A NO940009 A NO 940009A NO 940009 A NO940009 A NO 940009A NO 940009 L NO940009 L NO 940009L
Authority
NO
Norway
Prior art keywords
pyrazolopyrimidine
inflammatory agents
pyrimidinyl
esters
bisphosphonic esters
Prior art date
Application number
NO940009A
Other languages
English (en)
Norwegian (no)
Other versions
NO940009D0 (no
Inventor
Richard Allen Nugent
Stephen Thomas Schlachter
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of NO940009D0 publication Critical patent/NO940009D0/no
Publication of NO940009L publication Critical patent/NO940009L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NO940009A 1991-07-03 1994-01-03 Pyrazolopyrimidin og pyrimidinylbisfosfonsyreestere som anti-inflammatoriske midler NO940009L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72504791A 1991-07-03 1991-07-03
US72504691A 1991-07-03 1991-07-03
PCT/US1992/005398 WO1993001198A1 (en) 1991-07-03 1992-07-01 Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories

Publications (2)

Publication Number Publication Date
NO940009D0 NO940009D0 (no) 1994-01-03
NO940009L true NO940009L (no) 1994-01-09

Family

ID=27111084

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940009A NO940009L (no) 1991-07-03 1994-01-03 Pyrazolopyrimidin og pyrimidinylbisfosfonsyreestere som anti-inflammatoriske midler

Country Status (19)

Country Link
US (1) US5397774A (de)
EP (2) EP0521622B1 (de)
JP (1) JPH06509100A (de)
CN (1) CN1031826C (de)
AT (1) ATE152728T1 (de)
AU (1) AU653428B2 (de)
CA (1) CA2110167A1 (de)
CZ (1) CZ19595A3 (de)
DE (1) DE69219602D1 (de)
FI (1) FI935944A (de)
HU (2) HUT70758A (de)
IE (1) IE922162A1 (de)
IL (1) IL102171A (de)
MX (1) MX9203945A (de)
NO (1) NO940009L (de)
RU (1) RU2079506C1 (de)
SK (1) SK277986B6 (de)
TW (1) TW222638B (de)
WO (1) WO1993001198A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003463A1 (en) * 1992-08-07 1994-02-17 The Upjohn Company Phosphonoacetic esters and acids as anti-inflammatories
WO1994009017A1 (en) * 1992-10-09 1994-04-28 The Upjohn Company Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
EP0724573A1 (de) * 1993-10-20 1996-08-07 PHARMACIA & UPJOHN COMPANY Pyrimidinonen als antiarthritische und entzündungs hemmende mittel
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
CA2321864A1 (en) * 1998-12-25 2000-07-06 Toray Industries, Inc. Interleukin-6 production inhibitor
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
AU783516B2 (en) 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
EP1926734A1 (de) 2005-08-22 2008-06-04 Amgen Inc. Als modulatoren von kinaseenzymen geeignete pyrazolopyridin- und pyrazolopyrimidinverbindungen
EP1884516A1 (de) * 2006-08-04 2008-02-06 Ferrer Internacional, S.A. Pyrazolo[1,5-a]pyrimidine, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung
EP2270021A1 (de) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonatsynthone zur Synthese von Phosphonat-Derivaten mit besserer Bioverfügbarkeit
EP2767543B1 (de) * 2011-10-14 2017-08-30 Aktsionernoe Obshcestvo "Proizvodstvenno-Kommercheskaya Assotsiatsiya AZT" Salze aus carbamoylphosphonsäureester als selektive inhibitoren der produktion des humanen immundefizienzvirus hiv-1
EP3187492A4 (de) * 2014-08-29 2018-05-09 The University of Tokyo Pyrimidinonderivat mit autotaxin-hemmender wirkung
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2703712A1 (de) * 1977-01-29 1978-08-03 Bayer Ag Substituierte pyrimidinon eckige klammer auf (di)-thio eckige klammer zu -phosphor-(phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3770787D1 (en) * 1986-11-21 1991-07-18 Ciba Geigy Ag Aromatisch substituierte azacyclo-alkylalkandiphosphonsaeuren.
US5071840A (en) * 1986-12-19 1991-12-10 Norwich Eaton Pharmaceuticals, Inc. Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
DE3719513A1 (de) * 1987-06-11 1988-12-22 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
EP0650360A1 (de) * 1992-07-16 1995-05-03 The Upjohn Company Phosphonoderivate als entzündungshemmende und antiarthritische wirkstoffe
WO1994009017A1 (en) * 1992-10-09 1994-04-28 The Upjohn Company Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories

Also Published As

Publication number Publication date
RU2079506C1 (ru) 1997-05-20
CN1068332A (zh) 1993-01-27
NO940009D0 (no) 1994-01-03
ATE152728T1 (de) 1997-05-15
IE922162A1 (en) 1993-01-13
US5397774A (en) 1995-03-14
HUT70758A (en) 1995-10-30
FI935944A0 (fi) 1993-12-30
HU211488A9 (en) 1995-11-28
HU9400003D0 (en) 1994-05-30
CA2110167A1 (en) 1993-01-21
EP0521622B1 (de) 1997-08-13
TW222638B (de) 1994-04-21
AU2240892A (en) 1993-02-11
MX9203945A (es) 1993-04-01
EP0521622A1 (de) 1993-01-07
JPH06509100A (ja) 1994-10-13
WO1993001198A1 (en) 1993-01-21
IL102171A0 (en) 1993-01-14
SK150493A3 (en) 1994-11-09
CN1031826C (zh) 1996-05-22
CZ19595A3 (en) 1995-10-18
EP0593575B1 (de) 1997-05-07
AU653428B2 (en) 1994-09-29
IL102171A (en) 1996-11-14
DE69219602D1 (de) 1997-06-12
EP0593575A1 (de) 1994-04-27
FI935944A (fi) 1993-12-30
SK277986B6 (en) 1995-09-13

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