NO933596L - Nye 2-spirocyklopropylcefalosporinsulfonderivater og deres fremstilling - Google Patents
Nye 2-spirocyklopropylcefalosporinsulfonderivater og deres fremstillingInfo
- Publication number
- NO933596L NO933596L NO93933596A NO933596A NO933596L NO 933596 L NO933596 L NO 933596L NO 93933596 A NO93933596 A NO 93933596A NO 933596 A NO933596 A NO 933596A NO 933596 L NO933596 L NO 933596L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- substituted
- ring
- phenyl
- optionally substituted
- Prior art date
Links
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical class O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- -1 sulfone compound Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000016387 Pancreatic elastase Human genes 0.000 abstract 1
- 108010067372 Pancreatic elastase Proteins 0.000 abstract 1
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
2-spirocyklopropylcefalosporlnsulfonforbindelsermed formelen: der R1 er OR6 eller NR7R8; R2 er en C- ,-alkylgruppe som kan være substituert med en triazolylgruppe; R3 er fenyl; R4 er fenyl; R5 er en Cj.-alkoksygruppe; R(, er hydrogen, eventuelt substituert -CH2-fenyl eller eventuelt substituert -CH(fenyl )2, der fenylgruppene kan være substituert med minst en C1_,-alkoksygruppe; R7 er C. ,-alkyl som kan være substituert med 1-2 COOH eller C- 7-alkoksykarbonyl, eventuelt substituert tlazolyl, eller R7 sammen med Rg kan danne en eventuelt substituert ring der ringen kan være substituert med minst en av C^-alkyl, hydroksy-C^-alkyl. -COQH, C^-alkyl-COOH, C2_7-alkoksykarbonyl, C^-alkoksy- karbonyl-C ,-alkyl, karboksamid som kan være substituert med (^ ,-alkyl-COOH eller Cjj^-alkoksykarbonyl- C1_6-alkyl, heterocykllsk ring som kan være substituert med C^-alkyl, COOH eller C-, -alkenyloksykarbonyl, og ringen kan inneholde minst et annet nltrogenatom, i hvilket tilfelle ringen ytterligere kan være substi- tuert på karbonatomet eller på nitrogenatoniet med de ovenfor nevnte grupper; Rg er hydrogen eller sammen med R7 danner en eventuelt substituert ring som angitt ovenfor; eller et farmasaytlsk eller et veterlnærmedisinsk akseptabelt salt derav. Forbindelsene med formel (I) rapporteres å ha interessante terapeutiske egenskaper for kontroll av inflanuiato- riske eller degenerative tilstander, særlig elastase-medlerte patologiske tilstander, hos pattedyr. COR. Forbindelsenes fremstilling beskrives.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/685,960 US5264430A (en) | 1989-10-06 | 1991-04-08 | 2-spirocyclopropyl cephalosporin sulfone derivatives |
| US07/747,762 US5264429A (en) | 1989-10-06 | 1991-08-20 | 2-spirocyclopropyl cephalosporin sulfone derivatives |
| PCT/CA1992/000146 WO1992018474A2 (en) | 1991-04-08 | 1992-04-07 | Novel 2-spirocyclopropyl cephalosporin sulfone derivatives and processes for the preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO933596L true NO933596L (no) | 1993-10-07 |
| NO933596D0 NO933596D0 (no) | 1993-10-07 |
Family
ID=27171659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO933596A NO933596D0 (no) | 1991-04-08 | 1993-10-07 | Nye 2-spirocyklopropylcefalosporinsulfonderivater og deres fremstilling |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO933596D0 (no) |
-
1993
- 1993-10-07 NO NO933596A patent/NO933596D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO933596D0 (no) | 1993-10-07 |
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