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Priority claimed from US07/616,021external-prioritypatent/US5114953A/en
Application filed by Univ FloridafiledCriticalUniv Florida
Publication of NO931803D0publicationCriticalpatent/NO931803D0/en
Publication of NO931803LpublicationCriticalpatent/NO931803L/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Forbindelser med formlene (1) eller (2) der R1 er H og R2 er alkyl (3-8C) eller der R1 og R2 tatt sammen er -(CH2)n- hvori n - 3-5: R3 er H eller alkyl (1-4C); R4 er en sammensmeltet eller konjugert substituert eller usubstltuert bicykloarylmetylen; X er OR5 eller NER5, der R5 er H eller substituert eller usubstltuert alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); eller X er et aminosyreresldle eller amld derav; eller X er resldlet til et cyklisk amin eller heterocykllsk arain, er nyttige for behandling eller forhindring av ulkerasjon i vev, særlig kornea.Compounds of formulas (1) or (2) wherein R1 is H and R2 is alkyl (3-8C) or wherein R1 and R2 taken together are - (CH2) n- wherein n - 3-5: R3 is H or alkyl ( 1-4C); R4 is a fused or conjugated substituted or unsubstituted bicycloarylmethylene; X is OR5 or NER5, where R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); or X is an amino acid saddle or amide thereof; or X is resiled to a cyclic amine or heterocyclic surface, useful for treating or preventing tissue ulceration, especially cornea.
NO93931803A1990-11-211993-05-18
TREATMENT OF TISSUE SULKATION
NO931803L
(en)
Cyclic and heterocyclic n-substituted alpha-iminohydroxamic and carboxylic acids with metalloproteinase inhibitor activity, preparation and use thereof
SWEETENING AGENTS DERIVED FROM GUANIDINOACETIC AND ETHANAMIDINOACETIC ACIDS, METHOD FOR SWEETENING VARIOUS PRODUCTS, AND COMPOSITIONS CONTAINING SUCH SWEETENING AGENTS