NO931841L - IMPROVED MATRIX METAL PROTEASE INHIBITORS - Google Patents

IMPROVED MATRIX METAL PROTEASE INHIBITORS

Info

Publication number
NO931841L
NO931841L NO93931841A NO931841A NO931841L NO 931841 L NO931841 L NO 931841L NO 93931841 A NO93931841 A NO 93931841A NO 931841 A NO931841 A NO 931841A NO 931841 L NO931841 L NO 931841L
Authority
NO
Norway
Prior art keywords
alkyl
matrix metal
metal protease
protease inhibitors
substituted
Prior art date
Application number
NO93931841A
Other languages
Norwegian (no)
Other versions
NO931841D0 (en
Inventor
Richard E Galardy
Damian Grobelny
Original Assignee
Richard E Galardy
Damian Grobelny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/615,798 external-priority patent/US5183900A/en
Priority claimed from US07/747,752 external-priority patent/US5189178A/en
Application filed by Richard E Galardy, Damian Grobelny filed Critical Richard E Galardy
Publication of NO931841L publication Critical patent/NO931841L/en
Publication of NO931841D0 publication Critical patent/NO931841D0/en

Links

Abstract

Forbindelser med formelene:. der hver R^ er uavhengig av hverandre H eller alkyl (1-8C) og Rer alkyl (1-8C) eller der proksimal Rog Rtatt sammen er -(CH)p- hvori p = 3-5;. Rer H eller alkyl (1-4C);. R 4 er sammensmeltet eller konjugert usubstituert eller substituert bicykloarylmetylen;. n er 0, 1 eller 2;. m er 0 eller 1; og. X er OReller NHR, der Rer H eller substituert eller usubstituert alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); eller. X er en aminosyreresidie eller amid derav; eller. X er resten av et cyklisk amin eller heterocyklisk amin;. der Rer H eller laverealkyl (1-4C) og Rer E, laverealkyl (1-4C) eller en acylglruppe, og der —CONRer eventuelt i modifisert isosterisk form.Forbindelsene er nyttige i behandling av tilstander som er kjennetegnet ved uønsket matriksmetallprotease-aktivitet.Compounds of the formulas:. where each R 2 is independently H or alkyl (1-8C) and R 1 is alkyl (1-8C) or where proximal Rog Rtag taken together is - (CH) p- wherein p = 3-5; R 1 is H or alkyl (1-4C); R 4 is fused or conjugated unsubstituted or substituted bicycloarylmethylene; n is 0, 1 or 2; m is 0 or 1; and. X is OR or NHR, wherein R 1 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); or. X is an amino acid residue or amide thereof; or. X is the residue of a cyclic amine or heterocyclic amine; where R is H or lower alkyl (1-4C) and R is E, lower alkyl (1-4C) or an acyl group, and where -CONRs are optionally in modified isosteric form. The compounds are useful in the treatment of conditions characterized by undesired matrix metal protease activity.

NO931841A 1990-11-21 1993-05-19 IMPROVED MATRIX METAL PROTEASE INHIBITORS NO931841D0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/615,798 US5183900A (en) 1990-11-21 1990-11-21 Matrix metalloprotease inhibitors
US07/747,752 US5189178A (en) 1990-11-21 1991-08-20 Matrix metalloprotease inhibitors
PCT/US1991/008723 WO1992009556A1 (en) 1990-11-21 1991-11-21 Improved matrix metalloprotease inhibitors

Publications (2)

Publication Number Publication Date
NO931841L true NO931841L (en) 1993-05-19
NO931841D0 NO931841D0 (en) 1993-05-19

Family

ID=27376844

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931841A NO931841D0 (en) 1990-11-21 1993-05-19 IMPROVED MATRIX METAL PROTEASE INHIBITORS

Country Status (1)

Country Link
NO (1) NO931841D0 (en)

Also Published As

Publication number Publication date
NO931841D0 (en) 1993-05-19

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