NO931841L - IMPROVED MATRIX METAL PROTEASE INHIBITORS - Google Patents
IMPROVED MATRIX METAL PROTEASE INHIBITORSInfo
- Publication number
- NO931841L NO931841L NO93931841A NO931841A NO931841L NO 931841 L NO931841 L NO 931841L NO 93931841 A NO93931841 A NO 93931841A NO 931841 A NO931841 A NO 931841A NO 931841 L NO931841 L NO 931841L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- matrix metal
- metal protease
- protease inhibitors
- substituted
- Prior art date
Links
Abstract
Forbindelser med formelene:. der hver R^ er uavhengig av hverandre H eller alkyl (1-8C) og Rer alkyl (1-8C) eller der proksimal Rog Rtatt sammen er -(CH)p- hvori p = 3-5;. Rer H eller alkyl (1-4C);. R 4 er sammensmeltet eller konjugert usubstituert eller substituert bicykloarylmetylen;. n er 0, 1 eller 2;. m er 0 eller 1; og. X er OReller NHR, der Rer H eller substituert eller usubstituert alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); eller. X er en aminosyreresidie eller amid derav; eller. X er resten av et cyklisk amin eller heterocyklisk amin;. der Rer H eller laverealkyl (1-4C) og Rer E, laverealkyl (1-4C) eller en acylglruppe, og der —CONRer eventuelt i modifisert isosterisk form.Forbindelsene er nyttige i behandling av tilstander som er kjennetegnet ved uønsket matriksmetallprotease-aktivitet.Compounds of the formulas:. where each R 2 is independently H or alkyl (1-8C) and R 1 is alkyl (1-8C) or where proximal Rog Rtag taken together is - (CH) p- wherein p = 3-5; R 1 is H or alkyl (1-4C); R 4 is fused or conjugated unsubstituted or substituted bicycloarylmethylene; n is 0, 1 or 2; m is 0 or 1; and. X is OR or NHR, wherein R 1 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); or. X is an amino acid residue or amide thereof; or. X is the residue of a cyclic amine or heterocyclic amine; where R is H or lower alkyl (1-4C) and R is E, lower alkyl (1-4C) or an acyl group, and where -CONRs are optionally in modified isosteric form. The compounds are useful in the treatment of conditions characterized by undesired matrix metal protease activity.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/615,798 US5183900A (en) | 1990-11-21 | 1990-11-21 | Matrix metalloprotease inhibitors |
US07/747,752 US5189178A (en) | 1990-11-21 | 1991-08-20 | Matrix metalloprotease inhibitors |
PCT/US1991/008723 WO1992009556A1 (en) | 1990-11-21 | 1991-11-21 | Improved matrix metalloprotease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO931841L true NO931841L (en) | 1993-05-19 |
NO931841D0 NO931841D0 (en) | 1993-05-19 |
Family
ID=27376844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO931841A NO931841D0 (en) | 1990-11-21 | 1993-05-19 | IMPROVED MATRIX METAL PROTEASE INHIBITORS |
Country Status (1)
Country | Link |
---|---|
NO (1) | NO931841D0 (en) |
-
1993
- 1993-05-19 NO NO931841A patent/NO931841D0/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO931841D0 (en) | 1993-05-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE265433T1 (en) | IMPROVED MATRIX METAL PROTEASE INHIBITORS | |
ATE157963T1 (en) | IMPROVED MATRIX METAL PROTEASE INHIBITORS | |
PT944617E (en) | BENZIMIDAZOLE DERIVATIVES CRYSTALS AND THEIR PRODUCTION | |
GB1498199A (en) | Fungicidal agents | |
ATE164767T1 (en) | TREATMENT FOR TISSUE ULCERATIONS | |
ES535552A0 (en) | A PROCEDURE FOR THE PREPARATION OF NEW THIAZOLIDINE DERIVATIVES. | |
DK0412404T3 (en) | Thiazole derivatives, processes for their preparation and pharmaceutical compositions comprising the derivatives | |
DK7490A (en) | AMINOPOLYCARBOXYLIC ACIDS AND DERIVATIVES THEREOF | |
DK0787726T3 (en) | New compound, method of preparation thereof and anti-tumor agent | |
NO943744L (en) | Process for Destroying Mercaptans, and Preparation of Quaternary Ammonium Hydroxides for This Purpose | |
FI860107A (en) | AMINOFENOLDERIVAT. | |
ATE285238T1 (en) | METHOD FOR LOWERING SERUM CHOLESTEROL LEVELS USING 2,6-DIALKYL-4 SILYL-PHENOL DERIVATIVES | |
DE3864707D1 (en) | BENZOXAZINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION. | |
NO931841L (en) | IMPROVED MATRIX METAL PROTEASE INHIBITORS | |
ES8308543A1 (en) | Substituted 2-phenyl-2-(pyridyloxy)-ethyl amines and isosteric compounds, process for their preparation and use. | |
NO931844L (en) | IMPROVED MATRIX METAL PROTEASE INHIBITORS | |
ES494257A0 (en) | PROCEDURE FOR THE PREPARATION OF A PEPTIDAMIDE | |
ES556048A0 (en) | A PROCEDURE FOR THE PREPARATION OF A THIAZOLIDINE DERIVATIVE. | |
ES8503655A1 (en) | Novel dihydropyridines. | |
NO931803L (en) | TREATMENT OF TISSUE SULKATION | |
BR9100971A (en) | COMPOUNDS, PROCESS FOR THE PREPARATION OF ARILA-PROPILA-AMINIC COMPOUNDS AND COMPOUNDS | |
ATE44741T1 (en) | 2-(N-SUBSTITUTED GUANIDINO)-4HETEROARYLTHIAZOLE AS ANTI-ULCER AGENTS. | |
JPS52254A (en) | Process for preparation of secopenicilanic acid amide derivatives | |
DE3560291D1 (en) | 1-ûn-(alpha-amino-alpha-methylacetyl)-aminophenyl¨-2-amino propanon derivatives, process for their preparation and their therapeutical use | |
MX9700828A (en) | Azaaspartic acid analogs as interleukin-1 beta converting enzyme inhibitors. |