NO931844L - IMPROVED MATRIX METAL PROTEASE INHIBITORS - Google Patents
IMPROVED MATRIX METAL PROTEASE INHIBITORSInfo
- Publication number
- NO931844L NO931844L NO93931844A NO931844A NO931844L NO 931844 L NO931844 L NO 931844L NO 93931844 A NO93931844 A NO 93931844A NO 931844 A NO931844 A NO 931844A NO 931844 L NO931844 L NO 931844L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- protease inhibitors
- matrix metal
- lower alkyl
- metal protease
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Forbindelser med formler: (1) eller (2) der hver R1 er uavhengig av hverandre H eller alkyl (1-8C) og R2 er alkyl (1-8C) eller der prokslmal R1 og R2 tatt sammen er -(CB2)p¿ hvori p - 3-5; R3 er H eller alkyl (1-4C); R4 er samnensmeltet eller konjugert usubstltuert eller substituert bicykloarylmetylen; n er O, l eller 2; m er O eller 1; og X er OR5 eller NHR5 der R5 er H eller substituert eller usubstltuert alkyl (1-12C), aryl (6-12C), arylalkyl (6- 16C); R7 er lavere alkyl (1-4C) eller en acylgruppe, eller X er et amlnosyreresldu eller amld derav; eller X er residuet av et cykllsk amln eller heterocykllsk amln; Y blir valgt fra gruppen som består av R7ONR6CONR6- , R62NCONOR7-, og R6CONOR7-, der hver R6 er uavhengig av hverandre H eller lavere alkyl (1-4C); R7 er lavere alkyl (1-4C) eller en acylgruppe. der -CONR3- er eventuelt l modifisert Isosterlsk form. Forbindelsene er hemnere av matrlksmetallproteaser .Compounds of formulas: (1) or (2) wherein each R1 is independently H or alkyl (1-8C) and R2 is alkyl (1-8C) or where proxylmal R1 and R2 taken together are - (CB2) p wherein p is 3-5; R 3 is H or alkyl (1-4C); R 4 is fused or conjugated unsubstituted or substituted bicycloarylmethylene; n is 0, 1 or 2; m is 0 or 1; and X is OR5 or NHR5 wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); R7 is lower alkyl (1-4C) or an acyl group, or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine; Y is selected from the group consisting of R7ONR6CONR6-, R62NCONOR7-, and R6CONOR7-, where each R6 is independently H or lower alkyl (1-4C); R7 is lower alkyl (1-4C) or an acyl group. where -CONR3- is optionally in modified Isosteric form. The compounds are inhibitors of metal metal proteases.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/615,798 US5183900A (en) | 1990-11-21 | 1990-11-21 | Matrix metalloprotease inhibitors |
| US07/747,751 US5239078A (en) | 1990-11-21 | 1991-08-20 | Matrix metalloprotease inhibitors |
| PCT/US1991/008722 WO1992009563A1 (en) | 1990-11-21 | 1991-11-21 | Improved matrix metalloprotease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO931844D0 NO931844D0 (en) | 1993-05-19 |
| NO931844L true NO931844L (en) | 1993-07-09 |
Family
ID=27376843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93931844A NO931844L (en) | 1990-11-21 | 1993-05-19 | IMPROVED MATRIX METAL PROTEASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO931844L (en) |
-
1993
- 1993-05-19 NO NO93931844A patent/NO931844L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO931844D0 (en) | 1993-05-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE157963T1 (en) | IMPROVED MATRIX METAL PROTEASE INHIBITORS | |
| ATE265433T1 (en) | IMPROVED MATRIX METAL PROTEASE INHIBITORS | |
| ATE164767T1 (en) | TREATMENT FOR TISSUE ULCERATIONS | |
| TW341573B (en) | New erythromycin derivatives, their preparation process and their use as medicaments | |
| YU49227B (en) | Process for producting n-amino-1-hydroksi-alkil-idene-1,1-bisphosphonic acid | |
| DE60028045D1 (en) | NEW AMBERIC DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS | |
| DE50301525D1 (en) | Dental materials based on acrylic ester phosphonic acids | |
| ES479931A1 (en) | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. | |
| RU94026909A (en) | DERIVATIVES OF PIPERAZINCARBONIC ACID, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION | |
| NO934628L (en) | Retroviral protease inhibitors | |
| ATE137757T1 (en) | GEM-DIPHOSPHONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS | |
| NO995963L (en) | Carboxamides useful as 5-HTIF agonists | |
| PH20327A (en) | New substituted 1,4-dihydropyridines and pharmaceutical compositions containing the same | |
| CO4970719A1 (en) | PIRROLOPYROLONE DERIVATIVES AS LEUCOCITARY ELASTASE INHIBITORS | |
| NO952610L (en) | pyridonecarboxylic | |
| NO931844L (en) | IMPROVED MATRIX METAL PROTEASE INHIBITORS | |
| TR199800588T1 (en) | Herbicide heterocyclic benzisoxazoles and benzisoxazolidinones. | |
| GB1112034A (en) | Merocyanine dyes,photographic silver halide emulsions containing them and multilayer photographic elements | |
| ATE3548T1 (en) | NEW 5,10-DIHYDRO11H-DIBENZO (B,E)(1,4)DIAZEPIN-11-ONE SUBSTITUTED IN THE 5-POSITION, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS. | |
| TNSN90153A1 (en) | PROCESS FOR THE PREPARATION OF GLYCEROL DERIVATIVES | |
| KR900007371B1 (en) | Storage stable aryl-nitrone composition and method thereof | |
| JPS55102556A (en) | 22hydroxyynaphthalene derivative and diazo type material containing it | |
| ES8608462A1 (en) | Rooperol and its derivatives. | |
| DK0873993T3 (en) | New heterocyclic compounds, processes for their preparation and compositions containing them | |
| DK0876393T3 (en) | 21- (2-oxo-tetrahydrofuran) -thio-pregnant derivatives, process for their preparation and pharmaceutical compositions containing |