NO863386L - Analogifremgangsmaate for fremstilling av komplekser av visse cardiotoniske fosfodiesterase-inhibitorer og vannopploeselige vitaminer. - Google Patents
Analogifremgangsmaate for fremstilling av komplekser av visse cardiotoniske fosfodiesterase-inhibitorer og vannopploeselige vitaminer. Download PDFInfo
- Publication number
- NO863386L NO863386L NO863386A NO863386A NO863386L NO 863386 L NO863386 L NO 863386L NO 863386 A NO863386 A NO 863386A NO 863386 A NO863386 A NO 863386A NO 863386 L NO863386 L NO 863386L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- alkyl
- acid
- complex
- hydrogen
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 39
- 238000000034 method Methods 0.000 title claims description 23
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title claims description 14
- 230000003177 cardiotonic effect Effects 0.000 title claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title description 26
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title description 8
- 150000001875 compounds Chemical class 0.000 claims description 68
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 52
- 125000004432 carbon atom Chemical group C* 0.000 claims description 50
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 44
- 125000000217 alkyl group Chemical group 0.000 claims description 42
- 229940088594 vitamin Drugs 0.000 claims description 42
- 229930003231 vitamin Natural products 0.000 claims description 42
- 235000013343 vitamin Nutrition 0.000 claims description 42
- 239000011782 vitamin Substances 0.000 claims description 42
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 32
- 239000011668 ascorbic acid Substances 0.000 claims description 26
- 235000010323 ascorbic acid Nutrition 0.000 claims description 26
- 229960005070 ascorbic acid Drugs 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 24
- -1 aryl acylate Chemical compound 0.000 claims description 22
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- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 18
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
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- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 9
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
- 229960003495 thiamine Drugs 0.000 claims description 7
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims description 7
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- ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 claims description 4
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- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76854985A | 1985-08-23 | 1985-08-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO863386D0 NO863386D0 (no) | 1986-08-22 |
| NO863386L true NO863386L (no) | 1987-02-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO863386A NO863386L (no) | 1985-08-23 | 1986-08-22 | Analogifremgangsmaate for fremstilling av komplekser av visse cardiotoniske fosfodiesterase-inhibitorer og vannopploeselige vitaminer. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0212647A3 (ja) |
| JP (1) | JPS6284022A (ja) |
| AU (1) | AU595826B2 (ja) |
| DK (1) | DK403086A (ja) |
| ES (1) | ES2001114A6 (ja) |
| FI (1) | FI863404A (ja) |
| HU (1) | HU198395B (ja) |
| IL (1) | IL79815A (ja) |
| NO (1) | NO863386L (ja) |
| NZ (1) | NZ217324A (ja) |
| ZA (1) | ZA866388B (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06508842A (ja) | 1991-07-05 | 1994-10-06 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 置換ピリダジンの皮膚病に対する使用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189492A (en) * | 1977-05-31 | 1980-02-19 | Richardson-Merrell Inc. | Antihypertensive compositions of 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole and N-(2-chloroethyl)-N-(1-methyl-2-phenoxy-ethyl)benzenemethanamine |
| EP0011828A1 (en) * | 1978-11-23 | 1980-06-11 | The Wellcome Foundation Limited | Pharmaceutical combinations including hydantoin derivatives, pharmaceutical formulations containing the combinations and methods of making the formulations |
-
1986
- 1986-08-22 FI FI863404A patent/FI863404A/fi not_active IP Right Cessation
- 1986-08-22 ZA ZA866388A patent/ZA866388B/xx unknown
- 1986-08-22 EP EP86111663A patent/EP0212647A3/en not_active Withdrawn
- 1986-08-22 NO NO863386A patent/NO863386L/no unknown
- 1986-08-22 HU HU863648A patent/HU198395B/hu not_active IP Right Cessation
- 1986-08-22 DK DK403086A patent/DK403086A/da not_active Application Discontinuation
- 1986-08-22 NZ NZ217324A patent/NZ217324A/xx unknown
- 1986-08-22 ES ES8601267A patent/ES2001114A6/es not_active Expired
- 1986-08-22 JP JP61197975A patent/JPS6284022A/ja active Pending
- 1986-08-22 IL IL79815A patent/IL79815A/xx unknown
- 1986-08-22 AU AU61746/86A patent/AU595826B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUT41639A (en) | 1987-05-28 |
| JPS6284022A (ja) | 1987-04-17 |
| IL79815A0 (en) | 1986-11-30 |
| DK403086D0 (da) | 1986-08-22 |
| FI863404A0 (fi) | 1986-08-22 |
| NZ217324A (en) | 1988-06-30 |
| IL79815A (en) | 1990-07-12 |
| AU595826B2 (en) | 1990-04-12 |
| AU6174686A (en) | 1987-02-26 |
| DK403086A (da) | 1987-02-24 |
| EP0212647A3 (en) | 1989-07-19 |
| HU198395B (en) | 1989-10-30 |
| ZA866388B (en) | 1988-04-27 |
| NO863386D0 (no) | 1986-08-22 |
| FI863404A (fi) | 1987-02-24 |
| EP0212647A2 (en) | 1987-03-04 |
| ES2001114A6 (es) | 1988-04-16 |
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