NO863115L - Medikament-utleveringsutstyr som forhindrer lokal og systemisk giftighet. - Google Patents
Medikament-utleveringsutstyr som forhindrer lokal og systemisk giftighet.Info
- Publication number
- NO863115L NO863115L NO863115A NO863115A NO863115L NO 863115 L NO863115 L NO 863115L NO 863115 A NO863115 A NO 863115A NO 863115 A NO863115 A NO 863115A NO 863115 L NO863115 L NO 863115L
- Authority
- NO
- Norway
- Prior art keywords
- fluid
- beneficial agent
- chamber
- delivery
- agent
- Prior art date
Links
- 231100000057 systemic toxicity Toxicity 0.000 title description 2
- 239000012530 fluid Substances 0.000 claims description 342
- 239000003795 chemical substances by application Substances 0.000 claims description 267
- 230000009286 beneficial effect Effects 0.000 claims description 172
- 238000001990 intravenous administration Methods 0.000 claims description 33
- 239000002245 particle Substances 0.000 claims description 32
- 230000007704 transition Effects 0.000 claims description 29
- 238000009792 diffusion process Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 230000001419 dependent effect Effects 0.000 claims description 15
- -1 polypropylene Polymers 0.000 claims description 15
- 239000004743 Polypropylene Substances 0.000 claims description 13
- 238000004090 dissolution Methods 0.000 claims description 13
- 229920001155 polypropylene Polymers 0.000 claims description 13
- 231100000816 toxic dose Toxicity 0.000 claims description 11
- 230000009885 systemic effect Effects 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 7
- 230000000007 visual effect Effects 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 230000035876 healing Effects 0.000 claims 15
- 239000002574 poison Substances 0.000 claims 2
- 231100000614 poison Toxicity 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 description 106
- 229940079593 drug Drugs 0.000 description 103
- 238000002347 injection Methods 0.000 description 29
- 239000007924 injection Substances 0.000 description 29
- 238000006243 chemical reaction Methods 0.000 description 25
- 239000003085 diluting agent Substances 0.000 description 22
- 208000005374 Poisoning Diseases 0.000 description 21
- 231100000572 poisoning Toxicity 0.000 description 21
- 230000000607 poisoning effect Effects 0.000 description 21
- 239000000843 powder Substances 0.000 description 21
- 239000004020 conductor Substances 0.000 description 20
- 239000004033 plastic Substances 0.000 description 20
- 229920003023 plastic Polymers 0.000 description 20
- 239000007788 liquid Substances 0.000 description 15
- 239000000243 solution Substances 0.000 description 14
- 238000012546 transfer Methods 0.000 description 14
- 238000013461 design Methods 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 239000012528 membrane Substances 0.000 description 10
- 230000008901 benefit Effects 0.000 description 9
- 230000008859 change Effects 0.000 description 8
- 230000008878 coupling Effects 0.000 description 8
- 238000010168 coupling process Methods 0.000 description 8
- 238000005859 coupling reaction Methods 0.000 description 8
- 230000005484 gravity Effects 0.000 description 8
- KLOHDWPABZXLGI-YWUHCJSESA-M ampicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 KLOHDWPABZXLGI-YWUHCJSESA-M 0.000 description 7
- 238000012377 drug delivery Methods 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 230000009466 transformation Effects 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241001631457 Cannula Species 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 238000011109 contamination Methods 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000012856 packing Methods 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000011800 void material Substances 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 238000011179 visual inspection Methods 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 229920002457 flexible plastic Polymers 0.000 description 2
- 238000007667 floating Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 239000003566 sealing material Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229960001931 ampicillin sodium Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1407—Infusion of two or more substances
- A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72199984A | 1984-12-03 | 1984-12-03 | |
PCT/US1985/002356 WO1986003416A1 (en) | 1984-12-03 | 1985-11-29 | Drug delivery apparatus preventing local and systemic toxicity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO863115D0 NO863115D0 (no) | 1986-08-01 |
NO863115L true NO863115L (no) | 1986-10-02 |
Family
ID=24900122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO863115A NO863115L (no) | 1984-12-03 | 1986-08-01 | Medikament-utleveringsutstyr som forhindrer lokal og systemisk giftighet. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5024657A (xx) |
EP (2) | EP0246715A3 (xx) |
JP (1) | JPS62501270A (xx) |
AU (1) | AU592546B2 (xx) |
CA (1) | CA1261701A (xx) |
DE (1) | DE3585530D1 (xx) |
NO (1) | NO863115L (xx) |
WO (1) | WO1986003416A1 (xx) |
ZA (1) | ZA859248B (xx) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
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SE461765B (sv) * | 1986-07-10 | 1990-03-26 | Haessle Ab | Anordning foer frisaettning av substans |
US4784495A (en) * | 1987-02-06 | 1988-11-15 | Gambro Ab | System for preparing a fluid intended for a medical procedure by mixing at least one concentrate in powder form with water |
US4804366A (en) * | 1987-10-29 | 1989-02-14 | Baxter International Inc. | Cartridge and adapter for introducing a beneficial agent into an intravenous delivery system |
US5030203A (en) * | 1987-11-16 | 1991-07-09 | Baxter International Inc. | Ampule for controlled administration of beneficial agent |
US5195992A (en) * | 1988-05-13 | 1993-03-23 | Baxter International Inc. | Protector shield for needles |
US5205820A (en) * | 1989-06-16 | 1993-04-27 | Science, Incorporated | Fluid delivery apparatus |
US5116316A (en) * | 1991-02-25 | 1992-05-26 | Baxter International Inc. | Automatic in-line reconstitution system |
US5207645A (en) * | 1991-06-25 | 1993-05-04 | Medication Delivery Devices | Infusion pump, treatment fluid bag therefor, and method for the use thereof |
ATE194086T1 (de) | 1991-12-18 | 2000-07-15 | Icu Medical Inc | Medizinisches ventil |
US5304130A (en) * | 1992-02-26 | 1994-04-19 | Baxter International Inc. | Container for the controlled administration of a beneficial agent |
US5397303A (en) * | 1993-08-06 | 1995-03-14 | River Medical, Inc. | Liquid delivery device having a vial attachment or adapter incorporated therein |
US5571261A (en) * | 1993-08-06 | 1996-11-05 | River Medical, Inc | Liquid delivery device |
US5578005A (en) * | 1993-08-06 | 1996-11-26 | River Medical, Inc. | Apparatus and methods for multiple fluid infusion |
US5398851A (en) * | 1993-08-06 | 1995-03-21 | River Medical, Inc. | Liquid delivery device |
JP3009944U (ja) * | 1994-06-27 | 1995-04-18 | 健次 森 | 溶解・点滴セット付輸液セット |
US5766147A (en) * | 1995-06-07 | 1998-06-16 | Winfield Medical | Vial adaptor for a liquid delivery device |
JPH0956782A (ja) * | 1995-08-24 | 1997-03-04 | Kanae:Kk | 受動的薬剤放出用具 |
US5738663A (en) | 1995-12-15 | 1998-04-14 | Icu Medical, Inc. | Medical valve with fluid escape space |
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US5954313A (en) * | 1995-12-29 | 1999-09-21 | Rymed Technologies, Inc. | Medical intravenous administration line connectors having a luer activated valve |
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US6159192A (en) | 1997-12-04 | 2000-12-12 | Fowles; Thomas A. | Sliding reconstitution device with seal |
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AR021220A1 (es) | 1998-09-15 | 2002-07-03 | Baxter Int | DISPOSITIVO DE CONEXIoN PARA ESTABLECER UNA COMUNICACIoN FLUíDA ENTRE UN PRIMER RECIPIENTE Y UN SEGUNDO RECIPIENTE. |
US6113583A (en) | 1998-09-15 | 2000-09-05 | Baxter International Inc. | Vial connecting device for a sliding reconstitution device for a diluent container |
US20050137566A1 (en) | 2003-12-23 | 2005-06-23 | Fowles Thomas A. | Sliding reconstitution device for a diluent container |
US6641556B1 (en) * | 1999-07-06 | 2003-11-04 | Respiratory Support Products, Inc. | Intravenous fluid heating system |
US6695817B1 (en) | 2000-07-11 | 2004-02-24 | Icu Medical, Inc. | Medical valve with positive flow characteristics |
US20030010717A1 (en) * | 2001-07-13 | 2003-01-16 | Nx Stage Medical, Inc. | Systems and methods for handling air and/or flushing fluids in a fluid circuit |
US6908459B2 (en) | 2001-12-07 | 2005-06-21 | Becton, Dickinson And Company | Needleless luer access connector |
US7470265B2 (en) * | 2003-03-20 | 2008-12-30 | Nxstage Medical, Inc. | Dual access spike for infusate bags |
US7641851B2 (en) | 2003-12-23 | 2010-01-05 | Baxter International Inc. | Method and apparatus for validation of sterilization process |
AU2005304987B2 (en) | 2004-11-05 | 2011-08-11 | Icu Medical, Inc. | Medical connector having high flow rate characteristics |
WO2006111967A2 (en) * | 2005-04-18 | 2006-10-26 | Mia Levite | Method for augmenting the ability of t-cells and other cells for fighting disease and invade diseased organs, for elevating cd3 zeta and tnf-alpha expression in t-cells, and mixing t-cell boosting devices and kit particularly useful in such method |
JP4686297B2 (ja) * | 2005-08-10 | 2011-05-25 | 大日本印刷株式会社 | 複数の収納部と複数の注出具を有する包装用袋 |
US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
WO2008052140A2 (en) | 2006-10-25 | 2008-05-02 | Icu Medical, Inc. | Medical connector |
US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
US8454579B2 (en) | 2009-03-25 | 2013-06-04 | Icu Medical, Inc. | Medical connector with automatic valves and volume regulator |
IT1394343B1 (it) * | 2009-06-15 | 2012-06-06 | Borla Ind | Dispositivo per la somministrazione controllata di un liquido ad una linea di flusso medicale |
USD644731S1 (en) | 2010-03-23 | 2011-09-06 | Icu Medical, Inc. | Medical connector |
US8758306B2 (en) | 2010-05-17 | 2014-06-24 | Icu Medical, Inc. | Medical connectors and methods of use |
US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
WO2013009998A2 (en) | 2011-07-12 | 2013-01-17 | Pursuit Vascular, Inc. | Device for delivery of antimicrobial agent into trans-dermal catheter |
CA2844950C (en) | 2011-08-11 | 2020-08-18 | Attilio Difiore | Insert for luer connection |
US9125992B2 (en) | 2011-09-16 | 2015-09-08 | Melvin A. Finke | Fluid delivery device with filtration |
WO2014169081A2 (en) * | 2013-04-09 | 2014-10-16 | Biodel, Inc. | Methods and devices for point of use mixing of pharmaceutical formulations |
AU2014364218B2 (en) | 2013-12-11 | 2019-06-06 | Icu Medical, Inc. | Check valve |
EP3137122B1 (en) | 2014-05-02 | 2019-09-04 | Excelsior Medical Corporation | Strip package for antiseptic cap |
JP2017518810A (ja) | 2014-05-21 | 2017-07-13 | アットウィル メディカル ソルーションズ ステリフロー エル. ピー. | カテーテルシステムのための挿入体 |
USD786427S1 (en) | 2014-12-03 | 2017-05-09 | Icu Medical, Inc. | Fluid manifold |
USD793551S1 (en) | 2014-12-03 | 2017-08-01 | Icu Medical, Inc. | Fluid manifold |
JP6822978B2 (ja) | 2015-05-08 | 2021-01-27 | アイシーユー・メディカル・インコーポレーテッド | 治療薬のエミッタを受け入れるように構成された医療用コネクタ |
US11752242B2 (en) | 2015-06-11 | 2023-09-12 | Ath Therapeutics Inc. | Medical devices, systems, and methods utilizing antithrombin-heparin composition |
CA3040277A1 (en) | 2016-10-14 | 2018-04-19 | Icu Medical, Inc. | Sanitizing caps for medical connectors |
CA2981018A1 (en) * | 2016-11-18 | 2018-05-18 | Becton, Dickinson And Company | Use of infrared light absorption for vein finding and patient identification |
WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
AU2019384564B2 (en) | 2018-11-21 | 2023-11-23 | Icu Medical, Inc. | Antimicrobial device comprising a cap with ring and insert |
CA3204371A1 (en) | 2020-12-07 | 2022-06-16 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
CN113451870B (zh) * | 2021-05-13 | 2023-04-07 | 中国科学院西安光学精密机械研究所 | 适用于极端环境的高功率激光器及其激光产生方法 |
WO2024206704A1 (en) * | 2023-03-28 | 2024-10-03 | Bayer Healthcare Llc | Convenient single dose mr contrast agent package and accurate delivery system |
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US4484920A (en) * | 1982-04-06 | 1984-11-27 | Baxter Travenol Laboratories, Inc. | Container for mixing a liquid and a solid |
US4515585A (en) * | 1982-05-24 | 1985-05-07 | Alza Corporation | System for parenteral administration of agent |
US4432754A (en) * | 1982-05-24 | 1984-02-21 | Alza Corporation | Apparatus for parenteral infusion of fluid containing beneficial agent |
US4534757A (en) * | 1982-06-14 | 1985-08-13 | Alza Corporation | Device for releasing active ingredient, insertable in a system of parenteral administering the ingredient |
US4623334A (en) * | 1983-03-07 | 1986-11-18 | Vanderbilt University | Intravenous drug infusion apparatus |
US4534758A (en) * | 1983-07-15 | 1985-08-13 | Eli Lilly & Company | Controlled release infusion system |
US4533348A (en) * | 1983-07-29 | 1985-08-06 | Alza Corporation | In-line drug dispenser for use in intravenous therapy |
US4573967A (en) * | 1983-12-06 | 1986-03-04 | Eli Lilly And Company | Vacuum vial infusion system |
US4511351A (en) * | 1984-05-14 | 1985-04-16 | Alza Corporation | Parenteral delivery system utilizing a hollow fiber cellular unit |
US4511352A (en) * | 1984-05-14 | 1985-04-16 | Alza Corporation | Parenteral delivery system with in-line container |
US4589867A (en) * | 1984-11-16 | 1986-05-20 | Israel Michael B | Exponential mixing and delivery system |
-
1985
- 1985-11-29 JP JP61500130A patent/JPS62501270A/ja active Pending
- 1985-11-29 DE DE8686900399T patent/DE3585530D1/de not_active Expired - Lifetime
- 1985-11-29 AU AU52331/86A patent/AU592546B2/en not_active Ceased
- 1985-11-29 EP EP87201289A patent/EP0246715A3/en not_active Withdrawn
- 1985-11-29 WO PCT/US1985/002356 patent/WO1986003416A1/en active IP Right Grant
- 1985-11-29 EP EP86900399A patent/EP0203186B1/en not_active Expired - Lifetime
- 1985-12-02 CA CA000496681A patent/CA1261701A/en not_active Expired
- 1985-12-03 ZA ZA859248A patent/ZA859248B/xx unknown
-
1986
- 1986-08-01 NO NO863115A patent/NO863115L/no unknown
-
1990
- 1990-05-04 US US07/518,272 patent/US5024657A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0203186A1 (en) | 1986-12-03 |
AU5233186A (en) | 1986-07-01 |
CA1261701A (en) | 1989-09-26 |
DE3585530D1 (de) | 1992-04-09 |
NO863115D0 (no) | 1986-08-01 |
US5024657A (en) | 1991-06-18 |
JPS62501270A (ja) | 1987-05-21 |
EP0203186A4 (en) | 1987-12-08 |
EP0203186B1 (en) | 1992-03-04 |
ZA859248B (en) | 1986-07-30 |
AU592546B2 (en) | 1990-01-18 |
WO1986003416A1 (en) | 1986-06-19 |
EP0246715A3 (en) | 1988-02-03 |
EP0246715A2 (en) | 1987-11-25 |
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