NO823506L - Fremgangsmaate for fremstilling av terapeutisk aktive triazinderivater. - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive triazinderivater.

Info

Publication number
NO823506L
NO823506L NO823506A NO823506A NO823506L NO 823506 L NO823506 L NO 823506L NO 823506 A NO823506 A NO 823506A NO 823506 A NO823506 A NO 823506A NO 823506 L NO823506 L NO 823506L
Authority
NO
Norway
Prior art keywords
lower alkyl
methyl
compound
general formula
triazine
Prior art date
Application number
NO823506A
Other languages
English (en)
Norwegian (no)
Inventor
Tsutomu Teraji
Youichi Shiokawa
Kazuo Okumara
Yoshinari Sato
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NO823506L publication Critical patent/NO823506L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO823506A 1981-10-22 1982-10-21 Fremgangsmaate for fremstilling av terapeutisk aktive triazinderivater. NO823506L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8131900 1981-10-22
GB8224151 1982-08-23

Publications (1)

Publication Number Publication Date
NO823506L true NO823506L (no) 1983-04-25

Family

ID=26281042

Family Applications (1)

Application Number Title Priority Date Filing Date
NO823506A NO823506L (no) 1981-10-22 1982-10-21 Fremgangsmaate for fremstilling av terapeutisk aktive triazinderivater.

Country Status (11)

Country Link
US (1) US4616014A (OSRAM)
EP (1) EP0077983B1 (OSRAM)
JP (1) JPS5899468A (OSRAM)
AU (1) AU8926982A (OSRAM)
DE (1) DE3276164D1 (OSRAM)
DK (1) DK453882A (OSRAM)
ES (3) ES8401042A1 (OSRAM)
FI (1) FI823544A7 (OSRAM)
GR (1) GR76714B (OSRAM)
NO (1) NO823506L (OSRAM)
OA (1) OA07236A (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1199027A (en) * 1981-11-12 1986-01-07 Stuart D. Mills Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
US4581356A (en) * 1983-03-22 1986-04-08 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same
JPS59196874A (ja) * 1983-04-22 1984-11-08 Fujisawa Pharmaceut Co Ltd トリアジン誘導体
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
GB8612796D0 (en) * 1986-05-27 1986-07-02 Fbc Ltd Fungicides
US4970210A (en) * 1987-07-17 1990-11-13 Abbott Laboratories Triazinone lipoxygenase compounds
CN1038249C (zh) * 1991-08-28 1998-05-06 罗姆和哈斯公司 含有二氢哒嗪酮及其相关化合物的杀菌组合物
IT1318392B1 (it) 2000-03-15 2003-08-25 Getters Spa Composizione getter di idrogeno.
CA2427134A1 (en) 2000-10-27 2002-07-25 Dow Agrosciences Llc Substituted 4,5-dihydro-1,2,4-triazin-3-ones, 1,2,4-triazin-3-ones, and their use as fungicides and insecticides
US7026515B2 (en) 2000-11-09 2006-04-11 Mitsui Chemicals, Inc. Optically active amine derivatives and preparation process therefor
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
CN1678608A (zh) * 2002-07-02 2005-10-05 先灵公司 新的神经肽yy5受体拮抗剂
US7323455B2 (en) 2004-03-24 2008-01-29 Wyeth 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators
RU2442775C2 (ru) * 2005-07-04 2012-02-20 Хай Пойнт Фармасьютикалс, ЛЛС Антагонисты гистаминовых н3-рецепторов
EP2386554A1 (en) * 2005-07-04 2011-11-16 High Point Pharmaceuticals, LLC Compounds active at the histamine H3 receptor
JP2009537596A (ja) * 2006-05-23 2009-10-29 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー ６−（４−シクロプロピルピペリジン−１−イル）−２’−メチル−［３，４’］−ビピリジン及びその医薬としての使用
MX2008014766A (es) * 2006-05-29 2009-03-06 High Point Pharmaceuticals Llc 3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperazin-1-il)-piperazi na, sus sales y solvatos y su uso como antagonista del receptor de h3 histamina.
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157392A (en) * 1977-05-17 1979-06-05 Diamond Shamrock Corporation Pharmacologically active substituted 1,2,4-triazines
FR2391202A1 (fr) * 1977-05-17 1978-12-15 Diamond Shamrock Corp Triazines-1,2,4 substituees, actives pharmacologiquement et medicaments contenant ces triazines
EP0052442B1 (en) * 1980-11-14 1985-09-11 Imperial Chemical Industries Plc Heterocyclic compounds
US4495185A (en) * 1981-11-12 1985-01-22 Imperial Chemical Industries, Plc 1,2,4-Triazin-3(2H) ones
US4581356A (en) * 1983-03-22 1986-04-08 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same

Also Published As

Publication number Publication date
DE3276164D1 (en) 1987-06-04
ES516724A0 (es) 1983-11-16
ES523299A0 (es) 1985-04-16
FI823544L (fi) 1983-04-23
ES523300A0 (es) 1984-10-01
DK453882A (da) 1983-04-23
EP0077983A1 (en) 1983-05-04
ES8601934A1 (es) 1985-04-16
ES8500247A1 (es) 1984-10-01
GR76714B (OSRAM) 1984-08-29
US4616014A (en) 1986-10-07
ES8401042A1 (es) 1983-11-16
AU8926982A (en) 1983-04-28
OA07236A (fr) 1984-04-30
FI823544A7 (fi) 1983-04-23
JPS5899468A (ja) 1983-06-13
FI823544A0 (fi) 1982-10-18
EP0077983B1 (en) 1987-04-29

Similar Documents

Publication Publication Date Title
NO823506L (no) Fremgangsmaate for fremstilling av terapeutisk aktive triazinderivater.
CN108602776B (zh) 用作irak抑制剂的杂芳基化合物及其用途
CN1894258B (zh) 可用作蛋白激酶抑制剂的组合物
KR100755577B1 (ko) 타키키닌 수용체 길항제로서의 트리아졸 유도체
AU2009263037B2 (en) Alkynyl alcohols as kinase inhibitors
JP5878859B2 (ja) ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体
US7598245B2 (en) Aminotriazole compounds useful as inhibitors of protein kinases
CA2643066A1 (en) Pyrazole compounds
WO2004058749A1 (en) Benzisoxazole derivatives useful as inhibitors of protein kinases
US7176314B2 (en) Inflammation modulators
WO2014047427A2 (en) Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors
CA2646952A1 (en) Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors
AU2004264440B2 (en) Pyrrole compositions useful as inhibitors of c-Met
EP1714961B1 (en) Indazole compound and pharmaceutical use thereof
MXPA06013954A (es) Indazoles sustituidos, composiciones que contienen los mismos, preparacion y uso.
JP2009536617A (ja) タンパク質キナーゼの阻害剤として有用なチアゾール、イミダゾール、およびピラゾール
CA2554551A1 (en) Compositions useful as inhibitors of protein kinases
CA3252194A1 (en) DHX9 HELICASE RNA INHIBITORS AND THEIR USES
Rezessy et al. Synthesis and structure elucidation of new thiazolotriazepines
WO2012054366A2 (en) Substituted amino-triazolyl pde10 inhibitors
JP2010510216A (ja) プロテインキナーゼのインヒビターとして有用な化合物
CA2168739A1 (en) Fused tricyclic heteroaromatic derivatives
WO2015155680A2 (en) Pyrazole derivatives as dihydroorotate dehydrogenase (dhodh) inhibitors
CA1321201C (en) Benzothiepino[5,4-c]pyridazine compounds and their pharmaceutical uses
CN114728949B (zh) 作为激酶抑制剂的杂环化合物及其用途