NO820468L - PROCEDURE FOR PREPARING 2-AMINO-3- (HALOBENZOYL) -METHYLPHENYLEDIC ACID ACIDS - Google Patents

PROCEDURE FOR PREPARING 2-AMINO-3- (HALOBENZOYL) -METHYLPHENYLEDIC ACID ACIDS

Info

Publication number
NO820468L
NO820468L NO820468A NO820468A NO820468L NO 820468 L NO820468 L NO 820468L NO 820468 A NO820468 A NO 820468A NO 820468 A NO820468 A NO 820468A NO 820468 L NO820468 L NO 820468L
Authority
NO
Norway
Prior art keywords
methylphenyledic
halobenzoyl
amino
preparing
procedure
Prior art date
Application number
NO820468A
Other languages
Norwegian (no)
Other versions
NO160133B (en
NO160133C (en
Inventor
David Allan Walsh
Dwight Allen Shamblee
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of NO820468L publication Critical patent/NO820468L/en
Publication of NO160133B publication Critical patent/NO160133B/en
Publication of NO160133C publication Critical patent/NO160133C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
NO820468A 1981-02-17 1982-02-16 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 2-AMINO-3- (HALOBENZOYL) -METHYLPHENYLEDIC ACETIC ACIDS, ESTERS AND SALTS THEREOF. NO160133C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23453181A 1981-02-17 1981-02-17

Publications (3)

Publication Number Publication Date
NO820468L true NO820468L (en) 1982-08-18
NO160133B NO160133B (en) 1988-12-05
NO160133C NO160133C (en) 1989-03-15

Family

ID=22881752

Family Applications (1)

Application Number Title Priority Date Filing Date
NO820468A NO160133C (en) 1981-02-17 1982-02-16 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 2-AMINO-3- (HALOBENZOYL) -METHYLPHENYLEDIC ACETIC ACIDS, ESTERS AND SALTS THEREOF.

Country Status (32)

Country Link
JP (1) JPS57149256A (en)
KR (1) KR880002289B1 (en)
AT (1) AT387213B (en)
AU (1) AU7950382A (en)
BE (1) BE892156A (en)
CA (1) CA1173852A (en)
CH (1) CH651294A5 (en)
DE (1) DE3204854C2 (en)
DK (1) DK155936C (en)
EG (1) EG15798A (en)
ES (1) ES8301895A1 (en)
FI (1) FI73970C (en)
FR (1) FR2499981B1 (en)
GB (1) GB2093027B (en)
GR (1) GR76516B (en)
HK (1) HK90384A (en)
HU (1) HU187644B (en)
IE (1) IE52289B1 (en)
IL (1) IL64724A0 (en)
IT (1) IT1157001B (en)
KE (1) KE3454A (en)
LU (1) LU83928A1 (en)
MY (1) MY8500908A (en)
NL (1) NL8200607A (en)
NO (1) NO160133C (en)
NZ (1) NZ199745A (en)
PL (1) PL139815B1 (en)
PT (1) PT74441B (en)
SE (1) SE453387B (en)
SG (1) SG68584G (en)
YU (1) YU44333B (en)
ZA (1) ZA82697B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
US6034266A (en) * 1996-03-11 2000-03-07 Fundacao Oswaldo Cruz-Fiocruz Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses
BR9600975A (en) * 1996-03-11 1997-12-30 Fundacao Oswaldo Cruz Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications
AR030346A1 (en) 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF NEURODEGENERATIVE DISORDERS OF THE RETINA AND HEAD OF OPTICAL NERVE
AR030345A1 (en) * 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF DISORDERS RELATED TO ANGIOGENESIS
AU2002247284A1 (en) 2001-04-02 2002-10-15 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (en) * 1967-07-31 1971-03-24
US3997368A (en) * 1975-06-24 1976-12-14 Bell Telephone Laboratories, Incorporated Elimination of stacking faults in silicon devices: a gettering process
SE400966B (en) * 1975-08-13 1978-04-17 Robins Co Inc A H PROCEDURE FOR PREPARING 2-AMINO-3- (OR 5-) BENZOYL-PHENYLETIC ACIDS
FR2366015A1 (en) * 1975-11-05 1978-04-28 Robins Co Inc A H Amino-benzoyl-phenylacetic acid derivs - antiinflammatory, hypocholesterolemic and blood platelet agglomeration inhibitory activity
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KE3454A (en) 1984-10-12
LU83928A1 (en) 1983-06-07
PL235095A1 (en) 1982-11-08
GB2093027B (en) 1984-07-04
MY8500908A (en) 1985-12-31
GR76516B (en) 1984-08-10
FI73970C (en) 1987-12-10
NL8200607A (en) 1982-09-16
EG15798A (en) 1986-06-30
IL64724A0 (en) 1982-03-31
YU44333B (en) 1990-06-30
KR830008990A (en) 1983-12-16
DK155936C (en) 1989-11-06
JPS57149256A (en) 1982-09-14
FR2499981B1 (en) 1986-05-23
PT74441B (en) 1983-08-24
NZ199745A (en) 1985-07-12
YU32582A (en) 1985-06-30
GB2093027A (en) 1982-08-25
AU7950382A (en) 1982-08-26
DK67382A (en) 1982-08-18
NO160133B (en) 1988-12-05
FR2499981A1 (en) 1982-08-20
IT1157001B (en) 1987-02-11
ATA43382A (en) 1988-05-15
ES509622A0 (en) 1982-12-16
SE8200891L (en) 1982-08-18
FI73970B (en) 1987-08-31
PT74441A (en) 1982-03-01
JPH0365338B2 (en) 1991-10-11
CA1173852A (en) 1984-09-04
NO160133C (en) 1989-03-15
ZA82697B (en) 1983-01-26
PL139815B1 (en) 1987-02-28
SE453387B (en) 1988-02-01
FI820392L (en) 1982-08-18
SG68584G (en) 1985-03-15
ES8301895A1 (en) 1982-12-16
IT8267152A0 (en) 1982-02-10
DK155936B (en) 1989-06-05
IE52289B1 (en) 1987-09-02
DE3204854C2 (en) 1994-06-16
CH651294A5 (en) 1985-09-13
DE3204854A1 (en) 1982-09-09
HU187644B (en) 1986-02-28
HK90384A (en) 1984-11-23
IE820310L (en) 1982-08-17
AT387213B (en) 1988-12-27
KR880002289B1 (en) 1988-10-22
BE892156A (en) 1982-06-16

Similar Documents

Publication Publication Date Title
NO820287L (en) PROCEDURE FOR THE PREPARATION OF ISOCYANOIC ACID DERIVATIVES
NO832701L (en) PROCEDURE FOR THE PREPARATION OF METHYLENE-DYPHOSPHONIC ACID DERIVATIVES.
NO794010L (en) PROCEDURE FOR THE PREPARATION OF AMINO ACID DERIVATIVES
NO813339L (en) R PROCEDURE FOR THE PREPARATION OF SUBSTITUTED IMINODIC ACID
DK271682A (en) PROCEDURE FOR THE PREPARATION OF CARBOXYLIC ACID DERIVATIVES
NO863574D0 (en) PROCEDURE FOR THE PREPARATION OF TETRAFLUOROBENZOIC ACID.
NO820468L (en) PROCEDURE FOR PREPARING 2-AMINO-3- (HALOBENZOYL) -METHYLPHENYLEDIC ACID ACIDS
NO157735C (en) PROCEDURE FOR THE PREPARATION OF ALFA-ARYLALIC ACIDS.
NO822127L (en) PROCEDURE FOR PREPARING ESTERS OF 3-METHYLFLAVON-8-CARBOXYLIC ACID.
DK215079A (en) PROCEDURE FOR THE PREPARATION OF PHENYLAMINOTHIOTHIOPHENIC ACID ACIDS
NO167976C (en) PROCEDURE FOR PREPARING 5-AMINOSALICYLIC ACID.
NO854414L (en) PROCEDURE FOR THE PREPARATION OF THE KINKONIDIN SALT OF D-2- (6-METOXY-2-Naphthyl) -Propionic Acid.
NO151619C (en) PROCEDURE FOR THE PREPARATION OF CYCLOPROPAN-CARBOXYLIC ACID ESTER DERIVATIVES
NO832178L (en) PROCEDURE FOR THE PREPARATION OF GLYOXYLIC ACID DERIVATIVES
NO790328L (en) PROCEDURE FOR THE PREPARATION OF NAFTHYL-1-ACETIC ACID DERIVATIVES.
ES522058A0 (en) PROCEDURE FOR THE PREPARATION OF CARBACIO ACID DERIVATIVES.
NO823535L (en) PROCEDURE FOR THE PREPARATION OF SULFURIC ACID
NO831794L (en) PROCEDURE FOR PREPARING 5-OXO-2-PYRROLIDINE PROPANIC ACID DERIVATIVES
IT1138463B (en) PROCEDURE FOR THE PREPARATION OF 5-SUBSTITUTED DIALURIC ACIDS
NO161677C (en) PROCEDURE FOR THE PREPARATION OF 2BETA-CHLOROMETHYL-2TYLPENAM-3ALFA-CARBOXYLIC ACID SULPHON.
NO802306L (en) PROCEDURE FOR THE PREPARATION OF 2-AMINO-3- (ALKYLTHIOBENZOYL) -PHENYLEDIC ACETIC ACID DERIVATIVES
AR229470A1 (en) PROCEDURE FOR THE PREPARATION OF PIRIDYLALKYL THIO-ESTERS OF ACID 1-P-CHLOROBENZOIL-5-METOXI-2-METHYL-INDOL-3-ACETIC
NO159786C (en) PROCEDURE FOR THE PREPARATION OF ARSENIC ACID.
NO793116L (en) PROCEDURE FOR THE PREPARATION OF TERPHALIC ACID
DE2965740D1 (en) Method for the determination of an amino acid or an amino sulfonic acid