BR9600975A - Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications - Google Patents

Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications

Info

Publication number
BR9600975A
BR9600975A BR9600975A BR9600975A BR9600975A BR 9600975 A BR9600975 A BR 9600975A BR 9600975 A BR9600975 A BR 9600975A BR 9600975 A BR9600975 A BR 9600975A BR 9600975 A BR9600975 A BR 9600975A
Authority
BR
Brazil
Prior art keywords
gem
difluorphenylacetic
difluorphenylacetamide
derivatives
preparation
Prior art date
Application number
BR9600975A
Other languages
Portuguese (pt)
Inventor
Nubia Boechat
Cunha Pinto Angelo Da
Original Assignee
Fundacao Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Oswaldo Cruz filed Critical Fundacao Oswaldo Cruz
Priority to BR9600975A priority Critical patent/BR9600975A/en
Priority to GB9605407A priority patent/GB2311066B/en
Priority to BE9600228A priority patent/BE1010031A5/en
Priority to DE19610357A priority patent/DE19610357C2/en
Priority to JP05892596A priority patent/JP3947242B2/en
Priority to ES009600651A priority patent/ES2130923B1/en
Priority to IT96MI000505A priority patent/IT1283256B1/en
Priority to FR9603314A priority patent/FR2745810B1/en
Priority to CH00782/96A priority patent/CH690722A5/en
Priority to CN96108142A priority patent/CN1101806C/en
Priority to US08/710,399 priority patent/US6034266A/en
Publication of BR9600975A publication Critical patent/BR9600975A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR9600975A 1996-03-11 1996-03-11 Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications BR9600975A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BR9600975A BR9600975A (en) 1996-03-11 1996-03-11 Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications
GB9605407A GB2311066B (en) 1996-03-11 1996-03-14 Novel gem-difluoro derivatives of phenylacetamide and phenylacetic acid and their pharmaceutical uses
BE9600228A BE1010031A5 (en) 1996-03-11 1996-03-15 DERIVATIVES DIFLUORO GEM-phenylacetamide and phenylacetic ACID, THEIR PREPARATION AND USES THEREOF.
DE19610357A DE19610357C2 (en) 1996-03-11 1996-03-15 Geminal difluoro derivatives of phenylacetamide and phenylacetic acid, process for their preparation and their pharmaceutical compositions
JP05892596A JP3947242B2 (en) 1996-03-11 1996-03-15 Novel gem-difluoro derivatives of phenylacetamide and phenylacetic acid and their pharmaceutical use
ES009600651A ES2130923B1 (en) 1996-03-11 1996-03-15 NEW GEM-DIFLUOROUS DERIVATIVES OF PHENYLACETAMIDE AND PHENYLACETIC ACID AND ITS PHARMACEUTICAL USES.
IT96MI000505A IT1283256B1 (en) 1996-03-11 1996-03-15 GEM-DIFLUORO DERIVATIVES OF PHENYLACETAMIDE AND PHENYLACETIC ACID AND THEIR PHARMACEUTICAL USES
FR9603314A FR2745810B1 (en) 1996-03-11 1996-03-15 NOVEL GEM-DIFLUORO PHENYLACETIC ACID AND PHENYLACETAMIDE COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AND ANTI-RHUMATISMAL DRUGS, AND METHOD OF MAKING
CH00782/96A CH690722A5 (en) 1996-03-11 1996-03-26 gem-difluoro derivatives phenylacetamide and phenylacetic acid and their pharmaceutical uses.
CN96108142A CN1101806C (en) 1996-03-11 1996-06-10 Novel gem-difluoro derivatives of phenylacetemide- and phenylacetic acid and their pharmaceutical uses
US08/710,399 US6034266A (en) 1996-03-11 1996-09-17 Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR9600975A BR9600975A (en) 1996-03-11 1996-03-11 Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications

Publications (1)

Publication Number Publication Date
BR9600975A true BR9600975A (en) 1997-12-30

Family

ID=38353109

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9600975A BR9600975A (en) 1996-03-11 1996-03-11 Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications

Country Status (10)

Country Link
JP (1) JP3947242B2 (en)
CN (1) CN1101806C (en)
BE (1) BE1010031A5 (en)
BR (1) BR9600975A (en)
CH (1) CH690722A5 (en)
DE (1) DE19610357C2 (en)
ES (1) ES2130923B1 (en)
FR (1) FR2745810B1 (en)
GB (1) GB2311066B (en)
IT (1) IT1283256B1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9922830D0 (en) 1999-09-27 1999-11-24 Novartis Ag Processes
JP5685384B2 (en) * 2010-03-29 2015-03-18 公益財団法人相模中央化学研究所 Method for producing 3,3-difluoro-2,3-dihydroindol-2-one derivative
CN108299137B (en) * 2018-04-09 2020-04-14 中南大学 Selective fluorination method of isatin hydrazone compound
CN113698308B (en) * 2021-08-25 2024-06-21 山东辰龙药业有限公司 Synthesis method of bromfenac sodium

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895063A (en) * 1965-04-08 1975-07-15 Ciba Geigy Corp Substituted Anilino Benzyl Alcohols
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
IL64724A0 (en) * 1981-02-17 1982-03-31 Robins Co Inc A H 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them
US5220064A (en) * 1986-11-26 1993-06-15 Warner-Lambert Company Substituted 4'-hydroxyphenylacetic acid derivatives having antiinflammatory and analgesic activity

Also Published As

Publication number Publication date
CN1159443A (en) 1997-09-17
ES2130923B1 (en) 2000-01-16
DE19610357A1 (en) 1997-09-18
ITMI960505A0 (en) 1996-03-15
ITMI960505A1 (en) 1997-09-15
JP3947242B2 (en) 2007-07-18
ES2130923A1 (en) 1999-07-01
IT1283256B1 (en) 1998-04-16
CN1101806C (en) 2003-02-19
FR2745810A1 (en) 1997-09-12
DE19610357C2 (en) 1998-08-13
FR2745810B1 (en) 1998-06-19
GB2311066A (en) 1997-09-17
CH690722A5 (en) 2000-12-29
BE1010031A5 (en) 1997-11-04
JPH09323962A (en) 1997-12-16
GB2311066B (en) 1999-12-08
GB9605407D0 (en) 1996-05-15

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BR9600975A (en) Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/10/2006, OBSERVADAS AS CONDICOES LEGAIS.

B24C Patent annual fee: request for for restoration

Free format text: REFERENTE 12A. E 15A, E 16A. ANUIDADE(S).

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2137 DE 20/12/2011 E AO NAO RECOLHIMENTO DA 17A ANUIDADE.