DK155936C - METHOD OF ANALOGY FOR THE PREPARATION OF 2-AMINO-3- (HALOGENBENZOYL) -METHYLPHENYL ACID ACID ACIDS OR ALKYL ESTERS OR METAL SALTS THEREOF - Google Patents

METHOD OF ANALOGY FOR THE PREPARATION OF 2-AMINO-3- (HALOGENBENZOYL) -METHYLPHENYL ACID ACID ACIDS OR ALKYL ESTERS OR METAL SALTS THEREOF

Info

Publication number
DK155936C
DK155936C DK067382A DK67382A DK155936C DK 155936 C DK155936 C DK 155936C DK 067382 A DK067382 A DK 067382A DK 67382 A DK67382 A DK 67382A DK 155936 C DK155936 C DK 155936C
Authority
DK
Denmark
Prior art keywords
acid
halogenbenzoyl
analogy
amino
preparation
Prior art date
Application number
DK067382A
Other languages
Danish (da)
Other versions
DK155936B (en
DK67382A (en
Inventor
David Allan Walsh
Dwight Allen Shamblee
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of DK67382A publication Critical patent/DK67382A/en
Publication of DK155936B publication Critical patent/DK155936B/en
Application granted granted Critical
Publication of DK155936C publication Critical patent/DK155936C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
DK067382A 1981-02-17 1982-02-16 METHOD OF ANALOGY FOR THE PREPARATION OF 2-AMINO-3- (HALOGENBENZOYL) -METHYLPHENYL ACID ACID ACIDS OR ALKYL ESTERS OR METAL SALTS THEREOF DK155936C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23453181A 1981-02-17 1981-02-17
US23453181 1981-02-17

Publications (3)

Publication Number Publication Date
DK67382A DK67382A (en) 1982-08-18
DK155936B DK155936B (en) 1989-06-05
DK155936C true DK155936C (en) 1989-11-06

Family

ID=22881752

Family Applications (1)

Application Number Title Priority Date Filing Date
DK067382A DK155936C (en) 1981-02-17 1982-02-16 METHOD OF ANALOGY FOR THE PREPARATION OF 2-AMINO-3- (HALOGENBENZOYL) -METHYLPHENYL ACID ACID ACIDS OR ALKYL ESTERS OR METAL SALTS THEREOF

Country Status (32)

Country Link
JP (1) JPS57149256A (en)
KR (1) KR880002289B1 (en)
AT (1) AT387213B (en)
AU (1) AU7950382A (en)
BE (1) BE892156A (en)
CA (1) CA1173852A (en)
CH (1) CH651294A5 (en)
DE (1) DE3204854C2 (en)
DK (1) DK155936C (en)
EG (1) EG15798A (en)
ES (1) ES8301895A1 (en)
FI (1) FI73970C (en)
FR (1) FR2499981B1 (en)
GB (1) GB2093027B (en)
GR (1) GR76516B (en)
HK (1) HK90384A (en)
HU (1) HU187644B (en)
IE (1) IE52289B1 (en)
IL (1) IL64724A0 (en)
IT (1) IT1157001B (en)
KE (1) KE3454A (en)
LU (1) LU83928A1 (en)
MY (1) MY8500908A (en)
NL (1) NL8200607A (en)
NO (1) NO160133C (en)
NZ (1) NZ199745A (en)
PL (1) PL139815B1 (en)
PT (1) PT74441B (en)
SE (1) SE453387B (en)
SG (1) SG68584G (en)
YU (1) YU44333B (en)
ZA (1) ZA82697B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
BR9600975A (en) * 1996-03-11 1997-12-30 Fundacao Oswaldo Cruz Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications
US6034266A (en) * 1996-03-11 2000-03-07 Fundacao Oswaldo Cruz-Fiocruz Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses
AR030346A1 (en) 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF NEURODEGENERATIVE DISORDERS OF THE RETINA AND HEAD OF OPTICAL NERVE
AR030345A1 (en) * 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF DISORDERS RELATED TO ANGIOGENESIS
AU2002247284A1 (en) 2001-04-02 2002-10-15 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (en) * 1967-07-31 1971-03-24
US3997368A (en) * 1975-06-24 1976-12-14 Bell Telephone Laboratories, Incorporated Elimination of stacking faults in silicon devices: a gettering process
CH577461A5 (en) * 1975-08-13 1976-07-15 Robins Co Inc A H
FR2366015A1 (en) * 1975-11-05 1978-04-28 Robins Co Inc A H Amino-benzoyl-phenylacetic acid derivs - antiinflammatory, hypocholesterolemic and blood platelet agglomeration inhibitory activity
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HK90384A (en) 1984-11-23
AU7950382A (en) 1982-08-26
ZA82697B (en) 1983-01-26
NL8200607A (en) 1982-09-16
PL139815B1 (en) 1987-02-28
JPS57149256A (en) 1982-09-14
SE453387B (en) 1988-02-01
BE892156A (en) 1982-06-16
FI73970C (en) 1987-12-10
DE3204854A1 (en) 1982-09-09
HU187644B (en) 1986-02-28
FR2499981B1 (en) 1986-05-23
KR880002289B1 (en) 1988-10-22
ATA43382A (en) 1988-05-15
NO160133C (en) 1989-03-15
PT74441A (en) 1982-03-01
MY8500908A (en) 1985-12-31
YU32582A (en) 1985-06-30
DK155936B (en) 1989-06-05
YU44333B (en) 1990-06-30
DE3204854C2 (en) 1994-06-16
DK67382A (en) 1982-08-18
KR830008990A (en) 1983-12-16
FI820392L (en) 1982-08-18
ES509622A0 (en) 1982-12-16
CA1173852A (en) 1984-09-04
IE820310L (en) 1982-08-17
CH651294A5 (en) 1985-09-13
NO820468L (en) 1982-08-18
IT8267152A0 (en) 1982-02-10
SE8200891L (en) 1982-08-18
NO160133B (en) 1988-12-05
AT387213B (en) 1988-12-27
EG15798A (en) 1986-06-30
ES8301895A1 (en) 1982-12-16
IT1157001B (en) 1987-02-11
GB2093027A (en) 1982-08-25
FI73970B (en) 1987-08-31
FR2499981A1 (en) 1982-08-20
SG68584G (en) 1985-03-15
PT74441B (en) 1983-08-24
GB2093027B (en) 1984-07-04
IE52289B1 (en) 1987-09-02
KE3454A (en) 1984-10-12
NZ199745A (en) 1985-07-12
LU83928A1 (en) 1983-06-07
PL235095A1 (en) 1982-11-08
JPH0365338B2 (en) 1991-10-11
GR76516B (en) 1984-08-10
IL64724A0 (en) 1982-03-31

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