NO802858L - Virkestoffblandinger og fremstilling derav - Google Patents
Virkestoffblandinger og fremstilling deravInfo
- Publication number
- NO802858L NO802858L NO802858A NO802858A NO802858L NO 802858 L NO802858 L NO 802858L NO 802858 A NO802858 A NO 802858A NO 802858 A NO802858 A NO 802858A NO 802858 L NO802858 L NO 802858L
- Authority
- NO
- Norway
- Prior art keywords
- nocardicin
- formula
- antibiotic
- compound
- lower alkyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 239000004615 ingredient Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 14
- 230000003115 biocidal effect Effects 0.000 claims description 13
- 229930189801 nocardicin Natural products 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- CTNZOGJNVIFEBA-UPSUJEDGSA-N nocardicin A Chemical compound C1=CC(OCC[C@@H](N)C(O)=O)=CC=C1C(=N\O)\C(=O)N[C@@H]1C(=O)N([C@@H](C(O)=O)C=2C=CC(O)=CC=2)C1 CTNZOGJNVIFEBA-UPSUJEDGSA-N 0.000 claims description 4
- CTNZOGJNVIFEBA-SCTDSRPQSA-N nocardicin A Natural products N[C@@H](CCOc1ccc(cc1)C(=NO)C(=O)N[C@@H]2CN([C@H](C(=O)O)c3ccc(O)cc3)C2=O)C(=O)O CTNZOGJNVIFEBA-SCTDSRPQSA-N 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims description 2
- 235000008206 alpha-amino acids Nutrition 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 125000004953 trihalomethyl group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 18
- 238000002347 injection Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 7
- 239000013543 active substance Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000008215 water for injection Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- JBXBOVLKPXAIDD-RITPCOANSA-N [(1r)-1-[[(2s)-2-aminopentanoyl]amino]ethyl]phosphonic acid Chemical compound CCC[C@H](N)C(=O)N[C@@H](C)P(O)(O)=O JBXBOVLKPXAIDD-RITPCOANSA-N 0.000 description 3
- -1 α-aminobutyryl Chemical group 0.000 description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
- SXIFAEWFOJETOA-UHFFFAOYSA-N 4-hydroxy-butyl Chemical group [CH2]CCCO SXIFAEWFOJETOA-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- SQLWIPBOTIUHBA-RQJHMYQMSA-N [(1r)-1-[[(2s)-2-aminohexanoyl]amino]ethyl]phosphonic acid Chemical compound CCCC[C@H](N)C(=O)N[C@@H](C)P(O)(O)=O SQLWIPBOTIUHBA-RQJHMYQMSA-N 0.000 description 1
- MSEBNAXFIZIHJN-YFKPBYRVSA-N [[(2s)-2-aminopentanoyl]amino]methylphosphonic acid Chemical compound CCC[C@H](N)C(=O)NCP(O)(O)=O MSEBNAXFIZIHJN-YFKPBYRVSA-N 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000004970 halomethyl group Chemical group 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- DEUWDIBQYKIQOA-ACRIIGJESA-N sodium;(2r)-2-amino-4-[4-[(z)-c-[[(3s)-1-[(r)-carboxy-(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl]-n-hydroxycarbonimidoyl]phenoxy]butanoic acid Chemical compound [Na+].C1=CC(OCC[C@@H](N)C(O)=O)=CC=C1C(=N\O)\C(=O)N[C@@H]1C(=O)N([C@@H](C(O)=O)C=2C=CC(O)=CC=2)C1 DEUWDIBQYKIQOA-ACRIIGJESA-N 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Seeds, Soups, And Other Foods (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7933698 | 1979-09-28 | ||
| GB8024890 | 1980-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO802858L true NO802858L (no) | 1981-03-30 |
Family
ID=26273034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO802858A NO802858L (no) | 1979-09-28 | 1980-09-26 | Virkestoffblandinger og fremstilling derav |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0026410A1 (OSRAM) |
| KR (1) | KR830004325A (OSRAM) |
| AU (1) | AU6278180A (OSRAM) |
| DK (1) | DK409680A (OSRAM) |
| FI (1) | FI802964A7 (OSRAM) |
| GR (1) | GR70015B (OSRAM) |
| IL (1) | IL61135A0 (OSRAM) |
| MC (1) | MC1349A1 (OSRAM) |
| NO (1) | NO802858L (OSRAM) |
| PT (1) | PT71846B (OSRAM) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4134972A (en) * | 1976-07-21 | 1979-01-16 | Hoffmann-La Roche Inc. | Compositions having antibiotic properties |
| DE2758867A1 (de) * | 1977-12-14 | 1979-06-21 | Fujisawa Pharmaceutical Co | Antimycobakterielle zubereitung und deren verwendung fuer die behandlung von mycobacteriose |
| US4210635A (en) * | 1978-02-15 | 1980-07-01 | Fujisawa Pharmaceutical Co., Ltd. | Antibacterial composition |
-
1980
- 1980-09-19 FI FI802964A patent/FI802964A7/fi not_active Application Discontinuation
- 1980-09-19 EP EP80105636A patent/EP0026410A1/de not_active Withdrawn
- 1980-09-24 IL IL61135A patent/IL61135A0/xx unknown
- 1980-09-26 GR GR62971A patent/GR70015B/el unknown
- 1980-09-26 NO NO802858A patent/NO802858L/no unknown
- 1980-09-26 PT PT71846A patent/PT71846B/pt unknown
- 1980-09-26 DK DK409680A patent/DK409680A/da unknown
- 1980-09-27 KR KR1019800003764A patent/KR830004325A/ko not_active Withdrawn
- 1980-09-29 MC MC801472A patent/MC1349A1/fr unknown
- 1980-09-29 AU AU62781/80A patent/AU6278180A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GR70015B (OSRAM) | 1982-07-23 |
| AU6278180A (en) | 1981-04-09 |
| IL61135A0 (en) | 1980-11-30 |
| FI802964A7 (fi) | 1981-03-28 |
| DK409680A (da) | 1981-03-29 |
| EP0026410A1 (de) | 1981-04-08 |
| PT71846B (en) | 1982-03-26 |
| MC1349A1 (fr) | 1981-06-22 |
| KR830004325A (ko) | 1983-07-09 |
| PT71846A (en) | 1980-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7117021B2 (ja) | 抗菌性化合物としてのポリミキシン誘導体 | |
| JP2023030213A (ja) | 新規デプシペプチドおよびその使用 | |
| HU201802B (en) | Pesticide preparation containing bacillus thuringiensis hybrid cells as agent and process for producing hybrid cells | |
| HU225297B1 (en) | Bis staurosporin derivatives and pharmaceutical composition containing them | |
| US8748617B2 (en) | Amide compound or salt thereof, and biofilm inhibitor, biofilm remover and disinfectant containing the same | |
| US10919935B2 (en) | Antimicrobial peptide derived from myxinidin peptide and uses thereof | |
| MX2010014528A (es) | Uso se surfactantes cationicos como agentes esporicidas. | |
| KR20170048546A (ko) | 신규 히드록삼산 유도체 또는 그 염을 함유하는 의약 조성물 | |
| TW200843787A (en) | N-halogenated amino compounds and derivatives; compositions and methods of using them | |
| CA2929560A1 (en) | Polycationic amphiphiles as antimicrobial agents | |
| CA3000032A1 (en) | Antimicrobial polymyxin derivative compounds | |
| PT92146B (pt) | Processo para a preparacao do inibidor de glicosidade salbostatina e de composicoes farmaceuticas que a contem | |
| CA2011365A1 (en) | Diluent formulation for daptomycin | |
| JP2024536768A (ja) | 操作された抗微生物ペプチドおよびその使用 | |
| DK173317B1 (da) | Stabiliseret præparat af anthracyclinderivat samt fremgangsmåde til fremstilling af dette | |
| KR20180118848A (ko) | 비결핵항산균 감염 질환 치료용 약학 조성물 | |
| CA2949328C (en) | Low substituted polymyxins and compositions thereof | |
| CA2970997C (en) | Atp synthase inhibitors and steroid alkaloids and uses thereof as antimicrobial agents and as potentiators for aminoglycosides against pathogenic bacteria | |
| NO802858L (no) | Virkestoffblandinger og fremstilling derav | |
| US6784204B2 (en) | Antibiotic cytosporacin | |
| Zygmunt et al. | DL-S-Trifluoromethylhomocysteine, a novel inhibitor of microbial growth | |
| KR101349752B1 (ko) | 정족수 감지 억제 활성 및 항균 활성을 갖는 항균용 조성물 | |
| TWI462743B (zh) | 使用4-電子己醣氧化酶生物合成新穎化合物之結構及機制基礎 | |
| US20120295838A1 (en) | Selective poly-substituted glycine antibiotics and related compositions | |
| US11998560B2 (en) | Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against multidrug and extensively drug-resistant Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates |