NO784235L - Fremgangsmaate ved fremstilling av benzazepin-derivater - Google Patents

Fremgangsmaate ved fremstilling av benzazepin-derivater

Info

Publication number
NO784235L
NO784235L NO784235A NO784235A NO784235L NO 784235 L NO784235 L NO 784235L NO 784235 A NO784235 A NO 784235A NO 784235 A NO784235 A NO 784235A NO 784235 L NO784235 L NO 784235L
Authority
NO
Norway
Prior art keywords
benzazepin
procedures
derivatives
preparation
benzazepin derivatives
Prior art date
Application number
NO784235A
Other languages
English (en)
Other versions
NO146468C (no
NO146468B (no
Inventor
William Edward Bondinell
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of NO784235L publication Critical patent/NO784235L/no
Publication of NO146468B publication Critical patent/NO146468B/no
Publication of NO146468C publication Critical patent/NO146468C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/38Oxygen atoms in positions 2 and 3, e.g. isatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/241,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26Two oxygen atoms, e.g. isatoic anhydride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO784235A 1977-12-21 1978-12-15 Analogifremgangsmaate ved fremstilling av terapeutisk aktive benzazepin derivater NO146468C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86289277A 1977-12-21 1977-12-21

Publications (3)

Publication Number Publication Date
NO784235L true NO784235L (no) 1979-06-22
NO146468B NO146468B (no) 1982-06-28
NO146468C NO146468C (no) 1982-10-06

Family

ID=25339656

Family Applications (1)

Application Number Title Priority Date Filing Date
NO784235A NO146468C (no) 1977-12-21 1978-12-15 Analogifremgangsmaate ved fremstilling av terapeutisk aktive benzazepin derivater

Country Status (18)

Country Link
EP (1) EP0002624B1 (no)
JP (1) JPS5488285A (no)
AR (1) AR220361A1 (no)
AT (1) AT367410B (no)
AU (1) AU517619B2 (no)
CA (1) CA1090798A (no)
DE (1) DE2861177D1 (no)
DK (1) DK541078A (no)
ES (1) ES476108A1 (no)
FI (1) FI783838A (no)
HU (1) HU177901B (no)
IL (1) IL56237A0 (no)
IT (1) IT1100851B (no)
NO (1) NO146468C (no)
PH (1) PH14063A (no)
PT (1) PT68919A (no)
YU (1) YU303278A (no)
ZA (1) ZA786230B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3001579A1 (de) * 1980-01-17 1981-07-23 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von anthranilsaeurealkylestern
EP0041627B1 (de) * 1980-05-16 1984-08-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 3H-2-Benzazepine, Zwischenprodukte und Verfahren zu ihrer Herstellung, sowie diese enthaltende Präparate
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
CA2347095A1 (en) * 1998-10-16 2000-04-27 Takeda Chemical Industries, Ltd. Nitrogen-containing condensed heterocyclic derivatives, their production and agent
JP2009500406A (ja) * 2005-07-05 2009-01-08 アストラゼネカ・アクチエボラーグ 新規化合物、その製造方法、中間体、医薬組成物、並びにアルツハイマー病、認知障害、統合失調症に伴う認識機能障害、肥満及びパーキンソン病のような5−ht6介在疾患の治療におけるそれらの使用
BRPI0613403A2 (pt) 2005-07-15 2009-02-10 Amr Technology Inc tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828096A (en) * 1966-11-22 1974-08-06 Mc Neil Labor Inc 2-alkoxycarbonyl-3-aryl-propylamines

Also Published As

Publication number Publication date
IT1100851B (it) 1985-09-28
HU177901B (en) 1982-01-28
AT367410B (de) 1982-07-12
CA1090798A (en) 1980-12-02
PT68919A (en) 1979-01-01
NO146468C (no) 1982-10-06
EP0002624A1 (en) 1979-06-27
IT7830974A0 (it) 1978-12-18
ZA786230B (en) 1979-10-31
JPS5488285A (en) 1979-07-13
ES476108A1 (es) 1979-11-16
NO146468B (no) 1982-06-28
DE2861177D1 (en) 1981-12-24
FI783838A (fi) 1979-06-22
AU517619B2 (en) 1981-08-13
PH14063A (en) 1981-01-26
AU4265278A (en) 1979-06-28
AR220361A1 (es) 1980-10-31
EP0002624B1 (en) 1981-10-14
YU303278A (en) 1983-06-30
IL56237A0 (en) 1979-03-12
DK541078A (da) 1979-06-22
ATA918878A (de) 1981-11-15

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