AR220361A1 - Procedimiento para la preparacion de una 2-benzazepina sustituida - Google Patents

Procedimiento para la preparacion de una 2-benzazepina sustituida

Info

Publication number
AR220361A1
AR220361A1 AR274873A AR27487378A AR220361A1 AR 220361 A1 AR220361 A1 AR 220361A1 AR 274873 A AR274873 A AR 274873A AR 27487378 A AR27487378 A AR 27487378A AR 220361 A1 AR220361 A1 AR 220361A1
Authority
AR
Argentina
Prior art keywords
benzazepine
substituted
procedure
preparation
Prior art date
Application number
AR274873A
Other languages
English (en)
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Application granted granted Critical
Publication of AR220361A1 publication Critical patent/AR220361A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/38Oxygen atoms in positions 2 and 3, e.g. isatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/241,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26Two oxygen atoms, e.g. isatoic anhydride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AR274873A 1977-12-21 1978-12-19 Procedimiento para la preparacion de una 2-benzazepina sustituida AR220361A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86289277A 1977-12-21 1977-12-21

Publications (1)

Publication Number Publication Date
AR220361A1 true AR220361A1 (es) 1980-10-31

Family

ID=25339656

Family Applications (1)

Application Number Title Priority Date Filing Date
AR274873A AR220361A1 (es) 1977-12-21 1978-12-19 Procedimiento para la preparacion de una 2-benzazepina sustituida

Country Status (18)

Country Link
EP (1) EP0002624B1 (es)
JP (1) JPS5488285A (es)
AR (1) AR220361A1 (es)
AT (1) AT367410B (es)
AU (1) AU517619B2 (es)
CA (1) CA1090798A (es)
DE (1) DE2861177D1 (es)
DK (1) DK541078A (es)
ES (1) ES476108A1 (es)
FI (1) FI783838A (es)
HU (1) HU177901B (es)
IL (1) IL56237A0 (es)
IT (1) IT1100851B (es)
NO (1) NO146468C (es)
PH (1) PH14063A (es)
PT (1) PT68919A (es)
YU (1) YU303278A (es)
ZA (1) ZA786230B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3001579A1 (de) * 1980-01-17 1981-07-23 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von anthranilsaeurealkylestern
EP0041627B1 (de) * 1980-05-16 1984-08-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 3H-2-Benzazepine, Zwischenprodukte und Verfahren zu ihrer Herstellung, sowie diese enthaltende Präparate
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
AU6123699A (en) * 1998-10-16 2000-05-08 Takeda Chemical Industries Ltd. Nitrogenous fused heterocycle compounds, process for the preparation thereof andagents containing the same
CN101258136A (zh) * 2005-07-05 2008-09-03 阿斯利康(瑞典)有限公司 新化合物、其制备方法、中间体、药物组合物和其在治疗5-ht6介导的疾病例如阿尔茨海默病、认知障碍、精神分裂症相关的认知缺损、肥胖和帕金森病中的用途
JP5258561B2 (ja) 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ, インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828096A (en) * 1966-11-22 1974-08-06 Mc Neil Labor Inc 2-alkoxycarbonyl-3-aryl-propylamines

Also Published As

Publication number Publication date
ES476108A1 (es) 1979-11-16
EP0002624B1 (en) 1981-10-14
YU303278A (en) 1983-06-30
HU177901B (en) 1982-01-28
NO146468C (no) 1982-10-06
EP0002624A1 (en) 1979-06-27
DK541078A (da) 1979-06-22
AU517619B2 (en) 1981-08-13
NO146468B (no) 1982-06-28
IT1100851B (it) 1985-09-28
ATA918878A (de) 1981-11-15
ZA786230B (en) 1979-10-31
NO784235L (no) 1979-06-22
CA1090798A (en) 1980-12-02
DE2861177D1 (en) 1981-12-24
AU4265278A (en) 1979-06-28
PH14063A (en) 1981-01-26
IT7830974A0 (it) 1978-12-18
FI783838A (fi) 1979-06-22
IL56237A0 (en) 1979-03-12
AT367410B (de) 1982-07-12
PT68919A (en) 1979-01-01
JPS5488285A (en) 1979-07-13

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