NO331274B1 - Apolipoproteinanaloger - Google Patents
ApolipoproteinanalogerInfo
- Publication number
- NO331274B1 NO331274B1 NO20032101A NO20032101A NO331274B1 NO 331274 B1 NO331274 B1 NO 331274B1 NO 20032101 A NO20032101 A NO 20032101A NO 20032101 A NO20032101 A NO 20032101A NO 331274 B1 NO331274 B1 NO 331274B1
- Authority
- NO
- Norway
- Prior art keywords
- apolipoproteinanaloger
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001682 | 2000-11-10 | ||
DKPA200100057 | 2001-01-15 | ||
US26402201P | 2001-01-26 | 2001-01-26 | |
PCT/DK2001/000739 WO2002038609A2 (en) | 2000-11-10 | 2001-11-09 | Apolipoprotein conjugates |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20032101D0 NO20032101D0 (no) | 2003-05-09 |
NO20032101L NO20032101L (no) | 2003-07-08 |
NO331274B1 true NO331274B1 (no) | 2011-11-14 |
Family
ID=27222453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20032101A NO331274B1 (no) | 2000-11-10 | 2003-05-09 | Apolipoproteinanaloger |
Country Status (10)
Country | Link |
---|---|
US (4) | US6897039B2 (de) |
EP (2) | EP2343317A1 (de) |
JP (2) | JP4344136B2 (de) |
CN (1) | CN1268641C (de) |
AU (2) | AU2002213843B2 (de) |
BR (1) | BR0115257A (de) |
CA (1) | CA2428114C (de) |
CY (1) | CY1111118T1 (de) |
NO (1) | NO331274B1 (de) |
WO (1) | WO2002038609A2 (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100330355B1 (ko) * | 1999-06-04 | 2002-04-01 | 장인순 | 회전유동발생 날개를 가진 덕트형 핵연료 집합체 지지격자 |
AU2002232642B2 (en) * | 2000-12-12 | 2007-02-01 | Lexicon Pharmaceuticals, Inc. | Novel human kinases and uses thereof |
ES2429528T3 (es) | 2001-01-02 | 2013-11-15 | The Cleveland Clinic Foundation | Mieloperoxidasa, un indicador de riesgo para enfermedad cardiovascular |
AU2002362612B2 (en) * | 2001-09-28 | 2007-11-15 | Cedars-Sinai Medical Center | Prevention and treatment of restenosis by local administration of drug |
WO2004069795A2 (en) * | 2003-02-03 | 2004-08-19 | Pfizer Products Inc. | Diagnosis and treatment of chronic tissue damage |
AU2004212944B2 (en) * | 2003-02-14 | 2008-08-21 | Children's Hospital & Research Center At Oakland | Lipophilic drug delivery vehicle and methods of use thereof |
EP1620120A4 (de) * | 2003-03-24 | 2010-01-06 | Sequoia Pharmaceuticals Inc | Biologisch aktive konjugate mit langzeitwirkung |
CA2522758A1 (en) * | 2003-04-22 | 2004-11-04 | Avanir Pharmaceuticals | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia |
WO2004094478A2 (en) | 2003-04-23 | 2004-11-04 | Borean Pharma A/S | Cleavage of fusion proteins using granzyme b protease |
US7459286B1 (en) * | 2003-10-22 | 2008-12-02 | The Cleveland Clinic Foundation | Assessing the risk of a major adverse cardiac event in patients with chest pain |
CA2549236C (en) | 2003-12-05 | 2017-06-13 | The Cleveland Clinic Foundation | Risk markers for cardiovascular disease |
US20050176623A1 (en) * | 2004-02-11 | 2005-08-11 | Neil Wagle | Non-invasive treatment of disease using amphipathic compounds |
US20100028995A1 (en) * | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
WO2005097206A2 (en) * | 2004-04-06 | 2005-10-20 | Cedars-Sinai Medical Center | Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein a-i and apolipoprotein a-i milano |
KR100560102B1 (ko) * | 2004-06-25 | 2006-03-13 | 한국생명공학연구원 | 프로아포리포단백질 a-ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제 |
US7378396B2 (en) * | 2004-08-11 | 2008-05-27 | The Cleveland Clinic Foundation | Therapeutic agents and methods for cardiovascular disease |
WO2007023476A2 (en) * | 2005-08-26 | 2007-03-01 | Cerenis Therapeutics Holding Sa | Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria |
US20070117179A1 (en) * | 2005-09-27 | 2007-05-24 | Invitrogen Corporation | In vitro protein synthesis systems for membrane proteins that include adolipoproteins and phospholipid-adolipoprotein particles |
US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
WO2008106660A2 (en) * | 2007-03-01 | 2008-09-04 | Invitrogen Corporation | Isolated phospholipid-protein particles |
CN101668537A (zh) * | 2007-04-23 | 2010-03-10 | 日本制药株式会社 | 急性肝炎治疗剂或爆发性肝炎预防、治疗剂 |
JP2010539995A (ja) * | 2007-10-08 | 2010-12-24 | アナフォア インコーポレイテッド | 三量体IL−1Ra |
US8999320B2 (en) * | 2008-01-30 | 2015-04-07 | The Rockefeller University | Nanoscale bound bilayers, methods of use and production |
US8268796B2 (en) | 2008-06-27 | 2012-09-18 | Children's Hospital & Research Center At Oakland | Lipophilic nucleic acid delivery vehicle and methods of use thereof |
WO2010057203A2 (en) * | 2008-11-17 | 2010-05-20 | The Board Of Regents Of The University Of Texas System | Hdl particles for delivery of nucleic acids |
WO2010141097A2 (en) * | 2009-06-05 | 2010-12-09 | The Trustees Of Columbia Univerity In The City Of New York | Pegylated human apoa-1 and process for production thereof |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
WO2011044545A2 (en) | 2009-10-09 | 2011-04-14 | Sigalov Alexander B | Methods and compositions for targeted imaging |
JP5784626B2 (ja) * | 2009-12-11 | 2015-09-24 | プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダProyecto De Biomedicina Cima, S.L. | 免疫療法および抗腫瘍治療のための新規な結合体および組成物 |
EP2582379A4 (de) * | 2010-06-15 | 2013-12-04 | Matthew C Lawyer | Zusammensetzungen und verfahren zur behandlung von arteriosklerose |
CN101923093B (zh) * | 2010-07-13 | 2013-12-18 | 昆明理工大学 | 树鼩IgG的三抗体夹心ELISA检测方法 |
CN103025875A (zh) * | 2010-08-30 | 2013-04-03 | 霍夫曼-拉罗奇有限公司 | 原核表达构建体 |
RU2631001C2 (ru) * | 2010-08-30 | 2017-09-15 | Ф.Хоффманн-Ля Рош Аг | Способ получения полипептида |
JP5860052B2 (ja) * | 2010-08-30 | 2016-02-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | テトラネクチン−アポリポタンパク質a−i、それを含有する脂質粒子及びその使用 |
US20120190609A1 (en) * | 2010-08-30 | 2012-07-26 | Martin Bader | Method for producing a lipid particle, the lipid particle itself and its use |
RU2013111676A (ru) * | 2010-08-30 | 2014-10-10 | Ф. Хоффманн-Ля Рош Аг | Способ получения тетранектин-аполипопротеин а-i частицы, полученная таким образом липидная частица и ее применение |
EP2611419A2 (de) * | 2010-08-30 | 2013-07-10 | F.Hoffmann-La Roche Ag | Verfahren zur herstellung eines tetranectin-apolipoprotein-a1-partikels, dieses partikel selbst und seine verwendung |
SG10201801372YA (en) | 2011-02-07 | 2018-04-27 | Cerenis Therapeutics Holding S A | Lipoprotein complexes and manufacturing and uses thereof |
BR112013033562A2 (pt) * | 2011-08-25 | 2017-02-14 | Hoffmann La Roche | proteína de fusão de tetranectina-apolipoproteína a-i encurtada, uma partícula de lipídio que a contém e uso das mesmas |
BR112014004463A2 (pt) | 2011-08-25 | 2017-03-28 | Hoffmann La Roche | método de cromatografia de troca de cátion e de ânion |
RU2014129505A (ru) * | 2011-12-21 | 2016-02-10 | СиЭсЭл ЛИМИТЕД | Схема дозирования для составов аполипопротеина |
WO2013125769A1 (ko) * | 2012-02-24 | 2013-08-29 | 성균관대학교 산학협력단 | 아포리포단백질을 포함하는 항체-약물 결합체 |
KR101536037B1 (ko) * | 2012-02-24 | 2015-07-13 | 성균관대학교산학협력단 | 아포리포단백질을 포함하는 항체-약물 결합체 |
PE20142405A1 (es) | 2012-04-19 | 2015-01-25 | Opko Biolog Ltd | Variantes de oxintomodulina de accion prolongada y metodos de produccion de las mismas |
WO2014023315A1 (en) * | 2012-08-10 | 2014-02-13 | Aarhus Universitet | Multimerization through beta-strand swapping in ccp domains |
PT2922867T (pt) | 2012-11-20 | 2021-10-29 | Opko Biologics Ltd | Método de aumentar o volume hidrodinâmico de polipéptidos anexando péptidos carboxi terminais de gonadotrofina |
KR102275477B1 (ko) * | 2013-06-05 | 2021-07-13 | 시에스엘 리미티드 | 아포지단백질 A―I(Apo A―I)의 제조방법 |
EP2853259A1 (de) | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Rekonstituierte hochdichte Lipoproteinzusammensetzung und Verwendungen davon |
US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
WO2015173633A2 (en) | 2014-05-02 | 2015-11-19 | Cerenis Therapeutics Holding Sa | Hdl therapy markers |
US10961286B2 (en) | 2014-08-15 | 2021-03-30 | Cornell University | Nucleic acids, vectors, host cells, and methods for recombinantly producing water-soluble membrane proteins |
KR102473014B1 (ko) | 2015-06-19 | 2022-11-30 | 옵코 바이오로직스 리미티드 | 장기-작용성 응고 인자 및 그의 제조 방법 |
WO2017044424A1 (en) | 2015-09-08 | 2017-03-16 | Theripion, Inc. | Apoa-1 fusion polypeptides and related compositions and methods |
IL264208B1 (en) | 2016-07-11 | 2024-10-01 | Opko Biologics Ltd | Long-term coagulation factors and methods for their preparation |
WO2018136163A2 (en) * | 2016-12-09 | 2018-07-26 | Theripion, Inc. | Tandem apoa-1 fusion polypeptides |
EP3668549B1 (de) | 2017-08-10 | 2024-05-15 | Abionyx Pharma SA | Apomere |
WO2019030574A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding | CARGOMÈRES |
JP2020534261A (ja) * | 2017-09-08 | 2020-11-26 | ザ ユニバーシティ オブ ブリストル | 膜へのタンパク質送達 |
CA3177243A1 (en) | 2020-04-16 | 2021-10-21 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
US20240000948A1 (en) | 2020-10-01 | 2024-01-04 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
MX2023012223A (es) | 2021-04-15 | 2023-10-26 | Abionyx Pharma Sa | Uso de complejos a base de proteinas de union a lipidos en soluciones de conservacion de organos. |
CN114940711B (zh) * | 2021-10-25 | 2023-05-12 | 中山大学 | 载脂蛋白a-i模拟肽及其应用 |
WO2023194797A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
WO2023194798A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes |
WO2023237935A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
WO2023237927A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes |
CN115290776A (zh) * | 2022-07-26 | 2022-11-04 | 云南大学 | 瘤牛锥虫病抗性蛋白的应用 |
WO2024150064A1 (en) | 2023-01-13 | 2024-07-18 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4970144A (en) * | 1984-12-31 | 1990-11-13 | International Genetic Engineering | Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use |
US5068045A (en) * | 1985-08-27 | 1991-11-26 | Mobil Oil Corporation | Grease composition containing alkoxylated amide borates |
GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
US5128318A (en) * | 1987-05-20 | 1992-07-07 | The Rogosin Institute | Reconstituted HDL particles and uses thereof |
US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
IT1229996B (it) | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
US5177189A (en) * | 1989-08-18 | 1993-01-05 | The Scripps Research Institute | Polypeptide analogs of Apolipoprotein E |
US5182364A (en) * | 1990-02-26 | 1993-01-26 | The Scripps Research Institute | Polypeptide analogs of apolipoprotein E |
US5473039A (en) * | 1989-08-18 | 1995-12-05 | The Scripps Research Institute | Polypeptide analogs of apolipoprotein E, diagnostic systems and methods using the analogs |
AU9088891A (en) * | 1990-11-29 | 1992-06-25 | John E. Carbaugh | Diagnostic and therapeutic compositions and methods for lipoprotein(a) |
CA2110899C (en) | 1991-06-21 | 2006-08-08 | Jacob G. Michael | Orally administrable therapeutic proteins and method of making |
WO1993000443A1 (en) * | 1991-06-26 | 1993-01-07 | Bio-Technology General Corp. | Purification of recombinant apolipoprotein e from bacteria |
US5408038A (en) * | 1991-10-09 | 1995-04-18 | The Scripps Research Institute | Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides |
US5716805A (en) * | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
EP0621284A4 (de) * | 1992-08-14 | 1996-06-12 | Shino Test Corp | PEPTIDE BESTEHEND AUS AMINOSÄURESEQUENZEN AUS ENTWEDER LIPOPROTEIN(a) ODER APOLIPOPROTEIN(a), ANTIKÖRPER, DIE DIESE AMINOSÄURESEQUENZEN ERKENNEN UND MESSVERFAHREN MIT DIESEN ANTIKÖRPERN. |
SE9203753D0 (sv) * | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
SG52402A1 (en) | 1992-12-22 | 1998-09-28 | Univ Cincinnati | Oral administration of immunologically active biomolecules and other therapeutic proteins |
CA2155335C (en) | 1993-02-04 | 2001-06-05 | HANS CHRISTIAN THõGERSEN | Improved method for the refolding of proteins |
SE9300937L (sv) | 1993-03-19 | 1994-09-20 | Anne Fjellestad Paulsen | Komposition för oral administrering av peptider |
FR2704556B1 (fr) * | 1993-04-30 | 1995-07-13 | Rhone Poulenc Rorer Sa | Virus recombinants et leur utilisation en thérapie génique. |
US5643757A (en) | 1994-03-21 | 1997-07-01 | American Cyanamid Company | High yield production of human apolipoprotein A1 in E. coli. |
GB9409768D0 (en) | 1994-05-16 | 1994-07-06 | Medical Res Council | Trimerising polypeptides |
SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
FR2734568B1 (fr) | 1995-05-22 | 1997-06-20 | Rhone Poulenc Rorer Sa | Nouveaux variants de l'apolipoproteine |
JP3628333B2 (ja) * | 1995-09-21 | 2005-03-09 | ジェネンテック インコーポレーテッド | ヒト成長ホルモン変異体 |
US5922680A (en) | 1996-10-23 | 1999-07-13 | Ferring, B.V. | Stabilized composition for oral administration of peptides |
WO1998056906A1 (en) | 1997-06-11 | 1998-12-17 | Thoegersen Hans Christian | Trimerising module |
US6004925A (en) * | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
IL138214A0 (en) | 1998-03-09 | 2001-10-31 | Zealand Pharmaceuticals As | Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
-
2001
- 2001-11-09 WO PCT/DK2001/000739 patent/WO2002038609A2/en active IP Right Grant
- 2001-11-09 CN CNB018218504A patent/CN1268641C/zh not_active Expired - Fee Related
- 2001-11-09 JP JP2002541940A patent/JP4344136B2/ja not_active Expired - Fee Related
- 2001-11-09 AU AU2002213843A patent/AU2002213843B2/en not_active Ceased
- 2001-11-09 AU AU1384302A patent/AU1384302A/xx active Pending
- 2001-11-09 BR BR0115257-2A patent/BR0115257A/pt active Search and Examination
- 2001-11-09 EP EP10177657A patent/EP2343317A1/de not_active Withdrawn
- 2001-11-09 CA CA2428114A patent/CA2428114C/en not_active Expired - Fee Related
- 2001-11-09 EP EP01982197A patent/EP1335938B1/de not_active Expired - Lifetime
- 2001-11-13 US US09/987,107 patent/US6897039B2/en not_active Expired - Fee Related
-
2003
- 2003-05-09 NO NO20032101A patent/NO331274B1/no not_active IP Right Cessation
-
2004
- 2004-12-21 US US11/017,037 patent/US20050096277A1/en not_active Abandoned
- 2004-12-21 US US11/017,059 patent/US20050142639A1/en not_active Abandoned
-
2008
- 2008-12-01 US US12/325,384 patent/US20090136467A1/en not_active Abandoned
- 2008-12-25 JP JP2008330674A patent/JP2009118849A/ja active Pending
-
2010
- 2010-11-29 CY CY20101101089T patent/CY1111118T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20090136467A1 (en) | 2009-05-28 |
CN1268641C (zh) | 2006-08-09 |
AU2002213843B2 (en) | 2008-02-07 |
US6897039B2 (en) | 2005-05-24 |
EP1335938B1 (de) | 2010-09-22 |
CA2428114C (en) | 2013-07-23 |
WO2002038609A2 (en) | 2002-05-16 |
JP4344136B2 (ja) | 2009-10-14 |
US20050096277A1 (en) | 2005-05-05 |
BR0115257A (pt) | 2003-08-12 |
AU1384302A (en) | 2002-05-21 |
NO20032101D0 (no) | 2003-05-09 |
EP2343317A1 (de) | 2011-07-13 |
CN1486327A (zh) | 2004-03-31 |
CA2428114A1 (en) | 2002-05-16 |
JP2009118849A (ja) | 2009-06-04 |
NO20032101L (no) | 2003-07-08 |
JP2004522424A (ja) | 2004-07-29 |
WO2002038609A3 (en) | 2002-09-26 |
EP1335938A2 (de) | 2003-08-20 |
CY1111118T1 (el) | 2015-06-11 |
US20020156007A1 (en) | 2002-10-24 |
AU2002213843A2 (en) | 2002-05-21 |
US20050142639A1 (en) | 2005-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE290000T1 (de) | Muscarinagonisten | |
ATE252099T1 (de) | Biarylcarboxamide | |
NO331274B1 (no) | Apolipoproteinanaloger | |
NO20032514L (no) | Polypropylenharpikssammensetninger | |
DE10136334B8 (de) | Hochgeschwindigkeitsvertikalresonatoroberflächenemissionslaser | |
ATE312098T1 (de) | Thiazinoxazolidinon | |
ATA2932001A (de) | Schneefräse | |
DE50102988D1 (de) | Bodenwischer | |
DE50104056D1 (de) | Gewichtsmanschette | |
DE50100710D1 (de) | Wischblatt | |
ATE298751T1 (de) | 7-oxopyridoryrimidine | |
DE50104651D1 (de) | Fahrzeugfaltverdeck | |
DE10192638T1 (de) | Bohrstangenladevorrichtung | |
ATE509008T1 (de) | Sulfonylguanidine | |
DE50100817D1 (de) | Kugelgelenk | |
DE50011511D1 (de) | Blowby-Heizung | |
ATE476423T1 (de) | Benzoylpyridazine | |
DE50007634D1 (de) | Kardioplegieballonkatheter | |
DE10052925B4 (de) | Schaukelbett | |
DE10195909T1 (de) | Viehfüttervorrichtung | |
DE10085445T1 (de) | Drahterodierbearbeitungseinrichtung | |
DE10195992T1 (de) | Oberflächenendbearbeitungsbelag | |
ATE284887T1 (de) | Thienopyrrolidinone | |
DE50103443D1 (de) | Doppelwandbohrrohr | |
DE50010192D1 (de) | Intaglio-druckmaschine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |