NO330896B1 - Nukleinsyre som koder for en mutert form av h-parkin, polypeptid, antistoff,sammensetning, probe, fremgangsmater, vektor, celle, ikke-humant pattedyr samt anvendelser. - Google Patents

Nukleinsyre som koder for en mutert form av h-parkin, polypeptid, antistoff,sammensetning, probe, fremgangsmater, vektor, celle, ikke-humant pattedyr samt anvendelser. Download PDF

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Publication number
NO330896B1
NO330896B1 NO20012342A NO20012342A NO330896B1 NO 330896 B1 NO330896 B1 NO 330896B1 NO 20012342 A NO20012342 A NO 20012342A NO 20012342 A NO20012342 A NO 20012342A NO 330896 B1 NO330896 B1 NO 330896B1
Authority
NO
Norway
Prior art keywords
parkin
gene
exons
nucleic acid
mutation
Prior art date
Application number
NO20012342A
Other languages
English (en)
Norwegian (no)
Other versions
NO20012342D0 (no
NO20012342L (no
Inventor
Patrice Denefle
Alexis Brice
Christophe Lucking
Nacer Eddine Abbas
Sylvain Ricard
Sandrine Bouley
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9814524A external-priority patent/FR2786199B1/fr
Priority claimed from FR9910140A external-priority patent/FR2797272B1/fr
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Publication of NO20012342D0 publication Critical patent/NO20012342D0/no
Publication of NO20012342L publication Critical patent/NO20012342L/no
Publication of NO330896B1 publication Critical patent/NO330896B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/104Aminoacyltransferases (2.3.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y603/00Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02019Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20012342A 1998-11-19 2001-05-11 Nukleinsyre som koder for en mutert form av h-parkin, polypeptid, antistoff,sammensetning, probe, fremgangsmater, vektor, celle, ikke-humant pattedyr samt anvendelser. NO330896B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9814524A FR2786199B1 (fr) 1998-11-19 1998-11-19 Mutations du gene de la parkine, compositions, methodes et utilisations
US12423999P 1999-03-12 1999-03-12
FR9910140A FR2797272B1 (fr) 1999-08-04 1999-08-04 Nouvelles mutations du gene de la parkine, compositions, methodes et utilisations
PCT/FR1999/002833 WO2000031253A2 (fr) 1998-11-19 1999-11-18 Mutations du gene de la parkine, compositions, methodes et utilisations

Publications (3)

Publication Number Publication Date
NO20012342D0 NO20012342D0 (no) 2001-05-11
NO20012342L NO20012342L (no) 2001-07-18
NO330896B1 true NO330896B1 (no) 2011-08-08

Family

ID=27253486

Family Applications (5)

Application Number Title Priority Date Filing Date
NO20012342A NO330896B1 (no) 1998-11-19 2001-05-11 Nukleinsyre som koder for en mutert form av h-parkin, polypeptid, antistoff,sammensetning, probe, fremgangsmater, vektor, celle, ikke-humant pattedyr samt anvendelser.
NO20110577A NO332174B1 (no) 1998-11-19 2011-04-14 Nukleinsyre som koder for humant parkin, polypeptid, antistoff, sammensetning, probe, fremgangsmate, vektor, celle, ikke-humant pattedyr samt anvendelse
NO20110582A NO333907B1 (no) 1998-11-19 2011-04-14 Nukleinsyre som koder for en deletert form av h-parkin, polypeptid, antistoff, sammensetning, probe, fremgangsmåter, vektor, celle, ikke-humant pattedyr samt anvendelse.
NO20110578A NO332173B1 (no) 1998-11-19 2011-04-14 Nukleinsyre som koder for humant parkin, polypeptid, antistoff, sammensetning, probe, fremgangsmate, vektor, celle, ikke-humant pattedyr samt anvendelse.
NO20110580A NO333906B1 (no) 1998-11-19 2011-04-14 Nukleinsyre som koder for en deletert form av h-parkin, polypeptid, antistoff, sammensetning, probe, fremgangsmåter, vektor, celle, ikke-humant pattedyr samt anvendelse

Family Applications After (4)

Application Number Title Priority Date Filing Date
NO20110577A NO332174B1 (no) 1998-11-19 2011-04-14 Nukleinsyre som koder for humant parkin, polypeptid, antistoff, sammensetning, probe, fremgangsmate, vektor, celle, ikke-humant pattedyr samt anvendelse
NO20110582A NO333907B1 (no) 1998-11-19 2011-04-14 Nukleinsyre som koder for en deletert form av h-parkin, polypeptid, antistoff, sammensetning, probe, fremgangsmåter, vektor, celle, ikke-humant pattedyr samt anvendelse.
NO20110578A NO332173B1 (no) 1998-11-19 2011-04-14 Nukleinsyre som koder for humant parkin, polypeptid, antistoff, sammensetning, probe, fremgangsmate, vektor, celle, ikke-humant pattedyr samt anvendelse.
NO20110580A NO333906B1 (no) 1998-11-19 2011-04-14 Nukleinsyre som koder for en deletert form av h-parkin, polypeptid, antistoff, sammensetning, probe, fremgangsmåter, vektor, celle, ikke-humant pattedyr samt anvendelse

Country Status (15)

Country Link
US (3) US8835618B2 (el)
EP (5) EP2128257A3 (el)
JP (1) JP5424519B2 (el)
AT (1) ATE440138T1 (el)
AU (1) AU778281B2 (el)
CA (1) CA2351567C (el)
CY (1) CY1110535T1 (el)
DE (1) DE69941300D1 (el)
DK (1) DK1131424T3 (el)
ES (1) ES2330281T3 (el)
IL (3) IL142755A0 (el)
NO (5) NO330896B1 (el)
NZ (1) NZ512313A (el)
PT (1) PT1131424E (el)
WO (1) WO2000031253A2 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1081225A1 (en) * 1999-08-30 2001-03-07 Biofrontera Pharmaceuticals GmbH Transgenic animal model for neurodegenerative diseases
US20040248092A1 (en) * 2000-05-26 2004-12-09 Vance Jeffrey M Methods of screening for parkinsons's disease
FR2845245A1 (fr) * 2002-10-07 2004-04-09 Aventis Pharma Sa Modele animal de la maladie de parkinson
US7790390B2 (en) 2004-10-27 2010-09-07 Duke University Methods for identifying an individual at increased risk of developing coronary artery disease
US7807465B2 (en) 2004-10-27 2010-10-05 Duke University Methods for identifying an individual at increased risk of developing coronary artery disease
CN110295147A (zh) * 2019-07-22 2019-10-01 新乡医学院 一种食管癌细胞系中功能基因敲除后增殖表型的快速鉴定方法及其应用
WO2021237158A1 (en) * 2020-05-21 2021-11-25 Nysnobio Gt, Llc Gene therapy delivery of parkin mutants having increased activity to treat parkinson's disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0672753B1 (en) * 1993-10-05 2008-01-02 Asahi Glass Company Ltd. Multicloning vector, expression vector, and production of foreign protein with expression vector
WO1996039535A1 (en) 1995-06-06 1996-12-12 Jan Vijg Method of and apparatus for diagnostic dna testing
US6716621B1 (en) 1998-02-09 2004-04-06 Boehringer Ingelheim International Gmbh Isolated DNA or gene responsible for Parkinson's disease
CA2872581C (fr) * 1998-11-19 2018-04-10 Aventis Pharma S.A. Mutations du gene de la parkine, compositions, methodes et utilisations

Also Published As

Publication number Publication date
EP1131424B1 (fr) 2009-08-19
CY1110535T1 (el) 2015-04-29
EP2311954A1 (fr) 2011-04-20
JP2002536961A (ja) 2002-11-05
PT1131424E (pt) 2009-10-23
NO20012342D0 (no) 2001-05-11
DK1131424T3 (da) 2009-11-23
EP1131424A2 (fr) 2001-09-12
WO2000031253A2 (fr) 2000-06-02
IL142755A0 (en) 2002-03-10
CA2351567C (fr) 2016-01-12
IL142755A (en) 2009-08-03
EP2128257A2 (fr) 2009-12-02
NZ512313A (en) 2003-12-19
US9540693B2 (en) 2017-01-10
NO332173B1 (no) 2012-07-16
NO20012342L (no) 2001-07-18
NO20110580L (no) 2001-07-18
ES2330281T3 (es) 2009-12-07
NO332174B1 (no) 2012-07-16
ATE440138T1 (de) 2009-09-15
WO2000031253A3 (fr) 2000-09-28
CA2351567A1 (fr) 2000-06-02
EP2345722A1 (fr) 2011-07-20
NO20110582L (no) 2001-07-18
EP2305816A1 (fr) 2011-04-06
NO20110578L (no) 2001-07-18
US8835618B2 (en) 2014-09-16
US20150074836A1 (en) 2015-03-12
NO333907B1 (no) 2013-10-14
AU778281B2 (en) 2004-11-25
JP5424519B2 (ja) 2014-02-26
US20120064598A1 (en) 2012-03-15
NO333906B1 (no) 2013-10-14
US20170183736A1 (en) 2017-06-29
NO20110577L (no) 2001-07-18
DE69941300D1 (de) 2009-10-01
IL187652A (en) 2010-02-17
AU1276900A (en) 2000-06-13
EP2128257A3 (fr) 2010-03-03

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