CY1110535T1 - Μεταλλαξεις του γονιδιου της παρκινης, συνθεσεις, μεθοδοι και χρησεις - Google Patents
Μεταλλαξεις του γονιδιου της παρκινης, συνθεσεις, μεθοδοι και χρησειςInfo
- Publication number
- CY1110535T1 CY1110535T1 CY20091101178T CY091101178T CY1110535T1 CY 1110535 T1 CY1110535 T1 CY 1110535T1 CY 20091101178 T CY20091101178 T CY 20091101178T CY 091101178 T CY091101178 T CY 091101178T CY 1110535 T1 CY1110535 T1 CY 1110535T1
- Authority
- CY
- Cyprus
- Prior art keywords
- parkin
- gene
- exons
- deletion
- amplifying
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
- C12Y603/02019—Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε νουκλεϊκά οξέα τα οποία κωδικοποιούν τις μεταλλαγμένες, τις περικομμένες ή τις φέρουσες πολλαπλασιασμούς εξονίων μορφές της ανθρώπινης παρκίνης, και τις αντίστοιχες πρωτεΐνες και αντισώματα. Αφορά επίσης σε μεθόδους και κιτία για την ταυτοποίηση μεταλλάξεων του γονιδίου της παρκίνης, καθώς και στην μελέτη ενώσεων με θεραπευτικό σκοπό.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9814524A FR2786199B1 (fr) | 1998-11-19 | 1998-11-19 | Mutations du gene de la parkine, compositions, methodes et utilisations |
US12423999P | 1999-03-12 | 1999-03-12 | |
FR9910140A FR2797272B1 (fr) | 1999-08-04 | 1999-08-04 | Nouvelles mutations du gene de la parkine, compositions, methodes et utilisations |
EP99956079A EP1131424B1 (fr) | 1998-11-19 | 1999-11-18 | Mutations du gene de la parkine, compositions, methodes et utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110535T1 true CY1110535T1 (el) | 2015-04-29 |
Family
ID=27253486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091101178T CY1110535T1 (el) | 1998-11-19 | 2009-11-11 | Μεταλλαξεις του γονιδιου της παρκινης, συνθεσεις, μεθοδοι και χρησεις |
Country Status (15)
Country | Link |
---|---|
US (3) | US8835618B2 (el) |
EP (5) | EP2128257A3 (el) |
JP (1) | JP5424519B2 (el) |
AT (1) | ATE440138T1 (el) |
AU (1) | AU778281B2 (el) |
CA (1) | CA2351567C (el) |
CY (1) | CY1110535T1 (el) |
DE (1) | DE69941300D1 (el) |
DK (1) | DK1131424T3 (el) |
ES (1) | ES2330281T3 (el) |
IL (3) | IL142755A0 (el) |
NO (5) | NO330896B1 (el) |
NZ (1) | NZ512313A (el) |
PT (1) | PT1131424E (el) |
WO (1) | WO2000031253A2 (el) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1081225A1 (en) * | 1999-08-30 | 2001-03-07 | Biofrontera Pharmaceuticals GmbH | Transgenic animal model for neurodegenerative diseases |
US20040248092A1 (en) * | 2000-05-26 | 2004-12-09 | Vance Jeffrey M | Methods of screening for parkinsons's disease |
FR2845245A1 (fr) * | 2002-10-07 | 2004-04-09 | Aventis Pharma Sa | Modele animal de la maladie de parkinson |
US7790390B2 (en) | 2004-10-27 | 2010-09-07 | Duke University | Methods for identifying an individual at increased risk of developing coronary artery disease |
US7807465B2 (en) | 2004-10-27 | 2010-10-05 | Duke University | Methods for identifying an individual at increased risk of developing coronary artery disease |
CN110295147A (zh) * | 2019-07-22 | 2019-10-01 | 新乡医学院 | 一种食管癌细胞系中功能基因敲除后增殖表型的快速鉴定方法及其应用 |
WO2021237158A1 (en) * | 2020-05-21 | 2021-11-25 | Nysnobio Gt, Llc | Gene therapy delivery of parkin mutants having increased activity to treat parkinson's disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0672753B1 (en) * | 1993-10-05 | 2008-01-02 | Asahi Glass Company Ltd. | Multicloning vector, expression vector, and production of foreign protein with expression vector |
WO1996039535A1 (en) | 1995-06-06 | 1996-12-12 | Jan Vijg | Method of and apparatus for diagnostic dna testing |
US6716621B1 (en) | 1998-02-09 | 2004-04-06 | Boehringer Ingelheim International Gmbh | Isolated DNA or gene responsible for Parkinson's disease |
CA2872581C (fr) * | 1998-11-19 | 2018-04-10 | Aventis Pharma S.A. | Mutations du gene de la parkine, compositions, methodes et utilisations |
-
1999
- 1999-11-18 EP EP09167384A patent/EP2128257A3/fr not_active Withdrawn
- 1999-11-18 AU AU12769/00A patent/AU778281B2/en not_active Ceased
- 1999-11-18 PT PT99956079T patent/PT1131424E/pt unknown
- 1999-11-18 IL IL14275599A patent/IL142755A0/xx unknown
- 1999-11-18 JP JP2000584062A patent/JP5424519B2/ja not_active Expired - Lifetime
- 1999-11-18 DE DE69941300T patent/DE69941300D1/de not_active Expired - Lifetime
- 1999-11-18 AT AT99956079T patent/ATE440138T1/de active
- 1999-11-18 EP EP10184008A patent/EP2345722A1/fr not_active Withdrawn
- 1999-11-18 NZ NZ512313A patent/NZ512313A/en not_active IP Right Cessation
- 1999-11-18 DK DK99956079T patent/DK1131424T3/da active
- 1999-11-18 WO PCT/FR1999/002833 patent/WO2000031253A2/fr active Application Filing
- 1999-11-18 EP EP99956079A patent/EP1131424B1/fr not_active Expired - Lifetime
- 1999-11-18 ES ES99956079T patent/ES2330281T3/es not_active Expired - Lifetime
- 1999-11-18 CA CA2351567A patent/CA2351567C/fr not_active Expired - Lifetime
- 1999-11-18 EP EP10184042A patent/EP2305816A1/fr not_active Withdrawn
- 1999-11-18 EP EP10184027A patent/EP2311954A1/fr not_active Withdrawn
-
2001
- 2001-04-23 IL IL142755A patent/IL142755A/en not_active IP Right Cessation
- 2001-05-11 NO NO20012342A patent/NO330896B1/no not_active IP Right Cessation
-
2007
- 2007-11-26 IL IL187652A patent/IL187652A/en not_active IP Right Cessation
-
2009
- 2009-11-11 CY CY20091101178T patent/CY1110535T1/el unknown
-
2011
- 2011-04-14 NO NO20110577A patent/NO332174B1/no not_active IP Right Cessation
- 2011-04-14 NO NO20110582A patent/NO333907B1/no not_active IP Right Cessation
- 2011-04-14 NO NO20110578A patent/NO332173B1/no not_active IP Right Cessation
- 2011-04-14 NO NO20110580A patent/NO333906B1/no not_active IP Right Cessation
- 2011-08-15 US US13/209,495 patent/US8835618B2/en not_active Expired - Fee Related
-
2014
- 2014-08-07 US US14/454,026 patent/US9540693B2/en not_active Expired - Fee Related
-
2016
- 2016-11-04 US US15/343,323 patent/US20170183736A1/en not_active Abandoned
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