NO330195B1 - Farmasoytisk aerosolsammensetning inneholdende HFA 227 og HFA 134a - Google Patents
Farmasoytisk aerosolsammensetning inneholdende HFA 227 og HFA 134a Download PDFInfo
- Publication number
- NO330195B1 NO330195B1 NO20012517A NO20012517A NO330195B1 NO 330195 B1 NO330195 B1 NO 330195B1 NO 20012517 A NO20012517 A NO 20012517A NO 20012517 A NO20012517 A NO 20012517A NO 330195 B1 NO330195 B1 NO 330195B1
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- Norway
- Prior art keywords
- hfa
- aerosol
- propellant
- composition
- mmad
- Prior art date
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- 230000035515 penetration Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI002558A IT1303788B1 (it) | 1998-11-25 | 1998-11-25 | Formulazioni di aerosol medicinali. |
| PCT/EP1999/008959 WO2000030607A1 (en) | 1998-11-25 | 1999-11-22 | PHARMACEUTICAL AEROSOL COMPOSITION CONTAINING HFA 227 AND HFA 134a |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20012517D0 NO20012517D0 (no) | 2001-05-22 |
| NO20012517L NO20012517L (no) | 2001-07-23 |
| NO330195B1 true NO330195B1 (no) | 2011-03-07 |
Family
ID=11381136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012517A NO330195B1 (no) | 1998-11-25 | 2001-05-22 | Farmasoytisk aerosolsammensetning inneholdende HFA 227 og HFA 134a |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6713047B1 (ja) |
| EP (1) | EP1133277B1 (ja) |
| JP (1) | JP2002530316A (ja) |
| KR (1) | KR100794060B1 (ja) |
| CN (1) | CN1177582C (ja) |
| AT (1) | ATE368450T1 (ja) |
| AU (1) | AU770529B2 (ja) |
| BR (1) | BR9916865A (ja) |
| CA (1) | CA2352483C (ja) |
| CY (1) | CY1106904T1 (ja) |
| DE (1) | DE69936730T2 (ja) |
| DK (1) | DK1133277T3 (ja) |
| ES (1) | ES2289832T3 (ja) |
| IL (1) | IL143293A0 (ja) |
| IT (1) | IT1303788B1 (ja) |
| MA (1) | MA26763A1 (ja) |
| NO (1) | NO330195B1 (ja) |
| NZ (1) | NZ511923A (ja) |
| PT (1) | PT1133277E (ja) |
| TR (1) | TR200101442T2 (ja) |
| WO (1) | WO2000030607A1 (ja) |
| ZA (1) | ZA200104220B (ja) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010031244A1 (en) * | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| DZ2947A1 (fr) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| IT1303788B1 (it) * | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | Formulazioni di aerosol medicinali. |
| US6739333B1 (en) | 1999-05-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Stainless steel canister for propellant-driven metering aerosols |
| US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
| FR2798290B1 (fr) | 1999-09-11 | 2003-09-12 | Glaxo Group Ltd | Formulation pharmaceutique de propionate de fluticasone |
| US20030032632A1 (en) * | 1999-12-24 | 2003-02-13 | Crispps Leslie Alan | Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate |
| IT1317720B1 (it) * | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
| IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
| SK286694B6 (sk) * | 2000-05-22 | 2009-03-05 | Chiesi Farmaceutici S.P.A. | Aerosólový farmaceutický prostriedok |
| US20060257324A1 (en) | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
| GB2367011A (en) * | 2000-08-26 | 2002-03-27 | Glaxo Group Ltd | Metered dose inhaler for salmeterol |
| ES2222294T3 (es) * | 2001-07-02 | 2005-02-01 | Chiesi Farmaceutici S.P.A. | Formulacion optimizada de tobramicina para administracion en forma de aerosol. |
| EP1340503A1 (en) * | 2002-03-01 | 2003-09-03 | CHIESI FARMACEUTICI S.p.A. | Solution aerosol formulation containing esters of 3, 17-dihydroxy oestratriene derivates for pulmonary delivery |
| EP1415647A1 (en) * | 2002-10-23 | 2004-05-06 | CHIESI FARMACEUTICI S.p.A. | "Long-acting beta-2 agonists ultrafine formulations" |
| EP1340492A1 (en) * | 2002-03-01 | 2003-09-03 | CHIESI FARMACEUTICI S.p.A. | Aerosol formulations for pulmonary administration of medicaments having systemic effects |
| PT3494995T (pt) * | 2002-03-01 | 2020-03-30 | Chiesi Farm Spa | Formulação superfina de formoterol |
| US7311894B2 (en) | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
| ES2275778T3 (es) * | 2002-06-06 | 2007-06-16 | Chiesi Farmaceutici S.P.A. | Solubilizacion de farmacos en propulsores de hfa mediante emulsiones. |
| EP1452179A1 (en) * | 2003-02-27 | 2004-09-01 | CHIESI FARMACEUTICI S.p.A. | Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid |
| MXPA05009920A (es) | 2003-03-20 | 2005-11-04 | Boehringer Ingelheim Pharma | Formulacion para un inhalador con dosis medida que emplea hidrofluoroalcanos como propulsores. |
| EP1915985A1 (en) | 2003-03-20 | 2008-04-30 | Boehringer Ingelheim Pharmaceuticals Inc. | Formulation for a Metered Dose Inhaler Using Hydro-Fluoro-Alkanes as Propellants |
| US20080118442A1 (en) * | 2003-09-10 | 2008-05-22 | Map Pharmaceuticals, Inc. | Aerosol Formulations for Delivery of Dihydroergotamine to the Systemic Circulations Via Pulmonary Inhalation |
| AR041873A1 (es) * | 2003-10-30 | 2005-06-01 | Pablo Cassara Srl Lab | Una formulacion farmaceutica en aerosol adecuada para la inhalacion oral o nasal que contienen glucocorticoides en solucion estable al almacenamiento; un metodo para estabilzar formulaciones y uso de un agente estabilizante |
| EP1595531A1 (en) * | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
| KR20070000476A (ko) * | 2004-02-27 | 2007-01-02 | 키에시 파르마슈티시 엣스. 피. 에이. | 압축화 계량된 도스흡입용 안정된 약제용액 제제 |
| CN1583170A (zh) * | 2004-06-10 | 2005-02-23 | 安米 | 用于抗病毒抗耐药菌的人溶菌酶药物及其制法 |
| JP5209963B2 (ja) | 2004-07-02 | 2013-06-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 噴霧剤としてｔｇ２２７ｅａ又はｔｇ１３４ａを含有するエアロゾル懸濁製剤 |
| DE102006017320A1 (de) | 2006-04-11 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel |
| EP2011534A1 (en) * | 2007-07-03 | 2009-01-07 | CHIESI FARMACEUTICI S.p.A. | Metered dose inhaler actuator |
| WO2011150441A1 (en) * | 2010-06-03 | 2011-12-08 | Wholesome Biopharm Pty Ltd | Medical aerosol formulation comprising ribavirin |
| CN103052378A (zh) * | 2010-08-03 | 2013-04-17 | 奇斯药制品公司 | 包含磷酸二酯酶抑制剂的药物制剂 |
| WO2014205030A1 (en) * | 2013-06-19 | 2014-12-24 | Map Pharmaceuticals, Inc. | Pulmonary administration of rotigotine |
| WO2016170518A1 (en) | 2015-04-24 | 2016-10-27 | Glenmark Specialty S.A. | Pharmaceutical compositions comprising arformoterol and glycopyrronium |
| CN114796166A (zh) * | 2021-01-29 | 2022-07-29 | 北京远大九和药业有限公司 | 一种含有萜烯类挥发油的气雾剂及其制备方法 |
| CN114522143A (zh) * | 2022-02-22 | 2022-05-24 | 暨南大学 | 用于吸入气雾剂的低制冷效应复合抛射剂及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH89518A (de) * | 1919-03-22 | 1921-06-01 | Croning Johannes | Der Türdicke entsprechend einstellbares Gehäuse für Zylinderschlösser. |
| US3095355A (en) * | 1961-10-12 | 1963-06-25 | Revlon | Aerosol composition |
| US3860618A (en) * | 1967-08-08 | 1975-01-14 | Philip Saxton Hartley | Chromone |
| US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
| GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| JP2769925B2 (ja) | 1990-10-18 | 1998-06-25 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | ベクロメタゾン１７，２１ジプロピオネートを含んで成るエアロゾル製剤 |
| MX9203481A (es) * | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
| US5190029A (en) * | 1991-02-14 | 1993-03-02 | Virginia Commonwealth University | Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content |
| US5653961A (en) * | 1995-03-31 | 1997-08-05 | Minnesota Mining And Manufacturing Company | Butixocort aerosol formulations in hydrofluorocarbon propellant |
| TR199701167T1 (xx) | 1995-04-14 | 1998-03-21 | Glaxo Wellcome Inc. | Albuterol i�in �l��lm�� doz inhaleri. |
| GB9612297D0 (en) | 1996-06-11 | 1996-08-14 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
| EP0914143A1 (en) * | 1996-07-08 | 1999-05-12 | Rhone-Poulenc Rorer Limited | Medicinal cyclosporin-a aerosol solution formulation |
| GB9620187D0 (en) * | 1996-09-27 | 1996-11-13 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
| DK1014943T3 (da) * | 1997-02-05 | 2002-10-14 | Jago Res Ag | Medicinske aerosolformuleringer |
| US6126919A (en) * | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| GB2326334A (en) * | 1997-06-13 | 1998-12-23 | Chiesi Farma Spa | Pharmaceutical aerosol compositions |
| IT1303788B1 (it) * | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | Formulazioni di aerosol medicinali. |
| US6004537A (en) | 1998-12-18 | 1999-12-21 | Baker Norton Pharmaceuticals, Inc. | Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol |
| SK286694B6 (sk) * | 2000-05-22 | 2009-03-05 | Chiesi Farmaceutici S.P.A. | Aerosólový farmaceutický prostriedok |
| EP1415647A1 (en) * | 2002-10-23 | 2004-05-06 | CHIESI FARMACEUTICI S.p.A. | "Long-acting beta-2 agonists ultrafine formulations" |
| PT3494995T (pt) * | 2002-03-01 | 2020-03-30 | Chiesi Farm Spa | Formulação superfina de formoterol |
| EP1340492A1 (en) * | 2002-03-01 | 2003-09-03 | CHIESI FARMACEUTICI S.p.A. | Aerosol formulations for pulmonary administration of medicaments having systemic effects |
-
1998
- 1998-11-25 IT IT1998MI002558A patent/IT1303788B1/it active
-
1999
- 1999-11-22 AU AU15553/00A patent/AU770529B2/en not_active Ceased
- 1999-11-22 EP EP99958096A patent/EP1133277B1/en not_active Expired - Lifetime
- 1999-11-22 US US09/831,886 patent/US6713047B1/en not_active Expired - Fee Related
- 1999-11-22 PT PT99958096T patent/PT1133277E/pt unknown
- 1999-11-22 BR BR9916865-0A patent/BR9916865A/pt not_active Application Discontinuation
- 1999-11-22 KR KR1020017006520A patent/KR100794060B1/ko not_active IP Right Cessation
- 1999-11-22 NZ NZ511923A patent/NZ511923A/en not_active IP Right Cessation
- 1999-11-22 DE DE69936730T patent/DE69936730T2/de not_active Expired - Lifetime
- 1999-11-22 WO PCT/EP1999/008959 patent/WO2000030607A1/en active IP Right Grant
- 1999-11-22 ES ES99958096T patent/ES2289832T3/es not_active Expired - Lifetime
- 1999-11-22 AT AT99958096T patent/ATE368450T1/de active
- 1999-11-22 DK DK99958096T patent/DK1133277T3/da active
- 1999-11-22 IL IL14329399A patent/IL143293A0/xx not_active IP Right Cessation
- 1999-11-22 TR TR2001/01442T patent/TR200101442T2/xx unknown
- 1999-11-22 CA CA002352483A patent/CA2352483C/en not_active Expired - Fee Related
- 1999-11-22 CN CNB998148717A patent/CN1177582C/zh not_active Expired - Fee Related
- 1999-11-22 JP JP2000583491A patent/JP2002530316A/ja active Pending
-
2001
- 2001-05-22 NO NO20012517A patent/NO330195B1/no not_active IP Right Cessation
- 2001-05-22 MA MA26203A patent/MA26763A1/fr unknown
- 2001-05-23 ZA ZA200104220A patent/ZA200104220B/en unknown
-
2004
- 2004-01-30 US US10/766,857 patent/US20040184993A1/en not_active Abandoned
-
2007
- 2007-10-04 CY CY20071101264T patent/CY1106904T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2352483A1 (en) | 2000-06-02 |
| IT1303788B1 (it) | 2001-02-23 |
| ES2289832T3 (es) | 2008-02-01 |
| ZA200104220B (en) | 2002-05-23 |
| PT1133277E (pt) | 2007-10-09 |
| DK1133277T3 (da) | 2007-12-27 |
| KR100794060B1 (ko) | 2008-01-10 |
| DE69936730D1 (de) | 2007-09-13 |
| EP1133277B1 (en) | 2007-08-01 |
| NO20012517L (no) | 2001-07-23 |
| NZ511923A (en) | 2003-10-31 |
| AU1555300A (en) | 2000-06-13 |
| NO20012517D0 (no) | 2001-05-22 |
| IL143293A0 (en) | 2002-04-21 |
| DE69936730T2 (de) | 2008-04-30 |
| ITMI982558A1 (it) | 2000-05-25 |
| BR9916865A (pt) | 2001-11-13 |
| CN1177582C (zh) | 2004-12-01 |
| JP2002530316A (ja) | 2002-09-17 |
| CY1106904T1 (el) | 2012-05-23 |
| US20040184993A1 (en) | 2004-09-23 |
| WO2000030607A1 (en) | 2000-06-02 |
| EP1133277A1 (en) | 2001-09-19 |
| CN1331581A (zh) | 2002-01-16 |
| CA2352483C (en) | 2009-01-20 |
| AU770529B2 (en) | 2004-02-26 |
| US6713047B1 (en) | 2004-03-30 |
| KR20010080560A (ko) | 2001-08-22 |
| TR200101442T2 (tr) | 2002-05-21 |
| MA26763A1 (fr) | 2004-12-20 |
| WO2000030607A8 (en) | 2001-03-22 |
| ATE368450T1 (de) | 2007-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |