NO328599B1 - Ortosubstituerte og metasubstituerte bisarylforbindelser, deres anvendelse som et legemiddel, farmasoytiske preparater inneholdende forbindelsene, samt deres an-vendelse for fremstilling av medikamenter - Google Patents
Ortosubstituerte og metasubstituerte bisarylforbindelser, deres anvendelse som et legemiddel, farmasoytiske preparater inneholdende forbindelsene, samt deres an-vendelse for fremstilling av medikamenter Download PDFInfo
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- NO328599B1 NO328599B1 NO20032438A NO20032438A NO328599B1 NO 328599 B1 NO328599 B1 NO 328599B1 NO 20032438 A NO20032438 A NO 20032438A NO 20032438 A NO20032438 A NO 20032438A NO 328599 B1 NO328599 B1 NO 328599B1
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- Prior art keywords
- formula
- compounds
- phenyl
- atoms
- pharmaceutically acceptable
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10059418A DE10059418A1 (de) | 2000-11-30 | 2000-11-30 | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
PCT/EP2001/013294 WO2002044137A1 (de) | 2000-11-30 | 2001-11-17 | Ortho, meta-substituierte bisarylverbindungen, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen |
Publications (3)
Publication Number | Publication Date |
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NO20032438D0 NO20032438D0 (no) | 2003-05-28 |
NO20032438L NO20032438L (no) | 2003-07-09 |
NO328599B1 true NO328599B1 (no) | 2010-03-29 |
Family
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Family Applications (1)
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NO20032438A NO328599B1 (no) | 2000-11-30 | 2003-05-28 | Ortosubstituerte og metasubstituerte bisarylforbindelser, deres anvendelse som et legemiddel, farmasoytiske preparater inneholdende forbindelsene, samt deres an-vendelse for fremstilling av medikamenter |
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US (2) | US6605625B2 (ru) |
EP (1) | EP1339675B1 (ru) |
JP (1) | JP4051283B2 (ru) |
KR (1) | KR100968056B1 (ru) |
CN (1) | CN1290825C (ru) |
AR (1) | AR031430A1 (ru) |
AT (1) | ATE289292T1 (ru) |
AU (2) | AU2002227931B2 (ru) |
BR (1) | BR0115769A (ru) |
CA (1) | CA2430273C (ru) |
CZ (1) | CZ301631B6 (ru) |
DE (2) | DE10059418A1 (ru) |
EE (1) | EE05240B1 (ru) |
ES (1) | ES2236341T3 (ru) |
HK (1) | HK1061231A1 (ru) |
HR (1) | HRP20030436B1 (ru) |
HU (1) | HUP0303317A3 (ru) |
IL (2) | IL156097A0 (ru) |
MX (1) | MXPA03004386A (ru) |
NO (1) | NO328599B1 (ru) |
NZ (1) | NZ526177A (ru) |
PL (1) | PL206245B1 (ru) |
PT (1) | PT1339675E (ru) |
RS (1) | RS50403B (ru) |
RU (1) | RU2278858C2 (ru) |
SK (1) | SK286708B6 (ru) |
TW (1) | TWI254039B (ru) |
WO (1) | WO2002044137A1 (ru) |
ZA (1) | ZA200303893B (ru) |
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DE10060807A1 (de) * | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124941D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
MXPA04007838A (es) | 2002-02-12 | 2004-10-15 | Smithkline Beecham Corp | Derivados de nicotamida utiles como inhibidores p38. |
GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
DE60305053T2 (de) | 2002-08-19 | 2006-08-31 | Glaxo Group Ltd., Greenford | Pyrimidinderivate als selektive cox-2-inhibitoren |
GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
CA2508171C (en) * | 2002-12-13 | 2012-08-28 | Cytopia Pty Ltd | Nicotinamide-based kinase inhibitors |
AU2003291839B2 (en) * | 2002-12-13 | 2009-01-22 | Ym Biosciences Australia Pty Ltd | Nicotinamide-based kinase inhibitors |
US8030336B2 (en) | 2002-12-13 | 2011-10-04 | Ym Biosciences Australia Pty Ltd | Nicotinamide-based kinase inhibitors |
GB0308185D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
DE10341233A1 (de) * | 2003-09-08 | 2005-03-24 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien |
US20050054673A1 (en) * | 2003-09-08 | 2005-03-10 | Aventis Pharma Deutschland Gmbh | Combination of phenylcarboxylic acid amides with beta-adrenoreceptor blockers and their use for the treatment of atrial arrhythmias |
AU2004275720B2 (en) * | 2003-09-23 | 2008-04-24 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
US7647300B2 (en) * | 2004-01-26 | 2010-01-12 | Google Inc. | Methods and systems for output of search results |
GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0403744D0 (en) * | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
WO2005087236A1 (en) * | 2004-03-11 | 2005-09-22 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
CN1993348A (zh) * | 2004-07-29 | 2007-07-04 | 默克公司 | 钾通道抑制剂 |
US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
JP2008520579A (ja) | 2004-11-15 | 2008-06-19 | グラクソ グループ リミテッド | 新規m3ムスカリン性アセチルコリン受容体アンタゴニスト |
US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
AU2006276292B2 (en) * | 2005-07-22 | 2010-09-16 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
NZ572231A (en) * | 2006-04-27 | 2010-12-24 | Sanofi Aventis Deutschland | Inhibitors of the task-1 and task-3 ion channel |
CL2008000066A1 (es) | 2007-01-12 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem |
PE20090236A1 (es) | 2007-04-06 | 2009-03-13 | Neurocrine Biosciences Inc | Antagonistas de los receptores de la hormona liberadora de gonadotropina y procedimientos relacionados con ellos |
JP5735799B2 (ja) | 2007-04-06 | 2015-06-17 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | ゴナドトロピン放出ホルモン受容体拮抗薬およびそれに関連する方法 |
GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
NO3175985T3 (ru) | 2011-07-01 | 2018-04-28 | ||
WO2013112932A1 (en) | 2012-01-27 | 2013-08-01 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身tgr5促效劑之經取代之4-苯基吡啶化合物 |
CN107573292B (zh) * | 2017-09-04 | 2022-06-24 | 江苏艾立康医药科技有限公司 | 作用于脯氨酰羟化酶的吡嗪衍生化合物 |
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GB9416972D0 (en) * | 1994-08-23 | 1994-10-12 | Smithkline Beecham Plc | Carbon side chain/indole/indolene |
DE4430638A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von substituierten 4-Phenyl-6-amino-nicotinsäurederivaten als Arzneimittel |
DE4432101A1 (de) | 1994-09-09 | 1996-03-14 | Hoechst Ag | Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
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US6333337B1 (en) * | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
AU754204B2 (en) * | 1998-09-01 | 2002-11-07 | Bristol-Myers Squibb Company | Potassium channel inhibitors and method |
CA2343101A1 (en) * | 1998-09-11 | 2000-03-23 | Ajinomoto Co., Inc. | Benzene derivatives and medicinal use thereof |
DE19947457A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
-
2000
- 2000-11-30 DE DE10059418A patent/DE10059418A1/de not_active Withdrawn
-
2001
- 2001-11-17 BR BR0115769-8A patent/BR0115769A/pt not_active Application Discontinuation
- 2001-11-17 KR KR1020037007255A patent/KR100968056B1/ko not_active IP Right Cessation
- 2001-11-17 IL IL15609701A patent/IL156097A0/xx unknown
- 2001-11-17 RU RU2003119153/04A patent/RU2278858C2/ru not_active IP Right Cessation
- 2001-11-17 CA CA2430273A patent/CA2430273C/en not_active Expired - Fee Related
- 2001-11-17 NZ NZ526177A patent/NZ526177A/en unknown
- 2001-11-17 RS YUP-376/03A patent/RS50403B/sr unknown
- 2001-11-17 CZ CZ20031502A patent/CZ301631B6/cs not_active IP Right Cessation
- 2001-11-17 PT PT01989479T patent/PT1339675E/pt unknown
- 2001-11-17 ES ES01989479T patent/ES2236341T3/es not_active Expired - Lifetime
- 2001-11-17 DE DE50105386T patent/DE50105386D1/de not_active Expired - Lifetime
- 2001-11-17 EE EEP200300183A patent/EE05240B1/xx not_active IP Right Cessation
- 2001-11-17 CN CNB01819740XA patent/CN1290825C/zh not_active Expired - Fee Related
- 2001-11-17 AT AT01989479T patent/ATE289292T1/de active
- 2001-11-17 HU HU0303317A patent/HUP0303317A3/hu unknown
- 2001-11-17 JP JP2002546507A patent/JP4051283B2/ja not_active Expired - Fee Related
- 2001-11-17 MX MXPA03004386A patent/MXPA03004386A/es active IP Right Grant
- 2001-11-17 SK SK653-2003A patent/SK286708B6/sk not_active IP Right Cessation
- 2001-11-17 WO PCT/EP2001/013294 patent/WO2002044137A1/de active IP Right Grant
- 2001-11-17 AU AU2002227931A patent/AU2002227931B2/en not_active Ceased
- 2001-11-17 EP EP01989479A patent/EP1339675B1/de not_active Expired - Lifetime
- 2001-11-17 PL PL362700A patent/PL206245B1/pl not_active IP Right Cessation
- 2001-11-17 AU AU2793102A patent/AU2793102A/xx active Pending
- 2001-11-28 TW TW090129358A patent/TWI254039B/zh not_active IP Right Cessation
- 2001-11-28 AR ARP010105540A patent/AR031430A1/es unknown
- 2001-11-29 US US09/995,771 patent/US6605625B2/en not_active Expired - Fee Related
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2003
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- 2003-05-28 NO NO20032438A patent/NO328599B1/no not_active IP Right Cessation
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2004
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