NO323630B1 - Anvendelse av blandinger omfattende BMP for fremstilling av medikament for forbedring av osteokondralt autotransplantat. - Google Patents
Anvendelse av blandinger omfattende BMP for fremstilling av medikament for forbedring av osteokondralt autotransplantat. Download PDFInfo
- Publication number
- NO323630B1 NO323630B1 NO20013744A NO20013744A NO323630B1 NO 323630 B1 NO323630 B1 NO 323630B1 NO 20013744 A NO20013744 A NO 20013744A NO 20013744 A NO20013744 A NO 20013744A NO 323630 B1 NO323630 B1 NO 323630B1
- Authority
- NO
- Norway
- Prior art keywords
- bmp
- rhbmp
- tissue
- osteochondral
- articular cartilage
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 9
- 239000003814 drug Substances 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 210000001519 tissue Anatomy 0.000 claims abstract description 36
- 210000001188 articular cartilage Anatomy 0.000 claims abstract description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 18
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 7
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 7
- 230000010354 integration Effects 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 210000002435 tendon Anatomy 0.000 claims description 5
- 102100035368 Growth/differentiation factor 6 Human genes 0.000 claims description 4
- 101710204281 Growth/differentiation factor 6 Proteins 0.000 claims description 4
- 230000003848 cartilage regeneration Effects 0.000 claims description 2
- 210000003041 ligament Anatomy 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 abstract description 14
- 206010061762 Chondropathy Diseases 0.000 abstract description 11
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 abstract description 10
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 abstract description 10
- 229940112869 bone morphogenetic protein Drugs 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 9
- 230000008439 repair process Effects 0.000 abstract description 8
- 230000008929 regeneration Effects 0.000 abstract description 4
- 238000011069 regeneration method Methods 0.000 abstract description 4
- 208000024429 articular cartilage disease Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 description 17
- 230000007547 defect Effects 0.000 description 16
- 235000018102 proteins Nutrition 0.000 description 16
- 210000000988 bone and bone Anatomy 0.000 description 10
- 239000000872 buffer Substances 0.000 description 10
- 230000035876 healing Effects 0.000 description 8
- 238000002054 transplantation Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 230000002188 osteogenic effect Effects 0.000 description 6
- 238000004113 cell culture Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 206010007710 Cartilage injury Diseases 0.000 description 4
- 239000000833 heterodimer Substances 0.000 description 4
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 210000001612 chondrocyte Anatomy 0.000 description 3
- 230000002648 chondrogenic effect Effects 0.000 description 3
- 230000007850 degeneration Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 210000005065 subchondral bone plate Anatomy 0.000 description 3
- 230000017423 tissue regeneration Effects 0.000 description 3
- 108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 description 2
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000008558 Osteophyte Diseases 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 2
- 101100472152 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) REL1 gene Proteins 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000000515 collagen sponge Substances 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 238000011496 digital image analysis Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 210000002414 leg Anatomy 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- JTIGKVIOEQASGT-UHFFFAOYSA-N proquazone Chemical compound N=1C(=O)N(C(C)C)C2=CC(C)=CC=C2C=1C1=CC=CC=C1 JTIGKVIOEQASGT-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 2
- UBWXUGDQUBIEIZ-UHFFFAOYSA-N (13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl) 3-phenylpropanoate Chemical compound CC12CCC(C3CCC(=O)C=C3CC3)C3C1CCC2OC(=O)CCC1=CC=CC=C1 UBWXUGDQUBIEIZ-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- RPAJSBKBKSSMLJ-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCC(O)=O RPAJSBKBKSSMLJ-DFWYDOINSA-N 0.000 description 1
- 102000005606 Activins Human genes 0.000 description 1
- 108010059616 Activins Proteins 0.000 description 1
- 108010049951 Bone Morphogenetic Protein 3 Proteins 0.000 description 1
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 description 1
- 108010049976 Bone Morphogenetic Protein 5 Proteins 0.000 description 1
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 description 1
- 102100028726 Bone morphogenetic protein 10 Human genes 0.000 description 1
- 101710118482 Bone morphogenetic protein 10 Proteins 0.000 description 1
- 102000003928 Bone morphogenetic protein 15 Human genes 0.000 description 1
- 108090000349 Bone morphogenetic protein 15 Proteins 0.000 description 1
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 description 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 description 1
- 102100022526 Bone morphogenetic protein 5 Human genes 0.000 description 1
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 description 1
- 102100022545 Bone morphogenetic protein 8B Human genes 0.000 description 1
- 238000012270 DNA recombination Methods 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 description 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 description 1
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 description 1
- 102100040892 Growth/differentiation factor 2 Human genes 0.000 description 1
- 101000899368 Homo sapiens Bone morphogenetic protein 8B Proteins 0.000 description 1
- 102000002746 Inhibins Human genes 0.000 description 1
- 108010004250 Inhibins Proteins 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 101100175313 Mus musculus Gdf3 gene Proteins 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 description 1
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 description 1
- 239000000488 activin Substances 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 230000037328 acute stress Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000022159 cartilage development Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229960003707 glutamic acid hydrochloride Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000011540 hip replacement Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000000893 inhibin Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 210000005222 synovial tissue Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000012762 unpaired Student’s t-test Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Materials For Photolithography (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11816099P | 1999-02-01 | 1999-02-01 | |
US09/493,543 US6281638B1 (en) | 1997-10-10 | 2000-01-28 | Converter/inverter full bridge ballast circuit |
PCT/US2000/002430 WO2000044413A1 (en) | 1999-02-01 | 2000-01-31 | Methods and compositions for healing and repair of articular cartilage |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20013744D0 NO20013744D0 (no) | 2001-07-31 |
NO20013744L NO20013744L (no) | 2001-09-18 |
NO323630B1 true NO323630B1 (no) | 2007-06-18 |
Family
ID=26816029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20013744A NO323630B1 (no) | 1999-02-01 | 2001-07-31 | Anvendelse av blandinger omfattende BMP for fremstilling av medikament for forbedring av osteokondralt autotransplantat. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1148897B1 (pt) |
JP (1) | JP2002535378A (pt) |
AT (1) | ATE255920T1 (pt) |
BR (1) | BR0007892A (pt) |
CZ (1) | CZ20012782A3 (pt) |
HU (1) | HUP0105312A3 (pt) |
IL (1) | IL144523A0 (pt) |
NO (1) | NO323630B1 (pt) |
PT (1) | PT1148897E (pt) |
WO (1) | WO2000044413A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1375301A (en) | 1999-11-15 | 2001-05-30 | Bio Syntech Canada Inc | Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution |
DK1294414T3 (da) | 2000-06-29 | 2006-07-24 | Biosyntech Canada Inc | Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv |
CA2365376C (en) | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
NZ528320A (en) * | 2001-02-23 | 2005-07-29 | Wyeth Corp | Composition for inducing cartilaginous tissue formation and maintenance comprising a non-culture expanded CD105+ cells and a BMP |
US7005127B2 (en) * | 2002-03-29 | 2006-02-28 | Tissuegene, Inc. | Mixed-cell gene therapy |
US20040078090A1 (en) | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
US8197837B2 (en) | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
US8226715B2 (en) | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
US10583220B2 (en) | 2003-08-11 | 2020-03-10 | DePuy Synthes Products, Inc. | Method and apparatus for resurfacing an articular surface |
US7316822B2 (en) | 2003-11-26 | 2008-01-08 | Ethicon, Inc. | Conformable tissue repair implant capable of injection delivery |
US7901461B2 (en) | 2003-12-05 | 2011-03-08 | Ethicon, Inc. | Viable tissue repair implants and methods of use |
US11395865B2 (en) | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
US8221780B2 (en) * | 2004-04-20 | 2012-07-17 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
WO2005115438A1 (en) * | 2004-05-25 | 2005-12-08 | Stryker Corporation | Use of morphogenic proteins for treating cartilage defects |
US20060194726A1 (en) * | 2004-05-25 | 2006-08-31 | Rueger David C | Methods of treating cartilage defects |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL83003A (en) * | 1986-07-01 | 1995-07-31 | Genetics Inst | Factors that soak bone formation |
IL106278A0 (en) * | 1992-07-13 | 1993-11-15 | Sumitomo Metal Ind | Bone formation-inducing protein |
EP0733109B9 (en) * | 1993-12-07 | 2006-07-05 | Genetics Institute, LLC | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
AU6245898A (en) * | 1997-01-21 | 1998-08-07 | Genetics Institute Inc. | Injectable formulations for treatment of osteoporotic bone |
DE69911609T2 (de) * | 1998-07-13 | 2004-07-01 | University Of Southern California, Los Angeles | Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel |
-
2000
- 2000-01-31 WO PCT/US2000/002430 patent/WO2000044413A1/en active IP Right Grant
- 2000-01-31 AT AT00905869T patent/ATE255920T1/de not_active IP Right Cessation
- 2000-01-31 IL IL14452300A patent/IL144523A0/xx unknown
- 2000-01-31 EP EP00905869A patent/EP1148897B1/en not_active Revoked
- 2000-01-31 CZ CZ20012782A patent/CZ20012782A3/cs unknown
- 2000-01-31 HU HU0105312A patent/HUP0105312A3/hu unknown
- 2000-01-31 PT PT00905869T patent/PT1148897E/pt unknown
- 2000-01-31 JP JP2000595715A patent/JP2002535378A/ja active Pending
- 2000-01-31 BR BR0007892-1A patent/BR0007892A/pt not_active Application Discontinuation
-
2001
- 2001-07-31 NO NO20013744A patent/NO323630B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT1148897E (pt) | 2004-04-30 |
EP1148897A1 (en) | 2001-10-31 |
BR0007892A (pt) | 2001-10-30 |
WO2000044413A1 (en) | 2000-08-03 |
IL144523A0 (en) | 2002-05-23 |
NO20013744D0 (no) | 2001-07-31 |
ATE255920T1 (de) | 2003-12-15 |
HUP0105312A2 (hu) | 2002-05-29 |
NO20013744L (no) | 2001-09-18 |
EP1148897B1 (en) | 2003-12-10 |
JP2002535378A (ja) | 2002-10-22 |
HUP0105312A3 (en) | 2003-12-29 |
CZ20012782A3 (cs) | 2002-01-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU771382B2 (en) | Methods and compositions for healing and repair of articular cartilage | |
EP0831884B1 (en) | Use of bone morphogenic proteins for healing and repair of connective tissue attachment | |
EP1148897B1 (en) | Methods and compositions for healing and repair of articular cartilage | |
Minamide et al. | Experimental spinal fusion using sintered bovine bone coated with type I collagen and recombinant human bone morphogenetic protein-2 | |
JP2004262758A (ja) | 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法 | |
US20030032586A1 (en) | Compositions for morphogen-induced osteogenesis | |
KR100704537B1 (ko) | 관절 연골의 치유 및 회복을 위한 조성물 | |
MXPA01007731A (en) | Methods and compositions for healing and repair of articular cartilage | |
Lewandrowski et al. | Advances in the biology of spinal fusion: growth factors and gene therapy | |
Hecht et al. | Advances in the Biology of Spinal Fusion: Growth Factors and Gene Therapy | |
Barr | Comparison of the Osteoinductivity of Infuse® and OP-1® via in vitro and in vivo Assays |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |