NO320089B1 - Anvendelse av en funksjonell barriere til fremstilling av en sammensetning for behandling av bruskdefekter, samt sammensetninger til slik anvendelse. - Google Patents
Anvendelse av en funksjonell barriere til fremstilling av en sammensetning for behandling av bruskdefekter, samt sammensetninger til slik anvendelse. Download PDFInfo
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- NO320089B1 NO320089B1 NO19986083A NO986083A NO320089B1 NO 320089 B1 NO320089 B1 NO 320089B1 NO 19986083 A NO19986083 A NO 19986083A NO 986083 A NO986083 A NO 986083A NO 320089 B1 NO320089 B1 NO 320089B1
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Surgery (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US08/672,618 US5853746A (en) | 1991-01-31 | 1996-06-28 | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier |
| PCT/US1997/011208 WO1998000183A2 (en) | 1996-06-28 | 1997-06-24 | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier |
Publications (3)
| Publication Number | Publication Date |
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| NO986083D0 NO986083D0 (no) | 1998-12-23 |
| NO986083L NO986083L (no) | 1999-03-01 |
| NO320089B1 true NO320089B1 (no) | 2005-10-24 |
Family
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| NO19986083A NO320089B1 (no) | 1996-06-28 | 1998-12-23 | Anvendelse av en funksjonell barriere til fremstilling av en sammensetning for behandling av bruskdefekter, samt sammensetninger til slik anvendelse. |
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| NO (1) | NO320089B1 (enExample) |
| NZ (1) | NZ333452A (enExample) |
| WO (1) | WO1998000183A2 (enExample) |
| ZA (1) | ZA975711B (enExample) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5989269A (en) | 1996-08-30 | 1999-11-23 | Vts Holdings L.L.C. | Method, instruments and kit for autologous transplantation |
| US6569172B2 (en) * | 1996-08-30 | 2003-05-27 | Verigen Transplantation Service International (Vtsi) | Method, instruments, and kit for autologous transplantation |
| US20020173806A1 (en) * | 1996-08-30 | 2002-11-21 | Verigen Transplantation Service International (Vtsi) Ag | Method for autologous transplantation |
| US7468075B2 (en) | 2001-05-25 | 2008-12-23 | Conformis, Inc. | Methods and compositions for articular repair |
| US7618451B2 (en) | 2001-05-25 | 2009-11-17 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty |
| US8480754B2 (en) | 2001-05-25 | 2013-07-09 | Conformis, Inc. | Patient-adapted and improved articular implants, designs and related guide tools |
| US8771365B2 (en) | 2009-02-25 | 2014-07-08 | Conformis, Inc. | Patient-adapted and improved orthopedic implants, designs, and related tools |
| US9603711B2 (en) | 2001-05-25 | 2017-03-28 | Conformis, Inc. | Patient-adapted and improved articular implants, designs and related guide tools |
| US8556983B2 (en) | 2001-05-25 | 2013-10-15 | Conformis, Inc. | Patient-adapted and improved orthopedic implants, designs and related tools |
| US8735773B2 (en) | 2007-02-14 | 2014-05-27 | Conformis, Inc. | Implant device and method for manufacture |
| US8545569B2 (en) | 2001-05-25 | 2013-10-01 | Conformis, Inc. | Patient selectable knee arthroplasty devices |
| US8083745B2 (en) | 2001-05-25 | 2011-12-27 | Conformis, Inc. | Surgical tools for arthroplasty |
| US7534263B2 (en) | 2001-05-25 | 2009-05-19 | Conformis, Inc. | Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty |
| US8882847B2 (en) | 2001-05-25 | 2014-11-11 | Conformis, Inc. | Patient selectable knee joint arthroplasty devices |
| EP1350525A3 (en) * | 1997-02-07 | 2003-12-10 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods thereof |
| US20010016646A1 (en) * | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
| US7041641B2 (en) * | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
| DE19752900A1 (de) * | 1997-11-28 | 1999-06-02 | Biotechnolog Forschung Gmbh | Knochenmatrix und/oder osteogene Zellen, deren Verwendung, therapeutische Zubereitung und Kit |
| US6123731A (en) | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
| EP1067959A2 (en) * | 1998-04-03 | 2001-01-17 | Chiron Corporation | Use of igf1 for treating articular cartilage disorders |
| CA2338909C (en) * | 1998-08-14 | 2011-06-28 | Bruno Gianetti | Methods, instruments and materials for chondrocyte cell transplantation |
| US7239908B1 (en) | 1998-09-14 | 2007-07-03 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and devising treatment |
| AU772012B2 (en) | 1998-09-14 | 2004-04-08 | Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and preventing damage |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| ES2395057T3 (es) | 1999-03-25 | 2013-02-07 | Metabolix, Inc. | Dispositivos y aplicaciones médicas de polímeros polihidroxialcanoato |
| EP1441028A3 (en) * | 1999-07-28 | 2005-01-05 | Interface Biotech A/S | Cell cultivation method for the preparation of chondrocytes/chondroblasts |
| US20020116063A1 (en) * | 1999-08-02 | 2002-08-22 | Bruno Giannetti | Kit for chondrocyte cell transplantation |
| DE19957388A1 (de) | 1999-11-24 | 2001-06-13 | Michael Sittinger | Chondroinduktive und implantierbare Substrate zur Knorpelheilung und -protektion |
| EP1237511B1 (de) | 1999-12-15 | 2004-09-01 | Sulzer Orthopedics Ltd. | Präparat für die reparatur von knorpel- oder knorpel/knochen-defekten in menschlichen oder tierischen gelenken |
| US20030095993A1 (en) * | 2000-01-28 | 2003-05-22 | Hanne Bentz | Gel-infused sponges for tissue repair and augmentation |
| US9387094B2 (en) | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
| AU2001296873A1 (en) | 2000-09-14 | 2002-03-26 | Leland Stanford Junior University | Technique for manipulating medical images |
| ATE414310T1 (de) | 2000-09-14 | 2008-11-15 | Univ Leland Stanford Junior | Verfahren zur manipulation medizinischer bilder |
| AU2001290888B8 (en) | 2000-09-14 | 2007-07-26 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and devising treatment |
| AU2002247044B2 (en) * | 2001-01-30 | 2006-11-16 | Orthogene, Inc. | Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells |
| DE60239674D1 (de) | 2001-05-25 | 2011-05-19 | Conformis Inc | Verfahren und zusammensetzungen zur reparatur der oberfläche von gelenken |
| US8439926B2 (en) | 2001-05-25 | 2013-05-14 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools |
| US20030166274A1 (en) * | 2001-11-15 | 2003-09-04 | Hewitt Charles W. | Three-dimensional matrix for producing living tissue equivalents |
| US7381426B2 (en) * | 2002-01-24 | 2008-06-03 | Southwest Research Institute | Targeted delivery of bioactive factors to the systemic skeleton |
| WO2003083079A2 (en) * | 2002-03-28 | 2003-10-09 | Tissuegene, Inc. | Bone generation by gene therapy |
| US20040136968A1 (en) * | 2002-09-27 | 2004-07-15 | Verigen Ag | Autologous cells on a support matrix for tissue repair |
| WO2004032806A1 (en) | 2002-10-07 | 2004-04-22 | Conformis, Inc. | Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces |
| AU2003290757A1 (en) | 2002-11-07 | 2004-06-03 | Conformis, Inc. | Methods for determing meniscal size and shape and for devising treatment |
| AU2003297583B2 (en) | 2002-11-26 | 2010-01-14 | Biocon, Ltd | Modified naturetic compounds, conjugates, and uses thereof |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7488348B2 (en) | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| CA2528086C (en) | 2003-06-11 | 2013-01-08 | Osteotech, Inc. | Osteoimplants and methods for their manufacture |
| US20050202067A1 (en) * | 2003-10-28 | 2005-09-15 | Gkss Forschungszentrum | Matrix structure and hybrid matrix system for inducing a neofacia, their use and method for generating a neofacia |
| ATE515245T1 (de) | 2003-12-11 | 2011-07-15 | Isto Technologies Inc | Teilchenförmiges knorpelsystem |
| WO2006002332A1 (en) * | 2004-06-23 | 2006-01-05 | Angiotech Biomaterials Corporation | Methods and crosslinked polymer compositions for cartilage repair |
| US8512730B2 (en) | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| WO2006050213A2 (en) * | 2004-10-29 | 2006-05-11 | Michalow Alexander E | Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway |
| US7270655B2 (en) * | 2005-01-14 | 2007-09-18 | Haidukewych George J | Autologous material delivery apparatus and method |
| US7825083B2 (en) * | 2005-02-10 | 2010-11-02 | Spine Wave, Inc. | Synovial fluid barrier |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| US8480757B2 (en) | 2005-08-26 | 2013-07-09 | Zimmer, Inc. | Implants and methods for repair, replacement and treatment of disease |
| AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
| CA2630077C (en) * | 2005-11-17 | 2014-07-15 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix |
| US8623026B2 (en) | 2006-02-06 | 2014-01-07 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief |
| EP2710967B1 (en) | 2006-02-06 | 2019-05-01 | ConforMIS, Inc. | Patient specific joint arthroplasty system |
| EP2311505B1 (en) * | 2006-02-09 | 2013-11-06 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
| ES2664229T3 (es) | 2006-06-30 | 2018-04-18 | Biomimetic Therapeutics, Llc | Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| CA2668189C (en) | 2006-11-03 | 2016-01-26 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures comprising a solution of platelet derived growth factor (pdgf) incorporated in a biocompatible matrix |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| US8870871B2 (en) | 2007-01-17 | 2014-10-28 | University Of Massachusetts Lowell | Biodegradable bone plates and bonding systems |
| EP2117578B1 (en) * | 2007-01-22 | 2015-04-22 | OrthoTrophix, Inc. | A peptide composition and a method of promoting cartilage formation |
| EP2591756A1 (en) | 2007-02-14 | 2013-05-15 | Conformis, Inc. | Implant device and method for manufacture |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| CA2684040C (en) | 2007-04-12 | 2016-12-06 | Isto Technologies, Inc. | Method of forming an implant using a mold that mimics the shape of the tissue defect site and implant formed therefrom |
| WO2008157412A2 (en) | 2007-06-13 | 2008-12-24 | Conformis, Inc. | Surgical cutting guide |
| AU2009212151C1 (en) | 2008-02-07 | 2015-09-17 | Stryker Corporation | Compositions and methods for distraction osteogenesis |
| WO2009111626A2 (en) | 2008-03-05 | 2009-09-11 | Conformis, Inc. | Implants for altering wear patterns of articular surfaces |
| AU2009246474B2 (en) | 2008-05-12 | 2015-04-16 | Conformis, Inc. | Devices and methods for treatment of facet and other joints |
| NZ591338A (en) | 2008-09-09 | 2013-02-22 | Biomimetic Therapeutics Inc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
| US8808303B2 (en) | 2009-02-24 | 2014-08-19 | Microport Orthopedics Holdings Inc. | Orthopedic surgical guide |
| US9017334B2 (en) | 2009-02-24 | 2015-04-28 | Microport Orthopedics Holdings Inc. | Patient specific surgical guide locator and mount |
| US12383287B2 (en) | 2009-02-24 | 2025-08-12 | Microport Orthopedics Holdings, Inc. | Systems and methods for installing an orthopedic implant |
| EP2405865B1 (en) | 2009-02-24 | 2019-04-17 | ConforMIS, Inc. | Automated systems for manufacturing patient-specific orthopedic implants and instrumentation |
| US8808297B2 (en) | 2009-02-24 | 2014-08-19 | Microport Orthopedics Holdings Inc. | Orthopedic surgical guide |
| SG10201401326SA (en) | 2009-04-16 | 2014-10-30 | Conformis Inc | Patient-specific joint arthroplasty devices for ligament repair |
| EP2509539B1 (en) | 2009-12-11 | 2020-07-01 | ConforMIS, Inc. | Patient-specific and patient-engineered orthopedic implants |
| JP6144049B2 (ja) | 2010-02-22 | 2017-06-07 | バイオミメティック セラピューティクス,リミテッド ライアビリティ カンパニー | 腱障害を処置するための血小板由来成長因子組成物及び方法 |
| US8435305B2 (en) | 2010-08-31 | 2013-05-07 | Zimmer, Inc. | Osteochondral graft delivery device and uses thereof |
| US9717779B2 (en) * | 2011-01-31 | 2017-08-01 | Warsaw Orthopedic, Inc. | Implantable matrix having optimum ligand concentrations |
| WO2012112698A2 (en) | 2011-02-15 | 2012-08-23 | Conformis, Inc. | Patient-adapted and improved articular implants, procedures and tools to address, assess, correct, modify and/or accommodate anatomical variation and/or asymmetry |
| US9486226B2 (en) | 2012-04-18 | 2016-11-08 | Conformis, Inc. | Tibial guides, tools, and techniques for resecting the tibial plateau |
| US9675471B2 (en) | 2012-06-11 | 2017-06-13 | Conformis, Inc. | Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components |
| BR112015000670A2 (pt) | 2012-07-11 | 2017-06-27 | Osiris Therapeutics Inc | métodos de fabricação de produtos de cartilagem |
| US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| US11083755B2 (en) * | 2015-01-08 | 2021-08-10 | The Board Of Trustees Of The Leland Stanford Junior University | Factors and cells that provide for induction of bone, bone marrow, and cartilage |
| EP3975939B1 (en) | 2019-05-29 | 2024-11-13 | Wright Medical Technology, Inc. | Device for preparing a tibia for receiving tibial implant component of a replacement ankle |
| EP4044941A4 (en) | 2020-01-17 | 2023-11-15 | Wright Medical Technology, Inc. | GUIDANCE TOOLS, SYSTEMS AND METHODS |
| US12440227B2 (en) | 2021-02-24 | 2025-10-14 | Wright Medical Technology, Inc. | Preparing a tibia for receiving tibial implant component of a replacement ankle |
| CN114984298A (zh) * | 2022-07-18 | 2022-09-02 | 重庆大学 | 一类软骨组织粘合剂及其制备方法和用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001116A (en) * | 1982-12-20 | 1991-03-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
| US4994443A (en) * | 1982-12-20 | 1991-02-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
| IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| US4609551A (en) * | 1984-03-20 | 1986-09-02 | Arnold Caplan | Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites |
| US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
| ATE81254T1 (de) * | 1985-02-26 | 1992-10-15 | Univ Johns Hopkins | Neovaskularisierungsinhibitoren und deren herstellung. |
| US5041138A (en) * | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
| US4846835A (en) * | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
| US5306311A (en) * | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
| US4904259A (en) * | 1988-04-29 | 1990-02-27 | Samuel Itay | Compositions and methods for repair of cartilage and bone |
| US4950483A (en) * | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| US5236456A (en) * | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
| ATE144710T1 (de) * | 1990-01-25 | 1996-11-15 | Childrens Hosp Medical Center | Verfahren und zusammensetzungen zur hemmung der angiogenese |
| DE4006609A1 (de) * | 1990-03-02 | 1991-09-26 | Max Planck Gesellschaft | Inhibitor der proliferation von endothelzellen |
| US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| WO1992010210A1 (en) * | 1990-12-14 | 1992-06-25 | E.I. Du Pont De Nemours And Company | Inhibition of angiogenesis by il-1 |
| US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
| US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
| US5382514A (en) * | 1992-03-31 | 1995-01-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | In vivo angiogenesis assay |
| US5368051A (en) * | 1993-06-30 | 1994-11-29 | Dunn; Allan R. | Method of regenerating articular cartilage |
| ATE154757T1 (de) * | 1993-07-19 | 1997-07-15 | Angiotech Pharm Inc | Anti-angiogene mittel und verfahren zu deren verwendung |
| EP0637450A3 (en) * | 1993-08-04 | 1995-04-05 | Collagen Corp | Method and composition for resuscitation of hereditary tissue. |
| EP0726773A1 (en) * | 1993-11-17 | 1996-08-21 | Massachusetts Institute Of Technology | Method for inhibiting angiogenesis using heparinase |
| ATE241340T1 (de) * | 1994-02-17 | 2003-06-15 | New York Blood Ct Inc | Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung |
-
1996
- 1996-06-28 US US08/672,618 patent/US5853746A/en not_active Expired - Lifetime
-
1997
- 1997-06-24 AT AT97932329T patent/ATE327781T1/de not_active IP Right Cessation
- 1997-06-24 WO PCT/US1997/011208 patent/WO1998000183A2/en not_active Ceased
- 1997-06-24 JP JP10504318A patent/JP2000513721A/ja not_active Ceased
- 1997-06-24 ES ES97932329T patent/ES2267145T3/es not_active Expired - Lifetime
- 1997-06-24 EP EP97932329A patent/EP0912204B1/en not_active Expired - Lifetime
- 1997-06-24 BR BR9710088A patent/BR9710088A/pt not_active Application Discontinuation
- 1997-06-24 AU AU35815/97A patent/AU731172B2/en not_active Ceased
- 1997-06-24 DE DE69735998T patent/DE69735998T2/de not_active Expired - Fee Related
- 1997-06-24 NZ NZ333452A patent/NZ333452A/xx unknown
- 1997-06-24 KR KR1019980710600A patent/KR20000022182A/ko not_active Withdrawn
- 1997-06-24 CN CNB97196887XA patent/CN1321681C/zh not_active Expired - Fee Related
- 1997-06-24 IL IL12755097A patent/IL127550A/en not_active IP Right Cessation
- 1997-06-26 ZA ZA9705711A patent/ZA975711B/xx unknown
-
1998
- 1998-12-23 NO NO19986083A patent/NO320089B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998000183A2 (en) | 1998-01-08 |
| WO1998000183A3 (en) | 1998-02-12 |
| AU3581597A (en) | 1998-01-21 |
| ES2267145T3 (es) | 2007-03-01 |
| IL127550A0 (en) | 1999-10-28 |
| ZA975711B (en) | 1998-01-26 |
| AU731172B2 (en) | 2001-03-22 |
| DE69735998T2 (de) | 2007-03-15 |
| EP0912204B1 (en) | 2006-05-31 |
| KR20000022182A (ko) | 2000-04-25 |
| CN1321681C (zh) | 2007-06-20 |
| EP0912204A2 (en) | 1999-05-06 |
| ATE327781T1 (de) | 2006-06-15 |
| CN1226839A (zh) | 1999-08-25 |
| NO986083L (no) | 1999-03-01 |
| DE69735998D1 (de) | 2006-07-06 |
| US5853746A (en) | 1998-12-29 |
| NO986083D0 (no) | 1998-12-23 |
| HK1017276A1 (en) | 1999-11-19 |
| NZ333452A (en) | 2000-04-28 |
| BR9710088A (pt) | 1999-08-10 |
| JP2000513721A (ja) | 2000-10-17 |
| IL127550A (en) | 2004-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |