NO319055B1 - Defekte, rekombinante adenoviruser med inaktivt IVa2-gen - Google Patents

Defekte, rekombinante adenoviruser med inaktivt IVa2-gen Download PDF

Info

Publication number
NO319055B1
NO319055B1 NO19971247A NO971247A NO319055B1 NO 319055 B1 NO319055 B1 NO 319055B1 NO 19971247 A NO19971247 A NO 19971247A NO 971247 A NO971247 A NO 971247A NO 319055 B1 NO319055 B1 NO 319055B1
Authority
NO
Norway
Prior art keywords
plasmid
gene
adenovirus
iva2
defective
Prior art date
Application number
NO19971247A
Other languages
English (en)
Norwegian (no)
Other versions
NO971247L (no
NO971247D0 (no
Inventor
Patrice Yeh
Emmanuelle Vigne
Michel Perricaudet
Cecile Orsini
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO971247L publication Critical patent/NO971247L/no
Publication of NO971247D0 publication Critical patent/NO971247D0/no
Publication of NO319055B1 publication Critical patent/NO319055B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/075Adenoviridae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10361Methods of inactivation or attenuation
    • C12N2710/10362Methods of inactivation or attenuation by genetic engineering
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/108Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO19971247A 1994-09-27 1997-03-18 Defekte, rekombinante adenoviruser med inaktivt IVa2-gen NO319055B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9411511A FR2724945B1 (fr) 1994-09-27 1994-09-27 Vecteurs viraux et utilisation en therapie genique
PCT/FR1995/001228 WO1996010088A1 (fr) 1994-09-27 1995-09-22 ADENOVIRUS RECOMBINANTS DEFECTIFS AVEC UN GENE IVa2 INACTIVE

Publications (3)

Publication Number Publication Date
NO971247L NO971247L (no) 1997-03-18
NO971247D0 NO971247D0 (no) 1997-03-18
NO319055B1 true NO319055B1 (no) 2005-06-13

Family

ID=9467310

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19971247A NO319055B1 (no) 1994-09-27 1997-03-18 Defekte, rekombinante adenoviruser med inaktivt IVa2-gen

Country Status (18)

Country Link
US (1) US6200798B1 (es)
EP (1) EP0783585B1 (es)
JP (1) JPH10506018A (es)
KR (1) KR100484441B1 (es)
AT (1) ATE331801T1 (es)
AU (1) AU712304B2 (es)
CA (1) CA2197904A1 (es)
DE (1) DE69535093T2 (es)
DK (1) DK0783585T3 (es)
ES (1) ES2268695T3 (es)
FI (1) FI971275A (es)
FR (1) FR2724945B1 (es)
IL (1) IL115432A (es)
MX (1) MX9701766A (es)
NO (1) NO319055B1 (es)
PT (1) PT783585E (es)
WO (1) WO1996010088A1 (es)
ZA (1) ZA958128B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5738852A (en) * 1993-04-20 1998-04-14 Solis Therapeutics, Inc. Methods of enhancing antigen-specific T cell responses
WO1996018418A1 (en) * 1994-12-12 1996-06-20 Genetic Therapy, Inc. Improved adenoviral vectors and producer cells
AUPN477695A0 (en) * 1995-08-14 1995-09-07 Commonwealth Scientific And Industrial Research Organisation Gene therapy
FR2753379B1 (fr) 1996-09-13 1998-10-30 Rhone Poulenc Rorer Sa Methode de traitement de la sclerose laterale amyotrophique
GB9711957D0 (en) * 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
AU1288099A (en) 1997-10-30 1999-05-24 Cornell Research Foundation Inc. A method of inhibiting an immune response to a recombinant vector
IL141403A0 (en) * 1998-08-28 2002-03-10 Univ Duke Deleted adenoviruses and methods of making and administering the same
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
FR2799472B1 (fr) * 1999-10-07 2004-07-16 Aventis Pharma Sa Preparation d'adenovirus recombinants et de banques adenovirales
AUPR518501A0 (en) 2001-05-22 2001-06-14 Unisearch Limited Yin yang-1
EP1539937A4 (en) * 2002-08-22 2006-07-26 Merck & Co Inc METHODS OF PROPAGATION OF ADENOVIRUS AND VIRUS SO OBTAINED
US10000757B2 (en) 2005-05-27 2018-06-19 Ospedale San Raffaele S.R.L. Gene vector

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585362A (en) * 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
FR2707664B1 (fr) * 1993-07-13 1995-09-29 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.

Also Published As

Publication number Publication date
DK0783585T3 (da) 2006-10-23
NO971247L (no) 1997-03-18
AU3525095A (en) 1996-04-19
FR2724945A1 (fr) 1996-03-29
JPH10506018A (ja) 1998-06-16
PT783585E (pt) 2006-11-30
IL115432A0 (en) 1996-01-31
FR2724945B1 (fr) 1996-12-27
EP0783585B1 (fr) 2006-06-28
WO1996010088A1 (fr) 1996-04-04
DE69535093D1 (de) 2006-08-10
MX9701766A (es) 1997-06-28
DE69535093T2 (de) 2007-01-04
FI971275A0 (fi) 1997-03-26
CA2197904A1 (fr) 1996-04-04
US6200798B1 (en) 2001-03-13
EP0783585A1 (fr) 1997-07-16
ES2268695T3 (es) 2007-03-16
KR100484441B1 (ko) 2006-01-27
IL115432A (en) 2006-10-05
AU712304B2 (en) 1999-11-04
ZA958128B (en) 1996-04-24
NO971247D0 (no) 1997-03-18
KR970706397A (ko) 1997-11-03
FI971275A (fi) 1997-03-26
ATE331801T1 (de) 2006-07-15

Similar Documents

Publication Publication Date Title
RU2219241C2 (ru) Дефектный рекомбинантный аденовирусный вектор (варианты)
KR100379569B1 (ko) 개기원의아데노바이러스벡터및유전자치료에서이의사용방법
US6482617B2 (en) Viable contaminant particle free adenoviruses, their preparation and use
JP3416143B2 (ja) 組換えウイルスベクター製造用ヘルパーウイルス
NO320382B1 (no) Plasmid
JPH11507835A (ja) 組換えアデノウイルス、aavを作製するためのその使用、相補的細胞系、及び、該アデノウイルスを含む医薬組成物
JP4376454B2 (ja) アデノウイルスベクター及び相同組換えイベントの低減方法
NO327980B1 (no) Prokaryotisk plasmid, prokaryotisk celle samt fremgangsmate for fremstilling av et adenoviralt genom
NO319055B1 (no) Defekte, rekombinante adenoviruser med inaktivt IVa2-gen
MXPA97001766A (es) Adenovirus recombinantes defectuosos con un gen iva2 inactivado
AU752148B2 (en) Chimeric adenoviral vectors
JP4951204B2 (ja) 組換えアデノウイルスベクターとその応用
NO319893B1 (no) Defektiv, rekombinert adenovirus og farmasoytisk preparat omfattende denne.
AU725843B2 (en) Defective adenovirus vectors and use thereof in gene therapy
WO2011066615A1 (en) Methods and compositions for increasing titer of recombinant porcine adenovirus-3 vectors