NO318377B1 - Kontrastmidler for magnetresonanstomografi og fremgangsmate for fremstilling av disse - Google Patents
Kontrastmidler for magnetresonanstomografi og fremgangsmate for fremstilling av disse Download PDFInfo
- Publication number
- NO318377B1 NO318377B1 NO19990523A NO990523A NO318377B1 NO 318377 B1 NO318377 B1 NO 318377B1 NO 19990523 A NO19990523 A NO 19990523A NO 990523 A NO990523 A NO 990523A NO 318377 B1 NO318377 B1 NO 318377B1
- Authority
- NO
- Norway
- Prior art keywords
- magnetic
- separation space
- separation
- gradient field
- filter
- Prior art date
Links
- 230000005291 magnetic effect Effects 0.000 title claims description 49
- 238000000034 method Methods 0.000 title claims description 31
- 239000002872 contrast media Substances 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title description 7
- 238000003325 tomography Methods 0.000 title description 2
- 238000000926 separation method Methods 0.000 claims description 52
- 239000002245 particle Substances 0.000 claims description 25
- 239000000725 suspension Substances 0.000 claims description 13
- 230000005298 paramagnetic effect Effects 0.000 claims description 12
- 229910000831 Steel Inorganic materials 0.000 claims description 10
- 239000000696 magnetic material Substances 0.000 claims description 10
- 239000010959 steel Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 238000001802 infusion Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 239000004020 conductor Substances 0.000 claims description 5
- 230000005293 ferrimagnetic effect Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 16
- 239000000825 pharmaceutical preparation Substances 0.000 description 10
- 229910052742 iron Inorganic materials 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 239000006249 magnetic particle Substances 0.000 description 6
- 238000007885 magnetic separation Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 230000005294 ferromagnetic effect Effects 0.000 description 4
- 230000002706 hydrostatic effect Effects 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 230000005292 diamagnetic effect Effects 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000011241 protective layer Substances 0.000 description 3
- 238000002583 angiography Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- MVZXTUSAYBWAAM-UHFFFAOYSA-N iron;sulfuric acid Chemical compound [Fe].OS(O)(=O)=O MVZXTUSAYBWAAM-UHFFFAOYSA-N 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 2
- 229940031182 nanoparticles iron oxide Drugs 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 210000002268 wool Anatomy 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000012774 insulation material Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- VCMGMSHEPQENPE-UHFFFAOYSA-N ketamine hydrochloride Chemical compound [Cl-].C=1C=CC=C(Cl)C=1C1([NH2+]C)CCCCC1=O VCMGMSHEPQENPE-UHFFFAOYSA-N 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012907 medicinal substance Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000002907 paramagnetic material Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000006223 plastic coating Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940069575 rompun Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/06—Filters making use of electricity or magnetism
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Water Supply & Treatment (AREA)
- General Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Filtering Materials (AREA)
- Manipulator (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19632416 | 1996-08-05 | ||
| PCT/EP1997/004099 WO1998005430A1 (de) | 1996-08-05 | 1997-07-29 | Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO990523D0 NO990523D0 (no) | 1999-02-04 |
| NO990523L NO990523L (no) | 1999-03-30 |
| NO318377B1 true NO318377B1 (no) | 2005-03-14 |
Family
ID=7802388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19990523A NO318377B1 (no) | 1996-08-05 | 1999-02-04 | Kontrastmidler for magnetresonanstomografi og fremgangsmate for fremstilling av disse |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6517813B1 (pt) |
| EP (1) | EP0915738B1 (pt) |
| JP (1) | JP2000516131A (pt) |
| KR (1) | KR100502881B1 (pt) |
| CN (1) | CN1151846C (pt) |
| AR (1) | AR008817A1 (pt) |
| AT (1) | ATE211950T1 (pt) |
| AU (1) | AU727764B2 (pt) |
| CA (1) | CA2262685C (pt) |
| DE (2) | DE29713847U1 (pt) |
| DK (1) | DK0915738T3 (pt) |
| ES (1) | ES2171985T3 (pt) |
| HU (1) | HUP0001608A3 (pt) |
| IL (1) | IL128057A (pt) |
| NO (1) | NO318377B1 (pt) |
| NZ (1) | NZ333962A (pt) |
| PT (1) | PT915738E (pt) |
| WO (1) | WO1998005430A1 (pt) |
| ZA (1) | ZA976967B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998005430A1 (de) * | 1996-08-05 | 1998-02-12 | Schering Aktiengesellschaft | Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel |
| DE19938372A1 (de) * | 1999-08-09 | 2001-03-08 | Diagnostikforschung Inst | Verfahren und Vorrichtung zur Trennung magnetischer Teilchen |
| DE10010638A1 (de) | 2000-03-03 | 2001-09-13 | Osram Opto Semiconductors Gmbh | Verfahren zur Herstellung eines lichtabstrahlenden Halbleiterkörpers mit Lumineszenzkonversionselement |
| DE10046514A1 (de) | 2000-09-15 | 2002-04-25 | Diagnostikforschung Inst | Verfahren zur bildlichen Darstellung und Diagnose von Thromben mittels Kernspintomographie unter Verwendung partikulärer Kontrastmittel |
| DE10137515A1 (de) * | 2001-07-26 | 2003-02-13 | Diagnostikforschung Inst | Verfahren zur Herstellung pharmazeutischer Zubereitungen |
| WO2006107288A2 (en) | 2004-02-17 | 2006-10-12 | E.I.Dupont De Nemours And Company | Magnetic field enhanced cake-filtration solid-liquid separations |
| CA2577038A1 (en) * | 2004-09-09 | 2006-03-16 | Bell, Glenda Fay | Separation of plastic and elastomers for food and pharmaceutical products |
| US8066877B2 (en) | 2005-02-17 | 2011-11-29 | E. I. Du Pont De Nemours And Company | Apparatus for magnetic field and magnetic gradient enhanced filtration |
| US8075771B2 (en) * | 2005-02-17 | 2011-12-13 | E. I. Du Pont De Nemours And Company | Apparatus for magnetic field gradient enhanced centrifugation |
| EP1738774A1 (de) * | 2005-06-29 | 2007-01-03 | Schering AG | Magnetische Eisenoxidpartikel enthaltende Zusammensetzungen und deren Verwendung in bildgebenden Verfahren |
| EP1738773A1 (de) * | 2005-06-29 | 2007-01-03 | Schering AG | Magnetische Eisenoxidpartikel enthaltende Zusammensetzung und deren Vervendung in bildgebenden Verfahren |
| FR2918868A1 (fr) | 2006-06-06 | 2009-01-23 | Guerbet Sa | Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste |
| CN102178986A (zh) * | 2011-04-13 | 2011-09-14 | 李明 | 一种血液体外循环磁性杀菌装置 |
| CN103006589B (zh) * | 2011-09-27 | 2015-11-25 | 闫亚梅 | 阿莫西林分散片及其生产方法 |
| CN106975567B (zh) * | 2017-05-17 | 2018-10-09 | 谢齐容 | 药材中铁质杂质去除装置及其方法 |
| CN108287236B (zh) * | 2017-11-24 | 2020-03-13 | 中国农业大学 | 一种基于高梯度磁分离和量子点的荧光生物传感器及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817389A (en) * | 1973-01-15 | 1974-06-18 | Sherwood Medical Ind Inc | Filter device in tubular fitting for medical injection equipment and the like |
| JPS5913521B2 (ja) * | 1975-06-19 | 1984-03-30 | メイトウサンギヨウ カブシキガイシヤ | 磁性酸化鉄・デキストラン複合体の製造法 |
| GB8408127D0 (en) * | 1984-03-29 | 1984-05-10 | Nyegaard & Co As | Contrast agents |
| JPS60241914A (ja) * | 1984-05-16 | 1985-11-30 | Hitachi Plant Eng & Constr Co Ltd | 電磁フイルタ用耐食性濾過材 |
| US4641517A (en) | 1984-12-20 | 1987-02-10 | United Technologies Corporation | Control system actuator position synthesis for failure detection |
| JPS6211519A (ja) * | 1985-07-05 | 1987-01-20 | Agency Of Ind Science & Technol | 磁選機用選別素子 |
| US5160726A (en) * | 1990-02-15 | 1992-11-03 | Advanced Magnetics Inc. | Filter sterilization for production of colloidal, superparamagnetic MR contrast agents |
| US5055288A (en) | 1987-06-26 | 1991-10-08 | Advanced Magnetics, Inc. | Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides |
| NO159162C (no) | 1986-07-29 | 1988-12-07 | Fjeldsend As Olaf | Apparat for magnetisk paavirkning av stroemmende vaeske. |
| US5045304A (en) * | 1988-08-31 | 1991-09-03 | Wayne State University | Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same |
| WO1990007380A2 (en) * | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
| US5268165A (en) * | 1990-10-16 | 1993-12-07 | Biomedical Frontiers, Inc. | Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging |
| ES2131067T5 (es) | 1991-01-19 | 2004-10-16 | Meito Sangyo Kabushiki Kaisha | Composicion que contiene particulas ultrafinas de oxido metalico magnetico. |
| DE69223748T2 (de) | 1991-06-11 | 1998-04-23 | Meito Sangyo K.K., Nagoya, Aichi | Oxidierte zusammensetzung, enthaltend ein wasserlösliches carboxypolysaccharid und magnetisches eisenoxid |
| US5225282A (en) * | 1991-12-13 | 1993-07-06 | Molecular Bioquest, Inc. | Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer |
| DE69324591T3 (de) | 1992-08-05 | 2004-02-12 | Meito Sangyo K.K., Nagoya | Verbundmaterial mit kleinem durchmesser, welches ein wasserlösliches carboxylpolysaccharid und magnetisches eisenoxid enthaltet |
| DE4309333A1 (de) * | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
| EP0689430B1 (de) * | 1993-03-17 | 1997-08-13 | Silica Gel Ges.M.B.H | Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben |
| US5411730A (en) * | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| US5514340A (en) * | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
| DE4428851C2 (de) | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
| WO1996009840A1 (en) * | 1994-09-27 | 1996-04-04 | Nycomed Imaging A/S | Contrast agent |
| US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| US5855868A (en) | 1996-04-01 | 1999-01-05 | Nycomed Imaging As | Method of T1 -weighted resonance imaging of RES organs |
| WO1998005430A1 (de) | 1996-08-05 | 1998-02-12 | Schering Aktiengesellschaft | Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel |
-
1997
- 1997-07-29 WO PCT/EP1997/004099 patent/WO1998005430A1/de active IP Right Grant
- 1997-07-29 CA CA002262685A patent/CA2262685C/en not_active Expired - Fee Related
- 1997-07-29 DK DK97936669T patent/DK0915738T3/da active
- 1997-07-29 ES ES97936669T patent/ES2171985T3/es not_active Expired - Lifetime
- 1997-07-29 AT AT97936669T patent/ATE211950T1/de not_active IP Right Cessation
- 1997-07-29 HU HU0001608A patent/HUP0001608A3/hu unknown
- 1997-07-29 DE DE29713847U patent/DE29713847U1/de not_active Expired - Lifetime
- 1997-07-29 KR KR10-1999-7000966A patent/KR100502881B1/ko not_active IP Right Cessation
- 1997-07-29 AU AU39415/97A patent/AU727764B2/en not_active Ceased
- 1997-07-29 EP EP97936669A patent/EP0915738B1/de not_active Expired - Lifetime
- 1997-07-29 PT PT97936669T patent/PT915738E/pt unknown
- 1997-07-29 IL IL12805797A patent/IL128057A/xx not_active IP Right Cessation
- 1997-07-29 CN CNB971970351A patent/CN1151846C/zh not_active Expired - Fee Related
- 1997-07-29 DE DE59706019T patent/DE59706019D1/de not_active Expired - Fee Related
- 1997-07-29 NZ NZ333962A patent/NZ333962A/xx unknown
- 1997-07-29 JP JP10507563A patent/JP2000516131A/ja not_active Ceased
- 1997-08-01 US US08/904,765 patent/US6517813B1/en not_active Expired - Fee Related
- 1997-08-04 AR ARP970103534A patent/AR008817A1/es active IP Right Grant
- 1997-08-05 ZA ZA9706967A patent/ZA976967B/xx unknown
-
1999
- 1999-02-04 NO NO19990523A patent/NO318377B1/no not_active IP Right Cessation
-
2002
- 2002-12-19 US US10/322,475 patent/US20030108613A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA976967B (en) | 1998-02-19 |
| EP0915738B1 (de) | 2002-01-16 |
| CA2262685C (en) | 2008-09-23 |
| DK0915738T3 (da) | 2002-05-06 |
| IL128057A (en) | 2001-08-26 |
| US20030108613A1 (en) | 2003-06-12 |
| JP2000516131A (ja) | 2000-12-05 |
| CA2262685A1 (en) | 1998-02-12 |
| NO990523D0 (no) | 1999-02-04 |
| US6517813B1 (en) | 2003-02-11 |
| AU3941597A (en) | 1998-02-25 |
| KR100502881B1 (ko) | 2005-07-25 |
| EP0915738A1 (de) | 1999-05-19 |
| DE29713847U1 (de) | 1997-12-18 |
| CN1230136A (zh) | 1999-09-29 |
| ES2171985T3 (es) | 2002-09-16 |
| IL128057A0 (en) | 1999-11-30 |
| AR008817A1 (es) | 2000-02-23 |
| KR20000029821A (ko) | 2000-05-25 |
| WO1998005430A1 (de) | 1998-02-12 |
| HUP0001608A1 (hu) | 2000-09-28 |
| DE59706019D1 (de) | 2002-02-21 |
| HUP0001608A3 (en) | 2001-01-29 |
| PT915738E (pt) | 2002-07-31 |
| CN1151846C (zh) | 2004-06-02 |
| AU727764B2 (en) | 2000-12-21 |
| NZ333962A (en) | 2000-07-28 |
| NO990523L (no) | 1999-03-30 |
| ATE211950T1 (de) | 2002-02-15 |
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