NO316788B1 - Anvendelse av (+)-<alfa>-(2,3-dimethoxyfenyl)-1-[2-(4-fluorfenyl)-ethyl]-4-piperidinmethanol ved behandling av depressive sykdommer - Google Patents
Anvendelse av (+)-<alfa>-(2,3-dimethoxyfenyl)-1-[2-(4-fluorfenyl)-ethyl]-4-piperidinmethanol ved behandling av depressive sykdommer Download PDFInfo
- Publication number
- NO316788B1 NO316788B1 NO19984348A NO984348A NO316788B1 NO 316788 B1 NO316788 B1 NO 316788B1 NO 19984348 A NO19984348 A NO 19984348A NO 984348 A NO984348 A NO 984348A NO 316788 B1 NO316788 B1 NO 316788B1
- Authority
- NO
- Norway
- Prior art keywords
- ethyl
- fluorophenyl
- dimethoxyphenyl
- acid
- compound
- Prior art date
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- 208000020401 Depressive disease Diseases 0.000 title claims description 19
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96400591A EP0796619A1 (en) | 1996-03-21 | 1996-03-21 | Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders |
| PCT/US1997/002597 WO1997034603A1 (en) | 1996-03-21 | 1997-02-21 | USE OF (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL IN TREATING DEPRESSIVE DISORDERS AND BIPOLAR DISORDERS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO984348L NO984348L (no) | 1998-09-18 |
| NO984348D0 NO984348D0 (no) | 1998-09-18 |
| NO316788B1 true NO316788B1 (no) | 2004-05-10 |
Family
ID=8225234
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19984348A NO316788B1 (no) | 1996-03-21 | 1998-09-18 | Anvendelse av (+)-<alfa>-(2,3-dimethoxyfenyl)-1-[2-(4-fluorfenyl)-ethyl]-4-piperidinmethanol ved behandling av depressive sykdommer |
| NO20033184A NO20033184D0 (no) | 1996-03-21 | 2003-07-11 | Anvendelse av forbindelsen (+)-<alfa>-(2,3-dimetoksyfenyl)-1- [2-(4-fluorfenyl)etyl]-4-piperidinmetanol |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20033184A NO20033184D0 (no) | 1996-03-21 | 2003-07-11 | Anvendelse av forbindelsen (+)-<alfa>-(2,3-dimetoksyfenyl)-1- [2-(4-fluorfenyl)etyl]-4-piperidinmetanol |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6022877A (zh) |
| EP (2) | EP0796619A1 (zh) |
| JP (1) | JP4165906B2 (zh) |
| KR (1) | KR100423018B1 (zh) |
| CN (1) | CN1114406C (zh) |
| AR (1) | AR006281A1 (zh) |
| AT (1) | ATE219672T1 (zh) |
| AU (1) | AU704435B2 (zh) |
| BR (1) | BR9708109A (zh) |
| CA (1) | CA2250077C (zh) |
| DE (1) | DE69713571T2 (zh) |
| DK (1) | DK0888114T3 (zh) |
| ES (1) | ES2175356T3 (zh) |
| HK (1) | HK1019702A1 (zh) |
| HU (1) | HU226675B1 (zh) |
| IL (1) | IL126022A (zh) |
| NO (2) | NO316788B1 (zh) |
| NZ (1) | NZ331448A (zh) |
| PT (1) | PT888114E (zh) |
| SI (1) | SI0888114T1 (zh) |
| TW (1) | TW517048B (zh) |
| WO (1) | WO1997034603A1 (zh) |
| ZA (1) | ZA972345B (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0796619A1 (en) * | 1996-03-21 | 1997-09-24 | Merrell Pharmaceuticals Inc. | Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders |
| TWI249526B (en) * | 1998-03-13 | 2006-02-21 | Aventis Pharma Inc | Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| US6713627B2 (en) | 1998-03-13 | 2004-03-30 | Aventis Pharmaceuticals Inc. | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| US6277864B1 (en) | 1998-08-28 | 2001-08-21 | Aventis Pharmaceuticals Inc. | Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders |
| US6939879B2 (en) | 1998-08-28 | 2005-09-06 | Aventis Pharmaceuticals Inc. | Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia |
| NZ510083A (en) * | 1998-08-28 | 2003-08-29 | Aventis Pharma Inc | The use of R(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of sleep disorders |
| US20020099076A1 (en) * | 2000-05-25 | 2002-07-25 | Richard Scheyer D. | Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis |
| US20020161026A1 (en) * | 2000-11-07 | 2002-10-31 | Paralkar Vishwas M. | Combination therapies for the stimulation of bone growth |
| OA12541A (en) * | 2001-01-31 | 2006-06-05 | Pfizer Prod Inc | Ether derivatives useful as inhibitors of PDE4 isozymes. |
| WO2009152647A1 (zh) * | 2008-06-20 | 2009-12-23 | 江苏恩华药业股份有限公司 | 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用 |
| US8188119B2 (en) * | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169096A (en) * | 1985-07-02 | 1992-12-08 | Merrell Dow Pharmaceuticals Inc. | N-aralkyl-piperidine-methanol derivatives |
| US4912117A (en) * | 1985-07-02 | 1990-03-27 | Merrell Dow Pharmaceuticals Inc. | Novel chemical compounds |
| US5021428A (en) * | 1985-07-02 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Novel chemical compounds for the prophylactic treatment of migraine |
| US4783471A (en) * | 1985-07-02 | 1988-11-08 | Merrell Dow Pharmaceuticals Inc. | N-aralkyl piperidine methanol derivatives and the uses thereof |
| US4762842A (en) * | 1985-10-01 | 1988-08-09 | Eli Lilly And Company | Selective method for blocking 5HT2 receptors |
| US4877798A (en) * | 1987-11-23 | 1989-10-31 | Merrell Dow Pharmaceuticals Inc. | Treatment of fibromyalgia |
| JPH02138214A (ja) * | 1987-12-10 | 1990-05-28 | Merrell Dow Pharmaceut Inc | 不安を治療する方法 |
| ATE102482T1 (de) * | 1988-01-21 | 1994-03-15 | Merrell Dow Pharma | Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit. |
| US5064838A (en) * | 1988-01-21 | 1991-11-12 | Merrell Dow Pharmaceuticals | 1,4-disubstituted-piperidinyl compounds as pain relievers |
| ZA891901B (en) * | 1988-03-17 | 1989-11-29 | Merrell Dow Pharma | Method for the treatment of the extrapyramidal side effects associated with neuroleptic therapy |
| US4902691A (en) * | 1988-12-19 | 1990-02-20 | Eli Lilly And Company | Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors |
| US5106855A (en) * | 1989-12-20 | 1992-04-21 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of glaucoma |
| AU652759B2 (en) * | 1990-06-01 | 1994-09-08 | Aventisub Ii Inc. | (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)- 4-piperidinemethanol |
| US5643784A (en) * | 1990-12-04 | 1997-07-01 | H, Lundbeck A/S | Indan derivatives |
| US5618824A (en) * | 1994-03-09 | 1997-04-08 | Merrell Pharmaceuticals Inc. | Treatment of obsessive-compulsive disorders with 5-HT2 antagonists |
| KR19990076689A (ko) * | 1995-12-22 | 1999-10-15 | 피터 지. 스트링거 | 우울증 치료 방법 |
| EP0796619A1 (en) * | 1996-03-21 | 1997-09-24 | Merrell Pharmaceuticals Inc. | Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders |
-
1996
- 1996-03-21 EP EP96400591A patent/EP0796619A1/en not_active Withdrawn
-
1997
- 1997-02-21 CA CA002250077A patent/CA2250077C/en not_active Expired - Fee Related
- 1997-02-21 DE DE69713571T patent/DE69713571T2/de not_active Expired - Lifetime
- 1997-02-21 AT AT97907698T patent/ATE219672T1/de not_active IP Right Cessation
- 1997-02-21 NZ NZ331448A patent/NZ331448A/en unknown
- 1997-02-21 AU AU19631/97A patent/AU704435B2/en not_active Ceased
- 1997-02-21 EP EP97907698A patent/EP0888114B1/en not_active Expired - Lifetime
- 1997-02-21 CN CN97193148A patent/CN1114406C/zh not_active Expired - Fee Related
- 1997-02-21 JP JP53346797A patent/JP4165906B2/ja not_active Expired - Fee Related
- 1997-02-21 DK DK97907698T patent/DK0888114T3/da active
- 1997-02-21 ES ES97907698T patent/ES2175356T3/es not_active Expired - Lifetime
- 1997-02-21 WO PCT/US1997/002597 patent/WO1997034603A1/en active IP Right Grant
- 1997-02-21 PT PT97907698T patent/PT888114E/pt unknown
- 1997-02-21 KR KR10-1998-0707435A patent/KR100423018B1/ko not_active IP Right Cessation
- 1997-02-21 BR BR9708109A patent/BR9708109A/pt not_active Application Discontinuation
- 1997-02-21 IL IL12602297A patent/IL126022A/xx not_active IP Right Cessation
- 1997-02-21 SI SI9730363T patent/SI0888114T1/xx unknown
- 1997-02-21 HU HU9902135A patent/HU226675B1/hu not_active IP Right Cessation
- 1997-03-17 TW TW086103292A patent/TW517048B/zh not_active IP Right Cessation
- 1997-03-18 ZA ZA9702345A patent/ZA972345B/xx unknown
- 1997-03-19 AR ARP970101085A patent/AR006281A1/es unknown
-
1998
- 1998-02-19 US US09/026,323 patent/US6022877A/en not_active Expired - Lifetime
- 1998-09-18 NO NO19984348A patent/NO316788B1/no not_active IP Right Cessation
-
1999
- 1999-07-07 HK HK99102909A patent/HK1019702A1/xx not_active IP Right Cessation
-
2000
- 2000-10-30 US US09/699,647 patent/US6380216B1/en not_active Expired - Fee Related
-
2003
- 2003-07-11 NO NO20033184A patent/NO20033184D0/no not_active Application Discontinuation
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| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |