NO312275B1 - Fremgangsmåte for fremstilling av vannlöselige salter av karboksyl- og aminosyrer - Google Patents
Fremgangsmåte for fremstilling av vannlöselige salter av karboksyl- og aminosyrer Download PDFInfo
- Publication number
- NO312275B1 NO312275B1 NO19960131A NO960131A NO312275B1 NO 312275 B1 NO312275 B1 NO 312275B1 NO 19960131 A NO19960131 A NO 19960131A NO 960131 A NO960131 A NO 960131A NO 312275 B1 NO312275 B1 NO 312275B1
- Authority
- NO
- Norway
- Prior art keywords
- acid
- procedure
- anions
- water
- fermentation
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 title claims abstract description 54
- 150000001413 amino acids Chemical class 0.000 title claims abstract description 48
- 150000001735 carboxylic acids Chemical class 0.000 title claims abstract description 26
- 230000008569 process Effects 0.000 title claims description 15
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000012528 membrane Substances 0.000 claims abstract description 53
- 150000001450 anions Chemical class 0.000 claims abstract description 42
- 239000002253 acid Substances 0.000 claims abstract description 37
- 239000012266 salt solution Substances 0.000 claims abstract description 34
- 239000012527 feed solution Substances 0.000 claims abstract description 32
- 150000001768 cations Chemical class 0.000 claims abstract description 18
- 239000000126 substance Substances 0.000 claims abstract description 17
- 239000012535 impurity Substances 0.000 claims abstract description 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 5
- 238000000855 fermentation Methods 0.000 claims description 82
- 230000004151 fermentation Effects 0.000 claims description 82
- 235000001014 amino acid Nutrition 0.000 claims description 51
- 239000002585 base Substances 0.000 claims description 44
- 239000007788 liquid Substances 0.000 claims description 36
- 238000006243 chemical reaction Methods 0.000 claims description 35
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 30
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 238000004519 manufacturing process Methods 0.000 claims description 21
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- 238000006386 neutralization reaction Methods 0.000 claims description 18
- -1 amino acid salts Chemical class 0.000 claims description 15
- 150000001720 carbohydrates Chemical class 0.000 claims description 12
- 235000014633 carbohydrates Nutrition 0.000 claims description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 9
- 235000013922 glutamic acid Nutrition 0.000 claims description 9
- 239000004220 glutamic acid Substances 0.000 claims description 9
- 239000001509 sodium citrate Substances 0.000 claims description 7
- 150000007529 inorganic bases Chemical class 0.000 claims description 6
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical group [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 6
- 239000004310 lactic acid Substances 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 5
- 239000004223 monosodium glutamate Substances 0.000 claims description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
- 239000001639 calcium acetate Substances 0.000 claims description 3
- 235000011092 calcium acetate Nutrition 0.000 claims description 3
- 229960005147 calcium acetate Drugs 0.000 claims description 3
- 230000005684 electric field Effects 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 150000003863 ammonium salts Chemical class 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 2
- 235000018977 lysine Nutrition 0.000 claims description 2
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims description 2
- 239000011654 magnesium acetate Substances 0.000 claims description 2
- 235000011285 magnesium acetate Nutrition 0.000 claims description 2
- 229940069446 magnesium acetate Drugs 0.000 claims description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical group C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 239000003344 environmental pollutant Substances 0.000 claims 1
- 231100000719 pollutant Toxicity 0.000 claims 1
- 239000001540 sodium lactate Substances 0.000 claims 1
- 229940005581 sodium lactate Drugs 0.000 claims 1
- 235000011088 sodium lactate Nutrition 0.000 claims 1
- 239000000047 product Substances 0.000 description 43
- 239000000243 solution Substances 0.000 description 32
- 229940024606 amino acid Drugs 0.000 description 29
- 238000000605 extraction Methods 0.000 description 19
- 229960002989 glutamic acid Drugs 0.000 description 13
- 244000005700 microbiome Species 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 239000003011 anion exchange membrane Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 230000032258 transport Effects 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000000356 contaminant Substances 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 230000004907 flux Effects 0.000 description 4
- 239000003014 ion exchange membrane Substances 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 4
- 229940038773 trisodium citrate Drugs 0.000 description 4
- 239000002028 Biomass Substances 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 235000011941 Tilia x europaea Nutrition 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000004571 lime Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- 241000186226 Corynebacterium glutamicum Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- 235000012501 ammonium carbonate Nutrition 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 235000011083 sodium citrates Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000186063 Arthrobacter Species 0.000 description 1
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- 241001467578 Microbacterium Species 0.000 description 1
- 241000192041 Micrococcus Species 0.000 description 1
- XOJVVFBFDXDTEG-UHFFFAOYSA-N Norphytane Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 1
- 239000008156 Ringer's lactate solution Substances 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 235000011116 calcium hydroxide Nutrition 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001734 carboxylic acid salts Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002999 depolarising effect Effects 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229940049906 glutamate Drugs 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000037427 ion transport Effects 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 description 1
- 235000018342 monosodium citrate Nutrition 0.000 description 1
- 239000002524 monosodium citrate Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000029219 regulation of pH Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Water Supply & Treatment (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL106313A IL106313A0 (en) | 1993-07-12 | 1993-07-12 | A process for the production of water-soluble salts of carboxylic acids |
IL106314A IL106314A0 (en) | 1993-07-12 | 1993-07-12 | A process for the production of water-soluble salts of amino acids |
PCT/US1994/007585 WO1995002716A1 (fr) | 1993-07-12 | 1994-07-12 | Procede de production de sels hydrosolubles d'acides carboxyliques et amines |
Publications (3)
Publication Number | Publication Date |
---|---|
NO960131D0 NO960131D0 (no) | 1996-01-11 |
NO960131L NO960131L (no) | 1996-03-11 |
NO312275B1 true NO312275B1 (no) | 2002-04-22 |
Family
ID=26322651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19960131A NO312275B1 (no) | 1993-07-12 | 1996-01-11 | Fremgangsmåte for fremstilling av vannlöselige salter av karboksyl- og aminosyrer |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0725847B1 (fr) |
AT (1) | ATE183661T1 (fr) |
AU (1) | AU7471694A (fr) |
DE (1) | DE69420278D1 (fr) |
FI (1) | FI110758B (fr) |
NO (1) | NO312275B1 (fr) |
WO (1) | WO1995002716A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19604700C1 (de) * | 1996-02-09 | 1997-05-07 | Geesthacht Gkss Forschung | Verfahren zur Separierung organischer Säuren aus einem Fermentationsmedium |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3873425A (en) * | 1971-11-19 | 1975-03-25 | Tatsuyoshi Kobayashi | Process for producing itaconic acid |
IT1020235B (it) * | 1973-11-03 | 1977-12-20 | Benckiser Gmbh Joh A | Processo per la preparazione di citrati alcalini o di ammonio |
IL48701A (en) * | 1975-01-15 | 1979-01-31 | Monsanto Co | Membrane separation of weak acids from aqueous streams |
US4476025A (en) * | 1983-05-09 | 1984-10-09 | The United States Of America As Represented By The United States Department Of Energy | Separation of certain carboxylic acids utilizing cation exchange membranes |
JPS60207593A (ja) * | 1984-03-31 | 1985-10-19 | Ajinomoto Co Inc | 発酵液から塩基性アミノ酸の分離方法 |
DE3514348A1 (de) * | 1985-04-20 | 1986-10-23 | Basf Ag, 6700 Ludwigshafen | Verfahren zur gewinnung von waessrigen loesungen organischer saeuren oder basen aus waessrigen loesungen ihrer salze |
DE3629981A1 (de) * | 1986-09-03 | 1988-03-17 | Basf Ag | Verfahren zum entfernen von saeure aus kathodischen elektrotauchlackier-baedern |
US4720579A (en) * | 1986-12-18 | 1988-01-19 | Uop Inc. | Separation of citric acid from fermentation broth with a neutral polymeric adsorbent |
US4997754A (en) * | 1987-08-10 | 1991-03-05 | Ajinomoto Co., Inc. | Process for recovering L-amino acids from fermentation liquors containing them |
US4885247A (en) * | 1988-04-19 | 1989-12-05 | Michigan Biotechnology Institute | Recovery and purification of lactate salts from whole fermentation broth by electrodialysis |
DE3900379A1 (de) * | 1989-01-09 | 1990-07-12 | Basf Ag | Verfahren zur reinigung waessriger glyoxalloesungen |
US5049250A (en) * | 1989-08-14 | 1991-09-17 | Allied-Signal Inc. | Electrodialytic treatment of aqueous solutions containing amino acids |
US5231225A (en) * | 1989-12-11 | 1993-07-27 | Innova S.A. | Concurrent production of citric acid and alkali citrates |
US5104799A (en) * | 1990-10-05 | 1992-04-14 | Haarmann & Reimer | Method for the production of granular citric acid and salts thereof |
US5194130A (en) * | 1990-12-21 | 1993-03-16 | Allied-Signal Inc. | Method to produce sodium citrate using electrodialysis |
IL101906A0 (en) * | 1992-05-18 | 1992-12-30 | Yissum Res Dev Co | Extraction of electrolytes from aqueous solutions |
US5352825A (en) * | 1993-07-06 | 1994-10-04 | Hoarmann & Reimer Corp. | Recovery of organic acid salts from impure process streams by addition of bases |
-
1994
- 1994-07-12 DE DE69420278T patent/DE69420278D1/de not_active Expired - Lifetime
- 1994-07-12 AU AU74716/94A patent/AU7471694A/en not_active Abandoned
- 1994-07-12 WO PCT/US1994/007585 patent/WO1995002716A1/fr active IP Right Grant
- 1994-07-12 EP EP94924454A patent/EP0725847B1/fr not_active Expired - Lifetime
- 1994-07-12 AT AT94924454T patent/ATE183661T1/de not_active IP Right Cessation
-
1996
- 1996-01-11 NO NO19960131A patent/NO312275B1/no unknown
- 1996-01-11 FI FI960131A patent/FI110758B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI960131A0 (fi) | 1996-01-11 |
ATE183661T1 (de) | 1999-09-15 |
NO960131L (no) | 1996-03-11 |
EP0725847B1 (fr) | 1999-08-25 |
NO960131D0 (no) | 1996-01-11 |
FI960131A (fi) | 1996-03-06 |
EP0725847A4 (fr) | 1997-03-19 |
AU7471694A (en) | 1995-02-13 |
WO1995002716A1 (fr) | 1995-01-26 |
DE69420278D1 (de) | 1999-09-30 |
EP0725847A1 (fr) | 1996-08-14 |
FI110758B (fi) | 2003-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU626634B2 (en) | Fermentation and purification process for succinic acid | |
Hongo et al. | Novel method of lactic acid production by electrodialysis fermentation | |
Pal et al. | Manufacture of gluconic acid: A review towards process intensification for green production | |
JP2872723B2 (ja) | コハク酸の製造及び精製方法 | |
Kumar et al. | Production and purification of glutamic acid: A critical review towards process intensification | |
US4882277A (en) | Continuous process for preparing organic acids by fermentation | |
DK166507B1 (da) | Fremgangsmaade til kontinuerlig fremstilling af l-carnitin ad mikrobiologisk vej samt mikroorganisme til anvendelse derved | |
US4885247A (en) | Recovery and purification of lactate salts from whole fermentation broth by electrodialysis | |
JP5333213B2 (ja) | コハク酸およびコハク酸アンモニウム溶液の製造方法 | |
US4828993A (en) | Process for the preparation of organic acids | |
JP4554277B2 (ja) | 微生物によるコハク酸の製造方法 | |
US6001255A (en) | Process for the production of water-soluble salts of carboxylic and amino acids | |
RU2699538C2 (ru) | Способ очистки 1,4-диаминобутана | |
JP2010070474A (ja) | コハク酸の製造方法 | |
JP3959403B2 (ja) | 有機酸の精製方法 | |
JP5458565B2 (ja) | コハク酸塩の製造方法 | |
US6384276B2 (en) | Process for the preparation of lactic acid by evaporative crystallisation | |
NO312275B1 (no) | Fremgangsmåte for fremstilling av vannlöselige salter av karboksyl- og aminosyrer | |
CN114599634B (zh) | 允许氨的循环能够持续的支链氨基酸的结晶化方法 | |
GB2108128A (en) | Production of aspartase | |
RU2780399C1 (ru) | Способ очистки 1,4-диаминобутана | |
US6071728A (en) | Process for the production of crystalline aspartic acid | |
JP2023518460A (ja) | 炭酸含有ジアミノアルカン溶液の分離膜分離工程 | |
CN115678925A (zh) | 一种丙酸钙的制备方法 | |
Takamatsu et al. | Production of L‐alanine |