NO311007B1 - Fremgangsmate for preparering av ben for transplantasjon, samt ben passende for transplantasjon - Google Patents
Fremgangsmate for preparering av ben for transplantasjon, samt ben passende for transplantasjon Download PDFInfo
- Publication number
- NO311007B1 NO311007B1 NO19962874A NO962874A NO311007B1 NO 311007 B1 NO311007 B1 NO 311007B1 NO 19962874 A NO19962874 A NO 19962874A NO 962874 A NO962874 A NO 962874A NO 311007 B1 NO311007 B1 NO 311007B1
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- Norway
- Prior art keywords
- bone
- pressure
- matrix
- atmosphere
- leg
- Prior art date
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- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S623/92—Method or apparatus for preparing or treating prosthetic
- Y10S623/923—Bone
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Dermatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/184,164 US5513662A (en) | 1991-12-31 | 1994-01-21 | Preparation of bone for transplantation |
PCT/US1995/000880 WO1995019797A1 (fr) | 1994-01-21 | 1995-01-23 | Preparation d'os destine a une transplantation |
Publications (3)
Publication Number | Publication Date |
---|---|
NO962874D0 NO962874D0 (no) | 1996-07-08 |
NO962874L NO962874L (no) | 1996-09-03 |
NO311007B1 true NO311007B1 (no) | 2001-10-01 |
Family
ID=22675817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19962874A NO311007B1 (no) | 1994-01-21 | 1996-07-08 | Fremgangsmate for preparering av ben for transplantasjon, samt ben passende for transplantasjon |
Country Status (12)
Country | Link |
---|---|
US (1) | US5513662A (fr) |
EP (1) | EP0740555B1 (fr) |
JP (1) | JPH09508040A (fr) |
CN (1) | CN1143913A (fr) |
AT (1) | ATE262930T1 (fr) |
AU (1) | AU689227B2 (fr) |
BR (1) | BR9506498A (fr) |
CA (1) | CA2180447C (fr) |
DE (1) | DE69532798T2 (fr) |
ES (1) | ES2216008T3 (fr) |
NO (1) | NO311007B1 (fr) |
WO (1) | WO1995019797A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220233981A1 (en) * | 2021-01-27 | 2022-07-28 | John Ruszkowski | Air Filter Inactivation of Viruses and Micro-organisms |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5797871A (en) * | 1994-08-19 | 1998-08-25 | Lifenet Research Foundation | Ultrasonic cleaning of allograft bone |
US5977034A (en) * | 1994-08-19 | 1999-11-02 | Lifenet Research Foundation | Composition for cleaning bones |
US5556379A (en) * | 1994-08-19 | 1996-09-17 | Lifenet Research Foundation | Process for cleaning large bone grafts and bone grafts produced thereby |
US5976104A (en) * | 1994-08-19 | 1999-11-02 | Lifenet Research Foundation | Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone grafts produced thereby |
US5814084A (en) * | 1996-01-16 | 1998-09-29 | University Of Florida Tissue Bank, Inc. | Diaphysial cortical dowel |
US5788941A (en) * | 1996-01-31 | 1998-08-04 | Steris Corporation | Method of sterilization of bone tussue |
US6024735A (en) * | 1996-03-20 | 2000-02-15 | Lifenet Research Foundation | Process and composition for cleaning soft tissue grafts optionally attached to bone and soft tissue and bone grafts produced thereby |
KR100471773B1 (ko) * | 1997-09-19 | 2005-07-07 | 삼성전자주식회사 | 몰리브덴또는몰리브덴합금을이용한배선의제조방법및이를이용한박막트랜지스터의제조방법 |
US5782914A (en) * | 1996-11-29 | 1998-07-21 | Bio-Vascular, Inc. | Method for preparing heterogeneous tissue grafts |
US5846484A (en) * | 1997-03-20 | 1998-12-08 | Osteotech, Inc. | Pressure flow system and method for treating a fluid permeable workpiece such as a bone |
US5977432A (en) * | 1997-06-09 | 1999-11-02 | Life Net Research Foundation | Process for cleaning bone grafts using centrifugal force and bone grafts produced thereby |
ATE417927T1 (de) | 1997-07-30 | 2009-01-15 | Univ Emory | Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme |
US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
US20010031254A1 (en) * | 1998-11-13 | 2001-10-18 | Bianchi John R. | Assembled implant |
US6652818B1 (en) | 1998-11-13 | 2003-11-25 | Regeneration Technologies, Inc. | Implant sterilization apparatus |
US6613278B1 (en) | 1998-11-13 | 2003-09-02 | Regeneration Technologies, Inc. | Tissue pooling process |
US6482584B1 (en) * | 1998-11-13 | 2002-11-19 | Regeneration Technologies, Inc. | Cyclic implant perfusion cleaning and passivation process |
US7063726B2 (en) * | 1998-06-30 | 2006-06-20 | Lifenet | Plasticized bone grafts and methods of making and using same |
US20100030340A1 (en) * | 1998-06-30 | 2010-02-04 | Wolfinbarger Jr Lloyd | Plasticized Grafts and Methods of Making and Using Same |
US8563232B2 (en) | 2000-09-12 | 2013-10-22 | Lifenet Health | Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced |
US6293970B1 (en) | 1998-06-30 | 2001-09-25 | Lifenet | Plasticized bone and soft tissue grafts and methods of making and using same |
US20030217415A1 (en) * | 1998-06-30 | 2003-11-27 | Katrina Crouch | Plasticized bone grafts and methods of making and using same |
US6162258A (en) | 1999-08-25 | 2000-12-19 | Osteotech, Inc. | Lyophilized monolithic bone implant and method for treating bone |
FR2798294B1 (fr) * | 1999-09-10 | 2001-10-12 | Ost Dev | Procede de fabrication d'un materiau de prothese osseuse par traitement d'un tissu osseux naturel |
KR100331608B1 (ko) * | 1999-11-25 | 2002-04-09 | 김정근 | 동물 뼈를 이용한 골이식 대체재 및 그 제조 방법 |
US6488033B1 (en) * | 2000-05-15 | 2002-12-03 | Cryolife, Inc. | Osteochondral transplant techniques |
US7726319B1 (en) * | 2000-08-24 | 2010-06-01 | Osteotech, Inc. | Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization |
AU2001286755A1 (en) * | 2000-08-24 | 2002-03-04 | Osteotech, Inc. | Method of treating and dehydrating bone for implantation |
US6627230B2 (en) | 2000-12-22 | 2003-09-30 | Centerpulse Biologics Inc. | Method of preparing a bone product by removing cancellous bone matrix |
DE60224421D1 (de) * | 2001-03-28 | 2008-02-14 | Cybersonics Inc | Sonde für ultraschallwandler |
US7387612B2 (en) * | 2001-03-28 | 2008-06-17 | Cybersonics, Inc. | Floating probe for ultrasonic transducers |
EP1369095A3 (fr) * | 2002-06-04 | 2004-01-14 | MTF MediTech Franken GmbH | Procédé et dispositif pour l'humectage d'un implant médical ou d'une greffe |
NZ538196A (en) * | 2002-08-12 | 2007-05-31 | Osteotech Inc | Synthesis of a bone-polymer composite material for forming osteoimplants |
WO2004032988A2 (fr) * | 2002-10-08 | 2004-04-22 | Osteotech, Inc. | Agents de couplage pour biomateriaux orthopediques |
NZ540697A (en) * | 2002-12-12 | 2008-05-30 | Osteotech Inc | Formable and settable polymer bone composite and method of production thereof |
US20040161362A1 (en) * | 2002-12-27 | 2004-08-19 | Bogert David L. | Audible range acoustic cleaning process for implants |
WO2004067050A1 (fr) * | 2003-01-28 | 2004-08-12 | Osteotech, Inc. | Processus d'inactivation/d'elimination d'agents pathogenes tissulaires |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7071152B2 (en) * | 2003-05-30 | 2006-07-04 | Steris Inc. | Cleaning and decontamination formula for surfaces contaminated with prion-infected material |
US20050020506A1 (en) * | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
US8012210B2 (en) * | 2004-01-16 | 2011-09-06 | Warsaw Orthopedic, Inc. | Implant frames for use with settable materials and related methods of use |
US7648676B2 (en) * | 2004-04-20 | 2010-01-19 | Rti Biologics, Inc. | Process and apparatus for treating implants comprising soft tissue |
US20060228252A1 (en) * | 2004-04-20 | 2006-10-12 | Mills C R | Process and apparatus for treating implants comprising soft tissue |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
US7371260B2 (en) * | 2005-10-26 | 2008-05-13 | Biomet Sports Medicine, Inc. | Method and instrumentation for the preparation and transplantation of osteochondral allografts |
EP1976459A4 (fr) * | 2006-01-19 | 2012-06-20 | Warsaw Orthopedic Inc | Prothese osseuse poreuse |
WO2007084725A2 (fr) | 2006-01-19 | 2007-07-26 | Osteotech, Inc. | Matieres substituts d’os injectables et moulables |
US8506983B2 (en) * | 2006-05-01 | 2013-08-13 | Warsaw Orthopedic, Inc. | Bone filler material |
US7838022B2 (en) | 2006-05-01 | 2010-11-23 | Warsaw Orthopedic, Inc | Malleable implants containing demineralized bone matrix |
US20100209470A1 (en) * | 2006-05-01 | 2010-08-19 | Warsaw Orthopedic, Inc. An Indiana Corporation | Demineralized bone matrix devices |
US7771741B2 (en) * | 2006-05-01 | 2010-08-10 | Warsaw Orthopedic, Inc | Demineralized bone matrix devices |
US20070276506A1 (en) * | 2006-05-25 | 2007-11-29 | Biomet Manufacturing Corp. | Demineralized osteochondral plug |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
WO2008125851A2 (fr) * | 2007-04-16 | 2008-10-23 | Tissue Science Laboratories Plc | Implant vasculaire |
CA2684014A1 (fr) * | 2007-04-16 | 2008-10-23 | Tissue Science Laboratories Plc | Implant osseux |
WO2008135798A1 (fr) * | 2007-05-03 | 2008-11-13 | Nyarady Jozsef | Procédé et dispositif pour mesurer l'écoulement sanguin dans l'os après une fracture |
US20080294270A1 (en) * | 2007-05-24 | 2008-11-27 | Zimmer Orthobiologics, Inc. | Differentially processed tissue and processing methods thereof |
US9744043B2 (en) | 2007-07-16 | 2017-08-29 | Lifenet Health | Crafting of cartilage |
US8303592B2 (en) * | 2007-10-05 | 2012-11-06 | Biomet Manufacturing Corp. | System for forming a tendon-bone graft |
US8322256B2 (en) * | 2007-10-05 | 2012-12-04 | Biomet Manufacturing Corp. | System for forming a tendon-bone graft |
US9056150B2 (en) | 2007-12-04 | 2015-06-16 | Warsaw Orthopedic, Inc. | Compositions for treating bone defects |
EP2265220A1 (fr) | 2008-03-05 | 2010-12-29 | Musculoskeletal Transplant Foundation | Produits de recombinaison spongieux, particules de cartilage et associations de produits de recombinaison spongieux et de particules de cartilage |
US8840913B2 (en) | 2008-03-27 | 2014-09-23 | Warsaw Orthopedic, Inc. | Malleable multi-component implants and materials therefor |
CN101380488B (zh) * | 2008-10-27 | 2013-08-14 | 胡懿郃 | 牛皮质骨植骨材料的制备方法 |
CN102781487B (zh) * | 2009-12-13 | 2016-11-16 | 阿米特·普拉卡什·戈维 | 生物活性移植物和复合物 |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US8435305B2 (en) | 2010-08-31 | 2013-05-07 | Zimmer, Inc. | Osteochondral graft delivery device and uses thereof |
KR101163594B1 (ko) | 2010-10-27 | 2012-07-06 | 이윤진 | 치아 골 이식재 제조방법 및 그로 인해 제조된 골 이식재 |
GB201215725D0 (en) | 2012-09-04 | 2012-10-17 | Univ Leeds | Composite connective tissue and bone implants |
US10173375B2 (en) | 2014-03-05 | 2019-01-08 | Bacterin International, Inc. | Shaped fiber-based products and method of manufacture thereof |
US10004819B2 (en) | 2014-06-10 | 2018-06-26 | Vivex Biomedical, Inc. | Tissue allograft sterilization method |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
EP3297694A1 (fr) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Fibres osseuses corticales déminéralisées modifiées |
US10821004B2 (en) | 2015-06-30 | 2020-11-03 | Bacterin Interational, Inc. | Expandable bone grafts and methods of manufacture thereof |
RU2679121C1 (ru) * | 2018-11-23 | 2019-02-06 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ФГБНУ ВИЛАР) | Способ получения костного имплантата на основе стерильного деминерализованного костного матрикса |
RU2708235C1 (ru) * | 2019-09-18 | 2019-12-05 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ФГБНУ ВИЛАР) | Способ получения биоимплантата на основе стерильного деорганифицированного костного матрикса |
RU2732427C1 (ru) * | 2019-12-06 | 2020-09-16 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ФГБНУ ВИЛАР) | Способ получения костного имплантата с деминерализованным поверхностным слоем |
RU2756246C1 (ru) * | 2021-03-16 | 2021-09-28 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ФГБНУ ВИЛАР) | Способ получения костного имплантата на основе стерильного костного матрикса |
DE102021112930A1 (de) * | 2021-05-19 | 2022-11-24 | Hochschule Wismar | Vorrichtung und Verfahren zum Dezellularisieren und/oder Reinigen von Gewebe Beschreibung |
US20240245831A1 (en) * | 2023-01-19 | 2024-07-25 | University Of Sharjah | Development of decellularized bovine bone graft |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL275983A (fr) * | 1961-03-15 | 1900-01-01 | ||
US3318774A (en) * | 1961-03-15 | 1967-05-09 | Squibb & Sons Inc | Treatment of osseous and other tissue |
US4020183A (en) * | 1974-12-03 | 1977-04-26 | Ortho Pharmaceutical Corporation | Nonionic surface active anti-herpes simplex viral agents |
US4169123A (en) * | 1975-12-11 | 1979-09-25 | Moore-Perk Corporation | Hydrogen peroxide vapor sterilization method |
SU952189A1 (ru) * | 1980-08-19 | 1982-08-23 | Киевский научно-исследовательский институт ортопедии | Способ извлечени клеток костного мозга и консервирующих растворов из губчатого костного трансплантата |
US4412985A (en) * | 1980-10-06 | 1983-11-01 | Edward Shanbrom | Depyrogenation process |
US4315919A (en) * | 1980-10-06 | 1982-02-16 | Edward Shanbrom | Depyrogenation process |
US4456589A (en) * | 1982-07-08 | 1984-06-26 | Genetic Laboratories, Inc. | Preparation of animal tissues for surgical implantation in human recipients |
US4801299A (en) * | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
ATE31616T1 (de) * | 1983-10-20 | 1988-01-15 | Oscobal Ag | Knochenersatzmaterial auf der basis natuerlicher knochen. |
US4526751A (en) * | 1983-12-09 | 1985-07-02 | Gartner William J | Germicidal solutions effective for solid surface disinfection |
US4695536A (en) * | 1984-01-10 | 1987-09-22 | Lindstrom Richard L | Corneal storage system |
US4553974A (en) * | 1984-08-14 | 1985-11-19 | Mayo Foundation | Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor |
US4637931A (en) * | 1984-10-09 | 1987-01-20 | The United States Of America As Represented By The Secretary Of The Army | Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material |
US5053049A (en) * | 1985-05-29 | 1991-10-01 | Baxter International | Flexible prostheses of predetermined shapes and process for making same |
US4678470A (en) * | 1985-05-29 | 1987-07-07 | American Hospital Supply Corporation | Bone-grafting material |
US4923677A (en) * | 1985-08-07 | 1990-05-08 | Roy T. Witkin | Chemical sterilization |
US4950296A (en) * | 1988-04-07 | 1990-08-21 | Mcintyre Jonathan L | Bone grafting units |
US4994030A (en) * | 1988-06-28 | 1991-02-19 | Osteotech, Inc. | Reconstitution of human bone and tissue |
FR2637502A1 (fr) * | 1988-10-12 | 1990-04-13 | Duroselle Patrick | Materiau de xenogreffe osseuse et procede d'obtention |
US5071648A (en) * | 1989-04-06 | 1991-12-10 | Merocel Corporation | Polymeric broad-spectrum antimicrobial materials |
ES2096592T3 (es) * | 1989-08-09 | 1997-03-16 | Osteotech Inc | Proceso para la desinfeccion de tejido musculoesqueletico y tejidos asi preparados. |
US4946792A (en) * | 1989-08-18 | 1990-08-07 | Osteotech, Inc. | Process for debriding bone |
US5120656A (en) * | 1989-08-18 | 1992-06-09 | Osteotech, Inc. | Process for debriding bone |
US5290558A (en) * | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
US5112354A (en) * | 1989-11-16 | 1992-05-12 | Northwestern University | Bone allograft material and method |
US5037437B1 (en) * | 1990-01-18 | 1998-04-14 | Univ Washington | Method of bone preparation for prosthetic fixation |
WO1992004031A1 (fr) * | 1990-09-04 | 1992-03-19 | Edward Shanbrom | Preservation de sang, de tissus et de fluides biologiques |
US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
US5333626A (en) * | 1991-12-31 | 1994-08-02 | Cryolife, Inc. | Preparation of bone for transplantation |
-
1994
- 1994-01-21 US US08/184,164 patent/US5513662A/en not_active Expired - Lifetime
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1995
- 1995-01-23 AT AT95910113T patent/ATE262930T1/de not_active IP Right Cessation
- 1995-01-23 CN CN95192077A patent/CN1143913A/zh active Pending
- 1995-01-23 ES ES95910113T patent/ES2216008T3/es not_active Expired - Lifetime
- 1995-01-23 JP JP7519709A patent/JPH09508040A/ja active Pending
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- 1995-01-23 DE DE69532798T patent/DE69532798T2/de not_active Expired - Lifetime
- 1995-01-23 CA CA002180447A patent/CA2180447C/fr not_active Expired - Fee Related
- 1995-01-23 BR BR9506498A patent/BR9506498A/pt not_active Application Discontinuation
- 1995-01-23 WO PCT/US1995/000880 patent/WO1995019797A1/fr active IP Right Grant
- 1995-01-23 EP EP95910113A patent/EP0740555B1/fr not_active Expired - Lifetime
-
1996
- 1996-07-08 NO NO19962874A patent/NO311007B1/no not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220233981A1 (en) * | 2021-01-27 | 2022-07-28 | John Ruszkowski | Air Filter Inactivation of Viruses and Micro-organisms |
US12076675B2 (en) * | 2021-01-27 | 2024-09-03 | John Ruszkowski | Air filter inactivation of viruses and micro-organisms |
Also Published As
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DE69532798T2 (de) | 2005-03-17 |
NO962874L (no) | 1996-09-03 |
EP0740555A4 (fr) | 2000-04-05 |
WO1995019797A1 (fr) | 1995-07-27 |
EP0740555A1 (fr) | 1996-11-06 |
AU689227B2 (en) | 1998-03-26 |
DE69532798D1 (de) | 2004-05-06 |
ATE262930T1 (de) | 2004-04-15 |
JPH09508040A (ja) | 1997-08-19 |
MX9602719A (es) | 1997-07-31 |
US5513662A (en) | 1996-05-07 |
EP0740555B1 (fr) | 2004-03-31 |
AU1833295A (en) | 1995-08-08 |
ES2216008T3 (es) | 2004-10-16 |
BR9506498A (pt) | 1999-04-27 |
CA2180447A1 (fr) | 1995-07-27 |
CN1143913A (zh) | 1997-02-26 |
NO962874D0 (no) | 1996-07-08 |
CA2180447C (fr) | 2007-05-01 |
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