NO310919B1 - Koblingsenhet for peptider, fremgangsmate for anvendelse derav, samt peptider inneholdende en koblingsenhet, farmasoytiskpreparat inneholdende peptid og fremgangsmate for in vitroinhibering av asparaginsyreproteinaseaktivitet - Google Patents
Koblingsenhet for peptider, fremgangsmate for anvendelse derav, samt peptider inneholdende en koblingsenhet, farmasoytiskpreparat inneholdende peptid og fremgangsmate for in vitroinhibering av asparaginsyreproteinaseaktivitet Download PDFInfo
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- NO310919B1 NO310919B1 NO19942544A NO942544A NO310919B1 NO 310919 B1 NO310919 B1 NO 310919B1 NO 19942544 A NO19942544 A NO 19942544A NO 942544 A NO942544 A NO 942544A NO 310919 B1 NO310919 B1 NO 310919B1
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- amino acid
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- acid residue
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- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 229940108461 rennet Drugs 0.000 description 1
- 108010058314 rennet Proteins 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- VLLGKVRQXXHELH-YFKPBYRVSA-N tert-butyl (2s)-2,4-diamino-4-oxobutanoate Chemical compound CC(C)(C)OC(=O)[C@@H](N)CC(N)=O VLLGKVRQXXHELH-YFKPBYRVSA-N 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- IDELNEDBPWKHGK-UHFFFAOYSA-N thiobutabarbital Chemical compound CCC(C)C1(CC)C(=O)NC(=S)NC1=O IDELNEDBPWKHGK-UHFFFAOYSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Substances CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- GRGCWBWNLSTIEN-UHFFFAOYSA-N trifluoromethanesulfonyl chloride Chemical compound FC(F)(F)S(Cl)(=O)=O GRGCWBWNLSTIEN-UHFFFAOYSA-N 0.000 description 1
- CYTQBVOFDCPGCX-UHFFFAOYSA-N trimethyl phosphite Chemical compound COP(OC)OC CYTQBVOFDCPGCX-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3241—Esters of arylalkanephosphinic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B60—VEHICLES IN GENERAL
- B60W—CONJOINT CONTROL OF VEHICLE SUB-UNITS OF DIFFERENT TYPE OR DIFFERENT FUNCTION; CONTROL SYSTEMS SPECIALLY ADAPTED FOR HYBRID VEHICLES; ROAD VEHICLE DRIVE CONTROL SYSTEMS FOR PURPOSES NOT RELATED TO THE CONTROL OF A PARTICULAR SUB-UNIT
- B60W40/00—Estimation or calculation of non-directly measurable driving parameters for road vehicle drive control systems not related to the control of a particular sub unit, e.g. by using mathematical models
- B60W40/08—Estimation or calculation of non-directly measurable driving parameters for road vehicle drive control systems not related to the control of a particular sub unit, e.g. by using mathematical models related to drivers or passengers
- B60W40/09—Driving style or behaviour
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H59/00—Control inputs to control units of change-speed-, or reversing-gearings for conveying rotary motion
- F16H2059/003—Detecting or using driving style of a driver, e.g. for adapting shift schedules
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H2312/00—Driving activities
- F16H2312/02—Driving off
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81935692A | 1992-01-09 | 1992-01-09 | |
| PCT/US1993/000228 WO1993014114A1 (fr) | 1992-01-09 | 1993-01-11 | Unite de liaison peptidique comprenant de l'acide phosphinique et du methylene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO942544D0 NO942544D0 (no) | 1994-07-06 |
| NO942544L NO942544L (no) | 1994-08-19 |
| NO310919B1 true NO310919B1 (no) | 2001-09-17 |
Family
ID=25227921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19942544A NO310919B1 (no) | 1992-01-09 | 1994-07-06 | Koblingsenhet for peptider, fremgangsmate for anvendelse derav, samt peptider inneholdende en koblingsenhet, farmasoytiskpreparat inneholdende peptid og fremgangsmate for in vitroinhibering av asparaginsyreproteinaseaktivitet |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5563121A (fr) |
| EP (1) | EP0629210B1 (fr) |
| JP (1) | JP3547432B2 (fr) |
| AT (1) | ATE167194T1 (fr) |
| AU (1) | AU677949B2 (fr) |
| CA (1) | CA2127295A1 (fr) |
| DE (1) | DE69319101T2 (fr) |
| DK (1) | DK0629210T3 (fr) |
| ES (1) | ES2119888T3 (fr) |
| FI (1) | FI943282A (fr) |
| NO (1) | NO310919B1 (fr) |
| WO (1) | WO1993014114A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078780A1 (fr) * | 2003-03-04 | 2004-09-16 | Pepharm R&D Limited | Composition pharmaceutique contenant l-seryl-l-leucine |
| CN103525794A (zh) * | 2012-07-06 | 2014-01-22 | 天津市国际生物医药联合研究院 | 在原核系统中分离纯化包涵体形式hiv-1蛋白酶的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH634968A5 (de) * | 1977-04-01 | 1983-03-15 | Ciba Geigy Ag | Herbizides und pflanzenwuchsregulierendes mittel enthaltend eine neue phosphinsaeure oder deren salze, ester, amide oder hydrazide sowie verwendung derselben. |
| ES2110404T3 (es) * | 1989-12-16 | 1998-02-16 | Hoechst Ag | Inhibidores de proteasas retrovirales. |
-
1993
- 1993-01-11 ES ES93903068T patent/ES2119888T3/es not_active Expired - Lifetime
- 1993-01-11 WO PCT/US1993/000228 patent/WO1993014114A1/fr active IP Right Grant
- 1993-01-11 JP JP51261393A patent/JP3547432B2/ja not_active Expired - Fee Related
- 1993-01-11 EP EP93903068A patent/EP0629210B1/fr not_active Expired - Lifetime
- 1993-01-11 US US08/256,236 patent/US5563121A/en not_active Expired - Fee Related
- 1993-01-11 AU AU34418/93A patent/AU677949B2/en not_active Ceased
- 1993-01-11 AT AT93903068T patent/ATE167194T1/de not_active IP Right Cessation
- 1993-01-11 DE DE69319101T patent/DE69319101T2/de not_active Expired - Fee Related
- 1993-01-11 CA CA002127295A patent/CA2127295A1/fr not_active Abandoned
- 1993-01-11 DK DK93903068T patent/DK0629210T3/da active
-
1994
- 1994-07-06 NO NO19942544A patent/NO310919B1/no unknown
- 1994-07-08 FI FI943282A patent/FI943282A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3547432B2 (ja) | 2004-07-28 |
| ES2119888T3 (es) | 1998-10-16 |
| AU677949B2 (en) | 1997-05-15 |
| NO942544D0 (no) | 1994-07-06 |
| FI943282A (fi) | 1994-09-08 |
| DK0629210T3 (da) | 1998-10-12 |
| EP0629210B1 (fr) | 1998-06-10 |
| WO1993014114A1 (fr) | 1993-07-22 |
| NO942544L (no) | 1994-08-19 |
| JPH07503013A (ja) | 1995-03-30 |
| DE69319101D1 (de) | 1998-07-16 |
| ATE167194T1 (de) | 1998-06-15 |
| AU3441893A (en) | 1993-08-03 |
| DE69319101T2 (de) | 1998-11-05 |
| EP0629210A1 (fr) | 1994-12-21 |
| FI943282A0 (fi) | 1994-07-08 |
| US5563121A (en) | 1996-10-08 |
| CA2127295A1 (fr) | 1993-07-22 |
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