NO310445B1 - Biomaterialblanding og fremgangsmåte for fremstilling derav - Google Patents
Biomaterialblanding og fremgangsmåte for fremstilling derav Download PDFInfo
- Publication number
- NO310445B1 NO310445B1 NO19953977A NO953977A NO310445B1 NO 310445 B1 NO310445 B1 NO 310445B1 NO 19953977 A NO19953977 A NO 19953977A NO 953977 A NO953977 A NO 953977A NO 310445 B1 NO310445 B1 NO 310445B1
- Authority
- NO
- Norway
- Prior art keywords
- mixture
- weight
- phase
- liquid phase
- tissue
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 239000012620 biological material Substances 0.000 title claims abstract description 8
- 238000000034 method Methods 0.000 title description 6
- 239000012071 phase Substances 0.000 claims abstract description 20
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 19
- 239000011707 mineral Substances 0.000 claims abstract description 19
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 17
- 210000001519 tissue Anatomy 0.000 claims abstract description 16
- 229920000642 polymer Polymers 0.000 claims abstract description 13
- 239000007791 liquid phase Substances 0.000 claims abstract description 12
- 239000002245 particle Substances 0.000 claims abstract description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 9
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 9
- 238000006467 substitution reaction Methods 0.000 claims abstract description 9
- 239000007864 aqueous solution Substances 0.000 claims abstract description 7
- 239000011575 calcium Substances 0.000 claims abstract description 5
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 4
- PSKMQMATIKSZEV-UHFFFAOYSA-H calcium titanium(4+) diphosphate Chemical compound [Ca+2].[Ti+4].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O PSKMQMATIKSZEV-UHFFFAOYSA-H 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- 239000010936 titanium Substances 0.000 claims abstract description 4
- 239000001913 cellulose Substances 0.000 claims abstract description 3
- 229920002678 cellulose Polymers 0.000 claims abstract description 3
- 239000007788 liquid Substances 0.000 claims abstract description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 8
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 5
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract description 6
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 description 14
- 238000002347 injection Methods 0.000 description 13
- 239000007924 injection Substances 0.000 description 13
- 239000007943 implant Substances 0.000 description 11
- 210000003205 muscle Anatomy 0.000 description 10
- 210000000689 upper leg Anatomy 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 9
- 241000282472 Canis lupus familiaris Species 0.000 description 7
- 239000008346 aqueous phase Substances 0.000 description 4
- 238000002224 dissection Methods 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 206010011985 Decubitus ulcer Diseases 0.000 description 3
- IUJDSEJGGMCXSG-UHFFFAOYSA-N Thiopental Chemical compound CCCC(C)C1(CC)C(=O)NC(=S)NC1=O IUJDSEJGGMCXSG-UHFFFAOYSA-N 0.000 description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 description 3
- 235000011010 calcium phosphates Nutrition 0.000 description 3
- 238000005553 drilling Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 210000004705 lumbosacral region Anatomy 0.000 description 3
- 238000002271 resection Methods 0.000 description 3
- 238000000518 rheometry Methods 0.000 description 3
- LCSKNASZPVZHEG-UHFFFAOYSA-N 3,6-dimethyl-1,4-dioxane-2,5-dione;1,4-dioxane-2,5-dione Chemical group O=C1COC(=O)CO1.CC1OC(=O)C(C)OC1=O LCSKNASZPVZHEG-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 241000906034 Orthops Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 210000003195 fascia Anatomy 0.000 description 2
- -1 hydroxypropyl groups Chemical group 0.000 description 2
- 231100000518 lethal Toxicity 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 2
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 2
- 125000002496 methyl group Chemical class [H]C([H])([H])* 0.000 description 2
- 210000004417 patella Anatomy 0.000 description 2
- 210000004303 peritoneum Anatomy 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940072358 xylocaine Drugs 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- UPXRTVAIJMUAQR-UHFFFAOYSA-N 4-(9h-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Chemical compound C1C(C(O)=O)N(C(=O)OC(C)(C)C)CC1NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21 UPXRTVAIJMUAQR-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000766026 Coregonus nasus Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010023204 Joint dislocation Diseases 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 206010033892 Paraplegia Diseases 0.000 description 1
- 208000005646 Pneumoperitoneum Diseases 0.000 description 1
- 239000008156 Ringer's lactate solution Substances 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 229910000883 Ti6Al4V Inorganic materials 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 208000037873 arthrodesis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 239000003364 biologic glue Substances 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- ZEWYCNBZMPELPF-UHFFFAOYSA-J calcium;potassium;sodium;2-hydroxypropanoic acid;sodium;tetrachloride Chemical compound [Na].[Na+].[Cl-].[Cl-].[Cl-].[Cl-].[K+].[Ca+2].CC(O)C(O)=O ZEWYCNBZMPELPF-UHFFFAOYSA-J 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 description 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 1
- 229960004475 chlortetracycline Drugs 0.000 description 1
- 235000019365 chlortetracycline Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 231100000429 cutaneous necrosis Toxicity 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001687 destabilization Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000011833 dog model Methods 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 210000002745 epiphysis Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 229960004184 ketamine hydrochloride Drugs 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000001595 mastoid Anatomy 0.000 description 1
- 210000002161 motor neuron Anatomy 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000007586 pull-out test Methods 0.000 description 1
- 210000002466 splanchnic nerve Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000004154 testing of material Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000340 thiopental sodium Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Composite Materials (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9401414A FR2715853B1 (fr) | 1994-02-08 | 1994-02-08 | Composition pour bio-matériau; procédé de préparation. |
| PCT/FR1995/000150 WO1995021634A1 (fr) | 1994-02-08 | 1995-02-08 | Composition pour bio-materiau; procede de preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO953977D0 NO953977D0 (no) | 1995-10-06 |
| NO953977L NO953977L (no) | 1995-12-08 |
| NO310445B1 true NO310445B1 (no) | 2001-07-09 |
Family
ID=9459887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19953977A NO310445B1 (no) | 1994-02-08 | 1995-10-06 | Biomaterialblanding og fremgangsmåte for fremstilling derav |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5717006A (de) |
| EP (1) | EP0692986B1 (de) |
| JP (1) | JP3559565B2 (de) |
| AT (1) | ATE194779T1 (de) |
| AU (1) | AU693517B2 (de) |
| CA (1) | CA2159739C (de) |
| DE (1) | DE69518042T2 (de) |
| DK (1) | DK0692986T3 (de) |
| ES (1) | ES2149968T3 (de) |
| FI (1) | FI116830B (de) |
| FR (1) | FR2715853B1 (de) |
| GR (1) | GR3034590T3 (de) |
| NO (1) | NO310445B1 (de) |
| PT (1) | PT692986E (de) |
| WO (1) | WO1995021634A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962028A (en) | 1988-04-20 | 1999-10-05 | Norian Corporation | Carbonated hydroxyapatite compositions and uses |
| FR2737663B1 (fr) * | 1995-08-07 | 1997-10-03 | Centre Nat Rech Scient | Composition pour bio-materiau, procede de preparation |
| JPH1033562A (ja) * | 1996-07-25 | 1998-02-10 | Injietsukusu:Kk | 人工歯根 |
| US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
| US7041641B2 (en) * | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
| US6309420B1 (en) * | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
| US6818163B1 (en) | 1999-02-12 | 2004-11-16 | Dow Global Technologies Inc. | Nanocomposite articles and process for making |
| US6599516B1 (en) | 2000-09-14 | 2003-07-29 | Etex Corporation | Malleable implant containing solid element that resorbs or fractures to provide access channels |
| US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| US20070191964A1 (en) * | 2001-04-04 | 2007-08-16 | Arthrocare Corporation | Enhanced visibility materials for implantation in hard tissue |
| US8740987B2 (en) * | 2001-06-04 | 2014-06-03 | Warsaw Orthopedic, Inc. | Tissue-derived mesh for orthopedic regeneration |
| US8025684B2 (en) | 2001-11-09 | 2011-09-27 | Zimmer Spine, Inc. | Instruments and methods for inserting a spinal implant |
| FR2836681B1 (fr) * | 2002-03-04 | 2004-06-18 | Centre Nat Rech Scient | Compose phosphocalcique modifie, composition injectable le contenant |
| SG144742A1 (en) * | 2002-08-12 | 2008-08-28 | Osteotech Inc | Synthesis of a bone-polymer composite material |
| US20050251267A1 (en) * | 2004-05-04 | 2005-11-10 | John Winterbottom | Cell permeable structural implant |
| FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
| US8002843B2 (en) | 2003-02-04 | 2011-08-23 | Warsaw Orthopedic, Inc. | Polyurethanes for osteoimplants |
| US7985414B2 (en) * | 2003-02-04 | 2011-07-26 | Warsaw Orthopedic, Inc. | Polyurethanes for osteoimplants |
| US20060229627A1 (en) * | 2004-10-29 | 2006-10-12 | Hunt Margaret M | Variable angle spinal surgery instrument |
| US7806932B2 (en) | 2003-08-01 | 2010-10-05 | Zimmer Spine, Inc. | Spinal implant |
| US8012210B2 (en) * | 2004-01-16 | 2011-09-06 | Warsaw Orthopedic, Inc. | Implant frames for use with settable materials and related methods of use |
| AU2005210630A1 (en) * | 2004-01-30 | 2005-08-18 | Warsaw Orthopedic, Inc. | Stacking implants for spinal fusion |
| US7959675B2 (en) * | 2005-04-08 | 2011-06-14 | G&L Consulting, Llc | Spine implant insertion device and method |
| US8025903B2 (en) * | 2005-09-09 | 2011-09-27 | Wright Medical Technology, Inc. | Composite bone graft substitute cement and articles produced therefrom |
| WO2007030616A2 (en) | 2005-09-09 | 2007-03-15 | Wright Medical Technology, Inc. | Composite bone graft substitute cement and articles produced therefrom |
| WO2007084609A2 (en) * | 2006-01-19 | 2007-07-26 | Osteotech, Inc. | Porous osteoimplant |
| EP1976460A4 (de) | 2006-01-19 | 2012-06-20 | Warsaw Orthopedic Inc | Injizierbare und formbare knochenersatzmaterialien |
| EP1820522B1 (de) * | 2006-02-20 | 2012-05-16 | Straumann Holding AG | Granulatematrix |
| WO2007113762A2 (en) * | 2006-03-31 | 2007-10-11 | Csir | Bulking of soft tissue |
| EP2021043B1 (de) | 2006-05-26 | 2011-01-12 | Baxter International Inc. | Injizierbarer füllstoff für knochenhohlräume |
| EP2029184B1 (de) | 2006-05-26 | 2011-02-23 | Baxter International Inc. | Injizierbare fibrin-zusammensetzung zur knochenverstärkung |
| DE102006042142A1 (de) | 2006-09-06 | 2008-03-27 | Curasan Ag | Phasen- und sedimentationsstabile, plastisch verformbare Zubereitung mit intrinsischer Porenbildung, bspw. zum Auffüllen von Knochendefekten bzw. zur Verwendung als Knochenersatzmaterial, und Verfahren zu deren Herstellung |
| US8641764B2 (en) * | 2006-10-11 | 2014-02-04 | G&L Consulting, Llc | Spine implant insertion device and method |
| FR2908775B1 (fr) * | 2006-11-17 | 2012-08-31 | Biomatlante | Hydrogel et ses applications biomedicales |
| US20080140085A1 (en) * | 2006-12-11 | 2008-06-12 | G&L Consulting, Llc | Steerable spine implant insertion device and method |
| EP1958649A1 (de) * | 2007-02-14 | 2008-08-20 | Graftys | Injizierbarer Kalzium-Phospat-Zement zur Freisetzung eines Knochenschwund-Inhibitors |
| FR2913199B1 (fr) * | 2007-03-01 | 2009-05-08 | Biomatlante Sarl | Composition granulaire deshydratee et ses applications biomedicales. |
| CA2682034C (en) | 2007-03-26 | 2015-01-27 | Baxter International Inc. | Injectable void filler for soft tissue augmentation |
| DK2162531T3 (en) * | 2007-05-04 | 2019-04-23 | Ascendia Ab | METHOD AND METHOD FOR CULTIVATING OSTEOBLASTIC CELLS |
| FR2922454B1 (fr) * | 2007-10-22 | 2010-01-01 | Biomatlante | Substitut osseux comprenant un agent de contraste, son procede de preparation et ses utilisations |
| EP2306913A4 (de) * | 2008-03-28 | 2014-06-04 | Warsaw Orthopedic Inc | Knochenanker für orthopädische anwendungen |
| US20110159057A1 (en) * | 2008-08-22 | 2011-06-30 | Jose Domingos Da Silva Santos | Hydroxyapatite and bioglass-based pellets, production process and applications of thereof |
| WO2012134540A2 (en) | 2010-10-22 | 2012-10-04 | Vanderbilt University | Injectable synthetic pur composite |
| EP2358408A2 (de) * | 2008-10-30 | 2011-08-24 | Osteotech, Inc., | Knochen/polyurethane zusammensetzungen und verfahren davon |
| US8894958B2 (en) | 2009-03-03 | 2014-11-25 | Centre National De La Recherche Scientifique (C.N.R.S.) | Galliated calcium phosphate biomaterials |
| US8623311B2 (en) | 2009-03-03 | 2014-01-07 | Graftys | Gallium-doped phosphocalcic compounds |
| EP2228080A1 (de) | 2009-03-03 | 2010-09-15 | Graftys | Galliierte Calciumphosphat-Biomaterialien |
| EP2569342B1 (de) | 2010-05-11 | 2022-01-26 | Howmedica Osteonics Corp. | Mehrwertige phosphororganische metallverbindungen, polymerhaftstoff-durchdringende netzwerkzusammensetzungen und verfahren dafür |
| WO2012158527A2 (en) | 2011-05-13 | 2012-11-22 | Howmedica Osteonics | Organophosphorous & multivalent metal compound compositions & methods |
| CN103242846B (zh) * | 2012-02-10 | 2016-01-13 | 海洋王照明科技股份有限公司 | 钛磷酸盐发光薄膜、其制备方法及电致发光器件 |
| KR101443814B1 (ko) | 2013-03-28 | 2014-09-30 | 주식회사 바이오알파 | 골 이식재 조성물 및 이의 제조방법 |
| BR112017012289B1 (pt) * | 2014-12-12 | 2022-11-16 | Motejo. Ltd | Agente para injeção hipodérmica |
| PT116179A (pt) | 2020-03-20 | 2021-09-21 | Univ Do Porto | Método para produzir materiais de hidroxiapatite-biovidro, materiais e produtos resultantes |
| KR102482319B1 (ko) * | 2020-09-29 | 2022-12-29 | 주식회사 시지바이오 | 고탄성의 인산 칼슘계 주입형 골 이식재 조성물 및 이의 제조방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0115549B1 (de) * | 1983-02-03 | 1987-11-25 | Ethicon, Inc. | Paste zur Blutstillung und temporären Defektüberbrückung bei Knochentrauma |
| NL8402534A (nl) * | 1984-08-17 | 1986-03-17 | Gerrit Johannes Brinks | Materiaal, geschikt voor toepassing als implantatiemateriaal bij mens en dier ter vervanging van afwezig botweefsel, alsmede werkwijze ter bereiding van het materiaal. |
| JP2877840B2 (ja) * | 1989-06-08 | 1999-04-05 | 三金工業株式会社 | 生体硬組織用セメント材料 |
| JP2621622B2 (ja) * | 1990-09-27 | 1997-06-18 | 三菱マテリアル株式会社 | 水硬性リン酸カルシウムセメント |
| EP0511868B1 (de) * | 1991-05-01 | 1996-09-25 | Chichibu Onoda Cement Corporation | Erhärtende Zusammensetzungen zur Verwendung in der Medizin oder Zahnheilkunde |
-
1994
- 1994-02-08 FR FR9401414A patent/FR2715853B1/fr not_active Expired - Lifetime
-
1995
- 1995-02-08 PT PT95908998T patent/PT692986E/pt unknown
- 1995-02-08 AT AT95908998T patent/ATE194779T1/de active
- 1995-02-08 US US08/535,273 patent/US5717006A/en not_active Expired - Lifetime
- 1995-02-08 EP EP95908998A patent/EP0692986B1/de not_active Expired - Lifetime
- 1995-02-08 WO PCT/FR1995/000150 patent/WO1995021634A1/fr active IP Right Grant
- 1995-02-08 DK DK95908998T patent/DK0692986T3/da active
- 1995-02-08 JP JP52101095A patent/JP3559565B2/ja not_active Expired - Lifetime
- 1995-02-08 CA CA002159739A patent/CA2159739C/fr not_active Expired - Lifetime
- 1995-02-08 AU AU17117/95A patent/AU693517B2/en not_active Expired
- 1995-02-08 DE DE69518042T patent/DE69518042T2/de not_active Expired - Lifetime
- 1995-02-08 ES ES95908998T patent/ES2149968T3/es not_active Expired - Lifetime
- 1995-10-06 FI FI954787A patent/FI116830B/fi not_active IP Right Cessation
- 1995-10-06 NO NO19953977A patent/NO310445B1/no not_active IP Right Cessation
-
2000
- 2000-10-11 GR GR20000402279T patent/GR3034590T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI954787A (fi) | 1995-10-06 |
| DE69518042T2 (de) | 2001-03-22 |
| ES2149968T3 (es) | 2000-11-16 |
| GR3034590T3 (en) | 2001-01-31 |
| CA2159739A1 (fr) | 1995-08-17 |
| DE69518042D1 (de) | 2000-08-24 |
| NO953977L (no) | 1995-12-08 |
| FI954787A0 (fi) | 1995-10-06 |
| JP3559565B2 (ja) | 2004-09-02 |
| FI116830B (fi) | 2006-03-15 |
| AU1711795A (en) | 1995-08-29 |
| AU693517B2 (en) | 1998-07-02 |
| NO953977D0 (no) | 1995-10-06 |
| EP0692986B1 (de) | 2000-07-19 |
| PT692986E (pt) | 2000-12-29 |
| WO1995021634A1 (fr) | 1995-08-17 |
| DK0692986T3 (da) | 2000-09-18 |
| JPH08508922A (ja) | 1996-09-24 |
| FR2715853B1 (fr) | 1996-04-26 |
| US5717006A (en) | 1998-02-10 |
| ATE194779T1 (de) | 2000-08-15 |
| CA2159739C (fr) | 2004-12-14 |
| EP0692986A1 (de) | 1996-01-24 |
| FR2715853A1 (fr) | 1995-08-11 |
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