NO309926B1 - Farmasøytisk blanding egnet for nasal administrering, forbindelse og anvendelse derav - Google Patents
Farmasøytisk blanding egnet for nasal administrering, forbindelse og anvendelse derav Download PDFInfo
- Publication number
- NO309926B1 NO309926B1 NO955085A NO955085A NO309926B1 NO 309926 B1 NO309926 B1 NO 309926B1 NO 955085 A NO955085 A NO 955085A NO 955085 A NO955085 A NO 955085A NO 309926 B1 NO309926 B1 NO 309926B1
- Authority
- NO
- Norway
- Prior art keywords
- androsta
- dien
- methyl
- hydroxy
- androst
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 40
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 6
- 150000003431 steroids Chemical class 0.000 claims abstract description 65
- -1 Androstane steroid Chemical class 0.000 claims abstract description 46
- 230000002267 hypothalamic effect Effects 0.000 claims abstract description 16
- 239000003937 drug carrier Substances 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 85
- HNDHDMOSWUAEAW-VMXHOPILSA-N androstadienone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC2=C1 HNDHDMOSWUAEAW-VMXHOPILSA-N 0.000 claims description 26
- 230000008859 change Effects 0.000 claims description 23
- HNDHDMOSWUAEAW-UHFFFAOYSA-N (8alpha,9beta,10alpha,13alpha,14beta)-Androsta-4,6-dien-3-one Natural products O=C1CCC2(C)C3CCC(C)(C=CC4)C4C3CCC2=C1 HNDHDMOSWUAEAW-UHFFFAOYSA-N 0.000 claims description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 125000004043 oxo group Chemical group O=* 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
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- 230000037424 autonomic function Effects 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 7
- NYVFCEPOUVGTNP-UGCZWRCOSA-N (3r,8s,9s,10r,13r,14s)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15-decahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound O[C@@H]1CC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC2=C1 NYVFCEPOUVGTNP-UGCZWRCOSA-N 0.000 claims description 6
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- MSEZLHAVPJYYIQ-VMXHOPILSA-N (8s,9s,10r,13s,14s)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 MSEZLHAVPJYYIQ-VMXHOPILSA-N 0.000 claims description 6
- QXEURENTQIAFIS-FSGKZVOOSA-N (8s,9s,10r,13s,14s)-10,13-dimethyl-17-methylidene-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=C)[C@@H]4[C@@H]3CCC2=C1 QXEURENTQIAFIS-FSGKZVOOSA-N 0.000 claims description 6
- CHJXZIUSUPUNBC-VPAKFMSCSA-N (8s,9s,10s,13r,14s)-10-(hydroxymethyl)-13-methyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one Chemical compound O=C1CC[C@]2(CO)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC2=C1 CHJXZIUSUPUNBC-VPAKFMSCSA-N 0.000 claims description 6
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- IQUXBKUKXDWZLA-VMXHOPILSA-N (8s,9s,10r,13s,14s)-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 IQUXBKUKXDWZLA-VMXHOPILSA-N 0.000 claims description 5
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- 229910052736 halogen Inorganic materials 0.000 claims description 5
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- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 5
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- 125000005042 acyloxymethyl group Chemical group 0.000 claims description 4
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- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims description 2
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 claims description 2
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- 125000005843 halogen group Chemical group 0.000 claims description 2
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- UPALZTGKKPGEBX-UGCZWRCOSA-N (3R,8S,9S,10R,13S,14S)-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-ol Chemical compound C[C@@]12CCC[C@H]1[C@@H]1CCC3=C[C@@H](C=C[C@]3(C)[C@H]1CC2)O UPALZTGKKPGEBX-UGCZWRCOSA-N 0.000 claims 4
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7735993A | 1993-06-15 | 1993-06-15 | |
| PCT/US1993/009349 WO1994028904A1 (en) | 1993-06-15 | 1993-09-28 | Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO955085D0 NO955085D0 (no) | 1995-12-14 |
| NO955085L NO955085L (no) | 1996-02-14 |
| NO309926B1 true NO309926B1 (no) | 2001-04-23 |
Family
ID=22137596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO955085A NO309926B1 (no) | 1993-06-15 | 1995-12-14 | Farmasøytisk blanding egnet for nasal administrering, forbindelse og anvendelse derav |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP0711169B1 (de) |
| JP (1) | JP3705806B2 (de) |
| AT (1) | ATE255898T1 (de) |
| BG (1) | BG63452B1 (de) |
| BR (1) | BR9307867A (de) |
| CA (1) | CA2165325A1 (de) |
| DE (1) | DE69333352T2 (de) |
| ES (1) | ES2210243T3 (de) |
| FI (1) | FI956029A (de) |
| HU (1) | HUT74172A (de) |
| NO (1) | NO309926B1 (de) |
| NZ (1) | NZ257218A (de) |
| PL (1) | PL183582B1 (de) |
| WO (1) | WO1994028904A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5969168A (en) * | 1991-01-07 | 1999-10-19 | Pherin Corporation | Androstanes for inducing hypothalamic effects |
| US5883087A (en) * | 1991-01-07 | 1999-03-16 | Pherin Corporation | Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
| US5563131A (en) * | 1994-08-04 | 1996-10-08 | Pherin Corporation | Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
| US5994333A (en) * | 1994-08-04 | 1999-11-30 | Pherin Corporation | Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
| US6066627A (en) * | 1994-08-04 | 2000-05-23 | Pherin Corporation | Steroids as neurochemical initiators of change in human blood levels of LH |
| DE69634134D1 (de) * | 1995-10-19 | 2005-02-03 | Univ Columbia | Klonierung von pheromon rezeptoren aus vertebraten und deren verwendungen |
| US5922699A (en) * | 1996-06-07 | 1999-07-13 | Pherin Corporation | 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function |
| AU726625B2 (en) * | 1996-07-23 | 2000-11-16 | Pherin Pharmaceuticals, Inc. | Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety |
| US6093389A (en) * | 1997-12-01 | 2000-07-25 | American Cyanamid Company | Methods and compositions for attracting and controlling termites |
| US6544971B1 (en) | 2000-02-04 | 2003-04-08 | Pherin Pharmaceuticals, Inc. | Method of increasing alertness by administration of a vomeropherin, and vomeropherin-emitting alarm devices |
| US7019136B2 (en) | 2000-04-07 | 2006-03-28 | Novartis, Ag | 8-quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors |
| US6919337B2 (en) | 2000-04-07 | 2005-07-19 | Novartis, Ag | 8-Quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors |
| JP3705546B2 (ja) * | 2000-07-05 | 2005-10-12 | 松下電器産業株式会社 | 嗅粘膜刺激性化合物スクリーニング装置及び方法 |
| CA2894686C (en) | 2012-12-28 | 2021-05-04 | Pherin Pharmaceuticals, Inc. | Use of pregn-4-en-20-yn-3-one for the treatment of depressive disorders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB765509A (en) * | 1954-02-04 | 1957-01-09 | Pfizer & Co C | Improvements in or relating to steroids and the preparation thereof |
| FR7725M (de) * | 1967-06-22 | 1970-03-02 | ||
| GB1267514A (en) * | 1968-07-23 | 1972-03-22 | Nat Res Dev | Improvements relating to artificial insemination of pigs |
| DE2345376A1 (de) * | 1973-09-06 | 1975-03-20 | Schering Ag | Pharmazeutische zubereitung ii |
| GB1550343A (en) * | 1975-07-16 | 1979-08-15 | Gist Brocades Nv | Androstane derivatives |
| DE2758549A1 (de) * | 1977-12-23 | 1979-07-05 | Schering Ag | Pharmazeutische zubereitung |
| US5155045A (en) * | 1985-01-25 | 1992-10-13 | Trustees Of The University Of Penn. | Use of male essence to alter female endocrine response |
| DD251077A1 (de) * | 1986-07-21 | 1987-11-04 | Adw Ddr | Mittel zur anregung der brunstreaktion bei schweinen |
| US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| US5208227A (en) * | 1987-08-25 | 1993-05-04 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| FR2622194B1 (fr) * | 1987-10-27 | 1990-03-23 | Theramex Laboratoire | Nouveaux derives de la 19-nor progesterone, leur procede d'obtention et les compositions pharmaceutiques en contenant |
| US5969168A (en) * | 1991-01-07 | 1999-10-19 | Pherin Corporation | Androstanes for inducing hypothalamic effects |
| DK0614463T3 (da) * | 1991-11-22 | 2003-03-31 | Alcon Lab Inc | Angiostatiske steroider |
| US5272134A (en) * | 1992-03-24 | 1993-12-21 | Erox Corporation | Fragrance compositions and other compositions which contain human pheromones |
-
1993
- 1993-09-28 EP EP93923753A patent/EP0711169B1/de not_active Expired - Lifetime
- 1993-09-28 WO PCT/US1993/009349 patent/WO1994028904A1/en active IP Right Grant
- 1993-09-28 NZ NZ257218A patent/NZ257218A/en unknown
- 1993-09-28 HU HU9503578A patent/HUT74172A/hu unknown
- 1993-09-28 EP EP03076439A patent/EP1340502A3/de not_active Withdrawn
- 1993-09-28 AT AT93923753T patent/ATE255898T1/de not_active IP Right Cessation
- 1993-09-28 DE DE69333352T patent/DE69333352T2/de not_active Expired - Lifetime
- 1993-09-28 CA CA002165325A patent/CA2165325A1/en not_active Abandoned
- 1993-09-28 ES ES93923753T patent/ES2210243T3/es not_active Expired - Lifetime
- 1993-09-28 JP JP50171195A patent/JP3705806B2/ja not_active Expired - Fee Related
- 1993-09-28 PL PL93312279A patent/PL183582B1/pl unknown
- 1993-09-28 BR BR9307867A patent/BR9307867A/pt not_active Application Discontinuation
-
1995
- 1995-12-14 FI FI956029A patent/FI956029A/fi unknown
- 1995-12-14 NO NO955085A patent/NO309926B1/no not_active IP Right Cessation
-
1996
- 1996-01-15 BG BG100286A patent/BG63452B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1340502A3 (de) | 2004-01-21 |
| FI956029A (fi) | 1996-02-14 |
| BR9307867A (pt) | 1996-07-30 |
| CA2165325A1 (en) | 1994-12-22 |
| JPH09501409A (ja) | 1997-02-10 |
| EP0711169A4 (de) | 2000-05-31 |
| EP0711169A1 (de) | 1996-05-15 |
| DE69333352D1 (de) | 2004-01-22 |
| NO955085D0 (no) | 1995-12-14 |
| PL312279A1 (en) | 1996-04-15 |
| AU5350494A (en) | 1995-01-03 |
| BG100286A (bg) | 1997-02-28 |
| HU9503578D0 (en) | 1996-02-28 |
| JP3705806B2 (ja) | 2005-10-12 |
| DE69333352T2 (de) | 2004-07-22 |
| NZ257218A (en) | 1998-07-28 |
| ATE255898T1 (de) | 2003-12-15 |
| WO1994028904A1 (en) | 1994-12-22 |
| ES2210243T3 (es) | 2004-07-01 |
| FI956029A0 (fi) | 1995-12-14 |
| BG63452B1 (bg) | 2002-02-28 |
| PL183582B1 (pl) | 2002-06-28 |
| HUT74172A (en) | 1996-11-28 |
| EP1340502A2 (de) | 2003-09-03 |
| EP0711169B1 (de) | 2003-12-10 |
| NO955085L (no) | 1996-02-14 |
| AU691474B2 (en) | 1998-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN MARCH 2003 |