NO305518B1 - Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet - Google Patents
Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitetInfo
- Publication number
- NO305518B1 NO305518B1 NO941275A NO941275A NO305518B1 NO 305518 B1 NO305518 B1 NO 305518B1 NO 941275 A NO941275 A NO 941275A NO 941275 A NO941275 A NO 941275A NO 305518 B1 NO305518 B1 NO 305518B1
- Authority
- NO
- Norway
- Prior art keywords
- azidomethyl
- adenine
- purine
- alkynyl
- thymine
- Prior art date
Links
- -1 alkynyl purine Chemical compound 0.000 title abstract 7
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title abstract 3
- 230000000840 anti-viral effect Effects 0.000 title 1
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 6
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 6
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 6
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 4
- 229930024421 Adenine Natural products 0.000 abstract 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 4
- 229960000643 adenine Drugs 0.000 abstract 4
- 229940104302 cytosine Drugs 0.000 abstract 3
- 229940113082 thymine Drugs 0.000 abstract 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
- 229940035893 uracil Drugs 0.000 abstract 2
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
- WYDKPTZGVLTYPG-UHFFFAOYSA-N 2,8-diamino-3,7-dihydropurin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N=C(N)N2 WYDKPTZGVLTYPG-UHFFFAOYSA-N 0.000 abstract 1
- CRYCZDRIXVHNQB-UHFFFAOYSA-N 2-amino-8-bromo-3,7-dihydropurin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N=C(Br)N2 CRYCZDRIXVHNQB-UHFFFAOYSA-N 0.000 abstract 1
- YCFWZXAEOXKNHL-UHFFFAOYSA-N 2-amino-8-chloro-3,7-dihydropurin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N=C(Cl)N2 YCFWZXAEOXKNHL-UHFFFAOYSA-N 0.000 abstract 1
- TXGWTBFCLADKKR-UHFFFAOYSA-N 2-amino-8-hydrazinyl-3,7-dihydropurin-6-one Chemical compound N1=C(N)NC(=O)C2=C1N=C(NN)N2 TXGWTBFCLADKKR-UHFFFAOYSA-N 0.000 abstract 1
- DJGMEMUXTWZGIC-UHFFFAOYSA-N 2-amino-8-methyl-3,7-dihydropurin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N=C(C)N2 DJGMEMUXTWZGIC-UHFFFAOYSA-N 0.000 abstract 1
- MWBWWFOAEOYUST-UHFFFAOYSA-N 2-aminopurine Chemical compound NC1=NC=C2N=CNC2=N1 MWBWWFOAEOYUST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- BLXGZIDBSXVMLU-OWOJBTEDSA-N 5-[(e)-2-bromoethenyl]-1h-pyrimidine-2,4-dione Chemical compound Br\C=C\C1=CNC(=O)NC1=O BLXGZIDBSXVMLU-OWOJBTEDSA-N 0.000 abstract 1
- LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical compound BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 abstract 1
- ZRYZBEQILKESAW-UHFFFAOYSA-N 5-ethenyl-1h-pyrimidine-2,4-dione Chemical compound C=CC1=CNC(=O)NC1=O ZRYZBEQILKESAW-UHFFFAOYSA-N 0.000 abstract 1
- RHIULBJJKFDJPR-UHFFFAOYSA-N 5-ethyl-1h-pyrimidine-2,4-dione Chemical compound CCC1=CNC(=O)NC1=O RHIULBJJKFDJPR-UHFFFAOYSA-N 0.000 abstract 1
- KSNXJLQDQOIRIP-UHFFFAOYSA-N 5-iodouracil Chemical compound IC1=CNC(=O)NC1=O KSNXJLQDQOIRIP-UHFFFAOYSA-N 0.000 abstract 1
- JHEKLAXXCHLMNM-UHFFFAOYSA-N 5-propyl-1h-pyrimidine-2,4-dione Chemical compound CCCC1=CNC(=O)NC1=O JHEKLAXXCHLMNM-UHFFFAOYSA-N 0.000 abstract 1
- CLGFIVUFZRGQRP-UHFFFAOYSA-N 7,8-dihydro-8-oxoguanine Chemical compound O=C1NC(N)=NC2=C1NC(=O)N2 CLGFIVUFZRGQRP-UHFFFAOYSA-N 0.000 abstract 1
- MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical compound NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 abstract 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229960003087 tioguanine Drugs 0.000 abstract 1
- 229940075420 xanthine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77783591A | 1991-10-11 | 1991-10-11 | |
| PCT/US1992/008686 WO1993007157A1 (en) | 1991-10-11 | 1992-10-09 | Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO941275D0 NO941275D0 (no) | 1994-04-08 |
| NO941275L NO941275L (no) | 1994-06-10 |
| NO305518B1 true NO305518B1 (no) | 1999-06-14 |
Family
ID=25111455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO941275A NO305518B1 (no) | 1991-10-11 | 1994-04-08 | Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5696263A (no) |
| EP (1) | EP0630381B1 (no) |
| JP (1) | JP3497505B2 (no) |
| KR (1) | KR0184530B1 (no) |
| AT (1) | ATE151432T1 (no) |
| AU (1) | AU661347B2 (no) |
| CA (1) | CA2120743C (no) |
| CZ (1) | CZ287745B6 (no) |
| DE (1) | DE69218968T2 (no) |
| HU (1) | HU225970B1 (no) |
| IL (1) | IL103410A (no) |
| NO (1) | NO305518B1 (no) |
| TW (1) | TW371662B (no) |
| WO (1) | WO1993007157A1 (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0618214A1 (en) * | 1993-04-01 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Unsaturated phosphonate derivatives of purines and pyrimidines |
| US5817647A (en) * | 1993-04-01 | 1998-10-06 | Merrell Pharmaceuticals Inc. | Unsaturated acetylene phosphonate derivatives of purines |
| US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| IT1270008B (it) * | 1994-09-23 | 1997-04-16 | Ist Superiore Sanita | Derivati purinici ed 8-azapurinici atti al trattamento terapeutico dell'aids |
| US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
| US8586781B2 (en) | 1998-04-02 | 2013-11-19 | Mbc Pharma, Inc. | Bone targeted therapeutics and methods of making and using the same |
| PL213214B1 (pl) | 2000-07-21 | 2013-01-31 | Gilead Sciences | Diastereoizomerycznie wzbogacone proleki fosfonianowych analogów nukleotydowych oraz kompozycje zawierajace takie zwiazki |
| JP4545434B2 (ja) | 2001-06-29 | 2010-09-15 | インスティテュート オブ オーガニック ケミストリー アンド バイオケミストリー オブ ジ アカデミー オブ サイエンシーズ オブ ザ チェック リパブリック | 抗ウイルス活性を有する６−‘２−（ホスホノメトキシ）アルコキシピリミジン誘導体 |
| JP5280631B2 (ja) | 2003-06-16 | 2013-09-04 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー， アカデミー オブ サイエンシズ オブ ザ チェコ リパブリック | 抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物 |
| KR101033290B1 (ko) * | 2004-07-02 | 2011-05-09 | 주식회사 엘지생명과학 | 다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법 |
| FR2908133B1 (fr) | 2006-11-08 | 2012-12-14 | Centre Nat Rech Scient | Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux |
| TWI444384B (zh) | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
| US20130018018A1 (en) * | 2009-08-27 | 2013-01-17 | Epiphany Biosciences ,Inc. | Novel nucleoside phosphonates and analogs |
| US9334300B2 (en) * | 2011-08-01 | 2016-05-10 | Mbc Pharma, Inc. | Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates |
| WO2013095684A1 (en) | 2011-12-22 | 2013-06-27 | Geron Corporation | Guanine analogs as telomerase substrates and telomere length affectors |
| CA3082191C (en) | 2017-12-07 | 2021-09-21 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556643A (en) * | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
| CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
| CA1254525A (en) * | 1983-04-13 | 1989-05-23 | Christine L. Brakel | Kit for terminally chemically labeling dna |
| US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
| EP0144913A3 (en) * | 1983-12-12 | 1986-08-20 | Miles Inc. | Hybridization assay employing labeled probe and anti-hybrid |
| EP0146039A3 (en) * | 1983-12-12 | 1986-08-27 | Miles Inc. | Hybridization assay with immobilization of hybrids by antihybrid binding |
| CS263952B1 (en) * | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
| CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| AU613592B2 (en) * | 1986-11-18 | 1991-08-08 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives |
-
1992
- 1992-10-09 JP JP50723393A patent/JP3497505B2/ja not_active Expired - Lifetime
- 1992-10-09 HU HU9401002A patent/HU225970B1/hu unknown
- 1992-10-09 WO PCT/US1992/008686 patent/WO1993007157A1/en active IP Right Grant
- 1992-10-09 CA CA002120743A patent/CA2120743C/en not_active Expired - Lifetime
- 1992-10-09 CZ CZ1994845A patent/CZ287745B6/cs not_active IP Right Cessation
- 1992-10-09 KR KR1019940701174A patent/KR0184530B1/ko not_active IP Right Cessation
- 1992-10-09 AT AT92922088T patent/ATE151432T1/de not_active IP Right Cessation
- 1992-10-09 AU AU27831/92A patent/AU661347B2/en not_active Expired
- 1992-10-09 DE DE69218968T patent/DE69218968T2/de not_active Expired - Lifetime
- 1992-10-09 EP EP92922088A patent/EP0630381B1/en not_active Expired - Lifetime
- 1992-10-11 IL IL103410A patent/IL103410A/en not_active IP Right Cessation
-
1993
- 1993-01-27 TW TW082100500A patent/TW371662B/zh not_active IP Right Cessation
-
1994
- 1994-04-08 NO NO941275A patent/NO305518B1/no not_active IP Right Cessation
- 1994-12-06 US US08/350,851 patent/US5696263A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CZ287745B6 (cs) | 2001-01-17 |
| IL103410A (en) | 1998-01-04 |
| JPH07503453A (ja) | 1995-04-13 |
| DE69218968T2 (de) | 1997-10-09 |
| NO941275L (no) | 1994-06-10 |
| CZ84594A3 (en) | 1995-07-12 |
| KR0184530B1 (ko) | 1999-05-15 |
| HU225970B1 (en) | 2008-01-28 |
| EP0630381A4 (en) | 1995-01-04 |
| CA2120743A1 (en) | 1993-04-15 |
| EP0630381A1 (en) | 1994-12-28 |
| ATE151432T1 (de) | 1997-04-15 |
| CA2120743C (en) | 2005-03-08 |
| WO1993007157A1 (en) | 1993-04-15 |
| JP3497505B2 (ja) | 2004-02-16 |
| HUT66770A (en) | 1994-12-28 |
| DE69218968D1 (en) | 1997-05-15 |
| TW371662B (en) | 1999-10-11 |
| US5696263A (en) | 1997-12-09 |
| AU661347B2 (en) | 1995-07-20 |
| NO941275D0 (no) | 1994-04-08 |
| IL103410A0 (en) | 1993-03-15 |
| HU9401002D0 (en) | 1994-07-28 |
| AU2783192A (en) | 1993-05-03 |
| EP0630381B1 (en) | 1997-04-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |