NO305518B1 - Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet - Google Patents
Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitetInfo
- Publication number
- NO305518B1 NO305518B1 NO941275A NO941275A NO305518B1 NO 305518 B1 NO305518 B1 NO 305518B1 NO 941275 A NO941275 A NO 941275A NO 941275 A NO941275 A NO 941275A NO 305518 B1 NO305518 B1 NO 305518B1
- Authority
- NO
- Norway
- Prior art keywords
- azidomethyl
- adenine
- purine
- alkynyl
- thymine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77783591A | 1991-10-11 | 1991-10-11 | |
| PCT/US1992/008686 WO1993007157A1 (en) | 1991-10-11 | 1992-10-09 | Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO941275D0 NO941275D0 (no) | 1994-04-08 |
| NO941275L NO941275L (no) | 1994-06-10 |
| NO305518B1 true NO305518B1 (no) | 1999-06-14 |
Family
ID=25111455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO941275A NO305518B1 (no) | 1991-10-11 | 1994-04-08 | Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5696263A (de) |
| EP (1) | EP0630381B1 (de) |
| JP (1) | JP3497505B2 (de) |
| KR (1) | KR0184530B1 (de) |
| AT (1) | ATE151432T1 (de) |
| AU (1) | AU661347B2 (de) |
| CA (1) | CA2120743C (de) |
| CZ (1) | CZ287745B6 (de) |
| DE (1) | DE69218968T2 (de) |
| HU (1) | HU225970B1 (de) |
| IL (1) | IL103410A (de) |
| NO (1) | NO305518B1 (de) |
| TW (1) | TW371662B (de) |
| WO (1) | WO1993007157A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0618214A1 (de) * | 1993-04-01 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Ungesättigte Phosphonatderivate Purinen und Pyrimidinen |
| US5817647A (en) * | 1993-04-01 | 1998-10-06 | Merrell Pharmaceuticals Inc. | Unsaturated acetylene phosphonate derivatives of purines |
| US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| IT1270008B (it) * | 1994-09-23 | 1997-04-16 | Ist Superiore Sanita | Derivati purinici ed 8-azapurinici atti al trattamento terapeutico dell'aids |
| US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
| US8586781B2 (en) | 1998-04-02 | 2013-11-19 | Mbc Pharma, Inc. | Bone targeted therapeutics and methods of making and using the same |
| NZ535408A (en) | 2000-07-21 | 2006-09-29 | Gilead Sciences Inc | Method for selecting prodrugs of phosphonate nucleotide analogues |
| TR200302288T2 (tr) | 2001-06-29 | 2004-12-21 | Institute Of Organic Chemistry And Biochemistry Academy Of | Terapi için yeni bileşikler ve metotlar. |
| EA011948B1 (ru) | 2003-06-16 | 2009-06-30 | Инститьют Оф Оргэник Кемистри Энд Байокемистри, Экэдеми Оф Сайэнс Оф Зе Чек Рипаблик | Фосфонатзамещенные пиримидиновые соединения (варианты), способ их получения (варианты), фармацевтическая композиция на их основе и способ лечения вирусной инфекции |
| KR101033290B1 (ko) | 2004-07-02 | 2011-05-09 | 주식회사 엘지생명과학 | 다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법 |
| FR2908133B1 (fr) | 2006-11-08 | 2012-12-14 | Centre Nat Rech Scient | Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux |
| TWI444384B (zh) | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
| EP2470194A4 (de) * | 2009-08-27 | 2013-03-06 | Epiphany Biosciences Inc | Neuartige nukleosidphosphonate und -analoga |
| EP2739154B1 (de) * | 2011-08-01 | 2018-06-27 | MBC Pharma, Inc. | Vitamin-b6-derivate von nukleotiden, acyclonukleotiden und acyclonucleosid-phosphonaten |
| US9593137B2 (en) | 2011-12-22 | 2017-03-14 | Geron Corporation | Guanine analogs as telomerase substrates and telomere length affectors |
| RU2020116571A (ru) | 2017-12-07 | 2021-11-22 | Эмори Юниверсити | N4-гидроксицитидин и производные и связанные с этим противовирусные применения |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556643A (en) * | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
| CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
| CA1254525A (en) * | 1983-04-13 | 1989-05-23 | Christine L. Brakel | Kit for terminally chemically labeling dna |
| US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
| EP0144913A3 (de) * | 1983-12-12 | 1986-08-20 | Miles Inc. | Hybridisierungstest mittels einer markierten Probe und Anti-Hybrid |
| EP0146039A3 (de) * | 1983-12-12 | 1986-08-27 | Miles Inc. | Hybridisierungstest mit Immobilisierung von Hybriden mittels Antihybridbindung |
| CS263952B1 (en) * | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
| CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| IL84477A (en) * | 1986-11-18 | 1995-12-08 | Bristol Myers Squibb Co | History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them |
-
1992
- 1992-10-09 AT AT92922088T patent/ATE151432T1/de not_active IP Right Cessation
- 1992-10-09 JP JP50723393A patent/JP3497505B2/ja not_active Expired - Lifetime
- 1992-10-09 KR KR1019940701174A patent/KR0184530B1/ko not_active IP Right Cessation
- 1992-10-09 AU AU27831/92A patent/AU661347B2/en not_active Expired
- 1992-10-09 WO PCT/US1992/008686 patent/WO1993007157A1/en active IP Right Grant
- 1992-10-09 CA CA002120743A patent/CA2120743C/en not_active Expired - Lifetime
- 1992-10-09 EP EP92922088A patent/EP0630381B1/de not_active Expired - Lifetime
- 1992-10-09 DE DE69218968T patent/DE69218968T2/de not_active Expired - Lifetime
- 1992-10-09 HU HU9401002A patent/HU225970B1/hu unknown
- 1992-10-09 CZ CZ1994845A patent/CZ287745B6/cs not_active IP Right Cessation
- 1992-10-11 IL IL103410A patent/IL103410A/en not_active IP Right Cessation
-
1993
- 1993-01-27 TW TW082100500A patent/TW371662B/zh not_active IP Right Cessation
-
1994
- 1994-04-08 NO NO941275A patent/NO305518B1/no not_active IP Right Cessation
- 1994-12-06 US US08/350,851 patent/US5696263A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CZ287745B6 (cs) | 2001-01-17 |
| JPH07503453A (ja) | 1995-04-13 |
| HU225970B1 (en) | 2008-01-28 |
| AU661347B2 (en) | 1995-07-20 |
| CA2120743C (en) | 2005-03-08 |
| HU9401002D0 (en) | 1994-07-28 |
| NO941275L (no) | 1994-06-10 |
| WO1993007157A1 (en) | 1993-04-15 |
| EP0630381A1 (de) | 1994-12-28 |
| AU2783192A (en) | 1993-05-03 |
| DE69218968T2 (de) | 1997-10-09 |
| DE69218968D1 (en) | 1997-05-15 |
| US5696263A (en) | 1997-12-09 |
| IL103410A0 (en) | 1993-03-15 |
| ATE151432T1 (de) | 1997-04-15 |
| TW371662B (en) | 1999-10-11 |
| EP0630381B1 (de) | 1997-04-09 |
| IL103410A (en) | 1998-01-04 |
| HUT66770A (en) | 1994-12-28 |
| EP0630381A4 (en) | 1995-01-04 |
| CZ84594A3 (en) | 1995-07-12 |
| KR0184530B1 (ko) | 1999-05-15 |
| CA2120743A1 (en) | 1993-04-15 |
| JP3497505B2 (ja) | 2004-02-16 |
| NO941275D0 (no) | 1994-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |