NO305248B1 - Antimigrene 1,2,5-tiadiazolderivater av indolylalkylpyridinyl- og -pyrimidinylpiperaziner og anvendelse derav, samt farmas°ytiske preparater inneholdende dem - Google Patents

Antimigrene 1,2,5-tiadiazolderivater av indolylalkylpyridinyl- og -pyrimidinylpiperaziner og anvendelse derav, samt farmas°ytiske preparater inneholdende dem

Info

Publication number
NO305248B1
NO305248B1 NO960699A NO960699A NO305248B1 NO 305248 B1 NO305248 B1 NO 305248B1 NO 960699 A NO960699 A NO 960699A NO 960699 A NO960699 A NO 960699A NO 305248 B1 NO305248 B1 NO 305248B1
Authority
NO
Norway
Prior art keywords
pyrimidinylpiperazines
indolylalkylpyridinyl
migraine
well
pharmaceutical preparations
Prior art date
Application number
NO960699A
Other languages
English (en)
Norwegian (no)
Other versions
NO960699D0 (no
NO960699L (no
Inventor
Ronnie R Crenshaw
Edward H Ruediger
David W Smith
Carola Solomon
Joseph Yevich
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO960699D0 publication Critical patent/NO960699D0/no
Publication of NO960699L publication Critical patent/NO960699L/no
Publication of NO305248B1 publication Critical patent/NO305248B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO960699A 1995-03-02 1996-02-22 Antimigrene 1,2,5-tiadiazolderivater av indolylalkylpyridinyl- og -pyrimidinylpiperaziner og anvendelse derav, samt farmas°ytiske preparater inneholdende dem NO305248B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/396,825 US5618816A (en) 1995-03-02 1995-03-02 Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines

Publications (3)

Publication Number Publication Date
NO960699D0 NO960699D0 (no) 1996-02-22
NO960699L NO960699L (no) 1996-09-03
NO305248B1 true NO305248B1 (no) 1999-04-26

Family

ID=23568771

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960699A NO305248B1 (no) 1995-03-02 1996-02-22 Antimigrene 1,2,5-tiadiazolderivater av indolylalkylpyridinyl- og -pyrimidinylpiperaziner og anvendelse derav, samt farmas°ytiske preparater inneholdende dem

Country Status (17)

Country Link
US (1) US5618816A (fr)
EP (1) EP0729958A2 (fr)
JP (1) JPH08253479A (fr)
KR (1) KR960034200A (fr)
CN (1) CN1063177C (fr)
AR (1) AR002281A1 (fr)
AU (1) AU707770B2 (fr)
CA (1) CA2169804A1 (fr)
CZ (1) CZ46896A3 (fr)
HU (1) HUP9600498A3 (fr)
IL (1) IL117224A (fr)
NO (1) NO305248B1 (fr)
NZ (1) NZ286090A (fr)
PL (1) PL313022A1 (fr)
RU (1) RU2165420C2 (fr)
TW (1) TW331558B (fr)
ZA (1) ZA961392B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032196A1 (fr) * 1994-05-19 1995-11-30 Merck Sharp & Dohme Limited Derives piperazine, piperidine et tetrahydropyridine d'indol-3-ylalkyle utilises comme agonistes de 5-ht1d-alpha
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
WO2004060355A1 (fr) * 2002-12-26 2004-07-22 Pozen Inc. Formes galeniques multicouches contenant des ains et des triptanes
US20070184109A1 (en) * 2003-06-06 2007-08-09 Floyd Alison G Compositions comprising triptans and nsaids
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
FI76795C (fi) * 1979-09-04 1988-12-12 Bristol Myers Co Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider samt nya mellanprodukter.
US4600779A (en) * 1982-03-29 1986-07-15 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
US4440933A (en) * 1983-03-16 1984-04-03 Bristol-Myers Company Process for preparing 1,2,5-thiadiazoles
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
CA2043709C (fr) * 1990-06-29 2002-01-22 David W. Smith Derives pour combattre la migraine d'alcoxypirimidine
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
CA2084531A1 (fr) * 1991-12-19 1993-06-20 David W. Smith Derives antimigraines 4-pyrimidinyle et pyridinyle d'indol-3yl-alkylpiperazines
CA2130078A1 (fr) * 1993-09-16 1995-03-17 Jonas A. Gylys Derives cyclobutenediones de l'indolylakylpyridinyle et des pyrimidinylpiperazines ayant des proprietes antimigraineuses
WO1995032196A1 (fr) * 1994-05-19 1995-11-30 Merck Sharp & Dohme Limited Derives piperazine, piperidine et tetrahydropyridine d'indol-3-ylalkyle utilises comme agonistes de 5-ht1d-alpha
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
NZ286090A (en) 1997-12-19
JPH08253479A (ja) 1996-10-01
HUP9600498A3 (en) 1998-10-28
NO960699D0 (no) 1996-02-22
RU2165420C2 (ru) 2001-04-20
CN1138042A (zh) 1996-12-18
PL313022A1 (en) 1996-09-16
AR002281A1 (es) 1998-03-11
CZ46896A3 (en) 1996-09-11
IL117224A (en) 2000-06-29
TW331558B (en) 1998-05-11
AU4581996A (en) 1996-09-12
NO960699L (no) 1996-09-03
EP0729958A2 (fr) 1996-09-04
EP0729958A3 (fr) 1996-10-02
IL117224A0 (en) 1996-06-18
HUP9600498A2 (en) 1997-10-28
AU707770B2 (en) 1999-07-22
ZA961392B (en) 1997-08-21
CN1063177C (zh) 2001-03-14
KR960034200A (ko) 1996-10-22
HU9600498D0 (en) 1996-04-29
CA2169804A1 (fr) 1996-09-03
US5618816A (en) 1997-04-08

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