NO20074192L - [1,2,4]-Dithiazoli(di)nderivater, induksjonsmidler for glutation-S-transferase og NADPH-kinonoksidreduktase, for profylakse og behandling av ugunstige tilstander forbundet med cytotoksisitet generelt og apoptose spesielt - Google Patents

[1,2,4]-Dithiazoli(di)nderivater, induksjonsmidler for glutation-S-transferase og NADPH-kinonoksidreduktase, for profylakse og behandling av ugunstige tilstander forbundet med cytotoksisitet generelt og apoptose spesielt

Info

Publication number
NO20074192L
NO20074192L NO20074192A NO20074192A NO20074192L NO 20074192 L NO20074192 L NO 20074192L NO 20074192 A NO20074192 A NO 20074192A NO 20074192 A NO20074192 A NO 20074192A NO 20074192 L NO20074192 L NO 20074192L
Authority
NO
Norway
Prior art keywords
derivatives
general
nadph
inducers
glutathione
Prior art date
Application number
NO20074192A
Other languages
English (en)
Inventor
Hiskias G Keizer
Roelof W Feenstra
Maria L Pras-Raves
Bernard J Van Vliet
Gustaaf J M Van Scharrenburg
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2006/050744 external-priority patent/WO2006084854A2/en
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20074192L publication Critical patent/NO20074192L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører 5-imino-5H-[1,2,4]-ditiazol-3-yl-amin og [1,2,4]-ditiazolidin-3,5-diyliden-diaminderivater som induksjonsmidler for glutation-S-transferase (GST) og NADPH-kinon oksidoreduktase (NQO), fremgangsmåter ved fremstilling av disse forbindelsene og nye mellomprodukter som er nyttige ved syntesen av nevnte [1,2,4]-ditiazoli(di)en derivater. Oppfinnelsen vedrører også anvendelsen av en forbindelse som her er beskrevet for fremstilling av et medikament som er nyttig ved profilakse og behandling av ugunstige tilstander forbundet med cytotoksisitet generelt og apoptose spesielt. Oppfinnelsen vedrører forbindelser med den generelle formel (I): der symbolene har betydningene som er angitt i beskrivelsen.
NO20074192A 2005-02-11 2007-08-15 [1,2,4]-Dithiazoli(di)nderivater, induksjonsmidler for glutation-S-transferase og NADPH-kinonoksidreduktase, for profylakse og behandling av ugunstige tilstander forbundet med cytotoksisitet generelt og apoptose spesielt NO20074192L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65166105P 2005-02-11 2005-02-11
EP05101004 2005-02-11
PCT/EP2006/050744 WO2006084854A2 (en) 2005-02-11 2006-02-08 [1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-s-transferase and nadph quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular

Publications (1)

Publication Number Publication Date
NO20074192L true NO20074192L (no) 2007-09-07

Family

ID=36499387

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074192A NO20074192L (no) 2005-02-11 2007-08-15 [1,2,4]-Dithiazoli(di)nderivater, induksjonsmidler for glutation-S-transferase og NADPH-kinonoksidreduktase, for profylakse og behandling av ugunstige tilstander forbundet med cytotoksisitet generelt og apoptose spesielt

Country Status (2)

Country Link
IL (1) IL184542A (no)
NO (1) NO20074192L (no)

Also Published As

Publication number Publication date
IL184542A (en) 2012-08-30
IL184542A0 (en) 2007-10-31

Similar Documents

Publication Publication Date Title
NO20082934L (no) Antivirale nukleotider
NO20082496L (no) Pyrazinderivater
NO20076460L (no) Nye fluorenderivater, sammensetninger inneholdende nevnte derivater og anvendelse derav
WO2007103550A3 (en) Substituted aminothiazole derivatives with anti-hcv activity
NO20082090L (no) Pyridopyrimidinoninhibitorer av P13K alfa
NO20091553L (no) Fenylderivater og deres anvendelse som immunmodulatorer
UA89123C2 (ru) Производные пиримидина для лечения абнормального роста клеток
NO20084845L (no) 2-pyrazinonderivater for behandling av sykdom eller tilstander der inhibiering av neutrofil elastaseaktivitetet er gunstig
TW200833675A (en) Nicotinamide derivatives
NO20074012L (no) 1-tio-D-glucitolderivater
TN2009000199A1 (en) Heteromonocyclic compound and use thereof
TW200740435A (en) Therapeutic agent for diabetes
NO20064412L (no) Kondensert heterocykelderivat, medisinsk sammensetning inneholdende det samme og medisinsk anvendelse derav
CO6150162A2 (es) Pirrolopirimidinas para composiciones farmaceuticas
TW201000473A (en) Benzene or thiophene derivative and use thereof as VAP-1 inhibitor
NO20081217L (no) Nye benzotiazolonderivater
MX2010008460A (es) Derivado de tiazol y su uso como inhibidor de proteina-1 de adhesion vascular.
NO20071137L (no) Nye piperidinderivater for behandling av depresjon
EP1725536B8 (en) Imidazoline derivatives having cb1-antagonistic activity
NO20082096L (no) Azaindol-2-karboksamidderivativer
WO2007017728A3 (en) Novel heterocyclic compounds
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
NO20082112L (no) 3-Amino-2-arylpropylazaindoler og deres anvendelse
TW200715973A (en) Use of phenylsemicarbazones for seed treatment
TW200730498A (en) Compounds

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application