NO20074192L - [1,2,4] -Dithiazoli (di) derivatives, inducers of glutathione S-transferase and NADPH quinoxide reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular - Google Patents

[1,2,4] -Dithiazoli (di) derivatives, inducers of glutathione S-transferase and NADPH quinoxide reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular

Info

Publication number
NO20074192L
NO20074192L NO20074192A NO20074192A NO20074192L NO 20074192 L NO20074192 L NO 20074192L NO 20074192 A NO20074192 A NO 20074192A NO 20074192 A NO20074192 A NO 20074192A NO 20074192 L NO20074192 L NO 20074192L
Authority
NO
Norway
Prior art keywords
derivatives
general
nadph
inducers
glutathione
Prior art date
Application number
NO20074192A
Other languages
Norwegian (no)
Inventor
Hiskias G Keizer
Roelof W Feenstra
Maria L Pras-Raves
Bernard J Van Vliet
Gustaaf J M Van Scharrenburg
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2006/050744 external-priority patent/WO2006084854A2/en
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20074192L publication Critical patent/NO20074192L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører 5-imino-5H-[1,2,4]-ditiazol-3-yl-amin og [1,2,4]-ditiazolidin-3,5-diyliden-diaminderivater som induksjonsmidler for glutation-S-transferase (GST) og NADPH-kinon oksidoreduktase (NQO), fremgangsmåter ved fremstilling av disse forbindelsene og nye mellomprodukter som er nyttige ved syntesen av nevnte [1,2,4]-ditiazoli(di)en derivater. Oppfinnelsen vedrører også anvendelsen av en forbindelse som her er beskrevet for fremstilling av et medikament som er nyttig ved profilakse og behandling av ugunstige tilstander forbundet med cytotoksisitet generelt og apoptose spesielt. Oppfinnelsen vedrører forbindelser med den generelle formel (I): der symbolene har betydningene som er angitt i beskrivelsen.The present invention relates to 5-imino-5H- [1,2,4] -dithiazol-3-yl-amine and [1,2,4] -dithiazolidine-3,5-diylidene diamine derivatives as inducers of glutathione-S transferase (GST) and NADPH-quinone oxidoreductase (NQO), processes for preparing these compounds and novel intermediates useful in the synthesis of said [1,2,4] -dithiazole (di) derivatives. The invention also relates to the use of a compound described herein for the preparation of a medicament useful in the prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification.

NO20074192A 2005-02-11 2007-08-15 [1,2,4] -Dithiazoli (di) derivatives, inducers of glutathione S-transferase and NADPH quinoxide reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular NO20074192L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65166105P 2005-02-11 2005-02-11
EP05101004 2005-02-11
PCT/EP2006/050744 WO2006084854A2 (en) 2005-02-11 2006-02-08 [1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-s-transferase and nadph quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular

Publications (1)

Publication Number Publication Date
NO20074192L true NO20074192L (en) 2007-09-07

Family

ID=36499387

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074192A NO20074192L (en) 2005-02-11 2007-08-15 [1,2,4] -Dithiazoli (di) derivatives, inducers of glutathione S-transferase and NADPH quinoxide reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular

Country Status (2)

Country Link
IL (1) IL184542A (en)
NO (1) NO20074192L (en)

Also Published As

Publication number Publication date
IL184542A (en) 2012-08-30
IL184542A0 (en) 2007-10-31

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application