NO20071005L - Enantiomerer av selekterte kondenserte pyrimidoner og anvendelser for behandling og forebygging av cancer - Google Patents
Enantiomerer av selekterte kondenserte pyrimidoner og anvendelser for behandling og forebygging av cancerInfo
- Publication number
- NO20071005L NO20071005L NO20071005A NO20071005A NO20071005L NO 20071005 L NO20071005 L NO 20071005L NO 20071005 A NO20071005 A NO 20071005A NO 20071005 A NO20071005 A NO 20071005A NO 20071005 L NO20071005 L NO 20071005L
- Authority
- NO
- Norway
- Prior art keywords
- cancer
- pyrimidones
- enantiomers
- prevention
- applications
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Foreliggende oppfinnelse angår nye forbindelser som har strukturell formel (I) og deres farmasøytiske preparater og fremgangsmåter for anvendelse derav. Disse nye forbindelsene kan anvendes for behandling eller forebygging av kreft.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60236604P | 2004-08-18 | 2004-08-18 | |
PCT/GB2005/003207 WO2006018628A1 (en) | 2003-03-07 | 2005-08-16 | Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20071005L true NO20071005L (no) | 2007-05-16 |
Family
ID=37904998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20071005A NO20071005L (no) | 2004-08-18 | 2007-02-21 | Enantiomerer av selekterte kondenserte pyrimidoner og anvendelser for behandling og forebygging av cancer |
Country Status (18)
Country | Link |
---|---|
US (3) | US20080293744A1 (no) |
EP (1) | EP1781674A1 (no) |
JP (1) | JP2008509977A (no) |
KR (1) | KR20070046176A (no) |
CN (1) | CN101027309B (no) |
AU (1) | AU2005273705B8 (no) |
BR (1) | BRPI0514390A (no) |
CA (1) | CA2575188A1 (no) |
IL (1) | IL180810A0 (no) |
MX (1) | MX2007001953A (no) |
MY (1) | MY141233A (no) |
NO (1) | NO20071005L (no) |
RU (1) | RU2447077C2 (no) |
SA (1) | SA05260258B1 (no) |
TW (1) | TW200616977A (no) |
UA (1) | UA89201C2 (no) |
UY (1) | UY29070A1 (no) |
ZA (1) | ZA200701082B (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011503193A (ja) * | 2007-11-13 | 2011-01-27 | アイコス、コーポレーション | ヒトホスファチジルイノシトール3−キナーゼδの阻害剤 |
ES2486715T3 (es) | 2009-06-29 | 2014-08-19 | Incyte Corporation | Pirimidinonas como inhibidores de PI3K |
LT2751109T (lt) | 2011-09-02 | 2017-02-27 | Incyte Holdings Corporation | Heterociklilaminai kaip pi3k inhibitoriai |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN105793255B (zh) | 2013-10-04 | 2018-11-16 | 无限药品股份有限公司 | 杂环化合物及其用途 |
US9775844B2 (en) | 2014-03-19 | 2017-10-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2024103067A1 (en) * | 2022-11-10 | 2024-05-16 | Ribometrix, Inc. | COMPOUNDS AND COMPOSITIONS AS eIF4E INHIBITORS AND USES THEREOF |
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US5792767A (en) | 1995-01-27 | 1998-08-11 | Abbott Laboratories | Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists |
ES2176697T3 (es) | 1996-03-11 | 2002-12-01 | Syngenta Participations Ag | Derivados pirimidin-4-ona como pesticidas. |
BR9917080A (pt) | 1998-12-23 | 2002-03-12 | Du Pont Pharm Co | Composto, composição farmacêutica, uso do composto e método de tratamento ou prevenção de uma disfunção tromboembólica |
DE60017157T2 (de) | 1999-09-16 | 2005-12-22 | Curis, Inc., Cambridge | Vermittler von igel signalwegen, deren zusammenstellungen und verwendungen |
KR20050049562A (ko) | 1999-10-27 | 2005-05-25 | 싸이토키네틱스, 인코포레이티드 | 퀴나졸리논을 사용하는 방법 및 조성물 |
US7230000B1 (en) * | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
KR100883184B1 (ko) | 2000-12-11 | 2009-02-12 | 암젠 인코포레이션 | Cxcr3 길항제 |
US6900214B2 (en) | 2001-03-29 | 2005-05-31 | Bristol-Myers Squibb Company | Cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
US6809102B2 (en) * | 2001-03-29 | 2004-10-26 | Bristol-Myers Squibb Company | Cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
JP2005506298A (ja) | 2001-03-29 | 2005-03-03 | ブリストル−マイヤーズ スクイブ カンパニー | Eg5阻害剤を用いる増殖性疾患の治療方法 |
AU2002305205A1 (en) | 2001-04-20 | 2002-11-05 | Jingrong Cao | 9-deazaguanine derivatives as inhibitors of gsk-3 |
WO2003039460A2 (en) | 2001-11-07 | 2003-05-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
AU2002346471A1 (en) * | 2001-11-20 | 2003-06-10 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
US7244723B2 (en) * | 2001-12-06 | 2007-07-17 | Merck & Co., Inc. | Substituted furopyrimidinones as a mitotic kinesin inhibitors |
US7262187B2 (en) * | 2001-12-06 | 2007-08-28 | Merck & Co., Inc. | Substituted oxazolo- and thizaolopyrimidinones as a mitotic kinesin inhibitor |
DE60232994D1 (de) * | 2001-12-06 | 2009-08-27 | Merck & Co Inc | Inhibitoren von mitotischem kinesin |
ATE424388T1 (de) | 2001-12-06 | 2009-03-15 | Merck & Co Inc | Mitotische kinesinhemmer |
JP4597519B2 (ja) | 2001-12-06 | 2010-12-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 有糸分裂キネシン阻害薬 |
CA2475879A1 (en) | 2002-02-15 | 2003-08-28 | Cytokinetics, Inc. | Synthesis of quinazolinones |
US6924376B2 (en) | 2002-04-17 | 2005-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
WO2003094839A2 (en) * | 2002-05-09 | 2003-11-20 | Cytokinetics, Inc. | Pyrimidinone compounds, compositions and methods |
EP1553931A4 (en) | 2002-05-09 | 2006-08-30 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
TW200407143A (en) | 2002-05-21 | 2004-05-16 | Bristol Myers Squibb Co | Pyrrolotriazinone compounds and their use to treat diseases |
EP1513820A4 (en) * | 2002-05-23 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
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WO2003099211A2 (en) | 2002-05-23 | 2003-12-04 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
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DE60326248D1 (de) * | 2002-07-17 | 2009-04-02 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen |
US7211580B2 (en) | 2002-07-23 | 2007-05-01 | Cytokinetics, Incorporated | Compounds, compositions, and methods |
JP2005536553A (ja) | 2002-08-21 | 2005-12-02 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
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US7557115B2 (en) | 2002-09-30 | 2009-07-07 | Cytokinetics, Inc. | Compounds, compositions, and methods |
EP1558589A4 (en) | 2002-10-11 | 2008-01-09 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
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JP2006515886A (ja) | 2003-01-17 | 2006-06-08 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、および方法 |
BRPI0408150A (pt) * | 2003-03-07 | 2006-03-21 | Astrazeneca Ab | composto, seu uso e processo para preparação do mesmo, métodos para tratamento ou profilaxia de cáncer e para produção de um efeito inibidor do ciclo celular (anti - proliferação celular) em um animal de sangue quente e composição farmacêutica |
WO2006018628A1 (en) * | 2003-03-07 | 2006-02-23 | Astrazeneca Ab | Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer |
JP2006523232A (ja) | 2003-04-10 | 2006-10-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、および方法 |
WO2004100873A2 (en) | 2003-05-07 | 2004-11-25 | Cytokinetics, Inc. | Compounds, compositions, and methods |
EP1622613A4 (en) | 2003-05-14 | 2008-04-02 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
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US7345046B2 (en) * | 2003-05-30 | 2008-03-18 | Chiron Corporation | Heteroaryl-fused pyrimidinyl compounds as anticancer agents |
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US20050165089A1 (en) * | 2003-10-06 | 2005-07-28 | Gustave Bergnes | Compounds, compositions and methods |
US20050148593A1 (en) * | 2003-11-07 | 2005-07-07 | Gustave Bergnes | Compounds, compositions, and methods |
US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
DK1689724T3 (da) | 2003-11-25 | 2012-02-27 | Novartis Ag | Quinazolinonforbindelser som anticancermidler |
WO2005061460A1 (en) | 2003-12-08 | 2005-07-07 | Cytokinetics, Inc. | Compounds, compositions, and methods |
US7501416B2 (en) * | 2004-02-06 | 2009-03-10 | Bristol-Myers Squibb Company | Quinoxaline compounds and methods of using them |
ATE419249T1 (de) | 2004-04-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Inhibitoren von mitotischem kinesin |
BRPI0511433A (pt) | 2004-05-21 | 2007-12-11 | Chiron Corp | derivados de quinolina substituìda como inibidores de cinesina mitótica |
MXPA06014909A (es) | 2004-06-18 | 2007-02-28 | Chiron Corp | Derivados de n-(1-(1-bencil -4-fenil-1h -imidazol -2-il)-2, 2-dimetilpropil) benzamida y compuestos relacionados como inhibidores de proteina de huso de cinesina (ksp) para el tratamiento del cancer. |
US20070249636A1 (en) | 2004-08-18 | 2007-10-25 | Astrazeneca Ab | Selected Fused Heterocyclics and Uses Thereof |
US20060041128A1 (en) * | 2004-08-18 | 2006-02-23 | Astrazeneca Ab | Selected fused heterocyclics and uses thereof |
RU2007118523A (ru) * | 2004-10-19 | 2008-11-27 | Новартис Вэксинс Энд Диагностикс Инк. (Us) | Производные индола и бензимидазола |
-
2005
- 2005-08-16 CA CA002575188A patent/CA2575188A1/en not_active Abandoned
- 2005-08-16 KR KR1020077006179A patent/KR20070046176A/ko not_active Application Discontinuation
- 2005-08-16 MY MYPI20053847A patent/MY141233A/en unknown
- 2005-08-16 US US11/573,683 patent/US20080293744A1/en not_active Abandoned
- 2005-08-16 RU RU2007109866/04A patent/RU2447077C2/ru not_active IP Right Cessation
- 2005-08-16 UY UY29070A patent/UY29070A1/es unknown
- 2005-08-16 JP JP2007526565A patent/JP2008509977A/ja active Pending
- 2005-08-16 AU AU2005273705A patent/AU2005273705B8/en not_active Ceased
- 2005-08-16 EP EP05771880A patent/EP1781674A1/en not_active Withdrawn
- 2005-08-16 CN CN2005800282914A patent/CN101027309B/zh not_active Expired - Fee Related
- 2005-08-16 BR BRPI0514390-0A patent/BRPI0514390A/pt not_active IP Right Cessation
- 2005-08-16 UA UAA200702661A patent/UA89201C2/ru unknown
- 2005-08-16 MX MX2007001953A patent/MX2007001953A/es active IP Right Grant
- 2005-08-17 SA SA5260258A patent/SA05260258B1/ar unknown
- 2005-08-18 US US11/207,128 patent/US7498333B2/en not_active Expired - Fee Related
- 2005-08-18 TW TW094128220A patent/TW200616977A/zh unknown
-
2007
- 2007-01-18 IL IL180810A patent/IL180810A0/en unknown
- 2007-02-06 ZA ZA200701082A patent/ZA200701082B/en unknown
- 2007-02-21 NO NO20071005A patent/NO20071005L/no not_active Application Discontinuation
-
2008
- 2008-12-22 US US12/340,855 patent/US20090099210A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SA05260258B1 (ar) | 2009-12-22 |
AU2005273705A1 (en) | 2006-02-23 |
EP1781674A1 (en) | 2007-05-09 |
RU2447077C2 (ru) | 2012-04-10 |
MY141233A (en) | 2010-03-31 |
US20090099210A1 (en) | 2009-04-16 |
UA89201C2 (ru) | 2010-01-11 |
US7498333B2 (en) | 2009-03-03 |
AU2005273705B8 (en) | 2010-01-28 |
US20060041129A1 (en) | 2006-02-23 |
IL180810A0 (en) | 2007-06-03 |
BRPI0514390A (pt) | 2008-06-10 |
TW200616977A (en) | 2006-06-01 |
CN101027309A (zh) | 2007-08-29 |
AU2005273705B2 (en) | 2009-12-10 |
UY29070A1 (es) | 2006-03-31 |
US20080293744A1 (en) | 2008-11-27 |
MX2007001953A (es) | 2007-05-09 |
KR20070046176A (ko) | 2007-05-02 |
ZA200701082B (en) | 2008-07-30 |
JP2008509977A (ja) | 2008-04-03 |
CA2575188A1 (en) | 2006-02-23 |
RU2007109866A (ru) | 2008-09-27 |
CN101027309B (zh) | 2010-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |