NO20070139L - Heterosykliske derivater for behandling av hyperlipidemi og relaterte sykdommer - Google Patents

Heterosykliske derivater for behandling av hyperlipidemi og relaterte sykdommer

Info

Publication number
NO20070139L
NO20070139L NO20070139A NO20070139A NO20070139L NO 20070139 L NO20070139 L NO 20070139L NO 20070139 A NO20070139 A NO 20070139A NO 20070139 A NO20070139 A NO 20070139A NO 20070139 L NO20070139 L NO 20070139L
Authority
NO
Norway
Prior art keywords
treatment
hyperlipidemia
related diseases
heterocyclic derivatives
hypercholesterolemia
Prior art date
Application number
NO20070139A
Other languages
English (en)
Inventor
Jagadish C Sircar
Richard J Thomas
Haripada Khatuya
Igor Nikoulin
Original Assignee
Avanir Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34981590&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20070139(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals
Publication of NO20070139L publication Critical patent/NO20070139L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Foreliggende oppfinnelse tilveiebringer preparater som er avpasset for å forbedre revers kolesteroltransport hos pattedyr. Preparatene er egnet for oral avlevering og er anvendelige ved behandling og/eller forebygging av hyperkolesterolemi, aterosklerose og relaterte kardiovaskulære sykdommer.
NO20070139A 2004-06-09 2007-01-08 Heterosykliske derivater for behandling av hyperlipidemi og relaterte sykdommer NO20070139L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57822704P 2004-06-09 2004-06-09
PCT/US2005/020660 WO2005123686A1 (en) 2004-06-09 2005-06-09 Heterocyclic derivatives for treatment of hyperlipidemia and related diseases

Publications (1)

Publication Number Publication Date
NO20070139L true NO20070139L (no) 2007-03-08

Family

ID=34981590

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070139A NO20070139L (no) 2004-06-09 2007-01-08 Heterosykliske derivater for behandling av hyperlipidemi og relaterte sykdommer

Country Status (18)

Country Link
US (1) US20060009487A1 (no)
EP (1) EP1753724A1 (no)
JP (1) JP2008502736A (no)
KR (1) KR20070026598A (no)
CN (1) CN1968928A (no)
AR (1) AR049216A1 (no)
AU (1) AU2005255011A1 (no)
BR (1) BRPI0511822A (no)
CA (1) CA2568394A1 (no)
IL (1) IL179210A0 (no)
MX (1) MXJL06000069A (no)
NO (1) NO20070139L (no)
PE (1) PE20050986A1 (no)
RU (1) RU2006145961A (no)
TW (1) TW200602042A (no)
UY (1) UY28953A1 (no)
WO (1) WO2005123686A1 (no)
ZA (1) ZA200700156B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243197B (en) * 2001-03-08 2005-11-11 Univ Hong Kong Organometallic light-emitting material
TW200603795A (en) * 2004-06-09 2006-02-01 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
EP1847531A4 (en) * 2005-02-09 2009-04-22 Takeda Pharmaceutical PYRAZOLE DERIVATIVE
GB0619611D0 (en) * 2006-10-04 2006-11-15 Ark Therapeutics Ltd Compounds and their use
DE102009036604A1 (de) 2009-07-30 2011-02-03 Aicuris Gmbh & Co. Kg Substituierte Bis-Arylpyrazolamide mit terminaler primärer Amidfunktionalisierung und ihre Verwendung
SG10201507846YA (en) 2010-04-02 2015-10-29 Senomyx Inc Sweet flavor modifier
MY179876A (en) 2011-08-12 2020-11-18 Firmenich Incorporated Sweet flavor modifier
CN103497151B (zh) * 2013-10-30 2015-07-15 山东铂源药业有限公司 一种4-氨基-6-甲基烟酸的合成方法
WO2016073251A1 (en) 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
CN106187887B (zh) * 2016-07-01 2018-08-14 上海工程技术大学 4-羟基喹啉-3-甲酸的制备方法
WO2018035246A1 (en) * 2016-08-16 2018-02-22 Uwm Research Foundation, Inc. Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma
CN108623561A (zh) * 2017-03-24 2018-10-09 中国海洋大学 一种制备哌尼诺酸化合物的方法
CN108456154A (zh) * 2018-04-13 2018-08-28 昆明理工大学 一种n-叔丁氧羰基烃基胍的制备方法
EA202191890A1 (ru) * 2019-01-18 2022-02-03 Астразенека Аб Ингибиторы pcsk9 и способы их применения
MX2021008533A (es) * 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
US3773946A (en) * 1969-09-02 1973-11-20 Parke Davis & Co Triglyceride-lowering compositions and methods
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
IL64542A0 (en) * 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
JPS60136512A (ja) * 1983-12-26 1985-07-20 Eisai Co Ltd 脂質代謝改善剤
DE3423166A1 (de) * 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
JPH10316641A (ja) * 1997-03-14 1998-12-02 Sankyo Co Ltd カルボン酸誘導体
AU8334298A (en) * 1997-07-15 1999-02-10 Novo Nordisk A/S Nociceptin analogues
US6004925A (en) * 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
BR0009520A (pt) * 1999-04-01 2002-06-11 Esperion Therapeutics Inc Composto, método para sintetizar o mesmo, composição, metódos para o tratramento ou prevenção, em um paciente, de doença cardiovascular, dislipidemia, dislipoproteinemia, distúrbio de metabolismo de glucose, doença de alzheimer, sìndrome x ou sìndrome metabólica, septicemia, distúrbio trombótico, distúrbio associado com receptor ativado por proliferador de peroxissoma, obesidade, pancreatite, hipertensão, doença renal, câncer, inflamação, impotência, para reduzir o teor de gordura de carne de gado bovino, e, para reduzir o teor de colesterol de ovos de aves
US6664230B1 (en) * 2000-08-24 2003-12-16 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
FR2820435B1 (fr) * 2001-02-05 2004-02-27 Genfit S A Procedes d'identification de composes modulant le transport inverse du cholesterol
US20040248950A1 (en) * 2001-08-24 2004-12-09 Natsuki Ishizuka Apo ai expression accelerating agent
US7429593B2 (en) * 2001-09-14 2008-09-30 Shionogi & Co., Ltd. Utilities of amide compounds
WO2004094471A2 (en) * 2003-04-22 2004-11-04 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia

Also Published As

Publication number Publication date
TW200602042A (en) 2006-01-16
KR20070026598A (ko) 2007-03-08
AU2005255011A1 (en) 2005-12-29
PE20050986A1 (es) 2006-02-03
WO2005123686A1 (en) 2005-12-29
CN1968928A (zh) 2007-05-23
BRPI0511822A (pt) 2007-12-26
RU2006145961A (ru) 2008-07-20
EP1753724A1 (en) 2007-02-21
UY28953A1 (es) 2006-01-31
US20060009487A1 (en) 2006-01-12
JP2008502736A (ja) 2008-01-31
CA2568394A1 (en) 2005-12-29
IL179210A0 (en) 2007-03-08
AR049216A1 (es) 2006-07-05
MXJL06000069A (es) 2007-04-10
ZA200700156B (en) 2008-05-28

Similar Documents

Publication Publication Date Title
NO20070139L (no) Heterosykliske derivater for behandling av hyperlipidemi og relaterte sykdommer
NO20055474L (no) Mediatorer av revers kolesteroltransport for behandling av hyperkolesterolemi
NO20090469L (no) Substituerte piperidiner som oker P53-aktiviteten, og anvendelse derav
NO20073105L (no) Pyridazinonforbindelser
NO20050795L (no) Forbindelser, blandinger og fremgangsmater for utnyttelse av samme
NO20051100L (no) Pyrazolsammensetninger anvendelige som GSK-3-inhibitorer
NO20053845L (no) Gyraseinhibitorer og anvendelser derav
NO20076412L (no) Heterosykliske inhibitorer av mek og fremgangsmater for anvendelse derav
NO20070049L (no) Pyrrolotriazinderivater anvendelig for behandling av hyperproliferative forstyrrelser og sykdommer assosiert med angiogenese
DK1789419T3 (da) Gyraseinhibitorer og anvendelser deraf
ATE447568T1 (de) Neue pyrinderivate
NO20084256L (no) DPP IV inhibitorformuleringer
EA200800834A1 (ru) Модуляторы метаболизма и лечение связанных с ним нарушений
EA200900613A1 (ru) Спирокетоновые ингибиторы ацетил-коа-карбоксилаз
NO20081878L (no) Diacylindazolderivater som lipase- og fosfolipaseinhibitorer
WO2006121861A3 (en) Biphenylazetidinone cholesterol absorption inhibitors
NO20072223L (no) Glykogenfosforylaseinhibitor forbindelser med farmsoytiske preparater av disse
NO20064347L (no) Substituerte 1,2,3,4-tetrahydroisokinolinderivater
NO20064732L (no) Alfa-aminoamidderivater nyttige i behandlingen av urolige bein-syndromet og additive lidelser
NO20075731L (no) Inhibitorer av mikrosomalt triglyceridtransferprotein og APO-B-sekresjon
UA97369C2 (ru) Противоопухолевые соединения дигидропиран-2-она и фармацевтическая композиция на их основе
NO20092073L (no) Modulatorer av C3A-reseptor, og fremgangsmater for anvendelse derav
NO20051844L (no) Piperazinderivater og fremgangsmate for anvendelse derav.
EP1750703A4 (en) METHOD FOR REDUCING GASTROINTESTINAL TOXICITY BY ADMINISTRATION OF TEGAFUR
NO20076191L (no) Magnesiumsalter av HMG-COA reduktaseinhibitorer

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application